Metabolism-mediated interaction potential of standardized extract of Tinospora cordifolia through rat and human liver microsomes

Indian Journal of Pharmacology

Volumn 48, Issue 5, 2016, Pages 576-581

  Bahadur, Shiv ^a   Mukherjee, Pulok ^a   Milan Ahmmed, S ^a   Kar, Amit ^a   Harwansh, Ranjit ^a   Pandit, Subrata ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Cytochrome P450; human liver microsome; reverse phase high performance liquid chromatography; Tinospora cordifolia; tinosporaside

Indexed keywords

ACETONITRILE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 CARBON MONOXIDE COMPLEX; KETOCONAZOLE; PLANT MEDICINAL PRODUCT; TINOSPORA CORDIFOLIA EXTRACT; TINOSPORASIDE; UNCLASSIFIED DRUG; CARBON MONOXIDE; CYTOCHROME P450 INHIBITOR; PLANT EXTRACT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW RATE; FLUORESCENCE ANALYSIS; HERB DRUG INTERACTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIVER MICROSOME; METABOLISM; NONHUMAN; RAT; RETENTION TIME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TINOSPORA CORDIFOLIA; ANIMAL; TINOSPORA;

ANIMALS; CARBON MONOXIDE; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; HERB-DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER; PLANT EXTRACTS; RATS; TINOSPORA;

EID: 84988654371     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.190758     Document Type: Article

References (19)

1. Sharma P, Velu V, Indrani D, Singh RP. Effect of dried guduchi (Tinospora cordifolia) leaf powder on rheological, organoleptic and nutritional characteristics of cookies. Food Res Int 2013;50:704-9.
2. Sangeetha MK, Priya CD, Vasanthi HR. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine 2013;20:246-8.
3. Kumar V, Nagar S. Studies on Tinospora cordifolia monosugars and correlation analysis of uronic acids by spectrophotometric methods and GLC. Carbohydr Polym 2014;99:291-6.
4. Lee SY, Lee JY, Kang W, Kwon KI, Park SK, Oh SJ, et al. Cytochrome P450-mediated herb-drug interaction potential of Galgeun-tang. Food Chem Toxicol 2013;51:343-9.
5. Ponnusankar S, Pandit S, Babu R, Bandyopadhyay A, Mukherjee PK. Cytochrome P450 inhibitory potential of Triphala-A Rasayana from Ayurveda. J Ethnopharmacol 2011;133:120-5.
6. Mukherjee PK, Ponnusankar S, Pandit S, Hazam PK, Ahmmed M, Mukherjee K. Botanicals as medicinal food and their effects on drug metabolizing enzymes. Food Chem Toxicol 2011;49:3142-53.
7. Qi XY, Liang SC, Ge GB, Liu Y, Dong PP, Zhang JW, et al. Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes. Food Chem Toxicol 2013;56:392-7.
8. Choi SJ, Kim M, Kim SI, Jeon JK. Microplate assay measurement of cytochrome p450-carbon monoxide complexes. J Biochem Mol Biol 2003;36:332-5.
9. Ponnusankar S, Pandit S, Venkatesh M, Bandyopadhyay A, Mukherjee PK. Cytochrome P450 inhibition assay for standardized extract of Terminalia chebula Retz. Phytother Res 2011;25:151-4.
10. Ahmmed SM, Mukherjee PK, Bahadur S, Kar A, Mukherjee K, Karmakar S, et al. Interaction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition. Indian J Pharmacol 2015;47:530-4.
11. Pandit S, Mukharjee PK, Mukharjee K, Gajbhiye R, Venkatesh M, Ponnusankar S, et al. Cytochrome P450 inhibitory potential of selected Indian spices-Possible food drug interaction. Food Res Int 2012;45:69-74.
12. Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82:369-74.
13. Ahmmed SM, Mukherjee PK, Bahadur S, Harwansh RK, Kar A, Bandyopadhyay A, et al. CYP450 mediated inhibition potential of Swertia chirata: An herb from Indian traditional medicine. J Ethnopharmacol 2016;178:34-9.
14. Harwansh RK, Mukherjee K, Bhadra S, Kar A, Bahadur S, Mitra A, et al. Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu-A Rasayana from Indian Ayurveda. J Ethnopharmacol 2014;153:674-81.
15. Subash S, Seervi M, Lyer K, Anagha D. Assessment of rat hepatic cytochrome P450 induction and inhibition potential of chlorogenic acid. Indian J Pharm Educ Res 2011;45:32-40.
16. Choi EJ, Park JB, Yoon KD, Bae SK. Evaluation of the in vitro/in vivo potential of five berries (Bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase. Food Chem Toxicol 2014;72:13-9.
17. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet 2005;20:34-45.
18. Sieniawska E, Baj T, Dudka J, Gieroba R, Swiatek L, Rajtar B, et al. Cytotoxicity, antioxidant activity and an effect on CYP3A4 and CYP2D6 of Mutellina purpurea L. extracts. Food Chem Toxicol 2013;52:188-92.
19. Kim H, Choi HK, Jeong TC, Jahng Y, Kim DH, Lee SH, et al. Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes. Food Chem Toxicol 2013;51:33-7.