Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

Science Translational Medicine

Volumn 7, Issue 270, 2015, Pages

  Roberts, Angharad M ^a   Ware, James S ^a,b,c,d   Herman, Daniel S ^c,d,e   Schafer, Sebastian ^f   Baksi, John ^a   Bick, Alexander G ^c,d   Buchan, Rachel J ^a   Walsh, Roddy ^a   John, Shibu ^a   Wilkinson, Samuel ^a   Mazzarotto, Francesco ^a,b   Felkin, Leanne E ^a,b   Gong, Sungsam ^a   Macarthur, Jacqueline A L ^g   Cunningham, Fiona ^g   Flannick, Jason ^d,h   Gabriel, Stacey B ^d   Altshuler, David M ^d,h   MacDonald, Peter S ^i,j,k   Heinig, Matthias ^f   Keogh, Anne M ^i,j,k   Hayward, Christopher S ^i,j,k   Banner, Nicholas R ^b,l   Pennell, Dudley J ^a,b   O'Regan, Declan P ^a   San, Tan Ru ^m   De Marvao, Antonio ^a   Dawes, Timothy J W ^a   Gulati, Ankur ^a   Birks, Emma J ^b,n   Yacoub, Magdi H ^b   Radke, Michael ^f   Gotthardt, Michael ^f,o   Wilson, James G ^p   O'Donnell, Christopher J ^q,r   Prasad, Sanjay K ^a   Barton, Paul J R ^a,b   Fatkin, Diane ^i,j,k   Hubner, Norbert ^f,o,s   Seidman, Jonathan G ^c   Seidman, Christine E ^c,d,t,u   Cook, Stuart A ^a,b,m,v   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^g WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

ⁱ ST VINCENT S HOSPITAL   (Australia)

^j VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^k UNIVERSITY OF NEW SOUTH WALES   (Australia)

^l HAREFIELD HOSPITAL   (United Kingdom)

^m DEPARTMENT OF CARDIOLOGY   (Singapore)

ⁿ University of Louisville School of Medicine   (United States)

^o DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^p UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^q FRAMINGHAM HEART STUDY   (United States)

^r NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^s CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^t BRIGHAM AND WOMEN S HOSPITAL   (United States)

^u HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^v NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN; FIBRONECTIN; IMMUNOGLOBULIN; TRANSCRIPTOME; ISOPROTEIN; TTN PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BINDING AFFINITY; BODY SURFACE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ETHNICITY; FEMALE; FRAMESHIFT MUTATION; GENE; GENE FREQUENCY; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEART EJECTION FRACTION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; RNA SEQUENCE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; TTN GENE; ADOLESCENT; ALLELE; COHORT ANALYSIS; EXON; GENETIC VARIATION; GENETICS; HEART; HEART FAILURE; METABOLISM; MIDDLE AGED; MUTATION; NORMAL HUMAN; PATHOLOGY; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; CARDIOMYOPATHY, DILATED; COHORT STUDIES; CONNECTIN; EXONS; GENETIC VARIATION; HEALTHY VOLUNTEERS; HEART; HEART FAILURE; HUMANS; IMMUNOGLOBULINS; MIDDLE AGED; MUTATION; PROTEIN ISOFORMS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84988449067     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3010134     Document Type: Article

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