Morin inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition

Biomedicine and Pharmacotherapy

Volumn 84, Issue , 2016, Pages 622-627

  Ke, Ya qiong ^a   Liu, Chao ^a   Hao, Jian Bo ^a   Lu, Ling ^a   Lu, Nan nan ^a   Wu, Zhao ke ^a   Zhu, Shen shen ^a   Chen, Xi Ling ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Extracellular matrix (ECM); Mesangial cells (MCs); Morin

Indexed keywords

C JUN AMINO TERMINAL KINASE 1; C JUN AMINO TERMINAL KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FIBRONECTIN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; MORIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; FLAVONOID; NOX4 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOACCUMULATION; CELL CYCLE ARREST; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL PROTECTION; DIABETIC NEPHROPATHIES; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CYTOPROTECTION; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; FLAVONOIDS; GLUCOSE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MESANGIAL CELLS; NADPH OXIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84989170561     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.09.088     Document Type: Article

References (30)

1. [1] Gross, J.L., De Azevedo, M.J., Silveiro, S.P., Canani, L.H., Caramori, M.L., Zelmanovitz, T., Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 28 (2005), 164–176.
2. [2] Kikkawa, R., Koya, D., Haneda, M., Progression of diabetic nephropathy. Am. J. Kidney Dis. 41 (2003), S19–S21.
3. [3] Ziyadeh, F.N., The extracellular matrix in diabetic nephropathy. Am. J. Kidney Dis. 22 (1993), 736–744.
4. [4] Danesh, F.R., Sadeghi, M.M., Amro, N., Philips, C., Zeng, L., Lin, S., et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 8301–8305.
5. [5] Bartošíková, L., Nečas, J., Suchý, V., Kubinova, R., Vesela, D., Beneš, L., et al. Monitoring of antioxidative effect of morine in alloxan-induced diabetes mellitus in the laboratory rat. Acta Vet. Brno 72 (2003), 191–200.
6. [6] Zhang, Z.-t., Cao, X.-b., Xiong, N., Wang, H.-c., Huang, J.-s., Sun, S.-g., et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol. Sin. 31 (2010), 900–906.
7. [7] Hyun, H.-B., Lee, W.S., Go, S.-I., Nagappan, A., Park, C., Han, M.H., et al. The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. Int. J. Oncol. 46 (2015), 2670–2678.
8. [8] Athira, K., Madhana, R.M., Kasala, E.R., Samudrala, P.K., Lahkar, M., Gogoi, R., Morin hydrate mitigates cisplatin-induced renal and hepatic injury by impeding oxidative/nitrosative stress and inflammation in mice. J. Biochem. Mol. Toxicol., 2016, 10.1002/jbt.21817.
9. [9] Jin, H., Lee, W.S., Eun, S.Y., Jung, J.H., Park, H.S., Kim, G., et al. Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-231 partly through suppression of the Akt pathway. Int. J. Oncol. 45 (2014), 1629–1637.
10. [10] Vanitha, P., Uma, C., Suganya, N., Bhakkiyalakshmi, E., Suriyanarayanan, S., Gunasekaran, P., et al. Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environ. Toxicol. Pharmacol. 37 (2014), 326–335.
11. [11] Naowaboot, J., Wannasiri, S., Pannangpetch, P., Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice. J. Physiol. Biochem., 2016.
12. [12] Gennero, I., Fauvel, J., Niéto, M., Cariven, C., Gaits, F., Briand-Mésange, F., et al. Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. J. Biol. Chem. 277 (2002), 12724–12734.
13. [13] Hodgkinson, A.D., Bartlett, T., Oates, P.J., Millward, B.A., Demaine, A.G., The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Diabetes 52 (2003), 846–851.
14. [14] Yano, N., Suzuki, D., Endoh, M., Cao, T.N., Dahdah, J.R., Tseng, A., et al. High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells. Biochem. J. 423 (2009), 129–143.
15. [15] Sodhi, C.P., Phadke, S.A., Batlle, D., Sahai, A., Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontin. Am. J. Physiol. Ren. Physiol. 280 (2001), F667–F674.
16. [16] Okada, T., Wada, J., Hida, K., Eguchi, J., Hashimoto, I., Baba, M., et al. Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. Diabetes 55 (2006), 1666–1677.
17. [17] Jia, H., Qi, X., Fang, S., Jin, Y., Han, X., Wang, Y., et al. Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression. Regul. Pept. 154 (2009), 69–76.
18. [18] Adler, S., Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy. J. Am. Soc. Nephrol. 5 (1994), 1165–1172.
19. [19] Ziyadeh, F.N., Sharma, K., Ericksen, M., Wolf, G., Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. J. Clin. Invest. 93 (1994), 536–542.
20. [20] Ji, L., Yin, X.x., Wu, Z.m., Wang, J.y., Lu, Q., Gao, Y.y., Ginkgo biloba extract prevents glucose-induced accumulation of ECM in rat mesangial cells. Phytother. Res. 23 (2009), 477–485.
21. [21] Hua, H., Goldberg, H.J., Fantus, I., Whiteside, C.I., High glucose–enhanced mesangial cell extracellular signal–regulated protein kinase activation and α1 (IV) collagen expression in response to endothelin-1 role of specific protein kinase C isozymes. Diabetes 50 (2001), 2376–2383.
22. [22] Coughlan, M.T., Mibus, A.L., Forbes, J.M., Oxidative stress and advanced glycation in diabetic nephropathay. Ann. N. Y. Acad. Sci. 1126 (2008), 190–193.
23. [23] Gorin, Y., Block, K., Hernandez, J., Bhandari, B., Wagner, B., Barnes, J.L., et al. Nox4 NAD(P)H oxidase mediates hyperthophy and fibronecin expression in the diabetic kidney. J. Biol. Chem. 280 (2005), 39616–39626.
24. [24] Purves, T., Middlemas, A., Agthong, S., Jude, E.B., Boulton, A.J., Fernyhough, P., et al. A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy. FASEB J. 15 (2001), 2508–2514.
25. [25] Kanwar, Y.S., Wada, J., Sun, L., Xie, P., Wallner, E.I., Chen, S., et al. Diabetic nephropathy: mechanisms of renal disease progression. Exp. Biol. Med. 233 (2008), 4–11.
26. [26] Adhikary, L., Chow, F., Nikolic-Paterson, D., Stambe, C., Dowling, J., Atkins, R., et al. Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy. Diabetologia 47 (2004), 1210–1222.
27. [27] Sugaru, E., Sakai, M., Horigome, K., Tokunaga, T., Kitoh, M., Hume, W.E., et al. SMP-534 inhibits TGF-β-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis. Am. J. Physiol. Ren. Physiol. 289 (2005), F998–F1004.
28. [28] Li, X., Liu, W., Wang, Q., Liu, P., Deng, Y., Lan, T., et al. Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Mol. Cell Endocrinol. 307 (2009), 157–162.
29. [29] Park, M.J., Bae, C.S., Lim, S.K., Kim, D.I., Lim, J.C., Kim, J.C., et al. Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt. Arch. Pharm. Res. 33 (2010), 151–157.
30. [30] Li, X., Liu, W., Wang, Q., Liu, P., Deng, Y., Lan, T., et al. Emodin suppresses cell proliferation and fibronection expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Mol. Cell Endocrinol. 307 (2009), 157–162.