Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats

Toxicologic Pathology

Volumn 44, Issue 7, 2016, Pages 987-997

  Cullen, John M ^a   Faiola, Brenda ^b   Melich, David H ^b   Peterson, Richard A ^b   Jordan, Holly L ^b   Kimbrough, Carie L ^b   Miller, Richard T ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

alpha naphthylisothiocyanate; bile duct; germfree; liver; rat; toxicity

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ARYLDIALKYLPHOSPHATASE 1; BILE ACID; BILIRUBIN; GLUTAMATE DEHYDROGENASE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT INJURY; CELL PROLIFERATION; CHOLANGITIS; CLINICAL CHEMISTRY; CONTROLLED STUDY; EDEMA; HISTOPATHOLOGY; LIVER HISTOLOGY; LIVER TOXICITY; MALE; NECROSIS; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; GERMFREE ANIMAL; LIVER; SPRAGUE DAWLEY RAT;

1-NAPHTHYLISOTHIOCYANATE; ANIMALS; GERM-FREE LIFE; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84988689958     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623316662360     Document Type: Article

References (26)

1. Bjorkholm B., Bok C. M., Lundin A., Rafter J., Hibberd M. L., Petterrsson S., (2009). Intestinal microbiota regulate xenobiotic metabolism in the liver. Plos One 4, 1-8.
2. Clayton T. A., Baker D., Lindon J. C., Everett J. R., Nicholson J. K., (2009). Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA 106, 14728-33.
3. Cullen J. M., Faiola B., Melich D. H., Peterson R. A., Jordan H. L., Kimbrough C. L., Prescott J. S., Miller R. T., (2013). Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice. Toxicol Pathol 41, 7-17.
4. Dahm L. J., Roth R. A., (1991). Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content. Biochem Pharmacol 42, 1181-88.
5. Deng X., Luyendyk J. P., Ganey P. E., Roth R. A., (2009). Inflammatory stress and idiosyncratic hepatotoxicity: Hints from animal models. Pharmacol Rev 61, 262-82.
6. Fabris L., Strazzabosco M., (2011). Epithelial-mesenchymal interactions in biliary diseases. Semin Liver Dis 31, 11-32.
7. Faiola B., Peterson R. A., Kimbrough C. L., Jordan H. L., Cullen J. M., (2010). Acute ANIT toxicity in male IL-10 knockout and wild-type mice. Toxicol Pathol 38, 745-55.
8. Lhoste E. F., Ouriet V., Bruel S., Flinois J. P., Brezillon C., Magdalou J., Cheze C., Nugon-Baudon L., (2003). The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats. Food Chem Toxicol 41, 695-702.
9. Littell R. C., Stroup W. W., Freund R., (2002). SAS for Linear Models. 4th ed. John Wiley and Sons, Cary, NC.
10. Luyendyk J. P., Lehman-McKeeman L. D., Nelson D. M., Bhaskaran V. M., Reilly T. P., Car B. D., Cantor G. H., Deng X., Maddox J. F., Ganey P. E., Roth R. A., (2006). Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine. J Pharmacol Exp Ther 317, 635-43.
11. Maddox J. F., Luyendyk J. P., Cosma G. N., Breau A. P., Bible R. H. Jr., Harrigan G. G., Goodacre R., Ganey P. E., Cantor G. H., Cockerell G. L., Roth R. A., (2006). Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicol Appl Pharmacol 212, 35-44.
12. Meinl W., Sczesny S., Brigelius-Flohe R., Blaut M., Glatt H., (2009). Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab Dispos 37, 1179-86.
13. Midvedt T., Norman A., (2007). Bile acid transformations by microbial strains belonging to genera found in intestinal contents. 1967. APMIS 115, 592-601; discussion 602-3.
14. Nicholson J. K., Holmes E., Kinross J., Burcelin R., Gibson G., Jia W., Pettersson S., (2012). Host-gut microbiota metabolic interactions. Science 336, 1262-67.
15. Overvik E., Lindeskog P., Midtvedt T., Gustafsson J. A., (1990). Mutagen excretion and cytochrome P-450-dependent activity in germfree and conventional rats fed a diet containing fried meat. Food Chem Toxicol 28, 253-61.
16. Rowland I. R., (1988). Interactions of the gut microflora and the host in toxicology. Toxicol Pathol 16, 147-53.
17. Sayin S. I., Wahlstrom A., Felin J., Jantti S., Marschall H. U., Bamberg K., Angelin B., Hyotylainen T., Oresic M., Backhed F., (2013). Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17, 225-35.
18. Swann J., Wang Y., Abecia L., Costabile A., Tuohy K., Gibson G., Roberts D., Sidaway J., Jones H., Wilson I. D., Nicholson J., Holmes E., (2009). Gut microbiome modulates the toxicity of hydrazine: A metabonomic study. Mol Biosyst 5, 351-55.
19. Swann J. R., Want E. J., Geier F. M., Spagou K., Wilson I. D., Sidaway J. E., Nicholson J. K., Holmes E., (2011). Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci USA 108, 4523-30.
20. Upreti R. K., Shrivastava R., Chaturvedi U. C., (2004). Gut microflora & toxic metals: Chromium as a model. Indian J Med Res 119, 49-59.
21. Waring J. F., Liguori M. J., Luyendyk J. P., Maddox J. F., Ganey P. E., Stachlewitz R. F., North C., Blomme E. A., Roth R. A., (2006). Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther 316, 1080-87.
22. Wilson I. D., Nicholson J. K., (2009). The role of gut microbiota in drug response. Curr Pharm Des 15, 1519-23.
23. Wilson I. D., Nicholson J. K., (2015). The modulation of drug efficacy and toxicity by the gut microbiome. In Metabonomics and Gut Microbiota in Nutrition and Disease (Kochhar S., Martin F.-P., eds.), pp. 323-41. Springer-Verlag, London, UK.
24. Wostmann B. S., (1973). Intestinal bile acids and cholesterol absorption in the germfree rat. J Nutr 103, 982-90.
25. Zou W., Devi S. S., Sparkenbaugh E., Younis H. S., Roth R. A., Ganey P. E., (2009). Hepatotoxic interaction of sulindac with lipopolysaccharide: Role of the hemostatic system. Toxicol Sci 108, 184-93.
26. Zuo F., Nakamura N., Akao T., Hattori M., (2006). Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos 34, 2064-72.