Genes mirror migrations and cultures in prehistoric Europe — a population genomic perspective

Current Opinion in Genetics and Development

Volumn 41, Issue , 2016, Pages 115-123

  Günther, Torsten ^a   Jakobsson, Mattias ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL WORKER; ASIAN; BRONZE AGE; CULTURAL ANTHROPOLOGY; DEMOGRAPHY; EUROPE; EUROPEAN; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETIC VARIATION; GENOMICS; GEOGRAPHY; HUMAN; HUMAN GENETICS; LIFESTYLE; MESOLITHIC; MIGRATION; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NEOLITHIC; PALEOLITHIC; POPULATION GENETIC STRUCTURE; POPULATION GENETICS; POPULATION RESEARCH; PREHISTORIC PERIOD; PRIORITY JOURNAL; REVIEW; ANIMAL; GENETICS; HISTORY; HOMINID; HUMAN GENOME; METAGENOMICS;

MITOCHONDRIAL DNA;

ANIMALS; DNA, MITOCHONDRIAL; EUROPE; EVOLUTION, MOLECULAR; GENETIC VARIATION; GENOME, HUMAN; GEOGRAPHY; HISTORY, ANCIENT; HOMINIDAE; HUMAN MIGRATION; HUMANS; METAGENOMICS;

EID: 84988735508     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2016.09.004     Document Type: Review

References (84)

1. 1 Menozzi, P., Piazza, A., Cavalli-Sforza, L., Synthetic maps of human gene frequencies in Europeans. Science 201 (1978), 786–792.
2. 2 Lao, O., Lu, T.T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L.A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U., Werge, T., Rivadeneira, F., Hofman, A., Uitterlinden, A.G., Gieger, C., Wichmann, H.-E., Rüther, A., Schreiber, S., Becker, C., Nürnberg, P., Nelson, M.R., Krawczak, M., Kayser, M., Correlation between genetic and geographic structure in Europe. Curr Biol 18 (2008), 1241–1248.
3. 3 Novembre, J., Johnson, T., Bryc, K., Kutalik, Z., Boyko, A.R., Auton, A., Indap, A., King, K.S., Bergmann, S., Nelson, M.R., Stephens, M., Bustamante, C.D., Genes mirror geography within Europe. Nature 456 (2008), 98–101.
4. 4• Seguin-Orlando, A., Korneliussen, T.S., Sikora, M., Malaspinas, A.-S., Manica, A., Moltke, I., Albrechtsen, A., Ko, A., Margaryan, A., Moiseyev, V., Goebel, T., Westaway, M., Lambert, D., Khartanovich, V., Wall, J.D., Nigst, P.R., Foley, R.A., Lahr, M.M., Nielsen, R., Orlando, L., Willerslev, E., Paleogenomics. Genomic structure in Europeans dating back at least 36 200 years. Science 346 (2014), 1113–1118 Evidence of some level of continuity between present-day Europeans and Upper Palaeolithic Europeans.
5. 5•• Fu, Q., Posth, C., Hajdinjak, M., Petr, M., Mallick, S., Fernandes, D., Furtwängler, A., Haak, W., Meyer, M., Mittnik, A., Nickel, B., Peltzer, A., Rohland, N., Slon, V., Talamo, S., Lazaridis, I., Lipson, M., Mathieson, I., Schiffels, S., Skoglund, P., Derevianko, A.P., Drozdov, N., Slavinsky, V., Tsybankov, A., Cremonesi, R.G., Mallegni, F., Gély, B., Vacca, E., Morales, M.R.G., Straus, L.G., Neugebauer-Maresch, C., Teschler-Nicola, M., Constantin, S., Moldovan, O.T., Benazzi, S., Peresani, M., Coppola, D., Lari, M., Ricci, S., Ronchitelli, A., Valentin, F., Thevenet, C., Wehrberger, K., Grigorescu, D., Rougier, H., Crevecoeur, I., Flas, D., Semal, P., Mannino, M.A., Cupillard, C., Bocherens, H., Conard, N.J., Harvati, K., Moiseyev, V., Drucker, D.G., Svoboda, J., Richards, M.P., Caramelli, D., Pinhasi, R., Kelso, J., Patterson, N., Krause, J., Pääbo, S., Reich, D., The genetic history of ice age Europe. Nature, 2016 Large study on the European population structure before, during and after the last Ice Age. Samples used range from 45 000 to 7000 years ago.
6. 6 Skoglund, P., Malmström, H., Raghavan, M., Storå, J., Hall, P., Willerslev, E., Gilbert, M.T.P., Götherström, A., Jakobsson, M., Origins and genetic legacy of neolithic farmers and hunter-gatherers in Europe. Science 336 (2012), 466–469.
7. 7• Haak, W., Lazaridis, I., Patterson, N., Rohland, N., Mallick, S., Llamas, B., Brandt, G., Nordenfelt, S., Harney, E., Stewardson, K., Fu, Q., Mittnik, A., Bánffy, E., Economou, C., Francken, M., Friederich, S., Pena, R.G., Hallgren, F., Khartanovich, V., Khokhlov, A., Kunst, M., Kuznetsov, P., Meller, H., Mochalov, O., Moiseyev, V., Nicklisch, N., Pichler, S.L., Risch, R., Rojo Guerra, M.A., Roth, C., Szécsényi-Nagy, A., Wahl, J., Meyer, M., Krause, J., Brown, D., Anthony, D., Cooper, A., Alt, K.W., Reich, D., Massive migration from the steppe was a source for indo-European languages in Europe. Nature 522 (2015), 207–211 This paper provides genetic evidence for large-scale migrations of eastern origin during the Bronze Age.
8. 8• Allentoft, M.E., Sikora, M., Sjögren, K.-G., Rasmussen, S., Rasmussen, M., Stenderup, J., Damgaard, P.B., Schroeder, H., Ahlström, T., Vinner, L., Malaspinas, A.-S., Margaryan, A., Higham, T., Chivall, D., Lynnerup, N., Harvig, L., Baron, J., Della Casa, P., Dabrowski, P., Duffy, P.R., Ebel, A.V., Epimakhov, A., Frei, K., Furmanek, M., Gralak, T., Gromov, A., Gronkiewicz, S., Grupe, G., Hajdu, T., Jarysz, R., Khartanovich, V., Khokhlov, A., Kiss, V., Kolár, J., Kriiska, A., Lasak, I., Longhi, C., McGlynn, G., Merkevicius, A., Merkyte, I., Metspalu, M., Mkrtchyan, R., Moiseyev, V., Paja, L., Pálfi, G., Pokutta, D., Pospieszny, Ł., Price, T.D., Saag, L., Sablin, M., Shishlina, N., Smrčka, V., Soenov, V.I., Szeverényi, V., Tóth, G., Trifanova, S.V., Varul, L., Vicze, M., Yepiskoposyan, L., Zhitenev, V., Orlando, L., Sicheritz-Pontén, T., Brunak, S., Nielsen, R., Kristiansen, K., Willerslev, E., Population genomics of bronze age Eurasia. Nature 522 (2015), 167–172 This paper provides genetic evidence for large-scale migrations of eastern origin during the Bronze Age.
9. 9 Haber, M., Mezzavilla, M., Xue, Y., Tyler-Smith, C., Ancient dna and the rewriting of human history: be sparing with Occam's razor. Genome Biol, 17, 2016, 1.
10. 10 Mellars, P., A new radiocarbon revolution and the dispersal of modern humans in Eurasia. Nature 439 (2006), 931–935.
11. 11 Benazzi, S., Douka, K., Fornai, C., Bauer, C.C., Kullmer, O., Svoboda, J., Pap, I., Mallegni, F., Bayle, P., Coquerelle, M., Condemi, S., Ronchitelli, A., Harvati, K., Weber, G.W., Early dispersal of modern humans in Europe and implications for neanderthal behaviour. Nature 479 (2011), 525–528.
12. 12 Higham, T., Compton, T., Stringer, C., Jacobi, R., Shapiro, B., Trinkaus, E., Chandler, B., Gröning, F., Collins, C., Hillson, S., O'Higgins, P., FitzGerald, C., Fagan, M., The earliest evidence for anatomically modern humans in northwestern Europe. Nature 479 (2011), 521–524.
13. 13 Pagani, L., Schiffels, S., Gurdasani, D., Danecek, P., Scally, A., Chen, Y., Xue, Y., Haber, M., Ekong, R., Oljira, T., Mekonnen, E., Luiselli, D., Bradman, N., Bekele, E., Zalloua, P., Durbin, R., Kivisild, T., Tyler-Smith, C., Tracing the route of modern humans out of africa by using 225 human genome sequences from Ethiopians and Egyptians. Am J Hum Genet 96 (2015), 986–991.
14. 14 Green, R.E., Krause, J., Briggs, A.W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M.H.-Y., Hansen, N.F., Durand, E.Y., Malaspinas, A.-S., Jensen, J.D., Marques-Bonet, T., Alkan, C., Prüfer, K., Meyer, M., Burbano, H.A., Good, J.M., Schultz, R., Aximu-Petri, A., Butthof, A., Höber, B., Höffner, B., Siegemund, M., Weihmann, A., Nusbaum, C., Lander, E.S., Russ, C., Novod, N., Affourtit, J., Egholm, M., Verna, C., Rudan, P., Brajkovic, D., Kucan, Z., Gusic, I., Doronichev, V.B., Golovanova, L.V., Lalueza-Fox, C., de la Rasilla, M., Fortea, J., Rosas, A., Schmitz, R.W., Johnson, P.L.F., Eichler, E.E., Falush, D., Birney, E., Mullikin, J.C., Slatkin, M., Nielsen, R., Kelso, J., Lachmann, M., Reich, D., Pääbo, S., A draft sequence of the neandertal genome. Science 328 (2010), 710–722.
15. 15 Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P.H., de Filippo, C., Li, H., Mallick, S., Dannemann, M., Fu, Q., Kircher, M., Kuhlwilm, M., Lachmann, M., Meyer, M., Ongyerth, M., Siebauer, M., Theunert, C., Tandon, A., Moorjani, P., Pickrell, J., Mullikin, J.C., Vohr, S.H., Green, R.E., Hellmann, I., Johnson, P.L.F., Blanche, H., Cann, H., Kitzman, J.O., Shendure, J., Eichler, E.E., Lein, E.S., Bakken, T.E., Golovanova, L.V., Doronichev, V.B., Shunkov, M.V., Derevianko, A.P., Viola, B., Slatkin, M., Reich, D., Kelso, J., Pääbo, S., The complete genome sequence of a neanderthal from the altai mountains. Nature 505 (2014), 43–49.
16. 16 Fu, Q., Hajdinjak, M., Moldovan, O.T., Constantin, S., Mallick, S., Skoglund, P., Patterson, N., Rohland, N., Lazaridis, I., Nickel, B., Viola, B., Prüfer, K., Meyer, M., Kelso, J., Reich, D., Pääbo, S., An early modern human from romania with a recent neanderthal ancestor. Nature 524 (2015), 216–219.
17. 17 Posth, C., Renaud, G., Mittnik, A., Drucker, D.G., Rougier, H., Cupillard, C., Valentin, F., Thevenet, C., Furtwängler, A., Wiß ing, C., Francken, M., Malina, M., Bolus, M., Lari, M., Gigli, E., Capecchi, G., Crevecoeur, I., Beauval, C., Flas, D., Germonpré, M., van der Plicht, J., Cottiaux, R., Gély, B., Ronchitelli, A., Wehrberger, K., Grigorescu, D., Svoboda, J., Semal, P., Caramelli, D., Bocherens, H., Harvati, K., Conard, N.J., Haak, W., Powell, A., Krause, J., Pleistocene mitochondrial genomes suggest a single major dispersal of non-africans and a late glacial population turnover in europe. Curr Biol, 2016.
18. 18 Clark, P.U., Dyke, A.S., Shakun, J.D., Carlson, A.E., Clark, J., Wohlfarth, B., Mitrovica, J.X., Hostetler, S.W., McCabe, A.M., The last glacial maximum. Science 325 (2009), 710–714.
19. 19 Gamble, C., Davies, W., Pettitt, P., Richards, M., Climate change and evolving human diversity in Europe during the last glacial. Philos Trans R Soc Lond B Biol Sci 359 (2004), 243–253 discussion 253-4.
20. 20 Stewart, J.R., Stringer, C.B., Human evolution out of Africa: the role of refugia and climate change. Science 335 (2012), 1317–1321.
21. 21 Li, H., Durbin, R., Inference of human population history from individual whole-genome sequences. Nature 475 (2011), 493–496.
22. 22•• Skoglund, P., Malmström, H., Omrak, A., Raghavan, M., Valdiosera, C., Günther, T., Hall, P., Tambets, K., Parik, J., Sjögren, K.-G., Apel, J., Willerslev, E., Storå, J., Götherström, A., Jakobsson, M., Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Science 344 (2014), 747–750 First paper showing that hunter-gatherers and farmers met and admixed during the Neolithic while also studying their genetic diversities and differentiation.
23. 23 Sánchez-Quinto, F., Schroeder, H., Ramirez, O., Avila-Arcos, M.C., Pybus, M., Olalde, I., Velazquez, A.M.V., Marcos, M.E.P., Encinas, J.M.V., Bertranpetit, J., Orlando, L., Gilbert, M.T.P., Lalueza-Fox, C., Genomic affinities of two 7000-year-old Iberian hunter-gatherers. Curr Biol 22 (2012), 1494–1499.
24. 24•• Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P.H., Schraiber, J.G., Castellano, S., Lipson, M., Berger, B., Economou, C., Bollongino, R., Fu, Q., Bos, K.I., Nordenfelt, S., Li, H., de Filippo, C., Prüfer, K., Sawyer, S., Posth, C., Haak, W., Hallgren, F., Fornander, E., Rohland, N., Delsate, D., Francken, M., Guinet, J.-M., Wahl, J., Ayodo, G., Babiker, H.A., Bailliet, G., Balanovska, E., Balanovsky, O., Barrantes, R., Bedoya, G., Ben-Ami, H., Bene, J., Berrada, F., Bravi, C.M., Brisighelli, F., Busby, G.B.J., Cali, F., Churnosov, M., Cole, D.E.C., Corach, D., Damba, L., van Driem, G., Dryomov, S., Dugoujon, J.-M., Fedorova, S.A., Gallego Romero, I., Gubina, M., Hammer, M., Henn, B.M., Hervig, T., Hodoglugil, U., Jha, A.R., Karachanak-Yankova, S., Khusainova, R., Khusnutdinova, E., Kittles, R., Kivisild, T., Klitz, W., Kuč inskas, V., Kushniarevich, A., Laredj, L., Litvinov, S., Loukidis, T., Mahley, R.W., Melegh, B., Metspalu, E., Molina, J., Mountain, J., Näkkäläjärvi, K., Nesheva, D., Nyambo, T., Osipova, L., Parik, J., Platonov, F., Posukh, O., Romano, V., Rothhammer, F., Rudan, I., Ruizbakiev, R., Sahakyan, H., Sajantila, A., Salas, A., Starikovskaya, E.B., Tarekegn, A., Toncheva, D., Turdikulova, S., Uktveryte, I., Utevska, O., Vasquez, R., Villena, M., Voevoda, M., Winkler, C.A., Yepiskoposyan, L., Zalloua, P., Zemunik, T., Cooper, A., Capelli, C., Thomas, M.G., Ruiz-Linares, A., Tishkoff, S.A., Singh, L., Thangaraj, K., Villems, R., Comas, D., Sukernik, R., Metspalu, M., Meyer, M., Eichler, E.E., Burger, J., Slatkin, M., Pääbo, S., Kelso, J., Reich, D., Krause, J., Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513 (2014), 409–413 First paper publishing high-coverage Neolithic and Mesolithic genomes. Also presenting a model of three major source populations/migrations shaping modern Europeans.
25. 25• Jones, E.R., Gonzalez-Fortes, G., Connell, S., Siska, V., Eriksson, A., Martiniano, R., McLaughlin, R.L., Gallego Llorente, M., Cassidy, L.M., Gamba, C., Meshveliani, T., Bar-Yosef, O., Müller, W., Belfer-Cohen, A., Matskevich, Z., Jakeli, N., Higham, T.F.G., Currat, M., Lordkipanidze, D., Hofreiter, M., Manica, A., Pinhasi, R., Bradley, D.G., Upper palaeolithic genomes reveal deep roots of modern Eurasians. Nat Commun, 6, 2015, 8912 This paper shows an additional distinct group in Upper palaeolithic Eurasia, with geographic ties to the Caucasus.
26. 26 Olalde, I., Allentoft, M.E., Sánchez-Quinto, F., Santpere, G., Chiang, C.W.K., DeGiorgio, M., Prado-Martinez, J., Rodríguez, J.A., Rasmussen, S., Quilez, J., Ramírez, O., Marigorta, U.M., Fernández-Callejo, M., Prada, M.E., Encinas, J.M.V., Nielsen, R., Netea, M.G., Novembre, J., Sturm, R.A., Sabeti, P., Marquès-Bonet, T., Navarro, A., Willerslev, E., Lalueza-Fox, C., Derived immune and ancestral pigmentation alleles in a 7000-year-old mesolithic european. Nature 507 (2014), 225–228.
27. 27• Mathieson, I., Lazaridis, I., Rohland, N., Mallick, S., Patterson, N., Roodenberg, S.A., Harney, E., Stewardson, K., Fernandes, D., Novak, M., Sirak, K., Gamba, C., Jones, E.R., Llamas, B., Dryomov, S., Pickrell, J., Arsuaga, J.L., de Castro, J.M.B., Carbonell, E., Gerritsen, F., Khokhlov, A., Kuznetsov, P., Lozano, M., Meller, H., Mochalov, O., Moiseyev, V., Guerra, M.A.R., Roodenberg, J., Vergès, J.M., Krause, J., Cooper, A., Alt, K.W., Brown, D., Anthony, D., Lalueza-Fox, C., Haak, W., Pinhasi, R., Reich, D., Genome-wide patterns of selection in 230 ancient Eurasians. Nature 528 (2015), 499–503 This study identifies Neolithic Anatolians as a source population for European Neolithic groups. It also provides a comprehensive study of selection using ancient DNA from different time periods.
28. 28 Andersen, B., Borns, H., The Ice Age World. 1997, Scandinavian University Press.
29. 29 Hewitt, G., The genetic legacy of the quaternary ice ages. Nature 405 (2000), 907–913.
30. 30 François, O., Blum, M.G.B., Jakobsson, M., Rosenberg, N.A., Demographic history of European populations of Arabidopsis thaliana. PLoS Genet, 4, 2008, e1000075.
31. 31 Desrosiers, P., The Emergence of Pressure Blade Making. 2012, Springer Science + Business Media.
32. 32 Wang, G.-D., Zhai, W., Yang, H.-C., Wang, L., Zhong, L., Liu, Y.-H., Fan, R.-X., Yin, T.-T., Zhu, C.-L., Poyarkov, A.D., Irwin, D.M., Hytönen, M.K., Lohi, H., Wu, C.-I., Savolainen, P., Zhang, Y.-P., Out of southern east asia: the natural history of domestic dogs across the world. Cell Res 26 (2016), 21–33.
33. 33 Frantz, L.A.F., Mullin, V.E., Pionnier-Capitan, M., Lebrasseur, O., Ollivier, M., Perri, A., Linderholm, A., Mattiangeli, V., Teasdale, M.D., Dimopoulos, E.A., Tresset, A., Duffraisse, M., McCormick, F., Bartosiewicz, L., Gál, E., Nyerges, É.A., Sablin, M.V., Bréhard, S., Mashkour, M., Balasescu, A., Gillet, B., Hughes, S., Chassaing, O., Hitte, C., Vigne, J.-D., Dobney, K., Hänni, C., Bradley, D.G., Larson, G., Genomic and archaeological evidence suggest a dual origin of domestic dogs. Science 352 (2016), 1228–1231.
34. 34 Botigue, L., Song, S., Scheu, A., Gopalan, S., Pendleton, A., Oetjens, M., Taravella, A., Seregély, T., Zeeb-Lanz, A., Arbogast, R.-M., et al. Ancient European dog genomes reveal continuity since the early neolithic. bioRxiv, 2016.
35. 35 Diamond, J., Bellwood, P., Farmers and their languages: the first expansions. Science 300 (2003), 597–603.
36. 36 Whittle, A.W., Europe in the Neolithic: The Creation of New Worlds. 1996, Cambridge University Press.
37. 37 Renfrew, C., Boyle, K.V., Archaeogenetics: DNA and the Population Prehistory of Europe. 2000, McDonald Inst of Archeological.
38. 38 Ammerman, A., Cavalli-Sforza, L., The Neolithic Transition and the Genetics of Populations in Europe. 1984, Princeton: Princeton University Press.
39. 39 Wilson, J.F., Weiss, D.A., Richards, M., Thomas, M.G., Bradman, N., Goldstein, D.B., Genetic evidence for different male and female roles during cultural transitions in the British Isles. Proc Natl Acad Sci U S A 98 (2001), 5078–5083.
40. 40 Chikhi, L., Nichols, R.A., Barbujani, G., Beaumont, M.A., Y genetic data support the neolithic demic diffusion model. Proc Natl Acad Sci U S A 99 (2002), 11008–11013.
41. 41 Haak, W., Forster, P., Bramanti, B., Matsumura, S., Brandt, G., Tänzer, M., Villems, R., Renfrew, C., Gronenborn, D., Alt, K.W., Burger, J., Ancient DNA from the first european farmers in 7500-year-old neolithic sites. Science 310 (2005), 1016–1018.
42. 42 Battaglia, V., Fornarino, S., Al-Zahery, N., Olivieri, A., Pala, M., Myres, N.M., King, R.J., Rootsi, S., Marjanovic, D., Primorac, D., Hadziselimovic, R., Vidovic, S., Drobnic, K., Durmishi, N., Torroni, A., Santachiara-Benerecetti, A.S., Underhill, P.A., Semino, O., Y-chromosomal evidence of the cultural diffusion of agriculture in Southeast Europe. Eur J Hum Genet 17 (2009), 820–830.
43. 43 Bramanti, B., Thomas, M.G., Haak, W., Unterlaender, M., Jores, P., Tambets, K., Antanaitis-Jacobs, I., Haidle, M.N., Jankauskas, R., Kind, C.-J., Lueth, F., Terberger, T., Hiller, J., Matsumura, S., Forster, P., Burger, J., Genetic discontinuity between local hunter-gatherers and central europe's first farmers. Science 326 (2009), 137–140.
44. 44 Malmström, H., Gilbert, M.T.P., Thomas, M.G., Brandström, M., Storå, J., Molnar, P., Andersen, P.K., Bendixen, C., Holmlund, G., Götherström, A., Willerslev, E., Ancient dna reveals lack of continuity between neolithic hunter-gatherers and contemporary Scandinavians. Curr Biol 19 (2009), 1758–1762.
45. 45 Balaresque, P., Bowden, G.R., Adams, S.M., Leung, H.-Y., King, T.E., Rosser, Z.H., Goodwin, J., Moisan, J.-P., Richard, C., Millward, A., Demaine, A.G., Barbujani, G., Previderè, C., Wilson, I.J., Tyler-Smith, C., Jobling, M.A., A predominantly neolithic origin for european paternal lineages. PLoS Biol, 8, 2010, e1000285.
46. 46 Haak, W., Balanovsky, O., Sanchez, J.J., Koshel, S., Zaporozhchenko, V., Adler, C.J., Der Sarkissian, C.S.I., Brandt, G., Schwarz, C., Nicklisch, N., Dresely, V., Fritsch, B., Balanovska, E., Villems, R., Meller, H., Alt, K.W., Cooper, A., M.o.t., G.C., Ancient dna from european early neolithic farmers reveals their near eastern affinities. PLoS Biol, 8, 2010, e1000536.
47. 47 Lacan, M., Keyser, C., Ricaut, F.-X., Brucato, N., Duranthon, F., Guilaine, J., Crubézy, E., Ludes, B., Ancient dna reveals male diffusion through the neolithic Mediterranean route. Proc Natl Acad Sci U S A 108 (2011), 9788–9791.
48. 48 Lacan, M., Keyser, C., Ricaut, F.-X., Brucato, N., Tarrús, J., Bosch, A., Guilaine, J., Crubézy, E., Ludes, B., Ancient dna suggests the leading role played by men in the neolithic dissemination. Proc Natl Acad Sci U S A 108 (2011), 18255–18259.
49. 49 Brandt, G., Haak, W., Adler, C.J., Roth, C., Szécsényi-Nagy, A., Karimnia, S., Möller-Rieker, S., Meller, H., Ganslmeier, R., Friederich, S., Dresely, V., Nicklisch, N., Pickrell, J.K., Sirocko, F., Reich, D., Cooper, A., Alt, K.W., G.C., Ancient dna reveals key stages in the formation of central European mitochondrial genetic diversity. Science 342 (2013), 257–261.
50. 50• Gamba, C., Jones, E.R., Teasdale, M.D., McLaughlin, R.L., Gonzalez-Fortes, G., Mattiangeli, V., Domboróczki, L., Kovári, I., Pap, I., Anders, A., Whittle, A., Dani, J., Raczky, P., Higham, T.F.G., Hofreiter, M., Bradley, D.G., Pinhasi, R., Genome flux and stasis in a five millennium transect of European prehistory. Nat Commun, 5, 2014, 5257 This paper shows the different genetic turnovers from the Neolithic to the Iron Age in modern day Hungary.
51. 51 Olalde, I., Schroeder, H., Sandoval-Velasco, M., Vinner, L., Lobón, I., Ramirez, O., Civit, S., García Borja, P., Salazar-García, D.C., Talamo, S., María Fullola, J., Xavier Oms, F., Pedro, M., Martínez, P., Sanz, M., Daura, J., Zilhão, J., Marquès-Bonet, T., Gilbert, M.T.P., Lalueza-Fox, C., A common genetic origin for early farmers from mediterranean cardial and central European LBK cultures. Mol Biol Evol 32 (2015), 3132–3142.
52. 52• Günther, T., Valdiosera, C., Malmström, H., Ureña, I., Rodriguez-Varela, R., Sverrisdóttir, Ó.O., Daskalaki, E.A., Skoglund, P., Naidoo, T., Svensson, E.M., Bermúdez de Castro, J.M., Carbonell, E., Dunn, M., Storå, J., Iriarte, E., Arsuaga, J.L., Carretero, J.-M., Götherström, A., Jakobsson, M., Ancient genomes link early farmers from atapuerca in spain to modern-day basques. Proc Natl Acad Sci U S A 112 (2015), 11917–11922 This paper reveals Basques to descendants of Neolithic groups. It also demonstrates that increasing admixture between Neolithic farmers and hunter-gatherers as time passes.
53. 53 Cassidy, L.M., Martiniano, R., Murphy, E.M., Teasdale, M.D., Mallory, J., Hartwell, B., Bradley, D.G., Neolithic and bronze age migration to ireland and establishment of the insular atlantic genome. Proc Natl Acad Sci U S A 113 (2016), 368–373.
54. 54 Cavalli-Sforza, L.L., Menozzi, P., Piazza, A., The History and Geography of Human Genes. 1994, Princeton University Press.
55. 55 Behar, D.M., Harmant, C., Manry, J., van Oven, M., Haak, W., Martinez-Cruz, B., Salaberria, J., Oyharçabal, B., Bauduer, F., Comas, D., Quintana-Murci, L., G.C., The basque paradigm: genetic evidence of a maternal continuity in the franco-cantabrian region since pre-neolithic times. Am J Hum Genet 90 (2012), 486–493.
56. 56• Omrak, A., Günther, T., Valdiosera, C., Svensson, E.M., Malmström, H., Kiesewetter, H., Aylward, W., Storå, J., Jakobsson, M., Götherström, A., Genomic evidence establishes anatolia as the source of the european neolithic gene pool. Curr Biol 26 (2016), 270–275 This study confirms Neolithic Anatolians as a source population for European Neolithic groups. It also provides a suggestion for why modern Anatolians are different from ancient Anatolians.
57. 57• Lazaridis, I., Nadel, D., Rollefson, G., Merrett, D.C., Rohland, N., Mallick, S., Fernandes, D., Novak, M., Gamarra, B., Sirak, K., Connell, S., Stewardson, K., Harney, E., Fu, Q., Gonzalez-Fortes, G., Jones, E.R., Roodenberg, S.A., Lengyel, G., Bocquentin, F., Gasparian, B., Monge, J.M., Gregg, M., Eshed, V., Mizrahi, A.-S., Meiklejohn, C., Gerritsen, F., Bejenaru, L., Blüher, M., Campbell, A., Cavalleri, G., Comas, D., Froguel, P., Gilbert, E., Kerr, S.M., Kovacs, P., Krause, J., McGettigan, D., Merrigan, M., Merriwether, D.A., O'Reilly, S., Richards, M.B., Semino, O., Shamoon-Pour, M., Stefanescu, G., Stumvoll, M., Tönjes, A., Torroni, A., Wilson, J.F., Yengo, L., Hovhannisyan, N.A., Patterson, N., Pinhasi, R., Reich, D., Genomic insights into the origin of farming in the ancient near east. Nature, 2016, 10.1038/nature19310 Comprehensive genomic study of the transition to farming in and around the fertile crescent.
58. 58 Kılınç, G.M., Omrak, A., Özer, F., Günther, T., Büyükkarakaya, A.M., Bıçakçı, E., Baird, D., Dönertas, H.M., Ghalichi, A., Yaka, R., Koptekin, D., Açan, S.C., Parvizi, P., Krzewinska, M., Daskalaki, E.A., Yüncü, E., Dagtas, N.D., Fairbairn, A., Pearson, J., Mustafaoglu, G., Erdal, Y.S., Çakan, Y.G., Togan, İ., Somel, M., Storå, J., Jakobsson, M., Götherström, A., The demographic development of the first farmers in anatolia. Curr Biol, 2016 Genomic investigation of pre-pottery Nelithic groups in central Anatolia pin-pointing the source of Neolithic Europeans.
59. 59 Childe, V.G., The Dawn of European Civilization. 1925, Kegan Paul, Trench, Trubner & Co., London.
60. 60 Broushaki, F., Thomas, M.G., Link, V., López, S., van Dorp, L., Kirsanow, K., Hofmanová, Z., Diekmann, Y., Cassidy, L.M., Díez-del Molino, D., Kousathanas, A., Sell, C., Robson, H.K., Martiniano, R., Blöcher, J., Scheu, A., Kreutzer, S., Bollongino, R., Bobo, D., Davoudi, H., Munoz, O., Currat, M., Abdi, K., Biglari, F., Craig, O.E., Bradley, D.G., Shennan, S., Veeramah, K.R., Mashkour, M., Wegmann, D., Hellenthal, G., Burger, J., Early neolithic genomes from the eastern fertile crescent. Science 353 (2016), 499–503.
61. 61 Gallego-Llorente, M., Connell, S., Jones, E.R., Merrett, D.C., Jeon, Y., Eriksson, A., Siska, V., Gamba, C., Meiklejohn, C., Beyer, R., Jeon, S., Cho, Y.S., Hofreiter, M., Bhak, J., Manica, A., Pinhasi, R., The genetics of an early neolithic pastoralist from the Zagros, Iran. Sci Rep, 6, 2016, 31326.
62. 62 Özdoğan, M., Archaeological evidence on the westward expansion of farming communities from eastern anatolia to the aegean and the balkans. Curr Anthropol 52 (2011), S415–S430.
63. 63 Fernández, E., Pérez-Pérez, A., Gamba, C., Prats, E., Cuesta, P., Anfruns, J., Molist, M., Arroyo-Pardo, E., Turbón, D., Ancient dna analysis of 8000 b.c. near eastern farmers supports an early neolithic pioneer maritime colonization of mainland europe through cyprus and the aegean islands. PLoS Genet, 10, 2014, e1004401.
64. 64 Hofmanová, Z., Kreutzer, S., Hellenthal, G., Sell, C., Diekmann, Y., Díez-del Molino, D., van Dorp, L., López, S., Kousathanas, A., Link, V., et al. Early farmers from across Europe directly descended from neolithic aegeans. Proc Natl Acad Sci USA 113 (2016), 6886–6891.
65. 65 Pinhasi, R., Fort, J., Ammerman, A.J., Tracing the origin and spread of agriculture in europe. PLoS Biol, 3, 2005, e410.
66. 66 Fort, J., Synthesis between demic and cultural diffusion in the neolithic transition in europe. Proc Natl Acad Sci U S A 109 (2012), 18669–18673.
67. 67 Bollongino, R., Nehlich, O., Richards, M.P., Orschiedt, J., Thomas, M.G., Sell, C., Fajkosová, Z., Powell, A., Burger, J., 2000 years of parallel societies in stone age central europe. Science 342 (2013), 479–481.
68. 68 Novembre, J., Stephens, M., Interpreting principal component analyses of spatial population genetic variation. Nat Genet 40 (2008), 646–649.
69. 69 Keller, A., Graefen, A., Ball, M., Matzas, M., Boisguerin, V., Maixner, F., Leidinger, P., Backes, C., Khairat, R., Forster, M., Stade, B., Franke, A., Mayer, J., Spangler, J., McLaughlin, S., Shah, M., Lee, C., Harkins, T.T., Sartori, A., Moreno-Estrada, A., Henn, B., Sikora, M., Semino, O., Chiaroni, J., Rootsi, S., Myres, N.M., Cabrera, V.M., Underhill, P.A., Bustamante, C.D., Vigl, E.E., Samadelli, M., Cipollini, G., Haas, J., Katus, H., O'Connor, B.D., Carlson, M.R.J., Meder, B., Blin, N., Meese, E., Pusch, C.M., Zink, A., New insights into the tyrolean iceman's origin and phenotype as inferred by whole-genome sequencing. Nat Commun, 3, 2012, 698.
70. 70 Sikora, M., Carpenter, M.L., Moreno-Estrada, A., Henn, B.M., Underhill, P.A., Sánchez-Quinto, F., Zara, I., Pitzalis, M., Sidore, C., Busonero, F., Maschio, A., Angius, A., Jones, C., Mendoza-Revilla, J., Nekhrizov, G., Dimitrova, D., Theodossiev, N., Harkins, T.T., Keller, A., Maixner, F., Zink, A., Abecasis, G., Sanna, S., Cucca, F., Bustamante, C.D., Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the tyrolean iceman and the genetic structure of Europe. PLoS Genet, 10, 2014, e1004353.
71. 71 Šumkin, V.J., On the ethnogenesis of the sami: an archaeological view. Acta Boreal 7 (1990), 3–20.
72. 72 Cavalli-Sforza, L.L., The basque population and ancient migrations in Europe. Munibe 6 (1988), 129–137.
73. 73 Trask, R.L., The History of Basque. 1997, Routledge, London/New York.
74. 74•• Raghavan, M., Skoglund, P., Graf, K.E., Metspalu, M., Albrechtsen, A., Moltke, I., Rasmussen, S., Stafford, T.W. Jr., Orlando, L., Metspalu, E., Karmin, M., Tambets, K., Rootsi, S., Mägi, R., Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S., Osipova, L.P., Fedorova, S.A., Voevoda, M.I., DeGiorgio, M., Sicheritz-Ponten, T., Brunak, S., Demeshchenko, S., Kivisild, T., Villems, R., Nielsen, R., Jakobsson, M., Willerslev, E., Upper palaeolithic siberian genome reveals dual ancestry of native americans. Nature 505 (2014), 87–91 By sequencing the genome of an Upper Palaeolithic Siberian, this paper characterized a ‘ghost’ population that contributed to modern Europeans. Later research pinpointed the migration into Europe to Bronze Age populations from the Pontic steppe.
75. 75 Alexander, D.H., Novembre, J., Lange, K., Fast model-based estimation of ancestry in unrelated individuals. Genome Res 19 (2009), 1655–1664.
76. 76• 1000 Genomes Project Consortium, Auton, L.D., Brooks, R.M., Durbin, E.P., Garrison, H.M., Kang, J.O., Korbel, J.L., Marchini, S., McCarthy, G.A., McVean, G.R., Abecasis, A global reference for human genetic variation. Nature 526 (2015), 68–74 Large resequencing project of several modern populations.
77. 77 Patterson, N., Moorjani, P., Luo, Y., Mallick, S., Rohland, N., Zhan, Y., Genschoreck, T., Webster, T., Reich, D., Ancient admixture in human history. Genetics 192 (2012), 1065–1093.
78. 78 Ralph, P., Coop, G., The geography of recent genetic ancestry across Europe. PLoS Biol, 11, 2013, e1001555.
79. 79• Hellenthal, G., Busby, G.B.J., Band, G., Wilson, J.F., Capelli, C., Falush, D., Myers, S., A genetic atlas of human admixture history. Science 343 (2014), 747–751 Comprehensive study inferring and dating several worldwide migrations and admixture event using modern genotype data and a sophisticated statistical framework.
80. 80•• Leslie, S., Winney, B., Hellenthal, G., Davison, D., Boumertit, A., Day, T., Hutnik, K., Royrvik, E.C., Cunliffe, B., W.T.C.C.C., I.M.S.G.C., Lawson, D.J., Falush, D., Freeman, C., Pirinen, M., Myers, S., Robinson, M., Donnelly, P., Bodmer, W., The fine-scale genetic structure of the british population. Nature 519 (2015), 309–314 Very detailed study of the genetic structure of the people of the British isles making Great Britain the genetically best studied part of Europe.
81. 81• Busby, G.B.J., Hellenthal, G., Montinaro, F., Tofanelli, S., Bulayeva, K., Rudan, I., Zemunik, T., Hayward, C., Toncheva, D., Karachanak-Yankova, S., Nesheva, D., Anagnostou, P., Cali, F., Brisighelli, F., Romano, V., Lefranc, G., Buresi, C., Ben Chibani, J., Haj-Khelil, A., Denden, S., Ploski, R., Krajewski, P., Hervig, T., Moen, T., Herrera, R.J., Wilson, J.F., Myers, S., Capelli, C., The role of recent admixture in forming the contemporary west eurasian genomic landscape. Curr Biol 25 (2015), 2518–2526 Comprehensive study inferring and dating several European migrations and admixture event using modern genotype data and a sophisticated statistical framework.
82. 82 Martiniano, R., Caffell, A., Holst, M., Hunter-Mann, K., Montgomery, J., Müldner, G., McLaughlin, R.L., Teasdale, M.D., van Rheenen, W., Veldink, J.H., van den Berg, L.H., Hardiman, O., Carroll, M., Roskams, S., Oxley, J., Morgan, C., Thomas, M.G., Barnes, I., McDonnell, C., Collins, M.J., Bradley, D.G., Genomic signals of migration and continuity in britain before the anglo-saxons. Nat Commun, 7, 2016, 10326.
83. 83 Schiffels, S., Haak, W., Paajanen, P., Llamas, B., Popescu, E., Loe, L., Clarke, R., Lyons, A., Mortimer, R., Sayer, D., Tyler-Smith, C., Cooper, A., Durbin, R., Iron age and anglo-saxon genomes from east england reveal british migration history. Nat Commun, 7, 2016, 10408.
84. 84 Lampa, S., Dahlö, M., Olason, P.I., Hagberg, J., Spjuth, O., Lessons learned from implementing a national infrastructure in Sweden for storage and analysis of next-generation sequencing data. GigaSci, 2, 2013.