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Volumn 5, Issue 10, 2016, Pages 1425-1439

Umbilical cord-derived mesenchymal stem cell-derived exosomal micrornas suppress myofibroblast differentiation by inhibiting the transforming growth factor-β/SMAD2 pathway during wound healing

Author keywords

Exosome; Mesenchymal stem cells; MicroRNA; Myofibroblast; Transforming growth factor b

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CHLORAL HYDRATE; COLLAGEN; MICRORNA; MICRORNA 125B; MICRORNA 145; MICRORNA 21; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN, MOUSE;

EID: 84988637960     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2015-0367     Document Type: Article
Times cited : (460)

References (42)
  • 1
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: Therapeutic translation for fibrotic disease
    • Wynn TA, Ramalingam TR. Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nat Med 2012; 18: 1028-1040.
    • (2012) Nat Med , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 2
    • 84904960909 scopus 로고    scopus 로고
    • Mechanoregulation of the myofibroblast in wound contraction, scarring, and fibrosis: Opportunities for new therapeutic intervention
    • Van De Water L, Varney S, Tomasek JJ. Mechanoregulation of the myofibroblast in wound contraction, scarring, and fibrosis: Opportunities for new therapeutic intervention. Adv Wound Care (New Rochelle) 2013; 2: 122-141.
    • (2013) Adv Wound Care (New Rochelle) , vol.2 , pp. 122-141
    • Van De Water, L.1    Varney, S.2    Tomasek, J.J.3
  • 3
    • 84925596863 scopus 로고    scopus 로고
    • Transforming growth factor-b pathway activity in glioblastoma
    • Frei K, Gramatzki D, Tritschler I et al. Transforming growth factor-b pathway activity in glioblastoma. Oncotarget 2015; 6: 5963-5977.
    • (2015) Oncotarget , vol.6 , pp. 5963-5977
    • Frei, K.1    Gramatzki, D.2    Tritschler, I.3
  • 4
    • 84897147185 scopus 로고    scopus 로고
    • Fibromodulindeficiency alters temporospatial expression patterns of transforming growth factor-b ligands and receptors during adult mouse skin wound healing
    • Zheng Z, Lee KS, Zhang X et al. Fibromodulindeficiency alters temporospatial expression patterns of transforming growth factor-b ligands and receptors during adult mouse skin wound healing. PLoS One 2014; 9: e90817.
    • (2014) PLoS One , vol.9 , pp. 90817
    • Zheng, Z.1    Lee, K.S.2    Zhang, X.3
  • 5
    • 84872233600 scopus 로고    scopus 로고
    • Theroleof theTGF-bfamily inwoundhealing,burnsandscarring: A review
    • PennJW,GrobbelaarAO,RolfeKJ.Theroleof theTGF-bfamily inwoundhealing,burnsandscarring: A review. Int J Burns Trauma 2012; 2: 18-28.
    • (2012) Int J Burns Trauma , vol.2 , pp. 18-28
    • Penn, J.W.1    Grobbelaar, A.O.2    Rolfe, K.J.3
  • 6
    • 84922762082 scopus 로고    scopus 로고
    • Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy
    • Kourembanas S. Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol 2015; 77: 13-27.
    • (2015) Annu Rev Physiol , vol.77 , pp. 13-27
    • Kourembanas, S.1
  • 7
    • 84906964309 scopus 로고    scopus 로고
    • Paracrine mechanisms of mesenchymal stem cell-based therapy: Current status and perspectives
    • Liang X, Ding Y, Zhang Y et al. Paracrine mechanisms of mesenchymal stem cell-based therapy: Current status and perspectives. Cell Transplant 2014; 23: 1045-1059.
    • (2014) Cell Transplant , vol.23 , pp. 1045-1059
    • Liang, X.1    Ding, Y.2    Zhang, Y.3
  • 8
    • 84874607115 scopus 로고    scopus 로고
    • TGFb1- containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis
    • Borges FT, Melo SA, Özdemir BC et al. TGFb1- containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. JAmSoc Nephrol 2013; 24: 385-392.
    • (2013) JAmSoc Nephrol , vol.24 , pp. 385-392
    • Borges, F.T.1    Melo, S.A.2    Özdemir, B.C.3
  • 9
    • 84940703386 scopus 로고    scopus 로고
    • MiR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis
    • Solé C, Corté s-Hernández J, Felip ML et al. miR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis. Nephrol Dial Transplant 2015; 30: 1488-1496.
    • (2015) Nephrol Dial Transplant , vol.30 , pp. 1488-1496
    • Solé, C.1    Corté s-Hernández, J.2    Felip, M.L.3
  • 10
    • 84930636929 scopus 로고    scopus 로고
    • Exosomes for intramyocardial intercellularcommunication
    • Cervio E, Barile L, Moccetti T et al. Exosomes for intramyocardial intercellularcommunication. Stem Cells Int 2015; 2015: 482171.
    • (2015) Stem Cells Int , vol.2015 , pp. 482171
    • Cervio, E.1    Barile, L.2    Moccetti, T.3
  • 11
    • 84876241933 scopus 로고    scopus 로고
    • Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
    • Li T, Yan Y, Wang B et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev 2013; 22: 845-854.
    • (2013) Stem Cells Dev , vol.22 , pp. 845-854
    • Li, T.1    Yan, Y.2    Wang, B.3
  • 12
    • 84943365822 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells in liver fibrosis: Recent findings, old/new caveats and future perspectives
    • Fiore EJ, Mazzolini G, Aquino JB. Mesenchymal stem/stromal cells in liver fibrosis: Recent findings, old/new caveats and future perspectives. Stem Cell Rev 2015; 11: 586-597.
    • (2015) Stem Cell Rev , vol.11 , pp. 586-597
    • Fiore, E.J.1    Mazzolini, G.2    Aquino, J.B.3
  • 13
    • 84881400770 scopus 로고    scopus 로고
    • Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells
    • Ramakrishnaiah V, Thumann C, Fofana I et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci USA 2013; 110: 13109-13113.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 13109-13113
    • Ramakrishnaiah, V.1    Thumann, C.2    Fofana, I.3
  • 14
    • 85016304525 scopus 로고    scopus 로고
    • Exosomes provide a protective and enriched source of miRNAfor biomarker profiling compared to intracellular andcell-free blood
    • Cheng L, Sharples RA, Scicluna BJ et al. Exosomes provide a protective and enriched source of miRNAfor biomarker profiling compared to intracellular andcell-free blood. J ExtracellVesicles 2014; 3: 3.
    • (2014) J ExtracellVesicles , vol.3 , pp. 3
    • Cheng, L.1    Sharples, R.A.2    Scicluna, B.J.3
  • 15
    • 84898039042 scopus 로고    scopus 로고
    • MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease
    • Kordelas L, Rebmann V, Ludwig AK et al. MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 2014; 28: 970-973.
    • (2014) Leukemia , vol.28 , pp. 970-973
    • Kordelas, L.1    Rebmann, V.2    Ludwig, A.K.3
  • 16
    • 84876367541 scopus 로고    scopus 로고
    • Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal
    • Wang Y, Xu Z, Jiang J et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell 2013; 25: 69-80.
    • (2013) Dev Cell , vol.25 , pp. 69-80
    • Wang, Y.1    Xu, Z.2    Jiang, J.3
  • 17
    • 84890013875 scopus 로고    scopus 로고
    • MiR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
    • Hsieh JY, Huang TS, Cheng SM et al. miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells. Nucleic Acids Res 2013; 41: 9753-9763.
    • (2013) Nucleic Acids Res , vol.41 , pp. 9753-9763
    • Hsieh, J.Y.1    Huang, T.S.2    Cheng, S.M.3
  • 18
    • 84911805416 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice
    • Wu Y, Huang S, Enhe J et al. Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice. Int Wound J 2014; 11: 701-710.
    • (2014) Int Wound J , vol.11 , pp. 701-710
    • Wu, Y.1    Huang, S.2    Enhe, J.3
  • 20
    • 0035010796 scopus 로고    scopus 로고
    • The dynamic in vivo distribution of bone marrowderived mesenchymal stem cells after infusion
    • Gao J, Dennis JE, Muzic RF et al. The dynamic in vivo distribution of bone marrowderived mesenchymal stem cells after infusion. Cells Tissues Organs 2001; 169: 12-20.
    • (2001) Cells Tissues Organs , vol.169 , pp. 12-20
    • Gao, J.1    Dennis, J.E.2    Muzic, R.F.3
  • 21
    • 84934297053 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro
    • Shabbir A, Cox A, Rodriguez-Menocal L et al. Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro. Stem Cells Dev 2015; 24: 1635-1647.
    • (2015) Stem Cells Dev , vol.24 , pp. 1635-1647
    • Shabbir, A.1    Cox, A.2    Rodriguez-Menocal, L.3
  • 22
    • 84934903985 scopus 로고    scopus 로고
    • Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
    • Alexander M, Hu R, Runtsch MC et al. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun 2015; 6: 7321.
    • (2015) Nat Commun , vol.6 , pp. 7321
    • Alexander, M.1    Hu, R.2    Runtsch, M.C.3
  • 23
    • 31644445847 scopus 로고    scopus 로고
    • Critical role of the Rho-kinase pathway in TGF-beta2- dependent collagen gel contraction by retinal pigment epithelial cells
    • Miura M, Hata Y, Hirayama K et al. Critical role of the Rho-kinase pathway in TGF-beta2- dependent collagen gel contraction by retinal pigment epithelial cells. Exp Eye Res 2006; 82: 849-859.
    • (2006) Exp Eye Res , vol.82 , pp. 849-859
    • Miura, M.1    Hata, Y.2    Hirayama, K.3
  • 24
    • 84889069477 scopus 로고    scopus 로고
    • Role of miR-145 in cardiac myofibroblast differentiation
    • Wang YS, Li SH, Guo J et al. Role of miR-145 in cardiac myofibroblast differentiation. J Mol Cell Cardiol 2014; 66: 94-105.
    • (2014) J Mol Cell Cardiol , vol.66 , pp. 94-105
    • Wang, Y.S.1    Li, S.H.2    Guo, J.3
  • 25
    • 84940172573 scopus 로고    scopus 로고
    • Osteopontin is indispensible forAP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis
    • Lorenzen JM, Schauerte C, Hübner A et al. Osteopontin is indispensible forAP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. Eur Heart J 2015; 36: 2184-2196.
    • (2015) Eur Heart J , vol.36 , pp. 2184-2196
    • Lorenzen, J.M.1    Schauerte, C.2    Hübner, A.3
  • 26
    • 84885469901 scopus 로고    scopus 로고
    • A snapshot of direct cell-cell communications in wound healing and scarring
    • Ehrlich HP. A snapshot of direct cell-cell communications in wound healing and scarring. AdvWound Care (New Rochelle) 2013; 2: 113-121.
    • (2013) AdvWound Care (New Rochelle) , vol.2 , pp. 113-121
    • Ehrlich, H.P.1
  • 27
    • 84925338126 scopus 로고    scopus 로고
    • Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
    • Zhang J, Guan J, Niu X et al. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med 2015; 13: 49.
    • (2015) J Transl Med , vol.13 , pp. 49
    • Zhang, J.1    Guan, J.2    Niu, X.3
  • 28
    • 84866482255 scopus 로고    scopus 로고
    • Mesenchymal stem cells as all-round supporters in a normal and neoplasticmicroenvironment
    • Hass R, Otte A. Mesenchymal stem cells as all-round supporters in a normal and neoplasticmicroenvironment. Cell Commun Signal 2012; 10: 26.
    • (2012) Cell Commun Signal , vol.10 , pp. 26
    • Hass, R.1    Otte, A.2
  • 29
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. STEM CELLS 2007; 25: 1384-1392.
    • (2007) STEM CELLS , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 30
    • 84899483240 scopus 로고    scopus 로고
    • Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling
    • Arno AI, Amini-Nik S, Blit PH et al. Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling. Stem Cell Res Ther 2014; 5: 28.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 28
    • Arno, A.I.1    Amini-Nik, S.2    Blit, P.H.3
  • 31
    • 84864598081 scopus 로고    scopus 로고
    • Therapeutic potential of mesenchymal stem cell-derived microvesicles
    • Biancone L, Bruno S, Deregibus MC et al. Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrol Dial Transplant 2012; 27: 3037-3042.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 3037-3042
    • Biancone, L.1    Bruno, S.2    Deregibus, M.C.3
  • 32
    • 84899508957 scopus 로고    scopus 로고
    • Paracrine effects of stem cells in wound healing and cancer progression
    • Review
    • Dittmer J, Leyh B. Paracrine effects of stem cells in wound healing and cancer progression. Int J Oncol 2014; 44: 1789-1798 [Review].
    • (2014) Int J Oncol , vol.44 , pp. 1789-1798
    • Dittmer, J.1    Leyh, B.2
  • 33
    • 84859073207 scopus 로고    scopus 로고
    • Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling
    • Hinz B, Phan SH, Thannickal VJ et al. Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling. Am J Pathol 2012; 180: 1340-1355.
    • (2012) Am J Pathol , vol.180 , pp. 1340-1355
    • Hinz, B.1    Phan, S.H.2    Thannickal, V.J.3
  • 34
    • 84927520441 scopus 로고    scopus 로고
    • Mesenchymal stemcells suppress fibroblast proliferation and reduce skinfibrosis througha TGF-b3-dependentactivation
    • Wu Y, Peng Y, Gao D et al. Mesenchymal stemcells suppress fibroblast proliferation and reduce skinfibrosis througha TGF-b3-dependentactivation. Int J LowExtremWounds 2015; 14: 50-62.
    • (2015) Int J LowExtremWounds , vol.14 , pp. 50-62
    • Wu, Y.1    Peng, Y.2    Gao, D.3
  • 35
    • 84880797948 scopus 로고    scopus 로고
    • Exosomesmediate the cell-to-cell transmission of IFN-a-induced antiviral activity
    • Li J, LiuK, LiuYet al. Exosomesmediate the cell-to-cell transmission of IFN-a-induced antiviral activity. Nat Immunol 2013; 14: 793-803.
    • (2013) Nat Immunol , vol.14 , pp. 793-803
    • Li, J.1    Liu, K.2    Liu, Y.3
  • 36
    • 84898771564 scopus 로고    scopus 로고
    • Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery
    • Lv LL, Cao Y, Liu D et al. Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery. Int J Biol Sci 2013; 9: 1021-1031.
    • (2013) Int J Biol Sci , vol.9 , pp. 1021-1031
    • Lv, L.L.1    Cao, Y.2    Liu, D.3
  • 37
    • 84880316996 scopus 로고    scopus 로고
    • MicroRNA-21 in scleroderma fibrosis and its function in TGFb- regulated fibrosis-related genes expression
    • Zhu H, Luo H, Li Y et al. MicroRNA-21 in scleroderma fibrosis and its function in TGFb- regulated fibrosis-related genes expression. J Clin Immunol 2013; 33: 1100-1109.
    • (2013) J Clin Immunol , vol.33 , pp. 1100-1109
    • Zhu, H.1    Luo, H.2    Li, Y.3
  • 38
    • 79951974174 scopus 로고    scopus 로고
    • Micro-RNA-21 regulates TGF-beta-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction
    • Yao Q, Cao S, Li C et al. Micro-RNA-21 regulates TGF-beta-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. Int J Cancer 2011; 128: 1783-1792.
    • (2011) Int J Cancer , vol.128 , pp. 1783-1792
    • Yao, Q.1    Cao, S.2    Li, C.3
  • 39
    • 84906076816 scopus 로고    scopus 로고
    • The role of TGF-b1-miR-21-ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells
    • Jiang Y, Chen X, Tian W et al. The role of TGF-b1-miR-21-ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells. Br J Cancer 2014; 111: 772-780.
    • (2014) Br J Cancer , vol.111 , pp. 772-780
    • Jiang, Y.1    Chen, X.2    Tian, W.3
  • 40
    • 80051944105 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 (TGF-beta1)utilizesdistinctpathways for the transcriptional activation of microRNA 143/145 inhuman coronary arterysmoothmuscle cells
    • Long X, Miano JM. Transforming growth factor-beta1 (TGF-beta1)utilizesdistinctpathways for the transcriptional activation of microRNA 143/145 inhuman coronary arterysmoothmuscle cells. J Biol Chem 2011; 286: 30119-30129.
    • (2011) J Biol Chem , vol.286 , pp. 30119-30129
    • Long, X.1    Miano, J.M.2
  • 41
    • 84855591712 scopus 로고    scopus 로고
    • TGF-b-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-b in HaCaT cells
    • WangT, Zhang L, ShiC et al. TGF-b-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-b in HaCaT cells. Int J Biochem Cell Biol 2012; 44: 366-376.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 366-376
    • Wang, T.1    Zhang, L.2    Shi, C.3
  • 42
    • 79958048581 scopus 로고    scopus 로고
    • Body fluid derived exosomes as a novel template for clinical diagnostics
    • Keller S, Ridinger J, Rupp AK et al. Body fluid derived exosomes as a novel template for clinical diagnostics. J Transl Med 2011; 9: 86.
    • (2011) J Transl Med , vol.9 , pp. 86
    • Keller, S.1    Ridinger, J.2    Rupp, A.K.3


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