Effect of pre-stroke statin use on stroke severity and early functional recovery: A retrospective cohort study

BMC Neurology

Volumn 15, Issue 1, 2015, Pages

  Choi, Jay Chol ^a   Lee, Ji Sung ^b   Park, Tai Hwan ^c   Cho, Yong Jin ^d   Park, Jong Moo ^e   Kang, Kyusik ^e   Lee, Kyung Bok ^f   Lee, Soo Joo ^g   Ko, Youngchai ^g   Lee, Jun ^h   Kim, Joon Tae ⁱ   Yu, Kyung Ho ^j   Lee, Byung Chul ^j   Cha, Jae Kwan ^k   Kim, Dae Hyun ^k   Lee, Juneyoung ^l   Kim, Dong Eog ^m   Jang, Myung Suk ⁿ   Kim, Beom Joon ⁿ   Han, Moon Ku ⁿ   Bae, Hee Joon ⁿ   Hong, Keun Sik ^d   more..

^a Jeju National University College of Medicine   (South Korea)

^b Asan Medical Center   (South Korea)

^c Seoul Medical Center   (South Korea)

^d Inje University   (South Korea)

^e Eulji General Hospital   (South Korea)

^f Soonchunhyang University College of Medicine   (South Korea)

^g Eulji University   (South Korea)

^h Young Nam University Hospital   (South Korea)

ⁱ Chonnam National University Medical School   (South Korea)

^j Hallym University   (South Korea)

^k Dong A University College of Medicine   (South Korea)

^l Korea University College of Medicine   (South Korea)

^m Dongguk University Ilsan Hospital   (South Korea)

ⁿ Seoul National University Bundang Hospital   (South Korea)

more..

Author keywords

Acute stroke; Outcomes; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; FUNCTIONAL STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; RANKIN SCALE; RETROSPECTIVE STUDY; TIME TO TREATMENT; TREATMENT OUTCOME; BRAIN ISCHEMIA; CLINICAL TRIAL; CONVALESCENCE; HOSPITAL DISCHARGE; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; REGISTER; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; SOUTH KOREA; STROKE; STROKE REHABILITATION;

AGED; BRAIN ISCHEMIA; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATIENT DISCHARGE; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; REGISTRIES; REGRESSION ANALYSIS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STROKE; STROKE REHABILITATION; TREATMENT OUTCOME;

EID: 84989229121     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-015-0376-3     Document Type: Article

References (42)

1. Shook SJ, Gupta R, Vora NA, Tievsky AL, Katzan I, Krieger DW. Statin use is independently associated with smaller infarct volume in nonlacunar MCA territory stroke. J Neuroimaging. 2006;16(4):341-6.
2. Ovbiagele B, Saver JL, Starkman S, Kim D, Ali LK, Jahan R, et al. Statin enhancement of collateralization in acute stroke. Neurology. 2007;68(24):2129-31.
3. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1998;95(15):8880-5.
4. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000;6(9):1004-10.
5. Laufs U, Gertz K, Huang P, Nickenig G, Bohm M, Dirnagl U, et al. Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke. 2000;31(10):2442-9.
6. Amin-Hanjani S, Stagliano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke. 2001;32(4):980-6.
7. Asahi M, Huang Z, Thomas S, Yoshimura S, Sumii T, Mori T, et al. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005;25(6):722-9.
8. Chen J, Zhang ZG, Li Y, Wang Y, Wang L, Jiang H, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol. 2003;53(6):743-51.
9. Goldstein LB. Statins and ischemic stroke severity: cytoprotection. Curr Atheroscler Rep. 2009;11(4):296-300.
10. Marti-Fabregas J, Gomis M, Arboix A, Aleu A, Pagonabarraga J, Belvis R, et al. Favorable outcome of ischemic stroke in patients pretreated with statins. Stroke. 2004;35(5):1117-21.
11. Aslanyan S, Weir CJ, McInnes GT, Reid JL, Walters MR, Lees KR. Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study. Eur J Neurol. 2005;12(7):493-8.
12. Elkind MS, Flint AC, Sciacca RR, Sacco RL. Lipid-lowering agent use at ischemic stroke onset is associated with decreased mortality. Neurology. 2005;65(2):253-8.
13. Moonis M, Kane K, Schwiderski U, Sandage BW, Fisher M. HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke. 2005;36(6):1298-300.
14. Bushnell CD, Griffin J, Newby LK, Goldstein LB, Mahaffey KW, Graffagnino CA, et al. Statin use and sex-specific stroke outcomes in patients with vascular disease. Stroke. 2006;37(6):1427-31.
15. Deplanque D, Masse I, Lefebvre C, Libersa C, Leys D, Bordet R. Prior TIA, lipid-lowering drug use, and physical activity decrease ischemic stroke severity. Neurology. 2006;67(8):1403-10.
16. Martinez-Sanchez P, Rivera-Ordonez C, Fuentes B, Ortega-Casarrubios MA, Idrovo L, Diez-Tejedor E. The beneficial effect of statins treatment by stroke subtype. Eur J Neurol. 2009;16(1):127-33.
17. Biffi A, Devan WJ, Anderson CD, Cortellini L, Furie KL, Rosand J, et al. Statin treatment and functional outcome after ischemic stroke. Stroke. 2011;42(5):1314-9.
18. Ni Chroinin D, Callaly EL, Duggan J, Merwick A, Hannon N, Sheehan O, et al. Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. Stroke. 2011;42(4):1021-9.
19. Sacco S, Toni D, Bignamini AA, Zaninelli A, Gensini GF, Carolei A. Effect of prior medical treatments on ischemic stroke severity and outcome. Funct Neurol. 2011;26(3):133-9.
20. Aboa-Eboule C, Binquet C, Jacquin A, Hervieu M, Bonithon-Kopp C, Durier J, et al. Effect of previous statin therapy on severity and outcome in ischemic stroke patients: a population-based study. J Neurol. 2013;260(1):30-7.
21. Martinez-Sanchez P, Fuentes B, Martinez-Martinez M, Ruiz-Ares G, Fernandez-Travieso J, Sanz-Cuesta BE, et al. Treatment with statins and ischemic stroke severity: Does the dose matter? Neurology. 2013;80(19):1800-5.
22. Ni Chroinin D, Asplund K, Asberg S, Callaly E, Cuadrado-Godia E, Diez-Tejedor E, et al. Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials. Stroke. 2013;44(2):448-56.
23. Phipps MS, Zeevi N, Staff I, Fortunato G, Kuchel GA, McCullough LD. Stroke severity and outcomes for octogenarians receiving statins. Arch Gerontol Geriatr. 2013;57(3):377-82.
24. Goldstein LB, Amarenco P, Zivin J, Messig M, Altafullah I, Callahan A, et al. Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke. 2009;40(11):3526-31.
25. Kim BJ, Han MK, Park TH, Park SS, Lee KB, Lee BC, et al. Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry. Int J Stroke. 2014;9(4):514-8.
26. Adams Jr HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41.
27. Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MI. A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol. 2000;21(4):643-6.
28. Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med. 2007;357(6):562-71.
29. McQuay HJ, Moore. Using numerical results from systematic reviews in clinical practice. Ann Intern Med. 1997;126(9):712-20.
30. Chang KC, Tseng MC, Weng HH, Lin YH, Liou CW, Tan TY. Prediction of length of stay of first-ever ischemic stroke. Stroke. 2002;33(11):2670-4.
31. Schlegel D, Kolb SJ, Luciano JM, Tovar JM, Cucchiara BL, Liebeskind DS, et al. Utility of the NIH Stroke Scale as a predictor of hospital disposition. Stroke. 2003;34(1):134-7.
32. Pasceri V, Patti G, Nusca A, Pristipino C, Richichi G, Di Sciascio G, et al. Randomized trial of atorvastatin for reduction of myocardial damage during coronary intervention: results from the ARMYDA (Atorvastatin for Reduction of MYocardial Damage during Angioplasty) study. Circulation. 2004;110(6):674-8.
33. Spencer FA, Allegrone J, Goldberg RJ, Gore JM, Fox KA, Granger CB, et al. Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study. Ann Intern Med. 2004;140(11):857-66.
34. Patti G, Pasceri V, Colonna G, Miglionico M, Fischetti D, Sardella G, et al. Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial. J Am Coll Cardiol. 2007;49(12):1272-8.
35. European Association for Cardiovascular P, Rehabilitation, Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011;32(14):1769-818.
36. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: executive summary: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation. 2011;124(23):2574-609.
37. Blanco M, Nombela F, Castellanos M, Rodriguez-Yanez M, Garcia-Gil M, Leira R, et al. Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology. 2007;69(9):904-10.
38. Jauch EC, Saver JL, Adams Jr HP, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870-947.
39. Garcia-Bonilla L, Campos M, Giralt D, Salat D, Chacon P, Hernandez-Guillamon M, et al. Evidence for the efficacy of statins in animal stroke models: a meta-analysis. J Neurochem. 2012;122(2):233-43.
40. Kasner SE. Clinical interpretation and use of stroke scales. Lancet Neurol. 2006;5(7):603-12.
41. Lees KR, Bath PMW, Schellinger PD, Kerr DM, Fulton R, Hacke W, et al. Contemporary outcome measures in acute stroke research. Stroke. 2012;43(4):1163-70.
42. Ovbiagele B, Saver JL. Day-90 acute ischemic stroke outcomes can be derived from early functional activity level. Cerebrovasc Dis. 2010;29(1):50-6.