Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

Journal of Experimental and Clinical Cancer Research

Volumn 33, Issue 1, 2014, Pages

  Baker, Amanda F ^a   Hanke, Neale T ^a   Sands, Barbara J ^a   Carbajal, Liliana ^a   Anderl, Janet L ^b   Garland, Linda L ^a  

^a Section of Hematology Oncology   (United States)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

Carfilzomib; Cisplatin; Lung cancer; Proteasome inhibitor

Indexed keywords

CARFILZOMIB; CASPASE 3; CISPLATIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; OLIGOPEPTIDE; PROTEASOME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIMIT OF QUANTITATION; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SMALL CELL LUNG CANCER; TUMOR GROWTH; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; LUNG NEOPLASMS; MORTALITY; PATHOLOGY; SMALL CELL LUNG CARCINOMA; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; OLIGOPEPTIDES; PROTEASOME INHIBITORS; SMALL CELL LUNG CARCINOMA; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84988514169     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-014-0111-8     Document Type: Article

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