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Volumn 22, Issue 1, 2017, Pages 41-53

Advances in the pathophysiology of primary immune thrombocytopenia

Author keywords

autoantibodies; Immune thrombocytopenia; pathophysiology; thrombopoietin receptor agonists; Treg lymphocytes

Indexed keywords

AUTOANTIBODY; CORTICOSTEROID; DEXAMETHASONE; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 9; RITUXIMAB; THROMBOPOIETIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84988693982     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1080/10245332.2016.1219497     Document Type: Article
Times cited : (49)

References (104)
  • 1
    • 64049085194 scopus 로고    scopus 로고
    • Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group
    • Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children:report from an international working group. Blood. 2009;113(11):2386–93.
    • (2009) Blood. , vol.113 , Issue.11 , pp. 2386-2393
    • Rodeghiero, F.1    Stasi, R.2    Gernsheimer, T.3    Michel, M.4    Provan, D.5    Arnold, D.M.6
  • 2
    • 84864385195 scopus 로고    scopus 로고
    • Updated assessment of the prevalence, spectrum and case definition of autoimmune disease
    • Hayter SM, Cook MC. Updated assessment of the prevalence, spectrum and case definition of autoimmune disease. Autoimmun Rev. 2012;11(10):754–65.
    • (2012) Autoimmun Rev. , vol.11 , Issue.10 , pp. 754-765
    • Hayter, S.M.1    Cook, M.C.2
  • 3
    • 0033179664 scopus 로고    scopus 로고
    • The incidence of idiopathic thrombocytopenic purpura in adults increases with age
    • Frederiksen H, Schmidt K. The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood. 1999;94(3):909–13.
    • (1999) Blood. , vol.94 , Issue.3 , pp. 909-913
    • Frederiksen, H.1    Schmidt, K.2
  • 4
    • 0141763618 scopus 로고    scopus 로고
    • Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population-based cohort of 245 patients
    • Neylon AJ, Saunders PWG, Howard MR, Proctor SJ, Taylor PRA. Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults:a prospective study of a population-based cohort of 245 patients. Br J Haematol. 2003;122(6):966–74.
    • (2003) Br J Haematol. , vol.122 , Issue.6 , pp. 966-974
    • Neylon, A.J.1    Saunders, P.W.G.2    Howard, M.R.3    Proctor, S.J.4    Taylor, P.R.A.5
  • 5
    • 84997505695 scopus 로고    scopus 로고
    • , –2007: claves diagnosticas y tratamiento. Available from: [Accessed March 13, 2014]
    • Anon. Ferri consultor clinico, 2006–2007:claves diagnosticas y tratamiento. Available from:http://www.agapea.com/libros/Ferri-consultor-clinico-2006-2007-claves-diagnosticas-y-tratamiento-9788481749144-i.htm [Accessed March 13, 2014]
    • (2006) Anon. Ferri consultor clinico
  • 6
    • 33750061309 scopus 로고    scopus 로고
    • Prevalence of immune thrombocytopenia: analyses of administrative data
    • Segal JB, Powe NR. Prevalence of immune thrombocytopenia:analyses of administrative data. J Thromb Haemost JTH. 2006;4(11):2377–83.
    • (2006) J Thromb Haemost JTH. , vol.4 , Issue.11 , pp. 2377-2383
    • Segal, J.B.1    Powe, N.R.2
  • 7
    • 0031038008 scopus 로고    scopus 로고
    • Prevalence and treatment of chronic idiopathic thrombocytopenic purpura of childhood in Sweden
    • Hedman A, Henter JI, Hedlund I, Elinder G. Prevalence and treatment of chronic idiopathic thrombocytopenic purpura of childhood in Sweden. Acta Paediatr Oslo Nor 1992. 1997;86(2):226–7.
    • (1997) Acta Paediatr Oslo Nor 1992. , vol.86 , Issue.2 , pp. 226-227
    • Hedman, A.1    Henter, J.I.2    Hedlund, I.3    Elinder, G.4
  • 8
    • 0013831385 scopus 로고
    • The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura
    • Shulman NR, Weinrach RS, Libre EP, Andrews HL. The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura. Trans Assoc Am Physicians. 1965;78:374–90.
    • (1965) Trans Assoc Am Physicians. , vol.78 , pp. 374-390
    • Shulman, N.R.1    Weinrach, R.S.2    Libre, E.P.3    Andrews, H.L.4
  • 9
    • 0011075765 scopus 로고
    • Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura
    • Harrington WJ, Minnich V, Hollingsworth JW, Moore CV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med. 1951;38(1):1–10.
    • (1951) J Lab Clin Med. , vol.38 , Issue.1 , pp. 1-10
    • Harrington, W.J.1    Minnich, V.2    Hollingsworth, J.W.3    Moore, C.V.4
  • 10
    • 0013855839 scopus 로고
    • Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies
    • Shulman NR, Marder VJ, Weinrach RS. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies. Ann N Y Acad Sci. 1965;124(2):499–542.
    • (1965) Ann N Y Acad Sci. , vol.124 , Issue.2 , pp. 499-542
    • Shulman, N.R.1    Marder, V.J.2    Weinrach, R.S.3
  • 11
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994;77(7):1117–24.
    • (1994) Cell , vol.77 , Issue.7 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3    Li, Y.S.4    Lu, H.S.5    Martin, F.6
  • 12
    • 0028117771 scopus 로고
    • The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production
    • Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin:a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA. 1994;91(23):11104–8.
    • (1994) Proc Natl Acad Sci USA. , vol.91 , Issue.23 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 14
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994;369(6481):565–8.
    • (1994) Nature , vol.369 , Issue.6481 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3    Kuijper, J.L.4    Lofton-Day, C.E.5    Oort, P.J.6
  • 15
    • 0037071389 scopus 로고    scopus 로고
    • The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production
    • Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin:the primary regulator of platelet production. Oncogene 2002;21(21):3359–67.
    • (2002) Oncogene , vol.21 , Issue.21 , pp. 3359-3367
    • Kaushansky, K.1    Drachman, J.G.2
  • 16
    • 0036462410 scopus 로고    scopus 로고
    • Thrombopoietin: the novel hepatic hormone
    • Wolber E-M, Jelkmann W. Thrombopoietin:the novel hepatic hormone. News Physiol Sci. 2002;17:6–10.
    • (2002) News Physiol Sci. , vol.17 , pp. 6-10
    • Wolber, E.-M.1    Jelkmann, W.2
  • 17
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics
    • Li J, Xia Y, Kuter DJ. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma:binding, internalization, stability and pharmacokinetics. Br J Haematol. 1999;106(2):345–56.
    • (1999) Br J Haematol. , vol.106 , Issue.2 , pp. 345-356
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 18
    • 0035676365 scopus 로고    scopus 로고
    • Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura
    • Kappers-Klunne MC, de Haan M, Struijk PC, van Vliet HHDM. Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura. Br J Haematol. 2001;115(4):1004–6.
    • (2001) Br J Haematol. , vol.115 , Issue.4 , pp. 1004-1006
    • Kappers-Klunne, M.C.1    de Haan, M.2    Struijk, P.C.3    van Vliet, H.H.D.M.4
  • 19
    • 0023218341 scopus 로고
    • Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
    • Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter SJ. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest. 1987;80(1):33–40.
    • (1987) J Clin Invest. , vol.80 , Issue.1 , pp. 33-40
    • Ballem, P.J.1    Segal, G.M.2    Stratton, J.R.3    Gernsheimer, T.4    Adamson, J.W.5    Slichter, S.J.6
  • 20
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996;87(10):4068–71.
    • (1996) Blood , vol.87 , Issue.10 , pp. 4068-4071
    • Emmons, R.V.1    Reid, D.M.2    Cohen, R.L.3    Meng, G.4    Young, N.S.5    Dunbar, C.E.6
  • 21
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005;115(12):3339–47.
    • (2005) J Clin Invest. , vol.115 , Issue.12 , pp. 3339-3347
    • Kaushansky, K.1
  • 22
    • 0942287736 scopus 로고    scopus 로고
    • Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
    • Houwerzijl EJ, Blom NR, van der Want JJL, Esselink MT, Koornstra JJ, Smit JW, et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 2004;103(2):500–6.
    • (2004) Blood , vol.103 , Issue.2 , pp. 500-506
    • Houwerzijl, E.J.1    Blom, N.R.2    van der Want, J.J.L.3    Esselink, M.T.4    Koornstra, J.J.5    Smit, J.W.6
  • 23
    • 0025876206 scopus 로고
    • Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia
    • Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 1991;78(10):2619–25.
    • (1991) Blood , vol.78 , Issue.10 , pp. 2619-2625
    • Semple, J.W.1    Freedman, J.2
  • 24
    • 0029964421 scopus 로고    scopus 로고
    • Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity
    • Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, Blanchette V, et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura:relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 1996;87(10):4245–54.
    • (1996) Blood , vol.87 , Issue.10 , pp. 4245-4254
    • Semple, J.W.1    Milev, Y.2    Cosgrave, D.3    Mody, M.4    Hornstein, A.5    Blanchette, V.6
  • 25
    • 0141651537 scopus 로고    scopus 로고
    • High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura
    • Ogawara H, Handa H, Morita K, Hayakawa M, Kojima J, Amagai H, et al. High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;71(4):283–8.
    • (2003) Eur J Haematol. , vol.71 , Issue.4 , pp. 283-288
    • Ogawara, H.1    Handa, H.2    Morita, K.3    Hayakawa, M.4    Kojima, J.5    Amagai, H.6
  • 26
    • 0032190549 scopus 로고    scopus 로고
    • Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody
    • Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. J Clin Invest. 1998;102(7):1393–402.
    • (1998) J Clin Invest. , vol.102 , Issue.7 , pp. 1393-1402
    • Kuwana, M.1    Kaburaki, J.2    Ikeda, Y.3
  • 27
    • 0141684568 scopus 로고    scopus 로고
    • T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
    • Olsson B, Andersson P-O, Jernås M, Jacobsson S, Carlsson B, Carlsson LMS, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9(9):1123–4.
    • (2003) Nat Med. , vol.9 , Issue.9 , pp. 1123-1124
    • Olsson, B.1    Andersson, P.-O.2    Jernås, M.3    Jacobsson, S.4    Carlsson, B.5    Carlsson, L.M.S.6
  • 28
    • 33645711352 scopus 로고    scopus 로고
    • Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura
    • Zhang F, Chu X, Wang L, Zhu Y, Li L, Ma D, et al. Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2006;76(5):427–31.
    • (2006) Eur J Haematol. , vol.76 , Issue.5 , pp. 427-431
    • Zhang, F.1    Chu, X.2    Wang, L.3    Zhu, Y.4    Li, L.5    Ma, D.6
  • 29
    • 84863106330 scopus 로고    scopus 로고
    • Immune thrombocytopenia: pathophysiologic and clinical update
    • Stasi R. Immune thrombocytopenia:pathophysiologic and clinical update. Semin Thromb Hemost. 2012;38(5):454–62.
    • (2012) Semin Thromb Hemost. , vol.38 , Issue.5 , pp. 454-462
    • Stasi, R.1
  • 30
    • 75649104701 scopus 로고    scopus 로고
    • International consensus report on the investigation and management of primary immune thrombocytopenia
    • Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115(2):168–86.
    • (2010) Blood , vol.115 , Issue.2 , pp. 168-186
    • Provan, D.1    Stasi, R.2    Newland, A.C.3    Blanchette, V.S.4    Bolton-Maggs, P.5    Bussel, J.B.6
  • 31
    • 84857789700 scopus 로고    scopus 로고
    • [Guidelines for diagnosis, treatment and monitoring of primary immune thrombocytopenia]
    • Sanz MÁ, Vicente García V, Fernández A, López MF, Grande C, Jarque I, et al. [Guidelines for diagnosis, treatment and monitoring of primary immune thrombocytopenia]. Med Clínica. 2012;138(6):261.e1–e17.
    • (2012) Med Clínica. , vol.138 , Issue.6 , pp. 217-261
    • Sanz, M.Á.1    Vicente García, V.2    Fernández, A.3    López, M.F.4    Grande, C.5    Jarque, I.6
  • 32
    • 84880836525 scopus 로고    scopus 로고
    • Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS)
    • Neunert CE, Buchanan GR, Imbach P, Bolton-Maggs PHB, Bennett CM, Neufeld E, et al. Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia:data from the Intercontinental Cooperative ITP Study Group (ICIS). Blood 2013;121(22):4457–62.
    • (2013) Blood , vol.121 , Issue.22 , pp. 4457-4462
    • Neunert, C.E.1    Buchanan, G.R.2    Imbach, P.3    Bolton-Maggs, P.H.B.4    Bennett, C.M.5    Neufeld, E.6
  • 33
    • 3843112244 scopus 로고    scopus 로고
    • Long-term outcomes in adults with chronic ITP after splenectomy failure
    • McMillan R, Durette C. Long-term outcomes in adults with chronic ITP after splenectomy failure. Blood 2004;104(4):956–60.
    • (2004) Blood , vol.104 , Issue.4 , pp. 956-960
    • McMillan, R.1    Durette, C.2
  • 36
    • 0034698829 scopus 로고    scopus 로고
    • B lymphocytes regulate dendritic cell (DC) function in vivo: increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation
    • Moulin V, Andris F, Thielemans K, Maliszewski C, Urbain J, Moser M. B lymphocytes regulate dendritic cell (DC) function in vivo:increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation. J Exp Med. 2000;192(4):475–82.
    • (2000) J Exp Med. , vol.192 , Issue.4 , pp. 475-482
    • Moulin, V.1    Andris, F.2    Thielemans, K.3    Maliszewski, C.4    Urbain, J.5    Moser, M.6
  • 37
    • 20444396226 scopus 로고    scopus 로고
    • Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
    • Coutinho A, Caramalho I, Seixas E, Demengeot J. Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection. Curr Top Microbiol Immunol. 2005;293:43–71.
    • (2005) Curr Top Microbiol Immunol. , vol.293 , pp. 43-71
    • Coutinho, A.1    Caramalho, I.2    Seixas, E.3    Demengeot, J.4
  • 38
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • Hsieh C-S, Lee H-M, Lio C-WJ. Selection of regulatory T cells in the thymus. Nat Rev Immunol. 2012;12(3):157–67.
    • (2012) Nat Rev Immunol. , vol.12 , Issue.3 , pp. 157-167
    • Hsieh, C.-S.1    Lee, H.-M.2    Lio, C.-W.J.3
  • 39
    • 84870372431 scopus 로고    scopus 로고
    • The role of B lymphocytes in the progression from autoimmunity to autoimmune disease
    • Salinas GF, Braza F, Brouard S, Tak P-P, Baeten D. The role of B lymphocytes in the progression from autoimmunity to autoimmune disease. Clin Immunol Orlando Fla. 2013;146(1):34–45.
    • (2013) Clin Immunol Orlando Fla. , vol.146 , Issue.1 , pp. 34-45
    • Salinas, G.F.1    Braza, F.2    Brouard, S.3    Tak, P.-P.4    Baeten, D.5
  • 41
    • 0037103361 scopus 로고    scopus 로고
    • Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation
    • Roark JH, Bussel JB, Cines DB, Siegel DL. Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation. Blood 2002;100(4):1388–98.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1388-1398
    • Roark, J.H.1    Bussel, J.B.2    Cines, D.B.3    Siegel, D.L.4
  • 43
    • 0022637280 scopus 로고
    • Incomplete antigenic cross-reactivity between platelets and megakaryocytes: relevance to ITP
    • Stahl CP, Zucker-Franklin D, McDonald TP. Incomplete antigenic cross-reactivity between platelets and megakaryocytes:relevance to ITP. Blood 1986;67(2):421–8.
    • (1986) Blood , vol.67 , Issue.2 , pp. 421-428
    • Stahl, C.P.1    Zucker-Franklin, D.2    McDonald, T.P.3
  • 44
    • 0026772333 scopus 로고
    • Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura
    • Bettaieb A, Fromont P, Louache F, Oksenhendler E, Vainchenker W, Duédari N, et al. Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura. Blood 1992;80(1):162–9.
    • (1992) Blood , vol.80 , Issue.1 , pp. 162-169
    • Bettaieb, A.1    Fromont, P.2    Louache, F.3    Oksenhendler, E.4    Vainchenker, W.5    Duédari, N.6
  • 45
    • 0029842860 scopus 로고    scopus 로고
    • Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP)
    • Wright JF, Blanchette VS, Wang H, Arya N, Petric M, Semple JW, et al. Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP). Br J Haematol. 1996;95(1):145–52.
    • (1996) Br J Haematol. , vol.95 , Issue.1 , pp. 145-152
    • Wright, J.F.1    Blanchette, V.S.2    Wang, H.3    Arya, N.4    Petric, M.5    Semple, J.W.6
  • 46
    • 79751531096 scopus 로고    scopus 로고
    • The HSP60 immune system network
    • Quintana FJ, Cohen IR. The HSP60 immune system network. Trends Immunol. 2011;32(2):89–95.
    • (2011) Trends Immunol. , vol.32 , Issue.2 , pp. 89-95
    • Quintana, F.J.1    Cohen, I.R.2
  • 47
    • 0021871131 scopus 로고
    • Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes
    • Porges A, Bussel J, Kimberly R, Schulman I, Pollack M, Pandey J, et al. Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes. Tissue Antigens. 1985;26(2):132–7.
    • (1985) Tissue Antigens. , vol.26 , Issue.2 , pp. 132-137
    • Porges, A.1    Bussel, J.2    Kimberly, R.3    Schulman, I.4    Pollack, M.5    Pandey, J.6
  • 48
    • 1642386746 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura
    • Satoh T, Pandey JP, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y, et al. Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura. Br J Haematol. 2004;124(6):796–801.
    • (2004) Br J Haematol. , vol.124 , Issue.6 , pp. 796-801
    • Satoh, T.1    Pandey, J.P.2    Okazaki, Y.3    Yasuoka, H.4    Kawakami, Y.5    Ikeda, Y.6
  • 49
    • 84887361475 scopus 로고    scopus 로고
    • Fcγ receptor IIB gene polymorphism in adult Japanese patients with primary immune thrombocytopenia
    • Satoh T, Miyazaki K, Shimohira A, Amano N, Okazaki Y, Nishimoto T, et al. Fcγ receptor IIB gene polymorphism in adult Japanese patients with primary immune thrombocytopenia. Blood 2013;122(11):1991–2.
    • (2013) Blood , vol.122 , Issue.11 , pp. 1991-1992
    • Satoh, T.1    Miyazaki, K.2    Shimohira, A.3    Amano, N.4    Okazaki, Y.5    Nishimoto, T.6
  • 50
    • 84867350040 scopus 로고    scopus 로고
    • DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia
    • Pesmatzoglou M, Lourou M, Goulielmos GN, Stiakaki E. DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia. Clin Dev Immunol. 2012;2012:352059.
    • (2012) Clin Dev Immunol. , vol.2012 , pp. 352059
    • Pesmatzoglou, M.1    Lourou, M.2    Goulielmos, G.N.3    Stiakaki, E.4
  • 51
    • 30444436765 scopus 로고    scopus 로고
    • Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo
    • Aslam R, Speck ER, Kim M, Crow AR, Bang KWA, Nestel FP, et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 2006;107(2):637–41.
    • (2006) Blood , vol.107 , Issue.2 , pp. 637-641
    • Aslam, R.1    Speck, E.R.2    Kim, M.3    Crow, A.R.4    Bang, K.W.A.5    Nestel, F.P.6
  • 52
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1(2):135–45.
    • (2001) Nat Rev Immunol. , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 53
    • 20444382606 scopus 로고    scopus 로고
    • Direct and indirect role of Toll-like receptors in T cell mediated immunity
    • Xu D, Liu H, Komai-Koma M. Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol. 2004;1(4):239–46.
    • (2004) Cell Mol Immunol. , vol.1 , Issue.4 , pp. 239-246
    • Xu, D.1    Liu, H.2    Komai-Koma, M.3
  • 54
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • Akira S. Mammalian Toll-like receptors. Curr Opin Immunol. 2003;15(1):5–11.
    • (2003) Curr Opin Immunol. , vol.15 , Issue.1 , pp. 5-11
    • Akira, S.1
  • 55
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol. 1994;12:991–1045.
    • (1994) Annu Rev Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 56
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger P. The danger model:a renewed sense of self. Science 2002;296(5566):301–5.
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 57
    • 34249310057 scopus 로고    scopus 로고
    • Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets
    • Semple JW, Aslam R, Kim M, Speck ER, Freedman J. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets. Blood 2007;109(11):4803–5.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4803-4805
    • Semple, J.W.1    Aslam, R.2    Kim, M.3    Speck, E.R.4    Freedman, J.5
  • 58
    • 78650103795 scopus 로고    scopus 로고
    • TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic purpura
    • Yu H, Liu Y, Han J, Yang Z, Sheng W, Dai H, et al. TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic purpura. Eur J Haematol. 2011;86(1):67–74.
    • (2011) Eur J Haematol. , vol.86 , Issue.1 , pp. 67-74
    • Yu, H.1    Liu, Y.2    Han, J.3    Yang, Z.4    Sheng, W.5    Dai, H.6
  • 59
    • 80053481554 scopus 로고    scopus 로고
    • The isotype of autoantibodies influences the phagocytosis of antibody-coated platelets in autoimmune thrombocytopenic purpura
    • Hoemberg M, Stahl D, Schlenke P, Sibrowski W, Pachmann U, Cassens U. The isotype of autoantibodies influences the phagocytosis of antibody-coated platelets in autoimmune thrombocytopenic purpura. Scand J Immunol. 2011;74(5):489–95.
    • (2011) Scand J Immunol. , vol.74 , Issue.5 , pp. 489-495
    • Hoemberg, M.1    Stahl, D.2    Schlenke, P.3    Sibrowski, W.4    Pachmann, U.5    Cassens, U.6
  • 60
    • 84857373395 scopus 로고    scopus 로고
    • Increased number of B-cells in the red pulp of the spleen in ITP
    • Olsson B, Ridell B, Jernås M, Wadenvik H. Increased number of B-cells in the red pulp of the spleen in ITP. Ann Hematol. 2012;91(2):271–7.
    • (2012) Ann Hematol. , vol.91 , Issue.2 , pp. 271-277
    • Olsson, B.1    Ridell, B.2    Jernås, M.3    Wadenvik, H.4
  • 61
    • 80054834604 scopus 로고    scopus 로고
    • Immunologic effects of rituximab on the human spleen in immune thrombocytopenia
    • Audia S, Samson M, Guy J, Janikashvili N, Fraszczak J, Trad M, et al. Immunologic effects of rituximab on the human spleen in immune thrombocytopenia. Blood 2011;118(16):4394–400.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4394-4400
    • Audia, S.1    Samson, M.2    Guy, J.3    Janikashvili, N.4    Fraszczak, J.5    Trad, M.6
  • 62
    • 84868100092 scopus 로고    scopus 로고
    • Defective regulatory B-cell compartment in patients with immune thrombocytopenia
    • Li X, Zhong H, Bao W, Boulad N, Evangelista J, Haider MA, et al. Defective regulatory B-cell compartment in patients with immune thrombocytopenia. Blood 2012;120(16):3318–25.
    • (2012) Blood , vol.120 , Issue.16 , pp. 3318-3325
    • Li, X.1    Zhong, H.2    Bao, W.3    Boulad, N.4    Evangelista, J.5    Haider, M.A.6
  • 63
    • 74649083783 scopus 로고    scopus 로고
    • CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
    • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010;32(1):129–40.
    • (2010) Immunity , vol.32 , Issue.1 , pp. 129-140
    • Blair, P.A.1    Noreña, L.Y.2    Flores-Borja, F.3    Rawlings, D.J.4    Isenberg, D.A.5    Ehrenstein, M.R.6
  • 64
    • 84877652698 scopus 로고    scopus 로고
    • Immune dysregulation in immune thrombocytopenia (ITP)
    • Yazdanbakhsh K, Zhong H, Bao W. Immune dysregulation in immune thrombocytopenia (ITP). Semin Hematol. 2013;50(1):S63–7.
    • (2013) Semin Hematol. , vol.50 , Issue.1 , pp. S63-S67
    • Yazdanbakhsh, K.1    Zhong, H.2    Bao, W.3
  • 65
    • 77951667958 scopus 로고    scopus 로고
    • Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
    • Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol. 2010;125(5):1114–24.e8.
    • (2010) J Allergy Clin Immunol. , vol.125 , Issue.5 , pp. 1114-1128
    • Amu, S.1    Saunders, S.P.2    Kronenberg, M.3    Mangan, N.E.4    Atzberger, A.5    Fallon, P.G.6
  • 66
    • 79956224216 scopus 로고    scopus 로고
    • Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells
    • Carter NA, Vasconcellos R, Rosser EC, Tulone C, Muñoz-Suano A, Kamanaka M, et al. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells. J Immunol Baltim Md 1950. 2011;186(10):5569–79.
    • (2011) J Immunol Baltim Md 1950. , vol.186 , Issue.10 , pp. 5569-5579
    • Carter, N.A.1    Vasconcellos, R.2    Rosser, E.C.3    Tulone, C.4    Muñoz-Suano, A.5    Kamanaka, M.6
  • 67
    • 79960140263 scopus 로고    scopus 로고
    • Presence of Foxp3-expressing CD19(+)CD5(+) B cells in human peripheral blood mononuclear cells: human CD19(+)CD5(+)Foxp3(+) regulatory B cell (Breg)
    • Noh J, Choi WS, Noh G, Lee JH. Presence of Foxp3-expressing CD19(+)CD5(+) B cells in human peripheral blood mononuclear cells:human CD19(+)CD5(+)Foxp3(+) regulatory B cell (Breg). Immune Netw. 2010;10(6):247–9.
    • (2010) Immune Netw. , vol.10 , Issue.6 , pp. 247-249
    • Noh, J.1    Choi, W.S.2    Noh, G.3    Lee, J.H.4
  • 68
    • 84928635256 scopus 로고    scopus 로고
    • Changes in peripheral CD19(+)Foxp3(+) and CD19(+)TGFβ(+) regulatory B cell populations in rheumatoid arthritis patients with interstitial lung disease
    • Guo Y, Zhang X, Qin M, Wang X. Changes in peripheral CD19(+)Foxp3(+) and CD19(+)TGFβ(+) regulatory B cell populations in rheumatoid arthritis patients with interstitial lung disease. J Thorac Dis. 2015;7(3):471–7.
    • (2015) J Thorac Dis. , vol.7 , Issue.3 , pp. 471-477
    • Guo, Y.1    Zhang, X.2    Qin, M.3    Wang, X.4
  • 69
    • 84932190566 scopus 로고    scopus 로고
    • Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells
    • Aslam R, Segel GB, Burack R, Spence SA, Speck ER, Guo L, et al. Splenic lymphocyte subtypes in immune thrombocytopenia:increased presence of a subtype of B-regulatory cells. Br J Haematol. 2016;173(1):159–60.
    • (2016) Br J Haematol. , vol.173 , Issue.1 , pp. 159-160
    • Aslam, R.1    Segel, G.B.2    Burack, R.3    Spence, S.A.4    Speck, E.R.5    Guo, L.6
  • 70
    • 84868135867 scopus 로고    scopus 로고
    • CD16+ monocytes control T-cell subset development in immune thrombocytopenia
    • Zhong H, Bao W, Li X, Miller A, Seery C, Haq N, et al. CD16+ monocytes control T-cell subset development in immune thrombocytopenia. Blood 2012;120(16):3326–35.
    • (2012) Blood , vol.120 , Issue.16 , pp. 3326-3335
    • Zhong, H.1    Bao, W.2    Li, X.3    Miller, A.4    Seery, C.5    Haq, N.6
  • 71
    • 0036118781 scopus 로고    scopus 로고
    • Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura
    • Andersson P-O, Olsson A, Wadenvik H. Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura. Br J Haematol. 2002;116(4):862–7.
    • (2002) Br J Haematol. , vol.116 , Issue.4 , pp. 862-867
    • Andersson, P.-O.1    Olsson, A.2    Wadenvik, H.3
  • 72
    • 84883812683 scopus 로고    scopus 로고
    • Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura
    • Liu H, Ouyang X, Li Y, Zeng H, Wang X, Xie S, et al. Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura. Thromb Res. 2013;132(2):196–201.
    • (2013) Thromb Res. , vol.132 , Issue.2 , pp. 196-201
    • Liu, H.1    Ouyang, X.2    Li, Y.3    Zeng, H.4    Wang, X.5    Xie, S.6
  • 73
    • 80053646104 scopus 로고    scopus 로고
    • The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia
    • Rocha AMC, Souza C, Rocha GA, de Melo FF, Clementino NCD, Marino MCA, et al. The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia. Haematologica 2011;96(10):1560–4.
    • (2011) Haematologica , vol.96 , Issue.10 , pp. 1560-1564
    • Rocha, A.M.C.1    Souza, C.2    Rocha, G.A.3    de Melo, F.F.4    Clementino, N.C.D.5    Marino, M.C.A.6
  • 74
    • 84858278265 scopus 로고    scopus 로고
    • Circulating plasmacytoid dendritic cells in patients with primary and helicobacter pylori-associated immune thrombocytopenia
    • Saito A, Yokohama A, Osaki Y, Ogawa Y, Nakahashi H, Toyama K, et al. Circulating plasmacytoid dendritic cells in patients with primary and helicobacter pylori-associated immune thrombocytopenia. Eur J Haematol. 2012;88(4):340–9.
    • (2012) Eur J Haematol. , vol.88 , Issue.4 , pp. 340-349
    • Saito, A.1    Yokohama, A.2    Osaki, Y.3    Ogawa, Y.4    Nakahashi, H.5    Toyama, K.6
  • 75
    • 77956206822 scopus 로고    scopus 로고
    • [Profiles of different subsets of CD(4)(+) T cells in chronic idiopathic thrombocytopenic purpura]
    • Chang D, Ouyang J, Zhou R, Xu J, Chen B, Yang Y, et al. [Profiles of different subsets of CD(4)(+) T cells in chronic idiopathic thrombocytopenic purpura]. Zhonghua Nei Ke Za Zhi. 2010;49(3):213–6.
    • (2010) Zhonghua Nei Ke Za Zhi. , vol.49 , Issue.3 , pp. 213-216
    • Chang, D.1    Ouyang, J.2    Zhou, R.3    Xu, J.4    Chen, B.5    Yang, Y.6
  • 76
    • 80053132093 scopus 로고    scopus 로고
    • Elevated plasma IL-22 levels correlated with Th1 and Th22 cells in patients with immune thrombocytopenia
    • Cao J, Chen C, Zeng L, Li L, Li X, Li Z, et al. Elevated plasma IL-22 levels correlated with Th1 and Th22 cells in patients with immune thrombocytopenia. Clin Immunol Orlando Fla. 2011;141(1):121–3.
    • (2011) Clin Immunol Orlando Fla. , vol.141 , Issue.1 , pp. 121-123
    • Cao, J.1    Chen, C.2    Zeng, L.3    Li, L.4    Li, X.5    Li, Z.6
  • 77
    • 84877675455 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells in the pathophysiology of immune thrombocytopenia
    • Nishimoto T, Kuwana M. CD4+CD25+Foxp3+ regulatory T cells in the pathophysiology of immune thrombocytopenia. Semin Hematol. 2013;50(Suppl 1):S43–49.
    • (2013) Semin Hematol. , vol.50 , pp. S43-S49
    • Nishimoto, T.1    Kuwana, M.2
  • 79
    • 84870662738 scopus 로고    scopus 로고
    • The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia
    • Ji L, Zhan Y, Hua F, Li F, Zou S, Wang W, et al. The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia. PloS One. 2012;7(12):e50909.
    • (2012) PloS One. , vol.7 , Issue.12 , pp. e50909
    • Ji, L.1    Zhan, Y.2    Hua, F.3    Li, F.4    Zou, S.5    Wang, W.6
  • 81
    • 84866177904 scopus 로고    scopus 로고
    • Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia
    • Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, et al. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood 2012;120(10):2127–32.
    • (2012) Blood , vol.120 , Issue.10 , pp. 2127-2132
    • Aslam, R.1    Hu, Y.2    Gebremeskel, S.3    Segel, G.B.4    Speck, E.R.5    Guo, L.6
  • 82
    • 84870996379 scopus 로고    scopus 로고
    • Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
    • Daridon C, Loddenkemper C, Spieckermann S, Kuhl AA, Salama A, Burmester GR, et al. Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia. Blood 2012;120(25):5021–31.
    • (2012) Blood , vol.120 , Issue.25 , pp. 5021-5031
    • Daridon, C.1    Loddenkemper, C.2    Spieckermann, S.3    Kuhl, A.A.4    Salama, A.5    Burmester, G.R.6
  • 83
    • 84873828057 scopus 로고    scopus 로고
    • B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells
    • Mahévas M, Patin P, Huetz F, Descatoire M, Cagnard N, Bole-Feysot C, et al. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest. 2013;123(1):432–42.
    • (2013) J Clin Invest. , vol.123 , Issue.1 , pp. 432-442
    • Mahévas, M.1    Patin, P.2    Huetz, F.3    Descatoire, M.4    Cagnard, N.5    Bole-Feysot, C.6
  • 84
    • 84925936633 scopus 로고    scopus 로고
    • Decreased serum heat shock protein 60 levels in newly diagnosed immune thrombocytopenia patients
    • Dolasik I, Birtas Atesoglu E, Tarkun P, Mehtap O, Keski H, Dogru A, et al. Decreased serum heat shock protein 60 levels in newly diagnosed immune thrombocytopenia patients. Platelets 2015;26(3):220–3.
    • (2015) Platelets , vol.26 , Issue.3 , pp. 220-223
    • Dolasik, I.1    Birtas Atesoglu, E.2    Tarkun, P.3    Mehtap, O.4    Keski, H.5    Dogru, A.6
  • 85
    • 62449207161 scopus 로고    scopus 로고
    • Demographic data, natural history, and prognostic factors of idiopathic thrombocytopenic purpura in children: a multicentered study from Argentina
    • Donato H, Picón A, Martinez M, Rapetti MC, Rosso A, Gomez S, et al. Demographic data, natural history, and prognostic factors of idiopathic thrombocytopenic purpura in children:a multicentered study from Argentina. Pediatr Blood Cancer. 2009;52(4):491–6.
    • (2009) Pediatr Blood Cancer. , vol.52 , Issue.4 , pp. 491-496
    • Donato, H.1    Picón, A.2    Martinez, M.3    Rapetti, M.C.4    Rosso, A.5    Gomez, S.6
  • 86
    • 84869228561 scopus 로고    scopus 로고
    • Update on the Intercontinental Cooperative ITP Study Group (ICIS) and on the Pediatric and Adult Registry on Chronic ITP (PARC ITP)
    • Kühne T. Update on the Intercontinental Cooperative ITP Study Group (ICIS) and on the Pediatric and Adult Registry on Chronic ITP (PARC ITP). Pediatr Blood Cancer. 2013;60(Suppl 1):S15–18.
    • (2013) Pediatr Blood Cancer. , vol.60 , pp. S15-S18
    • Kühne, T.1
  • 87
    • 84866491758 scopus 로고    scopus 로고
    • Management of immune thrombocytopenic purpura: an update
    • Warrier R, Chauhan A. Management of immune thrombocytopenic purpura:an update. Ochsner J. 2012;12(3):221–7.
    • (2012) Ochsner J. , vol.12 , Issue.3 , pp. 221-227
    • Warrier, R.1    Chauhan, A.2
  • 88
    • 34648819037 scopus 로고    scopus 로고
    • The epidemiology of immune thrombocytopenic purpura
    • Fogarty PF, Segal JB. The epidemiology of immune thrombocytopenic purpura. Curr Opin Hematol. 2007;14(5):515–9.
    • (2007) Curr Opin Hematol. , vol.14 , Issue.5 , pp. 515-519
    • Fogarty, P.F.1    Segal, J.B.2
  • 89
    • 84997314131 scopus 로고    scopus 로고
    • A final analysis of a phase 2, single-arm study of platelet (Plt) responses and remission rates in patients with Immune Thrombocytopenia (ITP) receiving romiplostim. Abstract # 2775. Presented at the 56th ASH Annual Meeting, San Francisco, December, 6–9 2014. Available from:. [Accessed February 5, 2015]
    • Newland A, Godeau B, Priego V, Viallard J-F, Lopez Fernandez MF, Orejudos A, et al. A final analysis of a phase 2, single-arm study of platelet (Plt) responses and remission rates in patients with Immune Thrombocytopenia (ITP) receiving romiplostim. Abstract # 2775. Presented at the 56th ASH Annual Meeting, San Francisco, December, 6–9 2014. Available from:https://ash.confex.com/ash/2014/webprogram/Paper67031.html. [Accessed February 5, 2015].
    • Newland, A.1    Godeau, B.2    Priego, V.3    Viallard, J.-F.4    Lopez Fernandez, M.F.5    Orejudos, A.6
  • 90
    • 84895057726 scopus 로고    scopus 로고
    • Antiplatelet antibodies detected by the MAIPA assay in newly diagnosed immune thrombocytopenia are associated with chronic outcome and higher risk of bleeding
    • Grimaldi D, Canouï-Poitrine F, Croisille L, Lee K, Roudot-Thoraval F, Languille L, et al. Antiplatelet antibodies detected by the MAIPA assay in newly diagnosed immune thrombocytopenia are associated with chronic outcome and higher risk of bleeding. Ann Hematol. 2014;93(2):309–15.
    • (2014) Ann Hematol. , vol.93 , Issue.2 , pp. 309-315
    • Grimaldi, D.1    Canouï-Poitrine, F.2    Croisille, L.3    Lee, K.4    Roudot-Thoraval, F.5    Languille, L.6
  • 91
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
    • Kuter DJ, Bussel JB, Lyons RM, Pullarkat V, Gernsheimer TB, Senecal FM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura:a double-blind randomised controlled trial. Lancet 2008;371(9610):395–403.
    • (2008) Lancet , vol.371 , Issue.9610 , pp. 395-403
    • Kuter, D.J.1    Bussel, J.B.2    Lyons, R.M.3    Pullarkat, V.4    Gernsheimer, T.B.5    Senecal, F.M.6
  • 92
    • 84884192115 scopus 로고    scopus 로고
    • Correction of abnormal T cell subsets by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura
    • Li J, Wang Z, Hu S, Zhao X, Cao L. Correction of abnormal T cell subsets by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. Immunol Lett. 2013;154(1–2):42–8.
    • (2013) Immunol Lett. , vol.154 , Issue.1-2 , pp. 42-48
    • Li, J.1    Wang, Z.2    Hu, S.3    Zhao, X.4    Cao, L.5
  • 93
    • 84893808790 scopus 로고    scopus 로고
    • Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia
    • Li J, Wang Z, Dai L, Cao L, Su J, Zhu M, et al. Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia. Clin Dev Immunol. 2013;2013:548085.
    • (2013) Clin Dev Immunol. , vol.2013 , pp. 548085
    • Li, J.1    Wang, Z.2    Dai, L.3    Cao, L.4    Su, J.5    Zhu, M.6
  • 94
    • 78751580375 scopus 로고    scopus 로고
    • Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia
    • Li Z, Mou W, Lu G, Cao J, He X, Pan X, et al. Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia. Int J Hematol. 2011;93(1):91–8.
    • (2011) Int J Hematol. , vol.93 , Issue.1 , pp. 91-98
    • Li, Z.1    Mou, W.2    Lu, G.3    Cao, J.4    He, X.5    Pan, X.6
  • 95
    • 51649091745 scopus 로고    scopus 로고
    • Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab
    • Stasi R, Cooper N, Del Poeta G, Stipa E, Laura Evangelista M, Abruzzese E, et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood 2008;112(4):1147–50.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1147-1150
    • Stasi, R.1    Cooper, N.2    Del Poeta, G.3    Stipa, E.4    Laura Evangelista, M.5    Abruzzese, E.6
  • 96
    • 34548595302 scopus 로고    scopus 로고
    • Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome
    • Ling Y, Cao X, Yu Z, Ruan C. Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. Eur J Haematol. 2007;79(4):310–6.
    • (2007) Eur J Haematol. , vol.79 , Issue.4 , pp. 310-316
    • Ling, Y.1    Cao, X.2    Yu, Z.3    Ruan, C.4
  • 97
    • 85047691387 scopus 로고    scopus 로고
    • Immune complexes as therapy for autoimmunity
    • Clynes R. Immune complexes as therapy for autoimmunity. J Clin Invest. 2005;115(1):25–7.
    • (2005) J Clin Invest. , vol.115 , Issue.1 , pp. 25-27
    • Clynes, R.1
  • 98
    • 84901692618 scopus 로고    scopus 로고
    • The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study
    • Mahévas M, Fain O, Ebbo M, Roudot-Thoraval F, Limal N, Khellaf M, et al. The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study. Br J Haematol. 2014;165(6):865–9.
    • (2014) Br J Haematol. , vol.165 , Issue.6 , pp. 865-869
    • Mahévas, M.1    Fain, O.2    Ebbo, M.3    Roudot-Thoraval, F.4    Limal, N.5    Khellaf, M.6
  • 100
    • 84887817831 scopus 로고    scopus 로고
    • Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists
    • Ghadaki B, Nazi I, Kelton JG, Arnold DM. Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists. Transfusion (Paris) 2013;53(11):2807–12.
    • (2013) Transfusion (Paris) , vol.53 , Issue.11 , pp. 2807-2812
    • Ghadaki, B.1    Nazi, I.2    Kelton, J.G.3    Arnold, D.M.4
  • 101
    • 84983445479 scopus 로고    scopus 로고
    • Case study of remission in adults with immune thrombocytopenia following cessation of treatment with the thrombopoietin mimetic romiplostim
    • Bussel JB, Wang X, Lopez A, Eisen M. Case study of remission in adults with immune thrombocytopenia following cessation of treatment with the thrombopoietin mimetic romiplostim. Hematology. 2016;21(4):257–62.
    • (2016) Hematology , vol.21 , Issue.4 , pp. 257-262
    • Bussel, J.B.1    Wang, X.2    Lopez, A.3    Eisen, M.4
  • 103
    • 78649486228 scopus 로고    scopus 로고
    • Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents
    • Bao W, Bussel JB, Heck S, He W, Karpoff M, Boulad N, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood 2010;116(22):4639–45.
    • (2010) Blood , vol.116 , Issue.22 , pp. 4639-4645
    • Bao, W.1    Bussel, J.B.2    Heck, S.3    He, W.4    Karpoff, M.5    Boulad, N.6
  • 104
    • 0037109144 scopus 로고    scopus 로고
    • Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells
    • May AE, Kälsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 2002;106(16):2111–7.
    • (2002) Circulation , vol.106 , Issue.16 , pp. 2111-2117
    • May, A.E.1    Kälsch, T.2    Massberg, S.3    Herouy, Y.4    Schmidt, R.5    Gawaz, M.6


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