Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 20, 2016, Pages 4865-4869

  Demizu, Yosuke ^a   Shibata, Norihito ^a   Hattori, Takayuki ^a   Ohoka, Nobumichi ^a   Motoi, Hiromi ^a   Misawa, Takashi ^a   Shoda, Takuji ^a   Naito, Mikihiko ^a   Kurihara, Masaaki ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

BCR ABL; Bestatin; E3 ubiquitin ligase; Imatinib; Protein knockdown

Indexed keywords

BCR ABL PROTEIN; IMATINIB; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN; LIGAND; PROTEIN BINDING;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; DRUG CONJUGATION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; K562 CELL LINE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SURFACE PROPERTY; WESTERN BLOTTING; K-562 CELL LINE; METABOLISM;

FUSION PROTEINS, BCR-ABL; HUMANS; IMATINIB MESYLATE; INHIBITOR OF APOPTOSIS PROTEINS; K562 CELLS; LIGANDS; PROTEIN BINDING; PROTEOLYSIS;

EID: 84989184483     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.09.041     Document Type: Article

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