Hypoglycemic and hypolipidemic effects of Lactobacillus fermentum, fruit extracts of Syzygium cumini and Momordica charantia on diabetes induced mice

Pakistan Journal of Pharmaceutical Sciences

Volumn 29, Issue 5, 2016, Pages 1535-1540

  Yousaf, Sehar ^a   Hussain, Abid ^a   Rehman, Shafiq Ur ^a   Aslam, Muhammad Shahbaz ^a   Abbas, Zaigham ^a  

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Bitter gourd; Diabetes; Jamun; M. charantia; Natural diabetes therapy; Probiotics; Syzygiumcumini

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MOMORDICA CHARANTIA EXTRACT; PROBIOTIC AGENT; SYZYGIUM CUMINI EXTRACT; YOGHURT; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; LIPID; PLANT EXTRACT; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFICACY; DRUG ISOLATION; DRUG SCREENING; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPOLIPIDEMIC ACTIVITY; LACTOBACILLUS FERMENTUM; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MONOTHERAPY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; WEIGHT CHANGE; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; FRUIT; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; MICROBIOLOGY; MOMORDICA CHARANTIA; PHYSIOLOGY; PHYTOTHERAPY; SYZYGIUM;

ANIMALS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FRUIT; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LACTOBACILLUS FERMENTUM; LIPIDS; MICE; MOMORDICA CHARANTIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROBIOTICS; STREPTOZOCIN; SYZYGIUM;

EID: 84989902480     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ahmed I, Adeghate E, Sharma A, Pallot D and Singh J (1998). Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocindiabetic rat. Diabetes Res. Clin. Pract., 40: 145-151.
2. Ali S and Tariq A (2013). Analysis of secondary metabolites in callus cultures of Momordica charantia cv. Jaunpuri. Biological Society of Pakistan, 59: 23-32.
3. Chen Q, Chan LL and Li ET (2003). Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. The Journal of Nutrition, 133: 1088-1093.
4. Collaboration ERF (2010). Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. The Lancet, 375: 2215-2222.
5. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M and Mofid V (2012).Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition, 28: 539-543.
6. FAO/WHO (2002). Guidelines for the evaluation of probiotics in food. London, Ontario, Canada FAO/WHO Working Group Report. 1-11.
7. Fernandes NP, Lagishetty CV, Panda VS and Naik SR (2007). An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement.Altern. Med., 7: 29.
8. Garau C, Singh J and Cummings E (2003). Beneficial effect and mechanism of action of Momordica charantia in the treatment of diabetes mellitus: A mini review. Int. J. Diabetes, 11: 46-55.
9. Grover J, Vats V and Rathi S (2000). Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J. Ethnopharmacol., 73: 461-470.
10. Helland MH, Wicklund T and Narvhus JA (2004).Growth and metabolism of selected strains of probiotic bacteria in milk-and water-based cereal puddings. Int.Dairy J., 14: 957-965.
11. Hussain K, Nisar MF, Majeed A, Nawaz K and Bhatti KH (2010). Ethnomedicinal survey for important plants of Jalalpur Jattan, District Gujrat, Punjab, Pakistan.Ethnobotanical Leaflets, 11: 111-117.
12. Jayasooriya AP, Sakono M, Yukizaki C, Kawano M, Yamamoto K and Fukuda N (2000). Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J.Ethnopharmacol., 72: 331-6.
13. Karim A, Nouman M, Munir S and Sattar S (2011).Pharmacology and Phytochemistry of Pakistani herbs and herbal drugs used for treatment of diabetes.International Journal of Pharmacology, 7: 419-439.
14. Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EGT, Swapna S, Ramesh B and Rao CA (2010). Antihyperglycemic and antihyperlipidemic activities of methanol: water (4: 1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem.Toxicol., 48: 1078-1084.
15. Krauss RM (2004). Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care, 27: 1496-1504.
16. Lo HY, Ho TY, Lin C, Li CC and Hsiang CY (2013).Momordica charantia and its novel polypeptide regulate glucose homeostasis in mice via binding to insulin receptor. J. Agric. Food Chem., 61: 2461-2468.
17. Lye HS, Kuan CY, Ewe JA, Fung WY and Liong MT (2009). The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. International Journal of Molecular Sciences, 10: 3755-3775.
18. Pereira DI, Mccartney AL and Gibson GR (2003). An in vitro study of the probiotic potential of a bile-salthydrolyzing Lactobacillus fermentum strain, and determination of its cholesterol-lowering properties.Appl Environ Microbiol, 69: 4743-4752.
19. Qureshi R, Maqsood M, Arshad M and Chaudhry AK (2011). Ethnomedicinal uses of plants by the people of Kadhi Areas of Khushab, Punjab, Pakistan. Pak. J.Bot., 43: 121-133.
20. Saeed M, Shahzadi I, Ahmad I, Ahmad R, Shahzad K, Ashraf M and Nisa V (2010). Nutritional analysis and antioxidant activity of bitter gourd (Momordica charantia) from Pakistan. Pharmacologyonline, 1: 252-260.
21. Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, Placido J and Zito SW (2008). Alphaglucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto- Kakizaki (GK) rats. Carbohydr. Res., 343: 1278-1281.
22. Shukia R, Sharma, S, Puri D, Prabhu, K and Murthy P (2000). Medicinal plants for treatment of diabetes mellitus. Indian J. Clin. Biochem., 15: 169-177.
23. Steven D. and Ehrlich N (2012). Solutions Acupuncture: A private practice specializing in complementary and alternative medicine. Diabetes [Online]. Available: http://umm.edu/health/medical/altmed/condition/diabet es [Accessed 13-04 2014].
24. Tannock GW (1999). Identification of lactobacilli and bifidobacteria. Curr. Issues Mol. Biol., 1: 53-64.
25. Whiting DR, Guariguata L, Weil C and Shaw J (2011).IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin.Pract., 94: 311-321.
26. Yavuzdurmaz H (2007). Isolation, characterization, determination of probiotic properties of lactic acid bacteria from human milk. M. Sc. Thesis, The graduate School of Engineering and Sciences of Izmir Institute of Technology, pp.1-69.