SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer

Cancer Medicine

Volumn 3, Issue 6, 2014, Pages 1553-1561

  Noguchi, Akira ^a   Kikuchi, Keiji ^a   Zheng, Huachuan ^b   Takahashi, Hiroyuki ^c   Miyagi, Yohei ^a   Aoki, Ichiro ^d   Takano, Yasuo ^a  

^a KANAGAWA CANCER CENTER   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Cancer progression; Gastric cancer; P53 independency; Prognostic indicator; SIRT1 expression

Indexed keywords

DBC1 PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; SIRTUIN 1; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; BIOSYNTHESIS; DISEASE COURSE; ENZYMOLOGY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PROGNOSIS; STOMACH TUMOR; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SIRTUIN 1; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84990875187     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.310     Document Type: Article

References (32)

1. Shepherd, N. A., B. F. Warren, G. T. Williams, J. K. Grenson, G. Y. Lauwers, and M. R. Novelli, eds. 2013. Pp. 202-205 in Morson and dawson's gastrointestinal pathology, 5th ed. Wiley-Blackwell, Oxford, UK.
2. Whittle, J. R., M. J. Powell, V. M. Popov, L. A. Shirley, C. Wang, and R. G. Pestell. 2007. Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation. Trends Endocrinol. Metab. 18:356-364.
3. Longo, V. D., and B. K. Kennedy. 2006. Sirtuins in aging and age-related disease. Cell 126:257-268.
4. Ota, H., E. Tokunaga, K. Chang, M. Hikasa, K. Iijima, M. Eto, et al. 2006. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated ras-MAPK signaling in human cancer cells. Oncogene 25:176-185.
5. Saunders, L. R., and E. Verdin. 2007. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26:5489-5504.
6. Pruitt, K., R. L. Zinn, J. E. Ohm, K. M. McGarvey, S. H. L. Kang, D. N. Watkins, et al. 2006. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet. 2:e40.
7. Wang, R. H., K. Sengupta, C. Li, H. S. Kim, L. Cao, C. Xiao, et al. 2008. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14:312-323.
8. Firestein, R., G. Blander, S. Michan, P. Oberdoerffer, S. Ogino, J. Campbell, et al. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3:e2020.
9. Liu, T., P. Y. Liu, and G. M. Marchall. 2009. The critical role of the class III histone deacetylase SRT1 in cancer. Cancer Res. 69:1702-1705.
10. Hamaguchi, M., J. L. Meth, C. von Klitzing, W. Wei, D. Esposito, L. Rodgers, et al. 2002. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc. Natl. Acad. Sci. USA 99:13647-13652.
11. Sundararajan, R., G. Chen, C. Mukherjee, and E. White. 2005. Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene 24:4908-4920.
12. Zhao, W., J. P. Kruse, Y. Tang, S. Y. Jung, J. Qin, and W. Gu. 2008. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451:587-590.
13. Kim, J. E., J. Chen, and Z. Lou. 2008. DBC1 is a negative regulator of SIRT1. Nature 451:583-586.
14. Lee, H., K. R. Kim, S. J. Noh, H. S. Park, K. S. Kwon, B. H. Park, et al. 2011. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma. Hum. Pathol. 42:204-213.
15. Cha, E. J., S. J. Noh, K. S. Kwon, C. Y. Kim, B. H. Park, H. S. Park, et al. 2009. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin. Cancer Res. 15:4453-4459.
16. Vaquero, A., M. Scher, H. Erdjument-Bromage, P. Tempst, L. Serrano, and D. Reinberg. 2007. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450:440-444.
17. Murayama, A., K. Ohmori, A. Fujimura, H. Minami, K. Yasuzawa-Tanaka, T. Kuroda, et al. 2008. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133:627-639.
18. Calestagne-Morelli, A., and J. Ausió. 2006. Long-range histone acetylation: biological significance, structural implications, and mechanisms. Biochem. Cell Biol. 84:518-527.
19. Vaquero, A., R. Sternglanz, and D. Reinberg. 2007. NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 26:5505-5520.
20. Bosch-Presegue, L., and A. Vaquero. 2011. The dual role of sirtuins in cancer. Genes Cancer 2:648-662.
21. Knight, J. R., and J. Milner. 2012. SIRT1, metabolism and cancer. Curr. Opin. Oncol. 24:68-75.
22. Bosman, F. T., F. Carneiro, R. H. Hruban, and N. D. Theise, eds. 2009. Pp. 45-79 in WHO classification of tumors of the digestive systems. IARC, Lyon.
23. Sobin, L., M. Gospodarowics, and C. Wittekind, eds. 2009. Pp. 22-62 in TNM classification of malignant tumors, 7th ed. Wiley-Liss, New York, NY.
24. Zheng, H. C., P. Xia, and X. Y. Xu. 2011. The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas. Hum. Pathol. 42:424-433.
25. Feng, A. N., L. H. Zhang, X. S. Fan, Q. Huang, Q. Ye, H. Y. Wu, et al. 2011. Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance. Int. J. Surg. Pathol. 19:743-750.
26. Deng, C. X. 2009. SIRT1, is it a tumor promoter or tumor suppressor? Int. J. Biol. Sci. 5:147-152.
27. Brooks, C. L., and W. Gu. 2009. How does SIRT1 affect metabolism, senescence and cancer? Nat. Rev. Cancer 9:123-128.
28. Noguchi, A., X. Li, A. Kubota, K. Kikuchi, Y. Kameda, H. Zheng, et al. 2013. SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 115:385-392.
29. Kang, Y., W. Y. Jung, H. Lee, E. Lee, A. Kim, B. H. Kim. 2012. Expression of SIRT1 and DBC1 in gastric adenocarcinoma. Korean J. Pathol. 46:523-531.
30. Kikuchi, K., A. Noguchi, H. Takahashi, H. Zheng, Y. Kameda, H. Sekiguchi, et al. 2013. High SIRT1 expression and low DBC1 expression are associated with poor prognosis in colorectal cancer. J. Cancer Ther. Res. 2:1-8.
31. Hiraike, H., O. Wada-Hiraike, S. Nakagawa, S. Koyama, Y. Miyamoto, K. Sone, et al. 2010. Identification of DBC1 as a transcriptional repressor for BRCA1. Br. J. Cancer 102:1061-1067.
32. Kim, J., Z. Lou, and J. Chen. 2009. Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells. Cell Cycle 8:3784-3785.