The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer

PLoS Genetics

Volumn 12, Issue 9, 2016, Pages

  Ha, Ngoc Han ^a   Long, Jirong ^b   Cai, Qiuyin ^b   Shu, Xiao Ou ^b   Hunter, Kent W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; ESTROGEN RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNTL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARNTL2 GENE; ARTICLE; BACKCROSSING; BREAST CANCER; CANCER GROWTH; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CIRCADIAN RHYTHM; CONTROLLED STUDY; CRISPR CAS SYSTEM; DISEASE FREE SURVIVAL; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; FEMALE; FVB/N MOUSE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; METASTASIS POTENTIAL; METASTATIC BREAST CANCER; MOLF EIJ MOUSE; MOUSE; MOUSE STRAIN; NONHUMAN; PREDICTION; PROMOTER REGION; QUANTITATIVE TRAIT LOCUS; REPRODUCIBILITY; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN IDENTIFICATION; TRANSCRIPTION REGULATION; TUMOR GENE;

EID: 84990217901     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006267     Document Type: Article

References (39)

1. Surveillance Epidemiology, and Results End (SEER) Program 2016 [cited 2016]. Available from: http://seer.cancer.gov/statfacts/html/breast.html.
2. Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, et al. Breast cancer metastasis: challenges and opportunities. Cancer Res. 2009;69(12):4951–3. doi: 10.1158/0008-5472.CAN-09-009919470768.
3. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61–70. Epub 2012/09/25. doi: 10.1038/nature1141223000897; PubMed Central PMCID: PMC3465532.
4. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871):530–6. Epub 2002/02/02. doi: 10.1038/415530a11823860.
5. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, et al. A gene-expression signature as a predictor of survival in breast cancer. The New England journal of medicine. 2002;347(25):1999–2009. Epub 2002/12/20. doi: 10.1056/NEJMoa02196712490681.
6. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747–52. 10963602.
7. Guy CT, Cardiff R.D., Muller W.J, Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. MCB. 1992;12:954–61. 1312220
8. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, et al. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013;14(11):R125. Epub 2013/11/14. doi: 10.1186/gb-2013-14-11-r12524220145.
9. Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8(5):R76. Epub 2007/05/12. gb-2007-8-5-r76 [pii] doi: 10.1186/gb-2007-8-5-r7617493263.
10. Faraji F, Pang Y, Walker RC, Nieves Borges R, Yang L, Hunter KW, Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. PLoS Genet. 2012;8(9):e1002926. Epub 2012/10/03. doi: 10.1371/journal.pgen.100292623028344; PubMed Central PMCID: PMC3447942.
11. Faraji F, Hu Y, Wu G, Goldberger NE, Walker RC, Zhang J, et al. An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease. Genome research. 2014;24(2):227–40. Epub 2013/12/11. doi: 10.1101/gr.166223.11324322557; PubMed Central PMCID: PMC3912413.
12. Hsieh SM, Look MP, Sieuwerts AM, Foekens JA, Hunter KW, Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. Breast Cancer Res. 2009;11(5):R75. Epub 2009/10/15. doi: 10.1186/bcr241219825179; PubMed Central PMCID: PMC2790856.
13. Hu Y, Bai L, Geiger T, Goldberger N, Walker RC, Green JE, et al. Genetic background may contribute to PAM50 gene expression breast cancer subtype assignments. PLoS One. 2013;8(8):e72287. Epub 2013/09/10. doi: 10.1371/journal.pone.007228724015230; PubMed Central PMCID: PMC3756056.
14. Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, et al. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer. 1998;77(4):640–4. Epub 1998/07/29. 9679770.
15. Smith R, Sheppard K, DiPetrillo K, Churchill G, Quantitative trait locus analysis using J/qtl. Methods Mol Biol. 2009;573:175–88. doi: 10.1007/978-1-60761-247-6_1019763928.
16. Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009;106(23):9362–7. Epub 2009/05/29. doi: 10.1073/pnas.090310310619474294; PubMed Central PMCID: PMC2687147.
17. Testa G, Schaft J, van der Hoeven F, Glaser S, Anastassiadis K, Zhang Y, et al. A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles. Genesis. 2004;38(3):151–8. doi: 10.1002/gene.2001215048813.
18. Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet. 2005;37(10):1055–62. Epub 2005/09/06. doi: 10.1038/ng163516142231; PubMed Central PMCID: PMC2140048.
19. Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, et al. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A. 2008;105(17):6380–5. Epub 2008/04/23. 0710331105 [pii] doi: 10.1073/pnas.071033110518427120.
20. Goldberger N, Walker RC, Kim CH, Winter S, Hunter KW, Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b. Cancer research. 2013;73(8):2671–81. Epub 2013/03/01. doi: 10.1158/0008-5472.CAN-12-351323447578; PubMed Central PMCID: PMC3630248.
21. Winter SF, Lukes L, Walker RC, Welch DR, Hunter KW, Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis. PLoS Genet. 2012;8(5):e1002735. Epub 2012/06/14. doi: 10.1371/journal.pgen.100273522693453; PubMed Central PMCID: PMC3364935.
22. Consortium EPAn integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57–74. doi: 10.1038/nature1124722955616; PubMed Central PMCID: PMCPMC3439153.
23. Krishnakumar R, Gamble MJ, Frizzell KM, Berrocal JG, Kininis M, Kraus WL, Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science. 2008;319(5864):819–21. doi: 10.1126/science.114925018258916.
24. Zhao H, Sifakis EG, Sumida N, Millan-Arino L, Scholz BA, Svensson JP, et al. PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription. Molecular cell. 2015;59(6):984–97. doi: 10.1016/j.molcel.2015.07.01926321255.
25. Stracke ML, Liotta LA, Multi-step cascade of tumor cell metastasis. In Vivo. 1992;6(4):309–16. 1325842
26. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438(7069):820–7. Epub 2005/12/13. nature04186 [pii] doi: 10.1038/nature0418616341007.
27. Hunter KW, Host genetics and tumour metastasis. Br J Cancer. 2004;90(4):752–5. 14970848.
28. He C, Anand ST, Ebell MH, Vena JE, Robb SW, Circadian disrupting exposures and breast cancer risk: a meta-analysis. International archives of occupational and environmental health. 2015;88(5):533–47. doi: 10.1007/s00420-014-0986-x25261318.
29. Zienolddiny S, Haugen A, Lie JA, Kjuus H, Anmarkrud KH, Kjaerheim K, Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts. Breast cancer research: BCR. 2013;15(4):R53. doi: 10.1186/bcr344523822714; PubMed Central PMCID: PMCPMC3978690.
30. Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, et al. Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 2014;13(20):3282–91. doi: 10.4161/15384101.2014.95445425485508; PubMed Central PMCID: PMCPMC4613905.
31. Alsarraj J, Faraji F, Geiger TR, Mattaini KR, Williams M, Wu J, et al. BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PloS one. 2013;8(11):e80746. Epub 2013/11/22. doi: 10.1371/journal.pone.008074624260471; PubMed Central PMCID: PMC3834312.
32. Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, et al. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet. 2007;3(11):e214. Epub 2007/12/18. doi: 10.1371/journal.pgen.003021418081427; PubMed Central PMCID: PMC2098807.
33. Brady JJ, Chuang CH, Greenside PG, Rogers ZN, Murray CW, Caswell DR, et al. An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer cell. 2016;29(5):697–710. doi: 10.1016/j.ccell.2016.03.00327150038; PubMed Central PMCID: PMCPMC4864124.
34. Morel L, Blenman KR, Croker BP, Wakeland EK, The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A. 2001;98(4):1787–92. 11172029.
35. Bai L, Yang HH, Hu Y, Shukla A, Ha NH, Doran A, et al. An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes. PLoS Genet. 2016;12(4):e1005989. doi: 10.1371/journal.pgen.100598927074153; PubMed Central PMCID: PMCPMC4830524.
36. Deng WG, Zhu Y, Montero A, Wu KK, Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin-agarose pulldown assay. Analytical biochemistry. 2003;323(1):12–8. 14622953.
37. Long J, Shu XO, Cai Q, Gao YT, Zheng Y, Li G, et al. Evaluation of breast cancer susceptibility loci in Chinese women. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(9):2357–65. doi: 10.1158/1055-9965.EPI-10-005420699374; PubMed Central PMCID: PMCPMC2936687.
38. Shu XO, Zheng Y, Cai H, Gu K, Chen Z, Zheng W, et al. Soy food intake and breast cancer survival. JAMA: the journal of the American Medical Association. 2009;302(22):2437–43. doi: 10.1001/jama.2009.178319996398; PubMed Central PMCID: PMCPMC2874068.
39. Shu XO, Long J, Lu W, Li C, Chen WY, Delahanty R, et al. Novel genetic markers of breast cancer survival identified by a genome-wide association study. Cancer research. 2012;72(5):1182–9. doi: 10.1158/0008-5472.CAN-11-256122232737; PubMed Central PMCID: PMCPMC3294129.