Novel genetic markers of breast cancer survival identified by a genome-wide association study

Cancer Research

Volumn 72, Issue 5, 2012, Pages 1182-1189

  Shu, Xiao Ou ^a   Long, Jirong ^a   Lu, Wei ^c   Li, Chun ^b   Chen, Wendy Y ^e,f   Delahanty, Ryan ^a   Cheng, Jiarong ^d   Cai, Hui ^a   Zheng, Ying ^c   Shi, Jiajun ^a   Gu, Kai ^c   Wang, Wen Jing ^c   Kraft, Peter ^g   Gao, Yu Tang ^d   Cai, Qiuyin ^a   Zheng, Wei ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Shanghai Municipal Center for Disease Control and Prevention   (China)

^d SHANGHAI CANCER INSTITUTE   (China)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER MORTALITY; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHINESE; CHROMOSOME 14; CHROMOSOME 16; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; ONCOGENE; POLYMORPHIC LOCUS; PRIORITY JOURNAL; RAD51L1 GENE; RECURRENT CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 16; DNA-BINDING PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84863262523     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-2561     Document Type: Article

References (39)

1. Shu XO, Gao YT, Cai Q, Pierce L, Cai H, Ruan ZX, et al. Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study. Cancer Res 2004;64:836-9. (Pubitemid 38176881)
2. Lu H, Shu XO, Cui Y, Kataoka N, Wen W, Cai Q, et al. Association of genetic polymorphisms in the VEGF gene with breast cancer survival. Cancer Res 2005;65:5015-9. (Pubitemid 40827307)
3. Shu XO, Moore DB, Cai Q, Cheng J, Wen W, Pierce L, et al. Association of cyclin D1 genotype with breast cancer risk and survival. Cancer Epidemiol Biomarkers Prev 2005;14:91-7. (Pubitemid 40165288)
4. Zhang X, Shu XO, Cai Q, Ruan Z, Gao YT, Zheng W. Functional plasminogen activator inhibitor-1 gene variants and breast cancer survival. Clin Cancer Res 2006;12:6037-42. (Pubitemid 44703766)
5. Beeghly-Fadiel A, Shu XO, Long J, Li C, Cai Q, Cai H, et al. Genetic polymorphisms in the MMP-7 gene and breast cancer survival. Int J Cancer 2009;124:208-14.
6. Chappuis PO, Kapusta L, Begin LR, Wong N, Brunet JS, Narod SA, et al. Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer. J Clin Oncol 2000;18:4045-52. (Pubitemid 32038396)
7. Kriege M, Seynaeve C, Meijers-Heijboer H, Collee JM, Menke-Pluymers MB, Bartels CC, et al. Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 2009;27:3764-71.
8. Xu Y, Yao L, Ouyang T, Li J, Wang T, Fan Z, et al. p53 Codon 72 polymorphism predicts the pathologic response to neoadjuvant chemotherapy in patients with breast cancer. Clin Cancer Res 2005;11:7328-33. (Pubitemid 41507691)
9. Fagerholm R, Hofstetter B, Tommiska J, Aaltonen K, Vrtel R, Syrjakoski K, et al. NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet 2008;40:844-53. (Pubitemid 351913646)
10. Hoskins JM, Carey LA, McLeod HL. CYP2D6 and tamoxifen: DNA matters in breast cancer. Nat Rev Cancer 2009;9:576-86.
11. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007;447:1087-93.
12. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 2007;39:870-4. (Pubitemid 47014500)
13. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, et al. Commonvariants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 2007;39:865-9. (Pubitemid 47014497)
14. Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB, et al. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 2009;41:324-8.
15. Long J, Cai Q, Shu XO, Qu S, Li C, Zheng Y, et al. Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet 2010;6: e1001002.
16. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG, et al. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 2009;41:579-84.
17. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, Maranian M, et al. Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 2010;42:504-7.
18. Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 2010; 42:885-92.
19. Azzato EM, Tyrer J, Fasching PA, Beckmann MW, Ekici AB, Schulz-Wendtland R, et al. Association between a germline OCA2 polymorphism at chromosome15q13.1 and estrogen receptor-negative breast cancer survival. J Natl Cancer Inst 2010;102:650-62.
20. Azzato EM, Pharoah PD, Harrington P, Easton DF, Greenberg D, Caporaso NE, et al. A genome-wide association study of prognosis in breast cancer. Cancer Epidemiol Biomarkers Prev 2010;19:1140-3.
21. Shu XO, Zheng Y, Cai H, Gu K, Chen Z, Zheng W, et al. Soy food intake and breast cancer survival. JAMA 2009;302:2437-43.
22. Zheng W, Chow WH, Yang G, Jin F, Rothman N, Blair A, et al. The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol 2005;162:1123-31. (Pubitemid 41746625)
23. Chen X, Lu W, Zheng Y, Gu K, Chen Z, Zheng W, et al. Exercise, tea consumption, and depression among breast cancer survivors. J Clin Oncol 2010;28:991-8.
24. Epplein M, Zheng Y, Zheng W, Chen Z, Gu K, Penson D, et al. Quality of life after breast cancer diagnosis and survival. J Clin Oncol 2011;29:406-12.
25. Purcell S. PLINK. Available from: http://pngu.mgh.harvard.edu/~purcell/ plink/. Accessed: July 2011.
26. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81: 559-75. (Pubitemid 47330214)
27. Thacker J. The RAD51 gene family, genetic instability and cancer. Cancer Lett 2005;219:125-35. (Pubitemid 40269475)
28. Yoo S, McKee BD. Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis. Chromosoma 2004;113:92-101. (Pubitemid 39302466)
29. Takaku M, Machida S, Hosoya N, Nakayama S, Takizawa Y, Sakane I, et al. Recombination activator function of the novel R. J Biol Chem 2009;284:14326-36.
30. Cox N, Nicolae DL, Dolan ME, Gamazon ER. SCAN: SNP and CNV Annotation Database. Available from: http://www.scandb.org/newinterface/about.html. Accesssed: July 2011.
31. Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, Nicolae DL, et al. SCAN: SNP and copy number annotation. Bioinformatics 2010;26:259.
32. Jia T, Liu YE, Liu J, Shi YE. Stimulation of breast cancer invasion and metastasis by synuclein gamma. Cancer Res 1999;59:742-7. (Pubitemid 29076076)
33. Wu K, Weng Z, Tao Q, Lin G, Wu X, Qian H, et al. Stage-specific expression of breast cancer-specific gene gamma-synuclein. Cancer Epidemiol Biomarkers Prev 2003;12:920-5. (Pubitemid 37151530)
34. Liu J, Spence MJ, Zhang YL, Jiang Y, Liu YE, Shi YE. Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M. Breast Cancer Res Treat 2000;62:99-107.
35. Singh H, Sekinger EA, Gross DS. Chromatin and cancer: causes and consequences. J Cell Biochem Suppl 2000;Suppl 35:61-8.
36. Tanaka K, Tsurumi C. The 26S proteasome: subunits and functions. Mol Biol Rep 1997;24:3-11. (Pubitemid 27269419)
37. Luqmani YA, Al AA, Al BM, Abraham G, El ZM. Modification of gene expression induced by siRNA targeting of estrogen receptor alpha in MCF7 human breast cancer cells. Int J Oncol 2009;34:231-42.
38. Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433-43. (Pubitemid 34449723)
39. Zheng W, Wen W, Gao YT, Shyr Y, Zheng Y, Long J, et al. Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women. J Natl Cancer Inst 2010; 102:972-81.