Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: Role of osteopontin

American Journal of Physiology - Renal Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Sodhi, Chhinder P ^a   Phadke, Sarojini A ^a   Batlle, Daniel ^a   Sahai, Atul ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cell proliferation; Chronic hypoxia; Diabetes; Extracellular matrix; Hyperglycemia; Mesangial cells

Indexed keywords

COLLAGEN; COLLAGEN TYPE 4; COMPLEMENTARY DNA; INTEGRIN RECEPTOR; LEUCINE; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; OSTEOPONTIN; PHOSPHORUS 32; PROLINE; THYMIDINE; TRITIUM;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DNA SYNTHESIS; EXTRACELLULAR MATRIX; GLOMERULOPATHY; HYPERGLYCEMIA; HYPOXIA; ISOTOPE LABELING; KIDNEY DISEASE; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034997334     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2001.280.4.f667     Document Type: Article

References (39)

1. Alain-Pierre G, Campan M, Candresse T, and Desgranges C. Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro. Arterioscler Thromb 13: 120-125, 1993.
2. Amemiya T, Sasamura H, Mifune M, Kitamura Y, Hirasashi J, Hayashi M, and Saruta T. Vascular endothelial growth factor activates MAP kinase and enhances collagen syntheis in human mesangial cells. Kidney Int 56: 2055-2063, 1999.
3. Ayo SH, Radnik RA, Garoni JA, Glass WF II, and Kreisberg JI. High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells. Am J Pathol 136: 1339-1348, 1990.
4. Cameron NE and Cotter MA. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 46: S31-S37, 1997.
5. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986, 1993.
6. Elgavish A, Prince C, Chang PL, Lloyd K, Lindsey R, and Reed R. Osteopontin stimulates a subpopulation of quiescent human prostate epithelial cells with high proliferative potential to divide in vitro. Prostate 35: 83-94, 1998.
7. Eng E, Floege J, Young BA, Couser WG, and Johnson RJ. Does extracellular matrix expansion in glomerular disease require mesangial cell proliferation? Kidney Int 45: S45-S47, 1994.
8. Fine LG, Bandyopadhay D, and Norman JT. Is there a common mechanism for progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 57: S22-S26, 2000.
9. Fischer JM, Tschope C, Reinecke A, Giachelli CM, and Unger T. Upregulation of osteopontin expression in renal cortex of streptozotocin-induced diabetic rats is mediated by bradykinin. Diabetes 47: 1512-1518, 1998.
10. Floege J, Burns MW, Alpers CE, Yoshimura A, Pritzl P, Gorden K, Seifert RA, Bowen-Pope DF, Couser WG, and Johnson RJ. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int 41: 297-309, 1992.
11. Floege JM, Eng E, Young BA, Couser WG, and Johnson RJ. Heparin suppresses mesangial cell proliferation and matrix expansion in experimental masangio-proliferative glomerulonephritis. Kidney Int 43: 369-380, 1993.
12. Giachelli CM, Bae N, Almeida M, Denhardt D, Alpers CE, and Scharwartz SM. Osteopontin expression is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 92: 1686-1696, 1993.
13. Giachelli CM, Pichler RH, Lombardi D, Denhardt DT, Alpers CE, Schwartz SM, and Johnson RJ. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 45: 515-524, 1994.
14. Hasslacher C, Reichenbacher R, Gechter F, and Timpl R. Glomerular basement membrane synthesis and serum concentration of type IV collagen in streptozotocin-diabetic rats. Diabetologia 26: 150-154, 1984.
15. Johnson RJ, Raines E, Floege J, Yoshimura A, Pritzl P, Alpers C, and Ross R. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet derived growth factor. J Exp Med 175: 1413-1416, 1992.
16. Kaneto H, Morrisey J, McCracken R, Reyes A, and Klahr S. Osteopontin expression in the kidney during unilateral ureteral obstruction. Miner Electrolyte Metab 24: 227-237, 1998.
17. Koya D and King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 47: 859-866, 1998.
18. Lewis EJ, Hunsicker LG, Bain RP, and Rhode RD. The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. N Engl J Med 329: 1456-1462, 1993.
19. Liaw L, Lombardi DM, Almeida MM, Schwartz SM, Deblois D, and Giachclli CM. Neutralizing antibodies directed against osteopontin inhibit rat carotid neointimal thickening after endothelial denudation. Arterioscler Thromb Vasc Biol 17: 188-193, 1997.
20. Linsenmeier RA, Braun RD, McRipley MA, Padnick LB, Ahmed J, Hatchell DL, McLeod DS, and Lutty GA. Retinal hypoxia in long-term diabetic cats. Invest Ophthalmol Vis Sci 39: 1647-1657, 1998.
21. 2 and hyalurunan on mesangial cell proliferation: a potential contribution to glomerular hypercellularity in diabetes. Diabetes 45: 44-50, 1996.
22. Mauer SM, Steffes MW, and Brown DM. The kidney in diabetes. Am J Med 70: 603-612, 1981.
23. Melin J, Hellberg O, Akyurek LM, Kallskog O, Larson E, and Fellstrom BC. Ischemia causes rapidly progressive nephropathy in the diabetic rat. Kidney Int 52: 985-991, 1997.
24. Natarajan R, Gonzales N, Xu L, and Nadler J. Vascular smooth muscle cells exhibit increased growth response to elevated glucose. Biochem Biophys Res Commun 87: 552-560, 1992.
25. Norman JT, Stidwill R, Singer M, and Fine L. Dynamic, noninvasive measurement of interstitial oxygenation in the intact rat kidney: a window on the pathogenesis of chronic tubulointerstitial disease and the role of chronic hypoxia (Abstract). J Am Soc Nephrol A3379, 1999.
26. Orphanides C, Fine LG, and Norman JT. Hypoxia stimulates proximal tubular cell matrix production via a TGF-β1 independent mechanism. Kidney Int 52: 637-647, 1997.
27. 3-integrin in the development of coronary artery restenosis after angioplasty. Proc Natl Acad Sci USA 94: 9308-9313, 1997.
28. Ruoslahti E and Engvall E. Integrins and vascular extracellular matrix assembly. J Clin Invest 99: 1149-1152, 1997.
29. Sahai A, Mei C, Pattison T, and Tannen RL. Chronic hypoxia induces proliferation of cultured mesangial cells: role of calcium and protein kinase C. Am J Physiol Renal Physiol 273: F954-F960, 1997.
30. Sahai A, Mei C, Schrier RW, and Tannen RL. Mechanisms of chronic hypoxia-induced renal cell growth. Kidney Int 56: 1277-1281, 1999.
31. Santilli SM, Fiegel VD, and Knighton DR. Alloxan diabetes alters the rabbit transarterial wall oxygen gradient. J Vasc Surg 18: 227-233, 1993.
32. Sodhi CP, Battle D, and Sahai A. Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: role of PKC and p38 MAP kinase. Kidney Int 58: 691-700, 2000.
33. Takemoto M, Yokote K, Yamazaki M, Ridall AL, Butler WT, Matsumoto T, Tamura K, Saito Y, and Mori S. Enhanced expression of osteopontin by high glucose in cultured rat smooth muscle cells. Biochem Biophys Res Commun 258: 722-726, 1999.
34. Tucker MA, Chang P, Prince C, Gillespie GY, and Mapstone TB. TPA-mediated regulation of osteopontin in human malignant glioma cells. Anticancer Res 18: 807-812, 1998.
35. Wolf G, Sharma K, Chen Y, Erickson M, and Ziyadeh FN. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β1. Kidney Int 42: 647-656, 1992.
36. Wolf G and Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 56: 393-405, 1999.
37. Yang Y, Guh J, Yang M, Lai Y, Tsai J, Hung W, Chang C, and Chuang L. Interaction between high glucose and TGF-β in cell cycle protein regulation in MDCK cells. J Am Soc Nephrol 9: 182-193, 1998.
38. Young BA, Johnson RL, Alpers CE, Eng E, Gordon K, Floege J, and Couser WG. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 47: 935-944, 1995.
39. Yu XQ, fan JM, Paterson DJ, Yang N, Mu W, Pichler R, Johnson RJ, Atkins RC, and Lan HY. IL-1 upregulates osteopontin expression in experimental crescentric glomerulonephritis in the rat. Am J Pathol 154: 833-841, 1999.