A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice

Basic Research in Cardiology

Volumn 111, Issue 6, 2016, Pages

  Haubner, Bernhard J ^a,b   Schuetz, Thomas ^a,b   Penninger, Josef M ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Cardiac regeneration; Mouse model; Myocardial infarction; Neonatal LAD ligation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CARDIAC REGENERATION; CONTROLLED STUDY; FEASIBILITY STUDY; FOLLOW UP; HEART INFARCTION; IN VIVO STUDY; LEFT ANTERIOR DESCENDING ARTERY LIGATION; MICROSURGERY; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; REPRODUCIBILITY; TISSUE REGENERATION; TUNEL ASSAY; ANIMAL; C57BL MOUSE; DISEASE MODEL; HEART; INSTITUTE FOR CANCER RESEARCH MOUSE; PATHOLOGY; PHYSIOLOGY; REGENERATION;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; HEART; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MYOCARDIAL INFARCTION; REGENERATION;

EID: 84988596833     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0580-3     Document Type: Article

References (24)

1. Andersen DC, Ganesalingam S, Jensen CH, Sheikh SP (2014) Do neonatal mouse hearts regenerate following heart apex resection? Stem Cell Rep 2:406–413. doi:10.1016/j.stemcr.2014.02.008
2. Andersen DC, Jensen CH, Baun C, Hvidsten S, Zebrowski DC, Engel FB, Sheikh SP (2015) Persistent scarring and dilated cardiomyopathy suggest incomplete regeneration of the apex resected neonatal mouse myocardium—a 180 days follow up study. J Mol Cell Cardiol 90:47–52. doi:10.1016/j.yjmcc.2015.11.031
3. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J (2009) Evidence for cardiomyocyte renewal in humans. Science 324:98–102. doi:10.1126/science.1164680
4. Bryant DM, O’Meara CC, Ho NN, Gannon J, Cai L, Lee RT (2015) A systematic analysis of neonatal mouse heart regeneration after apical resection. J Mol Cell Cardiol 79:315–318. doi:10.1016/j.yjmcc.2014.12.011
5. Darehzereshki A, Rubin N, Gamba L, Kim J, Fraser J, Huang Y, Billings J, Mohammadzadeh R, Wood J, Warburton D, Kaartinen V, Lien CL (2015) Differential regenerative capacity of neonatal mouse hearts after cryoinjury. Dev Biol 399:91–99. doi:10.1016/j.ydbio.2014.12.018
6. Forbes SJ, Rosenthal N (2014) Preparing the ground for tissue regeneration: from mechanism to therapy. Nat Med 20:857–869. doi:10.1038/nm.3653
7. Garbern JC, Lee RT (2013) Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell 12:689–698. doi:10.1016/j.stem.2013.05.008
8. Haubner BJ, Adamowicz-Brice M, Khadayate S, Tiefenthaler V, Metzler B, Aitman T, Penninger JM (2012) Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY) 4:966–977
9. Haubner BJ, Schneider J, Schweigmann UU, Schuetz T, Dichtl W, Velik-Salchner C, Stein JI, Penninger JM (2015) Functional recovery of a human neonatal heart after severe myocardial infarction. Circ Res. doi:10.1161/CIRCRESAHA.115.307017
10. Konfino T, Landa N, Ben-Mordechai T, Leor J (2015) The type of injury dictates the mode of repair in neonatal and adult heart. J Am Heart Assoc 4:e001320. doi:10.1161/JAHA.114.001320
11. Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA (2013) Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 497:249–253. doi:10.1038/nature12054
12. Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Murray CJ, Naghavi M (2014) Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 study. Circulation 129:1483–1492. doi:10.1161/CIRCULATIONAHA.113.004042
13. Nabel EG, Braunwald E (2012) A tale of coronary artery disease and myocardial infarction. N Engl J Med 366:54–63. doi:10.1056/NEJMra1112570
14. Oberpriller JO, Oberpriller JC (1974) Response of the adult newt ventricle to injury. J Exp Zool 187:249–253. doi:10.1002/jez.1401870208
15. Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kuhn B (2016) A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc 11:542–552. doi:10.1038/nprot.2016.031
16. Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, Dos Remedios CG, Haubner BJ, Penninger JM, Kuhn B (2015) Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med 7:281ra245. doi:10.1126/scitranslmed.aaa5171
17. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA (2011) Transient regenerative potential of the neonatal mouse heart. Science 331:1078–1080. doi:10.1126/science.1200708
18. Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA (2013) Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci USA 110:187–192. doi:10.1073/pnas.1208863110
19. Poss KD, Wilson LG, Keating MT (2002) Heart regeneration in zebrafish. Science 298:2188–2190. doi:10.1126/science.1077857 (pii 298/5601/2188)
20. Sen S, Sadek HA (2015) Neonatal heart regeneration: mounting support and need for technical standards. J Am Heart Assoc 4:e001727. doi:10.1161/JAHA.114.001727
21. van Berlo JH, Molkentin JD (2014) An emerging consensus on cardiac regeneration. Nat Med 20:1386–1393. doi:10.1038/nm.3764
22. WHO (2012) The top 10 causes of death. Fact sheet N°310, Updated May 2014. http://www.who.int/mediacentre/factsheets/fs310/en/
23. Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN (2013) Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci USA 110:13839–13844. doi:10.1073/pnas.1313192110
24. Yang Y, Cheng HW, Qiu Y, Dupee D, Noonan M, Lin YD, Fisch S, Unno K, Sereti KI, Liao R (2015) MicroRNA-34a plays a key role in cardiac repair and regeneration following myocardial infarction. Circ Res 117:450–459. doi:10.1161/CIRCRESAHA.117.305962