Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells

American Journal of Nephrology

Volumn 44, Issue 4, 2016, Pages 276-285

  Kushida, Natsuki ^a,b   Nomura, Seitaro ^a   Mimura, Imari ^b   Fujita, Takanori ^a   Yamamoto, Shogo ^a   Nangaku, Masaomi ^b   Aburatani, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chromatin immunoprecipitation sequencing; Hypoxia; Hypoxia inducible factor 1a; Kidney tubular epithelial cell; RNA sequencing; SMAD3; Transforming growth factor

Indexed keywords

COLLAGEN TYPE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PEPTIDASE; SERINE PROTEINASE INHIBITOR; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; COLLAGEN TYPE I, ALPHA 1 CHAIN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERPINE1 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TRANSCRIPTOME;

ARTICLE; BINDING SITE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CONTROLLED STUDY; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HYPOXIA; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; UPREGULATION; CELL HYPOXIA; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; KIDNEY PROXIMAL TUBULE; METABOLISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

CELL HYPOXIA; CELL LINE; COLLAGEN TYPE I; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY TUBULES, PROXIMAL; PLASMINOGEN ACTIVATOR INHIBITOR 1; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84988428975     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000449323     Document Type: Article

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