Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 40, 2016, Pages 11283-11288

  Zheng, Hong ^a   Dai, Wei ^a   Cheung, Arthur Kwok Leung ^a   Ko, Josephine Mun Yee ^a   Kan, Rebecca ^a   Wong, Bonnie Wing Yan ^a   Leong, Merrin Man Long ^a   Deng, Mingdan ^a   Kwok, Tommy Chin Tung ^a   Chan, Jimmy Yu Wai ^a   Kwong, Dora Lai Wan ^a   Lee, Anne Wing Mui ^a   Ng, Wai Tong ^a,b   Ngan, Roger Kai Cheong ^a,c   Yau, Chun Chung ^a,d   Tung, Stewart ^a,e   Lee, Victor Ho Fun ^a   Lam, Ka On ^a   Kwan, Chung Kong ^a,c   Li, Wing Sum ^a,c   Yau, Stephen ^c   Chan, Kwok Wah ^a   Lung, Maria Li ^a   more..

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^c QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^d PRINCESS MARGARET HOSPITAL   (Hong Kong)

^e TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

APOBEC mediated signature; Nasopharyngeal carcinoma; NF B signaling; Somatic mutation landscape; Whole exome sequencing

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3A; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3B; CYTIDINE DEAMINASE; HYDROLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; I KAPPA B KINASE ALPHA; NFKBIA PROTEIN, HUMAN;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE PHASE; CELL DEATH; CONTROLLED STUDY; CYLD GENE; EPSTEIN BARR VIRUS INFECTION; EXOME; GENE; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; NASOPHARYNX CARCINOMA; NF KAPPA B INHIBITOR ALPHA GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TNF ALPHA INDUCED PROTEIN 3 GENE; VIRUS CARCINOGENESIS; CARCINOMA; GENE KNOCKDOWN; GENETICS; METABOLISM; MUTATION RATE; NASOPHARYNX TUMOR; PROCEDURES; TUMOR CELL LINE; WHOLE EXOME SEQUENCING;

CARCINOMA; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HUMANS; LOSS OF FUNCTION MUTATION; MUTATION RATE; NASOPHARYNGEAL NEOPLASMS; NF-KAPPA B; NF-KAPPAB INHIBITOR ALPHA; SIGNAL TRANSDUCTION; WHOLE EXOME SEQUENCING;

EID: 84989819048     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1607606113     Document Type: Article

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