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Volumn 45, Issue 4, 2014, Pages 1629-1637

Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB-231 partly through suppression of the Akt pathway

Author keywords

Akt pathway; Breast cancer; Invasion; Morin; N cadherin

Indexed keywords

BETA CATENIN; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; MORIN; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; ANTINEOPLASTIC AGENT; FLAVONOID; PLANT EXTRACT;

EID: 84907469716     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2535     Document Type: Article
Times cited : (97)

References (45)
  • 1
    • 0035495969 scopus 로고    scopus 로고
    • Prognostic factors in breast cancer: Current and new predictors of metastasis
    • Hayes DF, Isaacs C and Stearns V: Prognostic factors in breast cancer: current and new predictors of metastasis. J Mammary Gland Biol Neoplasia 6: 375-392, 2001.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 375-392
    • Hayes, D.F.1    Isaacs, C.2    Stearns, V.3
  • 3
    • 24644486140 scopus 로고    scopus 로고
    • Korean breast cancer data of 1996
    • Korean Breast Cancer Society
    • Korean Breast Cancer Society: Korean breast cancer data of 1996. J Korean Surg Soc 55: 621-635, 1998.
    • (1998) J Korean Surg Soc , vol.55 , pp. 621-635
  • 4
    • 0037304034 scopus 로고    scopus 로고
    • The biology of breast carcinoma
    • Keen JC and Davidson NE: The biology of breast carcinoma. Cancer 97: 825-833, 2003. (Pubitemid 36125819)
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 825-833
    • Keen, J.C.1    Davidson, N.E.2
  • 6
    • 67849124183 scopus 로고    scopus 로고
    • Circulating tumor cells (CTCs): Detection methods and their clinical relevance in breast cancer
    • Mostert B, Sleijfer S, Foekens JA and Gratama JW: Circulating tumor cells (CTCs): detection methods and their clinical relevance in breast cancer. Cancer Treat Rev 35: 463-474, 2009.
    • (2009) Cancer Treat Rev , vol.35 , pp. 463-474
    • Mostert, B.1    Sleijfer, S.2    Foekens, J.A.3    Gratama, J.W.4
  • 7
    • 0026518957 scopus 로고
    • Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets
    • Yugarani T, Tan BKH, The M and Das NP: Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Lipids 27: 181-186, 1992.
    • (1992) Lipids , vol.27 , pp. 181-186
    • Yugarani, T.1    Tan, B.K.H.2    The, M.3    Das, N.P.4
  • 8
    • 0028328375 scopus 로고
    • Morin: A wood pigment that protects three types of human cells in the cardiovascular system against oxyradical damage
    • DOI 10.1016/0006-2952(94)90424-3
    • Wu TW, Zeng LH, Wu J and Fung KP: Morin: a wood pigment that protects three types of human cells in the cardiovascular system against oxyradical damage. Biochem Pharmacol 47: 1099-1103, 1994. (Pubitemid 24103845)
    • (1994) Biochemical Pharmacology , vol.47 , Issue.6 , pp. 1099-1103
    • Wu, T.-W.1    Zeng, L.-H.2    Wu, J.3    Fung, K.-P.4
  • 9
    • 0026489096 scopus 로고
    • Ginkgo biloba
    • Kleijnen J and Knipschild P: Ginkgo biloba . Lancet 340: 1136-1139, 1992.
    • (1992) Lancet , vol.340 , pp. 1136-1139
    • Kleijnen, J.1    Knipschild, P.2
  • 10
    • 0031747808 scopus 로고    scopus 로고
    • Diets, food components and human cancer
    • McGregor D: Diets, food components and human cancer. Biotherapy 11: 189-200, 1998.
    • (1998) Biotherapy , vol.11 , pp. 189-200
    • McGregor, D.1
  • 11
    • 0008412315 scopus 로고    scopus 로고
    • Flavonoids are scavengers of superoxide anion
    • Robak J and Gryglewski RJ: Flavonoids are scavengers of superoxide anion. Biochem Pharmacol 37: 83-88, 1998.
    • (1998) Biochem Pharmacol , vol.37 , pp. 83-88
    • Robak, J.1    Gryglewski, R.J.2
  • 12
    • 0009538299 scopus 로고
    • Hydroxyl radical scavenging activity of flavonoids
    • Husain SR, Cillard J and Cillard P: Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 26: 2489-2492, 1987.
    • (1987) Phytochemistry , vol.26 , pp. 2489-2492
    • Husain, S.R.1    Cillard, J.2    Cillard, P.3
  • 13
    • 0028072649 scopus 로고
    • Role of chemopreventers in human diet
    • Stavric B: Role of chemopreventers in human diet. Clin Biochem 27: 319-332, 1994.
    • (1994) Clin Biochem , vol.27 , pp. 319-332
    • Stavric, B.1
  • 16
    • 0028318752 scopus 로고
    • The correlation between active oxygens scavenging and antioxidative effects of flavonoids
    • DOI 10.1016/0891-5849(94)90202-X
    • Hanasaki Y, Ogawaa S and Fukui S: The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic Biol Med 16: 845-850, 1994. (Pubitemid 24193534)
    • (1994) Free Radical Biology and Medicine , vol.16 , Issue.6 , pp. 845-850
    • Hanasaki, Y.1    Ogawa, S.2    Fukui, S.3
  • 17
    • 0021274213 scopus 로고
    • Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13- acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds
    • Nakadate T, Yamamoto S, Aizu E and Kato R: Effects of flavonoids and antioxidants on 12-O-tetradecanoylphorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Gann 75: 214-222, 1984. (Pubitemid 14107229)
    • (1984) Gann, The Japanese Journal of Cancer Research , vol.75 , Issue.3 , pp. 214-222
    • Nakadate, T.1    Yamamoto, S.2    Aizu, E.3    Kato, R.4
  • 18
    • 0019139791 scopus 로고
    • Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation
    • DOI 10.1016/0090-6980(80)90103-3
    • Baumann J, Bruchhausen FV and Wurm G: Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation. Prostaglandins 20: 627-639, 1980. (Pubitemid 11176169)
    • (1980) Prostaglandins , vol.20 , Issue.4 , pp. 627-639
    • Baumann, J.1    Von Bruchhausen, F.2    Wurm, G.3
  • 19
    • 0024366081 scopus 로고
    • Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine
    • Francis AR, Shetty TK and Bhattacharya RK: Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis 10: 1953-1955, 1989. (Pubitemid 19244876)
    • (1989) Carcinogenesis , vol.10 , Issue.10 , pp. 1953-1955
    • Francis, A.R.1    Shetty, T.K.2    Bhattacharya, R.K.3
  • 20
    • 0021052055 scopus 로고
    • Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids
    • Huang MT, Wood AW, Newmark HL, Sayer JM, Yagi H, Jerina DM and Conney AH: Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Carcinogenesis 4: 1631-1637, 1983. (Pubitemid 14206929)
    • (1983) Carcinogenesis , vol.4 , Issue.12 , pp. 1631-1637
    • Huang, M.T.1    Wood, A.W.2    Newmark, H.L.3
  • 23
    • 0037052641 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets
    • DOI 10.1002/ijc.10329
    • Vihinen P and Kahari VM: Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 99: 157-166, 2002. (Pubitemid 34309470)
    • (2002) International Journal of Cancer , vol.99 , Issue.2 , pp. 157-166
    • Vihinen, P.1    Kahari, V.-M.2
  • 24
    • 33646576169 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor metastasis
    • DOI 10.1007/s10555-006-7886-9, Metalloproteinases and Cancer
    • Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34, 2006. (Pubitemid 43723979)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.1 , pp. 9-34
    • Deryugina, E.I.1    Quigley, J.P.2
  • 25
    • 77954861244 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
    • Radisky ES and Radisky DC: Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia 15: 201-212, 2010.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 201-212
    • Radisky, E.S.1    Radisky, D.C.2
  • 26
    • 0030764771 scopus 로고    scopus 로고
    • Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro
    • DOI 10.1083/jcb.136.6.1363
    • Lelongt B, Trugnan G, Murphy G and Ronco PM: Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. J Cell Biol 136: 1363-1373, 1997. (Pubitemid 27421921)
    • (1997) Journal of Cell Biology , vol.136 , Issue.6 , pp. 1363-1373
    • Lelongt, B.1    Trugnan, G.2    Murphy, G.3    Ronco, P.M.4
  • 27
    • 0030292766 scopus 로고    scopus 로고
    • TNF-alpha and IL-1beta Selectively Induce Expression of 92-kDa Gelatinase by Human Macrophages
    • Sarén P, Welgus HG and Kovanen PT: TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol 157: 4159-4165, 1996. (Pubitemid 126449330)
    • (1996) Journal of Immunology , vol.157 , Issue.9 , pp. 4159-4165
    • Saren, P.1    Welgus, H.G.2    Kovanen, P.T.3
  • 29
    • 35148890452 scopus 로고    scopus 로고
    • Cancer: Micromanagement of metastasis
    • Steeg PS: Cancer: micromanagement of metastasis. Nature 449: 671-673, 2007.
    • (2007) Nature , vol.449 , pp. 671-673
    • Steeg, P.S.1
  • 30
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg PS: Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12: 895-904, 2006.
    • (2006) Nat Med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 31
    • 34248594553 scopus 로고    scopus 로고
    • Metastasis: Recent discoveries and novel treatment strategies
    • DOI 10.1016/S0140-6736(07)60781-8, PII S0140673607607818
    • Eccles SA and Welch DR: Metastasis: recent discoveries and novel treatment strategies. Lancet 369: 1742-1757, 2007. (Pubitemid 46755391)
    • (2007) Lancet , vol.369 , Issue.9574 , pp. 1742-1757
    • Eccles, S.A.1    Welch, D.R.2
  • 32
    • 0035876935 scopus 로고    scopus 로고
    • Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity
    • White ES, Strom SR, Wys NL and Arenberg DA: Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity. J Immunol 166: 7549-7555, 2001. (Pubitemid 32525635)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7549-7555
    • White, E.S.1    Strom, S.R.B.2    Wys, N.L.3    Arenberg, D.A.4
  • 33
    • 0033903714 scopus 로고    scopus 로고
    • Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
    • Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, Koike M, Inadera H and Matsushima K: Significance macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 6: 3282-3289, 2000. (Pubitemid 30637758)
    • (2000) Clinical Cancer Research , vol.6 , Issue.8 , pp. 3282-3289
    • Ueno, T.1    Toi, M.2    Saji, H.3    Muta, M.4    Bando, H.5    Kuroi, K.6    Koike, M.7    Inadera, H.8    Matsushima, K.9
  • 34
    • 0028178968 scopus 로고
    • Expression and activity of MMPS and their regulators in ovarian cancer
    • Naylor MS, Stamp GW, Davies BD and Balkwill FR: Expression and activity of MMPS and their regulators in ovarian cancer. Int J Cancer 58: 50-56, 1994.
    • (1994) Int J Cancer , vol.58 , pp. 50-56
    • Naylor, M.S.1    Stamp, G.W.2    Davies, B.D.3    Balkwill, F.R.4
  • 35
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141: 52-67, 2010.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 37
    • 0036781973 scopus 로고    scopus 로고
    • A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    • DOI 10.1016/S1535-6108(02)00150-2
    • Suyama K, Shapiro I, Guttman M and Hazan RB: A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2: 301-314, 2002. (Pubitemid 41043964)
    • (2002) Cancer Cell , vol.2 , Issue.4 , pp. 301-314
    • Suyama, K.1    Shapiro, I.2    Guttman, M.3    Hazan, R.B.4
  • 40
    • 0034949143 scopus 로고    scopus 로고
    • Invasive micropapillary carcinoma of the breast: Eighty cases of an underrecognized entity
    • DOI 10.1053/hupa.2001.24988
    • Walsh MM and Bleiweiss IJ: Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol 32: 583-589, 2001. (Pubitemid 32601239)
    • (2001) Human Pathology , vol.32 , Issue.6 , pp. 583-589
    • Walsh, M.M.1    Bleiweiss, I.J.2
  • 41
    • 0035955728 scopus 로고    scopus 로고
    • MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function
    • Ho AT, Voura EB, Soloway PD, Watson KL and Khokha R: MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. J Biol Chem 276: 40215-40224, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 40215-40224
    • Ho, A.T.1    Voura, E.B.2    Soloway, P.D.3    Watson, K.L.4    Khokha, R.5
  • 42
  • 43
    • 17644369682 scopus 로고    scopus 로고
    • Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase a pathway
    • DOI 10.1074/jbc.M410766200
    • Pon YL, Auersperg N and Wong AS: Gonadotropins regulate N-cadherinmediated human ovarian surface epithelial cell survival at both posttranslational and transcriptional levels through a cyclic AMP/protein kinase A pathway. J Biol Chem 280: 15438-15448, 2005. (Pubitemid 40562902)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.15 , pp. 15438-15448
    • Yuen, L.P.1    Auersperg, N.2    Wong, A.S.T.3
  • 44
    • 33845200847 scopus 로고    scopus 로고
    • Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression
    • Yoon SO, Shin S, Lee HJ, Chun HK and Chung AS: Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther 5: 2666-2675, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2666-2675
    • Yoon, S.O.1    Shin, S.2    Lee, H.J.3    Chun, H.K.4    Chung, A.S.5
  • 45
    • 7744229935 scopus 로고    scopus 로고
    • Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: Involvement of invasive potential
    • DOI 10.1096/fj.03-1429fje
    • Chung TW, Lee YC and Kim CH: Hepatitis B viral HBx induces matrix metallo- proteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18: 1123-1125, 2004. (Pubitemid 39561544)
    • (2004) FASEB Journal , vol.18 , Issue.10 , pp. 1123-1125
    • Chung, T.-W.1    Lee, Y.-C.2    Kim, C.-H.3


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