The type of injury dictates the mode of repair in neonatal and adult heart

Journal of the American Heart Association

Volumn 4, Issue 1, 2015, Pages

  Konfino, Tal ^a,b,c   Landa, Natalie ^a,b,c   Ben Mordechai, Tammy ^a,b,c   Leor, Jonathan ^a,b,c  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Stem Cells and Tissue Engineering Center   (Israel)

Author keywords

Cardiomyocytes; Fibrosis; Inflammation; Macrophages; Myocardial infarction; Myocardial regeneration

Indexed keywords

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL RESECTION; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ECHOCARDIOGRAPHY; FEMALE; GRANULATION TISSUE; HEART ANEURYSM; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART SURGERY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; NEWBORN; NONHUMAN; POLYETHYLENE SUTURE; PRIORITY JOURNAL; SCAR FORMATION; TISSUE REGENERATION; AGE; ANIMAL; CARDIAC MUSCLE CELL; CONVALESCENCE; DIAGNOSTIC IMAGING; DISEASE MODEL; DOPPLER ECHOCARDIOGRAPHY; HEART; HEART INJURIES; HEART VENTRICLE REMODELING; HUMAN; MALE; MYOCARDIAL INFARCTION; NEEDLE BIOPSY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; REGENERATION; RISK FACTOR; TRANSPLANTATION; TREATMENT OUTCOME;

ADULT; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOPSY, NEEDLE; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY, DOPPLER; HEART; HEART INJURIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RANDOM ALLOCATION; RECOVERY OF FUNCTION; REGENERATION; RISK FACTORS; TREATMENT OUTCOME; VENTRICULAR REMODELING;

EID: 84925439193     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001320     Document Type: Article

References (37)

1. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98-102.
2. Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, Dos Remedios CG, Graham D, Colan S, Kuhn B. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci USA. 2013;110:1446-1451.
3. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, Nadal-Ginard B, Silvestri F, Leri A, Beltrami CA, Anversa P. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 2001;344:1750-1757.
4. Braunwald E, Pfeffer MA. Ventricular enlargement and remodeling following acute myocardial infarction: mechanisms and management. Am J Cardiol. 1991;68:1D-6D.
5. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161-1172.
6. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331:1078-1080.
7. Robledo M. Myocardial regeneration in young rats. Am J Pathol. 1956;32:1215-1239.
8. Mahmoud AI, Porrello ER, Kimura W, Olson EN, Sadek HA. Surgical models for cardiac regeneration in neonatal mice. Nat Protoc. 2014;9:305-311.
9. Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci USA. 2013;110:13839-13844.
10. Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci USA. 2013;110:187-192.
11. Christoffels VM, Pu WT. Developing insights into cardiac regeneration. Development. 2013;140:3933-3937.
12. Jesty SA, Steffey MA, Lee FK, Breitbach M, Hesse M, Reining S, Lee JC, Doran RM, Nikitin AY, Fleischmann BK, Kotlikoff MI. c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci USA. 2012;109:13380-13385.
13. Andersen DC, Ganesalingam S, Jensen CH, Sheikh SP. Do neonatal mouse hearts regenerate following heart apex resection? Stem Cell Reports. 2014;2:406-413.
14. Phifer CB, Terry LM. Use of hypothermia for general anesthesia in preweanling rodents. Physiol Behav. 1986;38:887-890.
15. Blewett CJ, Cilley RE, Ehrlich HP, Blackburn JH II, Dillon PW, Krummel TM. Regenerative healing of incisional wounds in midgestational murine hearts in organ culture. J Thorac Cardiovasc Surg. 1997;113:880-885.
16. Hesse M, Fleischmann BK, Kotlikoff MI. Concise review: the role of C-kit expressing cells in heart repair at the neonatal and adult stage. Stem Cells. 2014;32:1701-1712.
17. Hans F, Dimitrov S. Histone H3 phosphorylation and cell division. Oncogene. 2001;20:3021-3027.
18. Kubin T, Poling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lorchner H, Schimanski S, Szibor M, Warnecke H, Braun T. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell. 2011;9:420-432.
19. Zogbi C, Saturi de Carvalho AE, Nakamuta JS, Caceres Vde M, Prando S, Giorgi MC, Rochitte CE, Meneghetti JC, Krieger JE. Early postnatal rat ventricle resection leads to long-term preserved cardiac function despite tissue hypoperfusion. Physiol Rep. 2014;2: Published 28 August 2014, Vol. 2 no. e12115 DOI 10.14814/phy2.12115.
20. Rui L, Yu N, Hong L, Feng H, Chunyong H, Jian M, Zhe Z, Shengshou H. Extending the time window of mammalian heart regeneration by thymosin beta 4. J Cell Mol Med. 2014;18:2417-2424.
21. O'Meara C, Wamstad JA, Gladstone R, Fomovsky G, Butty V, Shrikumar A, Gannon J, Boyer L, Lee RT. Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration. Circ Res. 2014; pil: CIRCRESAHA. 114.304269 [Epub ahead of print].
22. Strungs EG, Ongstad EL, O'Quinn MP, Palatinus JA, Jourdan LJ, Gourdie RG. Cryoinjury models of the adult and neonatal mouse heart for studies of scarring and regeneration. Methods Mol Biol. 2013;1037:343-353.
23. Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature. 2013;497:249-253.
24. Haubner BJ, Adamowicz-Brice M, Khadayate S, Tiefenthaler V, Metzler B, Aitman T, Penninger JM. Complete cardiac regeneration in a mouse model of myocardial infarction. Aging. 2012;4:966-977.
25. Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. Macrophages are required for neonatal heart regeneration. J Clin Invest. 2014;124:1382-1392.
26. Valeti US, Nishimura RA, Holmes DR, Araoz PA, Glockner JF, Breen JF, Ommen SR, Gersh BJ, Tajik AJ, Rihal CS, Schaff HV, Maron BJ. Comparison of surgical septal myectomy and alcohol septal ablation with cardiac magnetic resonance imaging in patients with hypertrophic obstructive cardiomyopathy. J Am Coll Cardiol. 2007;49:350-357.
27. Mercer SE, Odelberg SJ, Simon HG. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev Biol. 2013;382:457-469.
28. Bayomy AF, Bauer M, Qiu Y, Liao R. Regeneration in heart disease-Is ECM the key? Life Sci. 2012;91:823-827.
29. Porrello ER, Olson EN. A neonatal blueprint for cardiac regeneration. Stem Cell Res. 2014;13:556-570.
30. Sadek HA, Martin JF, Takeuchi JK, Leor J, Nei Y, Giacca M, Lee RT. Multiinvestigator letter on reproducibility of neonatal heart regeneration following apical resection. Stem Cell Reports. 2014;3:1.
31. Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity. 2014;40:91-104.
32. Ben-Mordechai T, Harel-Adar T, Holbova R, Landa-Rouben N, Feinberg MS, Silman Z, Cohen S, Leor J. Macrophage subpopulations are essential for infarct repair with and without stem cell therapy. Circulation. 2009;120:S898-S899.
33. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204:3037-3047.
34. Molawi K, Wolf Y, Kandalla PK, Favret J, Hagemeyer N, Frenzel K, Pinto AR, Klapproth K, Henri S, Malissen B, Rodewald HR, Rosenthal NA, Bajenoff M, Prinz M, Jung S, Sieweke MH. Progressive replacement of embryo-derived cardiac macrophages with age. J Exp Med. 2014;211:2151-2158.
35. Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci USA. 2014;111:16029-16034.
36. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT. Mammalian heart renewal by preexisting cardiomyocytes. Nature. 2013;493:433-436.
37. van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marban E, Molkentin JD. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-341.