Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu - A Rasayana from Indian Ayurveda

Journal of Ethnopharmacology

Volumn 153, Issue 3, 2014, Pages 674-681

  Harwansh, Ranjit K ^a   Mukherjee, Kakali ^a   Bhadra, Santanu ^a   Kar, Amit ^a   Bahadur, Shiv ^a   Mitra, Achintya ^b   Mukherjee, Pulok K ^a  

^a JADAVPUR UNIVERSITY   (India)

^b National Research Institute of Ayurveda for Drug Development   (India)

Author keywords

Ayurveda; Cytochrome P450; Herb drug interaction; Rasayana; Spices; Trikatu

Indexed keywords

(6) GINGEROL; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; PIPERINE; ALKENE; CYTOCHROME P450 3A; CYTOCHROME P450 INHIBITOR; PIPERIDINE DERIVATIVE; TRIKATU;

ANIMAL CELL; ARTICLE; AYURVEDA; BLACK PEPPER; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG POTENCY; ENZYME INHIBITION; GINGER; HERB DRUG INTERACTION; IC 50; LIVER MICROSOME; NONHUMAN; PIPER LONGUM; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STANDARDIZATION; TRIKATU; ANIMAL; DOSE RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM;

PIPER LONGUM; PIPER NIGRUM; RATTUS; ZINGIBER OFFICINALE;

ALKENES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HERB-DRUG INTERACTIONS; MICROSOMES, LIVER; PIPERIDINES; RATS;

EID: 84900303797     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.03.023     Document Type: Article

References (23)

1. D. Chanda, K. Shanker, A. Pal, S. Luqman, D.U. Bawankule, D. Mani, and M.P. Darokar Safety evaluation of Trikatu, a generic ayurvedic medicine in charles foster rats The Journal of Toxicological Sciences 34 2009 99 108
2. J.S. Chang, K.C. Wang, C.F. Yeh, D.E. Shieh, and L.C. Chiang Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines Journal of Ethnopharmacology 145 2013 146 151
3. P.J. Houghton, and P.K. Mukherjee Evaluation of herbal medicinal products 1st ed. 2009 Pharmaceutical Press London
4. ICH,1994. ICH harmonised tripartite guideline on validation of analytical procedures: text and methodology Q2 (R1). In: Proceedings of the International Conference on Harmonisation, October 1994.
5. R.K. Johri, and U. Zutshi An ayurvedic formulation 'Trikatu' and its constituents Journal of Ethnopharmacology 37 1992 85 91
6. K.B. Kaviraj 2nd ed. Sushruta Samhita 3 1963 (in Sanskrit)
7. I.B. Koul, and A. Kapil Evaluation of liver protective potential of piperine, an active principle of black and long peppers Planta Medica 59 1993 413 417
8. L.G. Lala, P.M. DMello, and S.R. Naik Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium Journal of Ethnopharmacology 91 2004 277 280
9. K.B. Lee, K.H. Shin, and W.S. Wan Central nervous depressant and anti-inflammatory activity of piperine Archives of Pharmacal Research 1 1984 127 132
10. A.M. Majumdar, J.N. Dhuley, V.K. Deshmukh, and S.R. Naik Effect of piperine bioavailability of oxyphenylbutazone in rats Indian Drugs 36 1999 14
11. P.K. Mukherjee Quality Control on Herbal Drugs 2nd ed. 2002 Eastern Publishers Business Horizons Ltd. New Delhi
12. P.K. Mukherjee, N.K. Nema, P. Venkatesh, and P.K. Debnath Changing scenario for promotion and development of Ayurveda - way forward Journal of Ethnopharmacology 143 2012 424 434
13. P.K. Mukherjee, S. Rai, S. Bhattacharya, A. Wahile, and B.P. Saha Marker analysis of polyherbal formulation, Triphala - a well known Indian traditional medicine Indian Journal of Traditional Knowledge 7 2008 379 383
14. P.K. Mukherjee, and A. Wahile Integrated approaches towards drug development from Ayurveda and other Indian system of medicines Journal of Ethnopharmacology 103 2006 25 35
15. S. Pandit, P.K. Mukherjee, K. Mukherjee, R. Gajbhiye, M. Venkatesh, S. Ponnusankar, and S. Bhadra Cytochrome P450 inhibitory potential of selected Indian spices-possible food drug interaction Food Research International 45 2012 69 74
16. S. Pandit, P.K. Mukherjee, S. Ponnusankar, M. Venkatesh, and N. Srikanth Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6 Fitoterapia 82 2011 369 374
17. S. Pandit, S. Ponnusankar, A. Bandyopadhyay, S. Ota, and P.K. Mukherjee Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6 Phytotherapy Research 25 2011 1429 1434
18. S. Pole Ayurvedic Medicine: The Principles of Traditional Practices 2006 Churchill Livingstone, Elsevier UK 302 303
19. S. Ponnusankar, S. Pandit, R. Babu, A. Bandyopadhyay, and P.K. Mukherjee Cytochrome P450 inhibitory potential of Triphala - a rasayana from Ayurveda Journal of Ethnopharmacology 133 2011 120 125
20. S. Ponnusankar, S. Pandit, M. Venkatesh, A. Bandyopadhyay, and P.K. Mukherjee Cytochrome P450 inhibition assay for standardized extract of Terminalia chebula Retz Phytotherapy Research 25 2011 151 154
21. S. Taqvi, A. Shah, and A. Gilani Insight into the possible mechanism of anti-diarrheal and antispasmodic activities of piperine Pharmaceutical Biology 47 2009 660 664
22. The Ayurvedic Formulary of India, 2002. Part II. Department of Indian System of Medicine and Homeopathy, New Delhi.
23. J. Wattanathorn, P. Chonpathompikunlert, S. Muchimapura, A. Priprem, and O. Tankamnerdthai Piperine the potential functional food for mood and cognitive disorders Food and Chemical Toxicology 46 2008 3106 3110