-
1
-
-
84989840753
-
Fact Sheet on Pancreatic Cancer
-
Cancer Association of South Africa (CANSA)
-
[1] Herbst, M.C., Fact Sheet on Pancreatic Cancer. 2015, Cancer Association of South Africa (CANSA), 1–20.
-
(2015)
, pp. 1-20
-
-
Herbst, M.C.1
-
2
-
-
0035165047
-
Gemcitabine: progress in treatment of pancreatic cancer
-
[2] Heinemann, V., Gemcitabine: progress in treatment of pancreatic cancer. Oncology 60 (2001), 8–18.
-
(2001)
Oncology
, vol.60
, pp. 8-18
-
-
Heinemann, V.1
-
3
-
-
84922819295
-
Addressing the challenges of pancreatic cancer: future directions for improving outcomes
-
[3] Hidalgo, M., Cascinu, S., Kleeff, J., Labianca, R., Löhr, J.M., Neoptolemos, J., Real, F.X., Van Laethem, J., Heinemann, V., Addressing the challenges of pancreatic cancer: future directions for improving outcomes. Pancreatology 15 (2015), 8–18.
-
(2015)
Pancreatology
, vol.15
, pp. 8-18
-
-
Hidalgo, M.1
Cascinu, S.2
Kleeff, J.3
Labianca, R.4
Löhr, J.M.5
Neoptolemos, J.6
Real, F.X.7
Van Laethem, J.8
Heinemann, V.9
-
4
-
-
84942848613
-
Pancreatic cancer
-
[4] Pai, M., Spalding, D., Pancreatic cancer. Medicine, 2015, 10.1016/j.mped.2015.03.001.
-
(2015)
Medicine
-
-
Pai, M.1
Spalding, D.2
-
5
-
-
84978138206
-
Pancreatic cancer stromal biology and therapy
-
[5] Xie, D., Xie, K., Pancreatic cancer stromal biology and therapy. Genes Dis., 2015, 10.1016/j.gendis.201501.002.
-
(2015)
Genes Dis.
-
-
Xie, D.1
Xie, K.2
-
6
-
-
84879532730
-
Pancreatic cancer: slow progression in the early stages
-
[6] Nakamura, T., Masuda, K., Harada, S., Akioka, K., Sako, H., Pancreatic cancer: slow progression in the early stages. Int. J. Surg. Case Rep. 4 (2013), 693–696.
-
(2013)
Int. J. Surg. Case Rep.
, vol.4
, pp. 693-696
-
-
Nakamura, T.1
Masuda, K.2
Harada, S.3
Akioka, K.4
Sako, H.5
-
7
-
-
67649993396
-
Future of cancer incidence in the United States: burdens upon an aging changing nation
-
[7] Smith, B.D., Smith, G.L., Hurria, A., Hortobagyi, G.N., Buchholz, T.A., Future of cancer incidence in the United States: burdens upon an aging changing nation. J. Clin. Oncol. 27 (2009), 2758–2765.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2758-2765
-
-
Smith, B.D.1
Smith, G.L.2
Hurria, A.3
Hortobagyi, G.N.4
Buchholz, T.A.5
-
8
-
-
84893160891
-
β-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: an update
-
[8] Tranoy-Opalinsky, I., Legigan, T., Barat, R., Clarhaut, J., Thomas, M., Renoux, B., Papot, S., β-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: an update. Eur. J. Med. Chem. 74 (2014), 302–313.
-
(2014)
Eur. J. Med. Chem.
, vol.74
, pp. 302-313
-
-
Tranoy-Opalinsky, I.1
Legigan, T.2
Barat, R.3
Clarhaut, J.4
Thomas, M.5
Renoux, B.6
Papot, S.7
-
9
-
-
40149088986
-
Prodrugs: design and clinical applications
-
[9] Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D., Järvinen, T., Savolainen, J., Prodrugs: design and clinical applications. Nat. Rev. Drug Discov. 7 (2008), 255–270.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 255-270
-
-
Rautio, J.1
Kumpulainen, H.2
Heimbach, T.3
Oliyai, R.4
Oh, D.5
Järvinen, T.6
Savolainen, J.7
-
10
-
-
84860387932
-
Enzyme-mediated hydrolytic activation of prodrugs
-
[10] Yang, Y., Aloysius, H., Inoyama, D., Chen, Y., Hu, L., Enzyme-mediated hydrolytic activation of prodrugs. Acta Pharm. Sin. B 1 (2011), 143–159.
-
(2011)
Acta Pharm. Sin. B
, vol.1
, pp. 143-159
-
-
Yang, Y.1
Aloysius, H.2
Inoyama, D.3
Chen, Y.4
Hu, L.5
-
11
-
-
0036620226
-
Emerging biological therapies for pancreatic carcinoma
-
[11] Gilliam, A.D., Watson, S.A., Emerging biological therapies for pancreatic carcinoma. Eur. J. Surg. Oncol. 28 (2002), 370–378.
-
(2002)
Eur. J. Surg. Oncol.
, vol.28
, pp. 370-378
-
-
Gilliam, A.D.1
Watson, S.A.2
-
12
-
-
0027468015
-
Use of guanidine hydrochloride and ammonium sulfate in comprehensive in-line sorption enrichment of xenobiotics in biological fluids by high performance liquid chromatography
-
[12] Kruger, P.B., Albrecht, C.F., Van Jaarsveld, P.P., Use of guanidine hydrochloride and ammonium sulfate in comprehensive in-line sorption enrichment of xenobiotics in biological fluids by high performance liquid chromatography. J. Chromatogr. 612 (1993), 191–198.
-
(1993)
J. Chromatogr.
, vol.612
, pp. 191-198
-
-
Kruger, P.B.1
Albrecht, C.F.2
Van Jaarsveld, P.P.3
-
13
-
-
0027942466
-
Studies on hypoxoside and rooperol analogues from Hypoxis rooperi and Hypoxis latifolia and their biotransformation in man by using high-performance liquid chromatography with in-line sorption enrichment and diode-array detection
-
[13] Kruger, P.B., Albrecht, C.F., Liebenberg, R.W., Van Jaarsveld, P.P., Studies on hypoxoside and rooperol analogues from Hypoxis rooperi and Hypoxis latifolia and their biotransformation in man by using high-performance liquid chromatography with in-line sorption enrichment and diode-array detection. J. Chromatogr. 662 (1994), 71–78.
-
(1994)
J. Chromatogr.
, vol.662
, pp. 71-78
-
-
Kruger, P.B.1
Albrecht, C.F.2
Liebenberg, R.W.3
Van Jaarsveld, P.P.4
-
14
-
-
0002425328
-
MTT-cell proliferation assay
-
J.E. Celis 2nd ed. Academic Press San Diego
-
[14] Holst-Hansen, C., Brünnner, N., MTT-cell proliferation assay. Celis, J.E., (eds.) Cell Biology: A Laboratory Handbook, 2nd ed., 1998, Academic Press, San Diego, 16–18.
-
(1998)
Cell Biology: A Laboratory Handbook
, pp. 16-18
-
-
Holst-Hansen, C.1
Brünnner, N.2
-
15
-
-
0026550830
-
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
-
[15] Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P.A., Wollheim, C.B., Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 (1992), 167–178.
-
(1992)
Endocrinology
, vol.130
, pp. 167-178
-
-
Asfari, M.1
Janjic, D.2
Meda, P.3
Li, G.4
Halban, P.A.5
Wollheim, C.B.6
-
16
-
-
0037051715
-
Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial c release and apoptosis
-
[16] Mouria, M., Gukovskaya, A.S., Jung, Y., Buechler, P., Hines, O.J., Reber, H.A., Pandol, S.J., Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial c release and apoptosis. Int. J. Cancer 98 (2002), 764–769.
-
(2002)
Int. J. Cancer
, vol.98
, pp. 764-769
-
-
Mouria, M.1
Gukovskaya, A.S.2
Jung, Y.3
Buechler, P.4
Hines, O.J.5
Reber, H.A.6
Pandol, S.J.7
-
17
-
-
79961167887
-
Effect of β-glucosidase hydrolyzed prodructs of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro
-
[17] Zhang, L., Feng, L., Jia, Q., Xu, J., Wang, R., Wang, Z., Wu, Y., Li, Y., Effect of β-glucosidase hydrolyzed prodructs of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorgan. Med. Chem. 19 (2011), 4882–4886.
-
(2011)
Bioorgan. Med. Chem.
, vol.19
, pp. 4882-4886
-
-
Zhang, L.1
Feng, L.2
Jia, Q.3
Xu, J.4
Wang, R.5
Wang, Z.6
Wu, Y.7
Li, Y.8
-
18
-
-
84876117475
-
Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using the ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
-
[18] Yang, J., Qian, D., Guo, J., Jiang, S., Shang, E., Duan, J., Xu, J., Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using the ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J. Ethnopharmacol. 147 (2013), 174–179.
-
(2013)
J. Ethnopharmacol.
, vol.147
, pp. 174-179
-
-
Yang, J.1
Qian, D.2
Guo, J.3
Jiang, S.4
Shang, E.5
Duan, J.6
Xu, J.7
-
19
-
-
79959334413
-
Identification of hyperoside metabolites in rat using ultra performance liquid chromatography/quadropole-time-of-flight mass spectrometry
-
[19] Guo, J., Xue, C., Shang, E., Duan, J., Tang, Y., Qian, D., Identification of hyperoside metabolites in rat using ultra performance liquid chromatography/quadropole-time-of-flight mass spectrometry. J. Chromatogr. B 879 (2011), 1987–1992.
-
(2011)
J. Chromatogr. B
, vol.879
, pp. 1987-1992
-
-
Guo, J.1
Xue, C.2
Shang, E.3
Duan, J.4
Tang, Y.5
Qian, D.6
-
20
-
-
0028792070
-
A phase I trial of hypoxoside as an oral prodrug for cancer therapy—absence of toxicity
-
[20] Smit, B.J., Albrecht, C.F., Liebenberg, R.W., Kruger, P.B., Freestone, M., Gouws, L., Theron, E., Bouic, P.J.D., Etsebeth, S., van Jaarsveld, P.P., A phase I trial of hypoxoside as an oral prodrug for cancer therapy—absence of toxicity. S. Afr. Med. J. 9 (1995), 865–870.
-
(1995)
S. Afr. Med. J.
, vol.9
, pp. 865-870
-
-
Smit, B.J.1
Albrecht, C.F.2
Liebenberg, R.W.3
Kruger, P.B.4
Freestone, M.5
Gouws, L.6
Theron, E.7
Bouic, P.J.D.8
Etsebeth, S.9
van Jaarsveld, P.P.10
-
21
-
-
84878348163
-
Protective role of oleuropein and its metabolite hydroxytyrosol on cancer
-
[21] Carrera-González, M.P., Ramírez-Expósito, M.J., Mayas, M.D., Martínez-Martos, J.M., Protective role of oleuropein and its metabolite hydroxytyrosol on cancer. Trends Food Sci. Technol. 31 (2013), 92–99.
-
(2013)
Trends Food Sci. Technol.
, vol.31
, pp. 92-99
-
-
Carrera-González, M.P.1
Ramírez-Expósito, M.J.2
Mayas, M.D.3
Martínez-Martos, J.M.4
-
22
-
-
84861102186
-
Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells
-
[22] Storniolo, C.E., Moreno, J.J., Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells. Food Chem. 134 (2012), 1385–1391.
-
(2012)
Food Chem.
, vol.134
, pp. 1385-1391
-
-
Storniolo, C.E.1
Moreno, J.J.2
-
23
-
-
0028892823
-
Morphological characterization of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy
-
[23] Albrecht, C.F., Theron, E.J., Kruger, P.B., Morphological characterization of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy. S. Afr. Med. J. 85 (1995), 853–860.
-
(1995)
S. Afr. Med. J.
, vol.85
, pp. 853-860
-
-
Albrecht, C.F.1
Theron, E.J.2
Kruger, P.B.3
-
24
-
-
77950579041
-
Cell survival or apoptosis: rooperol's role as anticancer agent
-
[24] Boukes, G.J., Daniels, B.B., Albrecht, C.F., van de Venter, M., Cell survival or apoptosis: rooperol's role as anticancer agent. Oncol. Res. 18 (2010), 365–376.
-
(2010)
Oncol. Res.
, vol.18
, pp. 365-376
-
-
Boukes, G.J.1
Daniels, B.B.2
Albrecht, C.F.3
van de Venter, M.4
-
25
-
-
0028304068
-
β-Glucosidase activity in fetal bovine serum renders the plant glucoside, hypoxoside, cytotoxic toward B16-F10-BL-6 mouse melanoma cells
-
[25] Theron, E.J., Albrecht, C.F., Kruger, P.B., Jenkins, K., van der Merwe, M.J., β-Glucosidase activity in fetal bovine serum renders the plant glucoside, hypoxoside, cytotoxic toward B16-F10-BL-6 mouse melanoma cells. In Vitro Cell. Dev. Biol. Anim. 30A (1994), 115–119.
-
(1994)
In Vitro Cell. Dev. Biol. Anim.
, vol.30A
, pp. 115-119
-
-
Theron, E.J.1
Albrecht, C.F.2
Kruger, P.B.3
Jenkins, K.4
van der Merwe, M.J.5
-
26
-
-
84949987497
-
Hyperoside induces apoptosis and inhibits growth in pancreatic cancer via Bcl-2 family and NF-κB signaling pathway both in vitro and in vivo
-
[26] Li, Y., Wang, Y., Li, L., Kong, R., Pan, S., Ji, L., Liu, H., Chen, H., Sun, B., Hyperoside induces apoptosis and inhibits growth in pancreatic cancer via Bcl-2 family and NF-κB signaling pathway both in vitro and in vivo. Tumor Biol., 2015, 10.1007/s13277-015-4552-2.
-
(2015)
Tumor Biol.
-
-
Li, Y.1
Wang, Y.2
Li, L.3
Kong, R.4
Pan, S.5
Ji, L.6
Liu, H.7
Chen, H.8
Sun, B.9
-
27
-
-
84903748312
-
Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells
-
[27] Zhang, N., Ying, M., Wu, Y., Zhou, Z., Ye, Z., Li, H., Lin, D., Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. PLoS One, 2014, 10.1371/journal.pone.0098973.
-
(2014)
PLoS One
-
-
Zhang, N.1
Ying, M.2
Wu, Y.3
Zhou, Z.4
Ye, Z.5
Li, H.6
Lin, D.7
-
28
-
-
84874118832
-
The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo
-
[28] Angst, E., Park, J.L., Moro, A., Lu, Q., Lu, X., Li, G., King, J., Chen, M., The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas 41 (2013), 223–229.
-
(2013)
Pancreas
, vol.41
, pp. 223-229
-
-
Angst, E.1
Park, J.L.2
Moro, A.3
Lu, Q.4
Lu, X.5
Li, G.6
King, J.7
Chen, M.8
-
29
-
-
84939846330
-
Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat
-
[29] Olayinka, E.T., Ore, A., Ola, O.S., Adeyemo, O.A., Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat. Chemother. Res. Pract., 2014, 10.1155/2014/936526.
-
(2014)
Chemother. Res. Pract.
-
-
Olayinka, E.T.1
Ore, A.2
Ola, O.S.3
Adeyemo, O.A.4
-
30
-
-
3042801604
-
Morphological features of cell death
-
[30] Ziegler, U., Groscurth, P., Morphological features of cell death. News Physiol. Sci. 19 (2004), 124–128.
-
(2004)
News Physiol. Sci.
, vol.19
, pp. 124-128
-
-
Ziegler, U.1
Groscurth, P.2
-
31
-
-
84962812251
-
Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro
-
[31] Fu, T., Wang, L., Jin, X., Sui, H., Liu, Z., Jin, Y., Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro. Acta Pharmacol. Sin. 37 (2016), 505–518.
-
(2016)
Acta Pharmacol. Sin.
, vol.37
, pp. 505-518
-
-
Fu, T.1
Wang, L.2
Jin, X.3
Sui, H.4
Liu, Z.5
Jin, Y.6
-
32
-
-
84960430778
-
Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells
-
[32] Guon, T.A., Chung, H.S., Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells. Oncol. Lett. 11 (2016), 2463–2470.
-
(2016)
Oncol. Lett.
, vol.11
, pp. 2463-2470
-
-
Guon, T.A.1
Chung, H.S.2
-
33
-
-
84891935266
-
Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a
-
[33] Li, W., Liu, M., Xu, Y., Feng, Y., Che, J., Wang, G., Zheng, J., Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. Oncol. Rep. 31 (2014), 118–124.
-
(2014)
Oncol. Rep.
, vol.31
, pp. 118-124
-
-
Li, W.1
Liu, M.2
Xu, Y.3
Feng, Y.4
Che, J.5
Wang, G.6
Zheng, J.7
-
34
-
-
80052965385
-
Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus
-
[34] Jung, S.K., Lim, T.G., Kim, J.E., Byun, S., Kim, G., Choi, J.N., Lee, C.H., Kim, B.Y., Lee, K.W., Lee, H.J., Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus. Food Chem. 13 (2012), 915–920.
-
(2012)
Food Chem.
, vol.13
, pp. 915-920
-
-
Jung, S.K.1
Lim, T.G.2
Kim, J.E.3
Byun, S.4
Kim, G.5
Choi, J.N.6
Lee, C.H.7
Kim, B.Y.8
Lee, K.W.9
Lee, H.J.10
-
35
-
-
77956524618
-
The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation
-
[35] Mukubou, H., Tsujimura, T., Sasaki, R., Ku, Y., The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. Int. J. Oncol. 37 (2010), 821–828.
-
(2010)
Int. J. Oncol.
, vol.37
, pp. 821-828
-
-
Mukubou, H.1
Tsujimura, T.2
Sasaki, R.3
Ku, Y.4
-
36
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
[36] Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J.M., Dell'Antonio, G., Mautner, J., Tonon, G., Haigis, M., Shirihai, O.S., Doglioni, C., Bardeesy, N., Kimmelman, A.C., Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25 (2011), 717–729.
-
(2011)
Genes Dev.
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'Antonio, G.10
Mautner, J.11
Tonon, G.12
Haigis, M.13
Shirihai, O.S.14
Doglioni, C.15
Bardeesy, N.16
Kimmelman, A.C.17
-
37
-
-
79957850849
-
Following autophagy step by step
-
[37] Hansen, T.E., Johansen, T., Following autophagy step by step. BMC Biol., 2011, 10.1186/1741-7007-9-39.
-
(2011)
BMC Biol.
-
-
Hansen, T.E.1
Johansen, T.2
-
38
-
-
36249025723
-
Autophagy: process and function
-
[38] Mizushima, N., Autophagy: process and function. Genes Dev. 21 (2007), 2861–2873.
-
(2007)
Genes Dev.
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
39
-
-
77954739712
-
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
-
[39] Geng, Y., Kohli, L., Klocke, B.J., Roth, K.A., Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro-Oncology 12 (2000), 473–481.
-
(2000)
Neuro-Oncology
, vol.12
, pp. 473-481
-
-
Geng, Y.1
Kohli, L.2
Klocke, B.J.3
Roth, K.A.4
-
40
-
-
84901852516
-
Rapamycin alleviates cisplatin-induced ototoxicity in vivo
-
[40] Fang, B., Xiao, H., Rapamycin alleviates cisplatin-induced ototoxicity in vivo. Biochem. Biophys. Res. Commun. 448 (2014), 443–447.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.448
, pp. 443-447
-
-
Fang, B.1
Xiao, H.2
-
41
-
-
84930926354
-
Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions
-
[41] Kim, S.E., Park, H.J., Jeong, H.K., Kim, M.J., Kim, M., Bae, O.N., Baek, S.H., Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions. Biochem. Biophys. Res. Commun. 463 (2015), 205–210.
-
(2015)
Biochem. Biophys. Res. Commun.
, vol.463
, pp. 205-210
-
-
Kim, S.E.1
Park, H.J.2
Jeong, H.K.3
Kim, M.J.4
Kim, M.5
Bae, O.N.6
Baek, S.H.7
-
42
-
-
79551553480
-
Dissecting the dynamic turnover of GFP-LC3 in the autolysosomes
-
[42] Ni, H., Bockus, A., Wozniak, A.L., Jones, K., Weinman, S., Yin, X., Ding, W., Dissecting the dynamic turnover of GFP-LC3 in the autolysosomes. Autophagy 7 (2011), 188–204.
-
(2011)
Autophagy
, vol.7
, pp. 188-204
-
-
Ni, H.1
Bockus, A.2
Wozniak, A.L.3
Jones, K.4
Weinman, S.5
Yin, X.6
Ding, W.7
|