Evolution: Ancient DNA from the first European farmers in 7500-year-old neolithic sites

Science

Volumn 310, Issue 5750, 2005, Pages 1016-1018

  Haak, Wolfgang ^a   Forster, Peter ^b   Bramanti, Barbara ^a   Matsumura, Shuichi ^b   Brandt, Guido ^a   Tänzer, Marc ^a   Villems, Richard ^c   Renfrew, Colin ^b   Gronenborn, Detlef ^d   Alt, Kurt Werner ^a   Burger, Joachim ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF TARTU   (Estonia)

^d Römisch Germanisches Zentralmuseum Archaeological Research Institute   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; GENETIC ENGINEERING; NATURAL FREQUENCIES;

ANTHROPOLOGISTS; ARCHAEOLOGISTS; GENETICISTS;

DNA;

MITOCHONDRIAL DNA; PRIMER DNA;

ANCESTRY; NEOLITHIC;

AGRICULTURAL WORKER; ARCHEOLOGY; ARTICLE; AUSTRIA; DNA DAMAGE; DNA DETERMINATION; DNA EXTRACTION; DNA SEQUENCE; EUROPE; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC DRIFT; GENOME ANALYSIS; GEOGRAPHIC DISTRIBUTION; GERMANY; HUMAN; HUNGARY; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MOLECULAR EVOLUTION; PHYLOGENETIC TREE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; AGRICULTURE; CAUCASIAN; CHEMISTRY; CLASSIFICATION; COMPUTER SIMULATION; CULTURAL ANTHROPOLOGY; FEMALE; GENETICS; HAPLOTYPE; HISTORY; MALE; MIGRATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POPULATION DYNAMICS; POPULATION GENETICS;

AGRICULTURE; AUSTRIA; BASE SEQUENCE; COMPUTER SIMULATION; CULTURAL EVOLUTION; DNA, MITOCHONDRIAL; EMIGRATION AND IMMIGRATION; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC DRIFT; GENETICS, POPULATION; GERMANY; HAPLOTYPES; HISTORY, ANCIENT; HUMANS; HUNGARY; MALE; MOLECULAR SEQUENCE DATA; POPULATION DYNAMICS;

EID: 27744447195     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. D. R. Harris, in The Origins and Spread of Agriculture and Pastoralism in Eurasia, D. R. Harris, Ed (University College of London Press, London, 1996), pp. 552-574.
2. J. Diamond, P. Bellwood, Science 300, 597 (2003).
3. D. Gronenborn, J. World Prehist. 13, 123 (1999).
4. E. Bánffy, The 6th Millenium BC Boundary in Western Transdanubia and its Role in the Central European Neolithic Transition (The Szentgyörgyvölgy-Pityerdomb Settlement) (Archaeological Institute of the Hungarian Academy of Science, Budapest Hungary, 2004).
5. J. Pavúk, in LBK Dialogues. Studies in the Formation of the Linear Pottery Culture, A. Lukes, M. Zvelebil, Eds. (Archeopress, Oxford, 2004), pp. 71-82.
6. C. Renfrew, Archaeology and Language: The Puzzle of Indo-European Origins (Cape, London, 1987).
7. P. Bogucki, in Europe's First Farmers, T. D. Price, Ed. (Cambridge Univ. Press, Cambridge, 2000), pp. 197-218.
8. A. J. Ammermann, L. Cavalli-Sforza, The Neolithic Transition and the Genetics of Populations in Europe (Princeton Univ. Press, Princeton, NJ, 1984).
9. A. Whittle, Europe in the Neolithic. The Creation of New Worlds (Cambridge Univ. Press, Cambridge, 1996).
10. D. Gronenborn, Before Farming (online version April 2004).
11. M. Zvelebil, in LBK Dialogues. Studies in the Formation of the Linear Pottery Culture, A. Lukes, M. Zvelebil, Eds. (Archaeopress, Oxford, 2004), pp. 183-205.
12. g. Barbujani, D. B. Goldstein, Annu. Rev. Genomics Hum. Genet. 5, 119 (2004).
13. L. Chikhi, G. Destro-Bisol, G. Bertorelle, V. Pascali, G. Barbujani, Proc. Natl. Acad. Sci. U.S.A. 95, 9053 (1998).
14. L. Chikhi, R. A. Nichols, G. Barbujani, M. A. Beaumont, Proc. Natl. Acad. Sci. U.S.A. 99, 11008 (2002).
15. M. Richards et al., Am. J. Hum. Genet 67, 1251 (2000).
16. I. Dupanloup, G. Bertorelle, L. Chikhi, G. Barbujani, Mol. Biol. Ivol. 21, 1361 (2004).
17. O. Semino et al., Science 290, 1155 (2000).
18. L. Simoni, F. Calafell, D. Pettener, J. Bertranpetit, G. Barbujani, Am. J. Hum. Genet. 66, 262 (2000).
19. A. Torroni et al., Am. J. Hum. Genet. 62, 1137 (1998).
20. G. Barbujani, G. Bertorelle, L. Chikhi, Am. J. Hum. Genet. 62, 488 (1998).
21. M. Currat, L. Excoffier, Proc. Biol. Sci. 272, 679 (2005).
22. Materials and methods are available as supporting material on Science Online.
23. A. Röhl, B. Brinkmann, L. Forster, P. Forster, Int. J. Legal Med. 115, 29 (2001).
24. R. Villems, unpublished data (Estonian Biocentre Database 2005).
25. See www.ncbi.nlm.nih.gov/Cenbank/index.html.
26. M. Hofreiter, V. Jaenicke, D. Serre, A. A. Haeseler, S. Pääbo, Nucleic Acids Res. 29, 4793 (2001).
27. M. T. Gilbert et al., Am. J. Hum. Genet. 72, 32 (2003).
28. L. Forster, P. Forster, S. Lutz-Bonengel, H. Willkomm, B. Brinkmann, Proc. Natl. Acad. Sci. U.S.A. 99, 13950 (2002).
29. R. A. Bentley et al., Curr. Anthropol. 43, 799 (2002).
30. F. X. Ricaut, C. Keyser-Tracqui, J. Bourgeois, E. Crubezy, B. Ludes, Hum. Biol. 76, 109 (2004).
31. S. Anderson et al., Nature 290, 457 (1981).
32. We thank the following for providing samples: V. Dresely, H. Meller, C.-H. Wunderlich, M. Porr, U. Müller, and T. Autze (Landesamt für Archäologie Sachsen-Anhalt, Halle/Saale, Germany); J. Wahl (Landesdenkmalamt Baden-Württemberg, Konstanz, Germany); H. Bruchhaus (Friedrich Schiller University Jena, Jena, Germany); R. Krause (Landesdenkmalamt Baden-Württemberg, Esslingen, Germany); M. Teschler-Nicola (Department of Anthropology, Natural History Museum, Vienna, Austria); M. Grünewald (Museum Andreasstift, Worms, Rheinland-Pfalz, Germany); I. Pap and Z. Cuba (Hungarian Natural History Museum, Budapest, Hungary); and J. Lüning (University of Frankfurt). We also thank A. Linderholm for primer design and M. Forster for editorial comments. Research grants were provided by the Bundesministerium für Bildung und Forschung.