Inclusion of sarcopenia within MELD (MELD-Sarcopenia) and the prediction of mortality in patients with cirrhosis

Clinical and Translational Gastroenterology

Volumn 6, Issue 7, 2015, Pages

  Montano Loza, Aldo J ^a   Duarte Rojo, Andres ^b   Meza Junco, Judith ^c   Baracos, Vickie E ^c   Sawyer, Michael B ^c   Pang, Jack X Q ^d,e   Beaumont, Crystal ^c   Esfandiari, Nina ^c   Myers, Robert P ^d,e  

^a UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CROSS CANCER INSTITUTE   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; ARTICLE; ASCITES; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; CONFIDENCE INTERVAL; ESOPHAGUS VARICES BLEEDING; FEMALE; GENDER; HAZARD RATIO; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LUMBAR VERTEBRA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MODEL FOR END STAGE LIVER DISEASE SCORE; MORTALITY; PREDICTION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SARCOPENIA; SKELETAL MUSCLE; SURVIVAL RATE;

EID: 84989354511     PISSN: 2155384X     EISSN: None     Source Type: Journal    
DOI: 10.1038/ctg.2015.31     Document Type: Article

References (33)

1. Freeman RB Jr, Wiesner RH, Harper A et al. The new liver allocation system: moving toward evidence-based transplantation policy. Liver Transpl 2002; 8: 851-858.
2. Wiesner R, Edwards E, Freeman R et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91-96.
3. Brown RS Jr, Lake JR. The survival impact of liver transplantation in the MELD era, and the future for organ allocation and distribution. Am J Transplant 2005; 5: 203-204.
4. Kim WR, Biggins SW, Kremers WK et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008; 359: 1018-1026.
5. Myers RP, Shaheen AA, Faris P et al. Revision of MELD to include serum albumin improves prediction of mortality on the liver transplant waiting list. PLoS One 2013; 8: e51926.
6. Baumgartner RN, Koehler KM, Gallagher D et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-763.
7. Lang T, Streeper T, Cawthon P et al. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 2010; 21: 543-559.
8. Montano-Loza AJ, Meza-Junco J, Prado CM et al. Muscle wasting is associated with mortality in patients with cirrhosis. Clin Gastroenterol Hepatol 2012; 10: 166-173 173e1.
9. Meza-Junco J, Montano-Loza AJ, Baracos VE et al. Sarcopenia as a prognostic index of nutritional status in concurrent cirrhosis and hepatocellular carcinoma. J Clin Gastroenterol 2013; 47: 861-870.
10. Kaido T, Ogawa K, Fujimoto Y et al. Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant 2013; 13: 1549-1556.
11. Krell RW, Kaul DR, Martin AR et al. Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation. Liver Transpl 2013; 19: 1396-1402.
12. Englesbe MJ, Patel SP, He K et al. Sarcopenia and mortality after liver transplantation. J Am Coll Surg 2010; 211: 271-278.
13. Johnson TM, Overgard EB, Cohen AE et al. Nutrition assessment and management in advanced liver disease. Nutr Clin Pract 2013; 28: 15-29.
14. O'Brien A, Williams R. Nutrition in end-stage liver disease: principles and practice. Gastroenterology 2008; 134: 1729-1740.
15. Mitsiopoulos N, Baumgartner RN, Heymsfield SB et al. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 1998; 85: 115-122.
16. Kvist H, Sjostrom L, Tylen U. Adipose tissue volume determinations in women by computed tomography: technical considerations. Int J Obes 1986; 10: 53-67.
17. Vehmas T, Kairemo KJ, Taavitsainen MJ. Measuring visceral adipose tissue content from contrast enhanced computed tomography. Int J Obes Relat Metab Disord 1996; 20: 570-573.
18. Mourtzakis M, Prado CM, Lieffers JR et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 2008; 33: 997-1006.
19. Martin L, Birdsell L, Macdonald N et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 2013; 31: 1539-1547.
20. Durand F, Buyse S, Francoz C et al. Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography. J Hepatol 2014; 60: 1151-1157.
21. Shen W, Punyanitya M, Wang Z et al. Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol (1985) 2004; 97: 2333-2338.
22. Somsouk M, Kornfield R, Vittinghoff E et al. Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk. Liver Transpl 2011; 17: 129-136.
23. Malinchoc M, Kamath PS, Gordon FD et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000; 31: 864-871.
24. Biggins SW, Kim WR, Terrault NA et al. Evidence-based incorporation of serum sodium concentration into MELD. Gastroenterology 2006; 130: 1652-1660.
25. Ruf AE, Kremers WK, Chavez LL et al. Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl 2005; 11: 336-343.
26. Myers RP, Tandon P, Ney M et al. Validation of the five-variable Model for End-stage Liver Disease (5vMELD) for prediction of mortality on the liver transplant waiting list. Liver Int 2014; 34: 1176-1183.
27. Dasarathy S. Consilience in sarcopenia of cirrhosis. J Cachexia Sarcopenia Muscle 2012; 3: 225-237.
28. Montano-Loza AJ. Muscle wasting: a nutritional criterion to prioritize patients for liver transplantation. Curr Opin Clin Nutr Metab Care 2014; 17: 219-225.
29. Montano-Loza AJ. New concepts in liver cirrhosis: clinical significance of sarcopenia in cirrhotic patients. Minerva Gastroenterol Dietol 2013; 59: 173-186.
30. Montano-Loza AJ, Meza-Junco J, Baracos VE et al. Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transpl 2014; 20: 640-648.
31. Merli M, Giusto M, Lucidi C et al. Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study. Metab Brain Dis 2012; 28: 281-284.
32. Jepsen P, Ott P, Andersen PK et al. Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. Hepatology 2010; 51: 1675-1682.
33. Montano-Loza AJ, Meza-Junco J, Prado CMM et al. New cutoff values for sarcopenia for predicting 6-months mortality in cirrhotic patients. J Hepatol 2013; 58: S95.