Homodimericin A: A Complex Hexacyclic Fungal Metabolite

Journal of the American Chemical Society

Volumn 138, Issue 38, 2016, Pages 12324-12327

  Mevers, Emily ^a   Saurí, Josep ^b   Liu, Yizhou ^b   Moser, Arvin ^c   Ramadhar, Timothy R ^a   Varlan, Maria ^c   Thomas Williamson, R ^b   Martin, Gary E ^b   Clardy, Jon ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Advanced Chemistry Development Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; CARBON; FUNGI; KETONES; MOLECULES;

ELECTRON OXIDATION; FUNGAL METABOLITES; MICROBIAL PRODUCTION; MOLECULAR EXCHANGES; NONENZYMATIC REACTION; PATHOGENIC FUNGI; RACEMIC MIXTURES; STEREOGENIC CARBONS;

METABOLITES;

ANTIFUNGAL AGENT; BAFILOMYCIN; BAFILOMYCIN C1; CARBON; HOMODIMERICIN A; HYDROGEN; MONOMER; POLYKETIDE; POLYKETIDE SYNTHASE; PROTON; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); ENDONUCLEASE V, PHAGE T4; VIRAL PROTEIN;

ANISOTROPY; AROMATIZATION; ARTICLE; BACTERIUM ISOLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM; COPTOTERMES FORMOSANUS; CYCLIZATION; DENSITY FUNCTIONAL THEORY; DIASTEREOISOMER; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; ISOMER; MICHAEL ADDITION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RACEMIC MIXTURE; RESIDUAL CHEMICAL SHIFT ANISOTROPY; SIX ELECTRON OXIDATION; STEREOCHEMISTRY; STREPTOMYCES; TAUTOMERIZATION; UPREGULATION; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRICHODERMA;

ANTIFUNGAL AGENTS; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYKETIDES; TRICHODERMA; UP-REGULATION; VIRAL PROTEINS;

EID: 84989216726     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b07588     Document Type: Article

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