Five-year mortality and hospital costs associated with surviving intensive care

American Journal of Respiratory and Critical Care Medicine

Volumn 194, Issue 2, 2016, Pages 198-208

  Lone, Nazir I ^a,b   Gillies, Michael A ^b   Haddow, Catriona ^c   Dobbie, Richard ^c   Rowan, Kathryn M ^d   Wild, Sarah H ^a   Murray, Gordon D ^a   Walsh, Timothy S ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c HEALTHCARE IMPROVEMENT SCOTLAND   (United Kingdom)

^d and London School of Hygiene Tropical Medicine   (United Kingdom)

Author keywords

Hospital costs; Hospital readmission; Intensive care; Mortality; Registries

Indexed keywords

ACUTE DISEASE; ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL COST; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MORTALITY RATE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SURVIVOR; AGE; CRITICAL ILLNESS; ECONOMICS; EPIDEMIOLOGY; INTENSIVE CARE; LENGTH OF STAY; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; REGISTER; SCOTLAND; SEX DIFFERENCE; STATISTICS AND NUMERICAL DATA;

ADULT; AGE FACTORS; AGED; COHORT STUDIES; CRITICAL CARE; CRITICAL ILLNESS; FEMALE; HOSPITAL COSTS; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; REGISTRIES; SCOTLAND; SEX FACTORS; SURVIVORS;

EID: 84988943701     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201511-2234OC     Document Type: Article

References (42)

1. Desai SV, Law TJ, Needham DM. Long-term complications of critical care. Crit Care Med 2011;39:371-379.
2. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007;33:1876-1891.
3. Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, et al.; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011;364:1293-1304.
4. Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW. Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South Med J 2009;102:1150-1157.
5. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM. Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 2009;35:796-809.
6. Dowdy DW, Eid MP, Sedrakyan A, Mendez-Tellez PA, Pronovost PJ, Herridge MS, Needham DM. Quality of life in adult survivors of critical illness: a systematic review of the literature. Intensive Care Med 2005; 31:611-620.
7. Cuthbertson BH, Roughton S, Jenkinson D, Maclennan G, Vale L. Quality of life in the five years after intensive care: a cohort study. Crit Care 2010;14:R6.
8. Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, Zawistowski C, Bemis-Dougherty A, Berney SC, Bienvenu OJ, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med 2012;40: 502-509.
9. Williams TA, Leslie GD. Challenges and possible solutions for long-term follow-up of patients surviving critical illness. Aust Crit Care 2011;24: 175-185.
10. Iwashyna TJ, Netzer G. The burdens of survivorship: an approach to thinking about long-term outcomes after critical illness. Semin Respir Crit Care Med 2012;33:327-338.
11. Lone NI, Haddow C, Dobbie R, Gillies MA, Rowan KM, Walsh TS, Wild SH, Murray GD. Major healthcare resource use in ICU survivors: a national data linkage cohort study [abstract]. J Intensive Care Soc 2013;14(1, Suppl):S6-S7.
12. Lone NI. Long-term mortality and major healthcare resource use following admission to Scottish intensive care units [abstract]. J Intensive Care Soc 2013;14:68-69.
13. Lone NI, Walsh TS. Healthcare cost trajectories before and after critical illness: a national data linkage cohort study [abstract]. J Intensive Care Soc 2015;16(1, Suppl):18.
14. Scottish Intensive Care Society Audit Group. Scottish Intensive Care Society Audit Group annual report: audit of intensive care units in Scotland 2014: reporting on 2013. 2014 [accessed 2016 Feb 1]. Available from: http://www.sicsag.scot.nhs.uk/docs/SICSAG-report-2014-web.pdf
15. National Records of Scotland. Vital events reference tables. 2015 [accessed 2016 Feb 1]. Available from: http://www.nrscotland.gov. uk/statistics-and-data/statistics/statistics-by-theme/vital-events/vital-events-reference-tables
16. Information Services Division Scotland. Scottish Health Service costs. 2014 [accessed 2016 Feb 1]. Available from: http://www.isdscotland. org/Health-Topics/Finance/Costs/
17. National Records of Scotland. Migration between Scotland and overseas. 2014 [accessed 2016 Feb 1]. Available from: http://www.nrscotland.gov.uk/statistics-and-data/statistics/statistics-by-theme/migration/migration-statistics/migration-between-scotland-and-overseas
18. National Statistics. Scottish Index of Multiple Deprivation: 2009 general report. 2009 [accessed 2016 Feb 1]. Available from: http://www.scotland. gov.uk/Resource/Doc/933/0115249.pdf
19. Scottish Government. Urban rural classification 2007-2008. 2010 [accessed 2016 Feb 1]. Available from: http://www.scotland.gov. uk/Resource/Doc/233802/0063988.pdf
20. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-383.
21. Hilbe JM. Negative binomial regression. Cambridge: Cambridge University Press; 2011.
22. Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999;94:496-509.
23. Andersen PK, Geskus RB, de Witte T, Putter H. Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol 2012;41: 861-870.
24. Lone NI, Walsh TS. Impact of intensive care unit organ failures on mortality during five years following critical illness. Am J Respir Crit Care Med 2012;186:640-647.
25. Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional trajectories among older persons before and after critical illness. JAMA Intern Med 2015;175:523-529.
26. Ranzani OT, Zampieri FG, Besen BA, Azevedo LC, Park M. One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil. Crit Care 2015;19:269.
27. Tan T, Brett SJ, Stokes T; Guideline Development Group. Rehabilitation after critical illness: summary of NICE guidance. BMJ 2009;338: b822.
28. Walsh TS, Salisbury LG, Merriweather JL, Boyd JA, Griffith DM, Huby G, Kean S, Mackenzie SJ, Krishan A, Lewis SC, et al.; RECOVER Investigators. Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the RECOVER randomized clinical trial. JAMA Intern Med 2015;175: 901-910.
29. Cuthbertson BH, Rattray J, Campbell MK, Gager M, Roughton S, Smith A, Hull A, Breeman S, Norrie J, Jenkinson D, et al.; PRaCTICaL study group. The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial. BMJ 2009; 339:b3723.
30. Elliott D, McKinley S, Alison J, Aitken LM, King M, Leslie GD, Kenny P, Taylor P, Foley R, Burmeister E. Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care 2011;15:R142.
31. Iwashyna TJ, Netzer G, Langa KM, Cigolle C. Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions. Am J Respir Crit Care Med 2012;185:835-841.
32. Iwashyna TJ. Trajectories of recovery and dysfunction after acute illness, with implications for clinical trial design. Am J Respir Crit Care Med 2012;186:302-304.
33. Wunsch H, Guerra C, Barnato AE, Angus DC, Li G, Linde-Zwirble WT. Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA 2010;303:849-856.
34. Keenan SP, Dodek P, Chan K, Hogg RS, Craib KJP, Anis AH, Spinelli JJ. Intensive care unit admission has minimal impact on long-term mortality. Crit Care Med 2002;30:501-507.
35. Lone NI, Seretny M, Wild SH, Rowan KM, Murray GD, Walsh TS. Surviving intensive care: a systematic review of healthcare resource use after hospital discharge. Crit Care Med 2013;41:1832-1843.
36. Ruhl AP, Lord RK, Panek JA, Colantuoni E, Sepulveda KA, Chong A, Dinglas VD, Shanholtz CB, Pronovost PJ, Steinwachs DM, et al. Health care resource use and costs of two-year survivors of acute lung injury: an observational cohort study. Ann Am Thorac Soc 2015; 12:392-401.
37. Keenan SP, Dodek P, Chan K, Simon M, Hogg RS, Anis AH, Spinelli JJ, Tilley J, Norena M, Wong H. Intensive care unit survivors have fewer hospital readmissions and readmission days than other hospitalized patients in British Columbia. Crit Care Med 2004;32:391-398.
38. Prescott HC, Langa KM, Liu V, Escobar GJ, Iwashyna TJ. Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med 2014;190:62-69.
39. Geue C, Briggs A, Lewsey J, Lorgelly P. Population ageing and healthcare expenditure projections: new evidence from a time to death approach. Eur J Health Econ 2014;15:885-896.
40. Bagshaw SM, Stelfox HT, Johnson JA, McDermid RC, Rolfson DB, Tsuyuki RT, Ibrahim Q, Majumdar SR. Long-term association between frailty and health-related quality of life among survivors of critical illness: a prospective multicenter cohort study. Crit Care Med 2015;43:973-982.
41. Maldonado G, Greenland S. Estimating causal effects. Int J Epidemiol 2002;31:422-429.
42. Griffiths J, Hatch RA, Bishop J, Morgan K, Jenkinson C, Cuthbertson BH, Brett SJ. An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Crit Care 2013;17:R100.