메뉴 건너뛰기




Volumn 14, Issue 5, 2016, Pages 451-463

Ceftazidime-avibactam (CTZ-AVI) as a treatment for hospitalized adult patients with complicated intra-abdominal infections

Author keywords

antibiotic resistance; carbapenem resistant Enterobacteriaceae; Ceftazidime avibactam; Gram negative infection; lactamase; lactamase inhibitor

Indexed keywords

AVIBACTAM; AVIBACTAM PLUS CEFTAZIDIME; BETA LACTAMASE; CEFTAZIDIME; IMIPENEM; ANTIINFECTIVE AGENT; AVIBACTAM, CEFTAZIDIME DRUG COMBINATION; AZABICYCLO DERIVATIVE;

EID: 84988346636     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2016.1173542     Document Type: Article
Times cited : (8)

References (104)
  • 1
    • 39449103059 scopus 로고    scopus 로고
    • The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America
    • B.Spellberg, R.Guidos, D.Gilbert, et al. The epidemic of antibiotic-resistant infections:a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(2):155–164.
    • (2008) Clin Infect Dis , vol.46 , Issue.2 , pp. 155-164
    • Spellberg, B.1    Guidos, R.2    Gilbert, D.3
  • 2
    • 84878278251 scopus 로고    scopus 로고
    • 10 x ‘20 progress–development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America
    • H.W.Boucher, G.H.Talbot, D.K.BenjaminJr., et al. 10 x ‘20 progress–development of new drugs active against gram-negative bacilli:an update from the Infectious Diseases Society of America. Clin Infect Dis. 2013;56(12):1685–1694.
    • (2013) Clin Infect Dis , vol.56 , Issue.12 , pp. 1685-1694
    • Boucher, H.W.1    Talbot, G.H.2    Benjamin, D.K.3
  • 3
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
    • H.W.Boucher, G.H.Talbot, J.S.Bradley, et al. Bad bugs, no drugs:no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(1):1–12.
    • (2009) Clin Infect Dis , vol.48 , Issue.1 , pp. 1-12
    • Boucher, H.W.1    Talbot, G.H.2    Bradley, J.S.3
  • 4
    • 81155162497 scopus 로고    scopus 로고
    • Diazabicyclooctanes (DBOs): a potent new class of non-beta-lactam beta-lactamase inhibitors
    • K.Coleman Diazabicyclooctanes (DBOs):a potent new class of non-beta-lactam beta-lactamase inhibitors. Curr Opin Microbiol. 2011;14(5):550–555.
    • (2011) Curr Opin Microbiol , vol.14 , Issue.5 , pp. 550-555
    • Coleman, K.1
  • 5
    • 84882239083 scopus 로고    scopus 로고
    • The ABCD’s of beta-lactamase nomenclature
    • K.Bush. The ABCD’s of beta-lactamase nomenclature. J Infect Chemother. 2013;19(4):549–559.
    • (2013) J Infect Chemother , vol.19 , Issue.4 , pp. 549-559
    • Bush, K.1
  • 6
    • 84872858103 scopus 로고    scopus 로고
    • Proliferation and significance of clinically relevant beta-lactamases
    • K.Bush. Proliferation and significance of clinically relevant beta-lactamases. Ann N Y Acad Sci. 2013;1277:84–90.
    • (2013) Ann N Y Acad Sci , vol.1277 , pp. 84-90
    • Bush, K.1
  • 7
    • 84882270910 scopus 로고    scopus 로고
    • Carbapenemases: partners in crime
    • K.Bush. Carbapenemases:partners in crime. J Global Antimicrob Resist. 2013;1(1):7–16.
    • (2013) J Global Antimicrob Resist , vol.1 , Issue.1 , pp. 7-16
    • Bush, K.1
  • 8
    • 84893488293 scopus 로고    scopus 로고
    • Widespread dissemination of CTX-M-15 genotype extended-spectrum-beta-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States
    • L.F.Chen, J.T.Freeman, B.Nicholson, et al. Widespread dissemination of CTX-M-15 genotype extended-spectrum-beta-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States. Antimicrob Agents Chemother. 2014;58(2):1200–1202.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.2 , pp. 1200-1202
    • Chen, L.F.1    Freeman, J.T.2    Nicholson, B.3
  • 9
    • 84906099443 scopus 로고    scopus 로고
    • A new clone sweeps clean: the enigmatic emergence of Escherichia coli sequence type 131
    • R.Banerjee, J.R.Johnson. A new clone sweeps clean:the enigmatic emergence of Escherichia coli sequence type 131. Antimicrob Agents Chemother. 2014;58(9):4997–5004.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.9 , pp. 4997-5004
    • Banerjee, R.1    Johnson, J.R.2
  • 10
    • 84898814306 scopus 로고    scopus 로고
    • Global dissemination of a multidrug resistant Escherichia coli clone
    • N.K.Petty, N.L.Ben Zakour, M.Stanton-Cook, et al. Global dissemination of a multidrug resistant Escherichia coli clone. Proc Natl Acad Sci U S A. 2014;111(15):5694–5699.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.15 , pp. 5694-5699
    • Petty, N.K.1    Ben Zakour, N.L.2    Stanton-Cook, M.3
  • 11
    • 74249108028 scopus 로고    scopus 로고
    • Three decades of beta-lactamase inhibitors
    • S.M.Drawz, R.A.Bonomo. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010;23(1):160–201.
    • (2010) Clin Microbiol Rev , vol.23 , Issue.1 , pp. 160-201
    • Drawz, S.M.1    Bonomo, R.A.2
  • 12
    • 84946567642 scopus 로고    scopus 로고
    • A resurgence of beta-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens
    • K.Bush. A resurgence of beta-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015;46(5):483–493.
    • (2015) Int J Antimicrob Agents , vol.46 , Issue.5 , pp. 483-493
    • Bush, K.1
  • 13
    • 84911483559 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam (CXA 201) for the treatment of intra-abdominal infections
    • E.Maseda, L.Aguilar, M.-J.Gimenez, et al. Ceftolozane/tazobactam (CXA 201) for the treatment of intra-abdominal infections. Expert Rev Anti Infect Ther. 2014;12(11):1311–1324.
    • (2014) Expert Rev Anti Infect Ther , vol.12 , Issue.11 , pp. 1311-1324
    • Maseda, E.1    Aguilar, L.2    Gimenez, M.-J.3
  • 14
    • 0020041206 scopus 로고
    • Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa
    • H.C.Neu, P.Labthavikul. Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1982;21(1):11–18.
    • (1982) Antimicrob Agents Chemother , vol.21 , Issue.1 , pp. 11-18
    • Neu, H.C.1    Labthavikul, P.2
  • 15
    • 84894441748 scopus 로고    scopus 로고
    • Ceftazidime-avibactam: an evidence-based review of its pharmacology and potential use in the treatment of gram-negative bacterial infections
    • P.Lagace-Wiens, A.Walkty, J.A.Karlowsky. Ceftazidime-avibactam:an evidence-based review of its pharmacology and potential use in the treatment of gram-negative bacterial infections. Core Evid. 2014;9:13–25.
    • (2014) Core Evid , vol.9 , pp. 13-25
    • Lagace-Wiens, P.1    Walkty, A.2    Karlowsky, J.A.3
  • 16
    • 84872732888 scopus 로고    scopus 로고
    • Ceftazidime-avibactam: a novel cephalosporin/beta-lactamase inhibitor combination
    • G.G.Zhanel, C.D.Lawson, H.Adam, et al. Ceftazidime-avibactam:a novel cephalosporin/beta-lactamase inhibitor combination. Drugs. 2013;73(2):159–177.
    • (2013) Drugs , vol.73 , Issue.2 , pp. 159-177
    • Zhanel, G.G.1    Lawson, C.D.2    Adam, H.3
  • 17
    • 84863905057 scopus 로고    scopus 로고
    • Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor
    • D.E.Ehmann, H.Jahic, P.L.Ross, et al. Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012;109(29):11663–11668.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.29 , pp. 11663-11668
    • Ehmann, D.E.1    Jahic, H.2    Ross, P.L.3
  • 18
    • 78649683457 scopus 로고    scopus 로고
    • Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor
    • T.Stachyra, M.C.Pechereau, J.M.Bruneau, et al. Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrob Agents Chemother. 2010;54(12):5132–5138.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.12 , pp. 5132-5138
    • Stachyra, T.1    Pechereau, M.C.2    Bruneau, J.M.3
  • 19
    • 4444347175 scopus 로고    scopus 로고
    • In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor
    • A.Bonnefoy, C.Dupuis-Hamelin, V.Steier, et al. In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. J Antimicrob Chemother. 2004;54(2):410–417.
    • (2004) J Antimicrob Chemother , vol.54 , Issue.2 , pp. 410-417
    • Bonnefoy, A.1    Dupuis-Hamelin, C.2    Steier, V.3
  • 20
    • 67650718178 scopus 로고    scopus 로고
    • In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and enterobacteriaceae expressing KPC carbapenemases
    • T.Stachyra, P.Levasseur, M.C.Pechereau, et al. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and enterobacteriaceae expressing KPC carbapenemases. J Antimicrob Chemother. 2009;64(2):326–329.
    • (2009) J Antimicrob Chemother , vol.64 , Issue.2 , pp. 326-329
    • Stachyra, T.1    Levasseur, P.2    Pechereau, M.C.3
  • 21
    • 84977964862 scopus 로고    scopus 로고
    • Randomized pharmacokinetic and drug-drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects
    • S.Das, J.Li, J.Armstrong, et al. Randomized pharmacokinetic and drug-drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects. Pharmacol Res Perspect. 2015;3(5):e00172.
    • (2015) Pharmacol Res Perspect , vol.3 , Issue.5 , pp. e00172
    • Das, S.1    Li, J.2    Armstrong, J.3
  • 22
    • 84940007604 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single and multiple ascending doses of avibactam alone and in combination with ceftazidime in healthy male volunteers: results of two randomized, placebo-controlled studies
    • H.Merdjan, M.Rangaraju, A.Tarral. Safety and pharmacokinetics of single and multiple ascending doses of avibactam alone and in combination with ceftazidime in healthy male volunteers:results of two randomized, placebo-controlled studies. Clin Drug Investig. 2015;35(5):307–317.
    • (2015) Clin Drug Investig , vol.35 , Issue.5 , pp. 307-317
    • Merdjan, H.1    Rangaraju, M.2    Tarral, A.3
  • 23
    • 84937627900 scopus 로고    scopus 로고
    • Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers
    • N.Tominaga, T.Edeki, J.Li, et al. Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers. J Infect Chemother. 2015;21(8):551–558.
    • (2015) J Infect Chemother , vol.21 , Issue.8 , pp. 551-558
    • Tominaga, N.1    Edeki, T.2    Li, J.3
  • 24
    • 84957426156 scopus 로고    scopus 로고
    • A randomized, phase I study to assess the safety, tolerability and pharmacokinetics of ceftazidime-avibactam in healthy Chinese subjects
    • J.Li, M.Learoyd, F.Qiu, et al. A randomized, phase I study to assess the safety, tolerability and pharmacokinetics of ceftazidime-avibactam in healthy Chinese subjects. Clin Drug Investig. 2016;36(2):119–126.
    • (2016) Clin Drug Investig , vol.36 , Issue.2 , pp. 119-126
    • Li, J.1    Learoyd, M.2    Qiu, F.3
  • 25
    • 84988397380 scopus 로고    scopus 로고
    • Avycaz (Ceftazidime-Avibactam). Package insert. Cincinnati, OH:Forest Pharmaceuticals; 2015.• Package insert.
    • (2015)
  • 26
    • 84906074469 scopus 로고    scopus 로고
    • Bactericidal activity, absence of serum effect, and time-kill kinetics of ceftazidime-avibactam against beta-lactamase-producing enterobacteriaceae and pseudomonas aeruginosa
    • T.R.Keepers, M.Gomez, C.Celeri, et al. Bactericidal activity, absence of serum effect, and time-kill kinetics of ceftazidime-avibactam against beta-lactamase-producing enterobacteriaceae and pseudomonas aeruginosa. Antimicrob Agents Chemother. 2014;58(9):5297–5305.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.9 , pp. 5297-5305
    • Keepers, T.R.1    Gomez, M.2    Celeri, C.3
  • 27
    • 84896844160 scopus 로고    scopus 로고
    • Efficacies of ceftazidime-avibactam and ceftazidime against pseudomonas aeruginosa in a murine lung infection model
    • S.T.Housman, J.L.Crandon, W.W.Nichols, et al. Efficacies of ceftazidime-avibactam and ceftazidime against pseudomonas aeruginosa in a murine lung infection model. Antimicrob Agents Chemother. 2014;58(3):1365–1371.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.3 , pp. 1365-1371
    • Housman, S.T.1    Crandon, J.L.2    Nichols, W.W.3
  • 29
    • 34547422759 scopus 로고    scopus 로고
    • Carbapenemases: the versatile beta-lactamases
    • A.M.Queenan, K.Bush. Carbapenemases:the versatile beta-lactamases. Clin Microbiol Rev. 2007;20(3):440–458.
    • (2007) Clin Microbiol Rev , vol.20 , Issue.3 , pp. 440-458
    • Queenan, A.M.1    Bush, K.2
  • 30
    • 0031952586 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men
    • W.A.Craig. Pharmacokinetic/pharmacodynamic parameters:rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26(1):1–10.
    • (1998) Clin Infect Dis , vol.26 , Issue.1 , pp. 1-10
    • Craig, W.A.1
  • 31
    • 84860188286 scopus 로고    scopus 로고
    • Novel modeling framework to guide design of optimal dosing strategies for beta-lactamase inhibitors
    • P.Bhagunde, K.T.Chang, E.B.Hirsch, et al. Novel modeling framework to guide design of optimal dosing strategies for beta-lactamase inhibitors. Antimicrob Agents Chemother. 2012;56(5):2237–2240.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.5 , pp. 2237-2240
    • Bhagunde, P.1    Chang, K.T.2    Hirsch, E.B.3
  • 32
    • 84901260013 scopus 로고    scopus 로고
    • Activities of ceftazidime and avibactam against beta-lactamase-producing Enterobacteriaceae in a hollow-fiber pharmacodynamic model
    • K.Coleman, P.Levasseur, A.M.Girard, et al. Activities of ceftazidime and avibactam against beta-lactamase-producing Enterobacteriaceae in a hollow-fiber pharmacodynamic model. Antimicrob Agents Chemother. 2014;58(6):3366–3372.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.6 , pp. 3366-3372
    • Coleman, K.1    Levasseur, P.2    Girard, A.M.3
  • 33
    • 84921784867 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime-avibactam combination in in vitro checkerboard assays
    • J.Berkhout, M.J.Melchers, A.C.Van Mil, et al. In vitro activity of ceftazidime-avibactam combination in in vitro checkerboard assays. Antimicrob Agents Chemother. 2015;59(2):1138–1144.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.2 , pp. 1138-1144
    • Berkhout, J.1    Melchers, M.J.2    Van Mil, A.C.3
  • 34
    • 84911896976 scopus 로고    scopus 로고
    • Microbiological interaction studies between ceftazidime-avibactam and pulmonary surfactant and between ceftazidime-avibactam and antibacterial agents of other classes
    • J.Dallow, L.G.Otterson, M.D.Huband, et al. Microbiological interaction studies between ceftazidime-avibactam and pulmonary surfactant and between ceftazidime-avibactam and antibacterial agents of other classes. Int J Antimicrob Agents. 2014;44(6):552–556.
    • (2014) Int J Antimicrob Agents , vol.44 , Issue.6 , pp. 552-556
    • Dallow, J.1    Otterson, L.G.2    Huband, M.D.3
  • 36
    • 84988355754 scopus 로고    scopus 로고
    • European committee on antimicrobial susceptibility testing: clinical breakpoints
    • European Society of Clinical Microbiology and Infectious Diseases
    • EUCAST. European committee on antimicrobial susceptibility testing:clinical breakpoints. EUCAST. European Society of Clinical Microbiology and Infectious Diseases; 2016 Available at www.eucast.org
    • (2016) EUCAST
  • 37
    • 84940186561 scopus 로고    scopus 로고
    • Validation of sensititre dry-form broth microdilution panels for susceptibility testing of ceftazidime-avibactam, a broad-spectrum-beta-lactamase inhibitor combination
    • R.N.Jones, N.M.Holliday, K.M.Krause. Validation of sensititre dry-form broth microdilution panels for susceptibility testing of ceftazidime-avibactam, a broad-spectrum-beta-lactamase inhibitor combination. Antimicrob Agents Chemother. 2015;59(8):5036–5039.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.8 , pp. 5036-5039
    • Jones, R.N.1    Holliday, N.M.2    Krause, K.M.3
  • 39
    • 84896833758 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftazidime-avibactam against Gram-negative organisms collected from U.S. medical centers in 2012
    • H.S.Sader, M.Castanheira, R.K.Flamm, et al. Antimicrobial activity of ceftazidime-avibactam against Gram-negative organisms collected from U.S. medical centers in 2012. Antimicrob Agents Chemother. 2014;58(3):1684–1692.• Large US-based microbiologic survey demonstrating in vitro activity of CTZ–AVI against a wide variety of Gram-negative organisms.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.3 , pp. 1684-1692
    • Sader, H.S.1    Castanheira, M.2    Flamm, R.K.3
  • 40
    • 84903893512 scopus 로고    scopus 로고
    • Ceftazidime/avibactam activity tested against Gram-negative bacteria isolated from bloodstream, pneumonia, intra-abdominal and urinary tract infections in US medical centres (2012)
    • R.K.Flamm, D.J.Farrell, H.S.Sader, et al. Ceftazidime/avibactam activity tested against Gram-negative bacteria isolated from bloodstream, pneumonia, intra-abdominal and urinary tract infections in US medical centres (2012). J Antimicrob Chemother. 2014;69(6):1589–1598.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.6 , pp. 1589-1598
    • Flamm, R.K.1    Farrell, D.J.2    Sader, H.S.3
  • 41
    • 84893488813 scopus 로고    scopus 로고
    • Contemporary diversity of beta-lactamases among Enterobacteriaceae in the nine U.S. census regions and ceftazidime-avibactam activity tested against isolates producing the most prevalent beta-lactamase groups
    • M.Castanheira, S.E.Farrell, K.M.Krause, et al. Contemporary diversity of beta-lactamases among Enterobacteriaceae in the nine U.S. census regions and ceftazidime-avibactam activity tested against isolates producing the most prevalent beta-lactamase groups. Antimicrob Agents Chemother. 2014;58(2):833–838.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.2 , pp. 833-838
    • Castanheira, M.1    Farrell, S.E.2    Krause, K.M.3
  • 42
    • 84929587395 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of beta-lactamase-producing strains
    • M.Castanheira, J.C.Mills, S.E.Costello, et al. Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of beta-lactamase-producing strains. Antimicrob Agents Chemother. 2015;59(6):3509–3517.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.6 , pp. 3509-3517
    • Castanheira, M.1    Mills, J.C.2    Costello, S.E.3
  • 43
    • 84927574043 scopus 로고    scopus 로고
    • Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011)
    • R.K.Flamm, H.S.Sader, D.J.Farrell, et al. Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011). Diagn Microbiol Infect Dis. 2014;80(3):233–238.
    • (2014) Diagn Microbiol Infect Dis , vol.80 , Issue.3 , pp. 233-238
    • Flamm, R.K.1    Sader, H.S.2    Farrell, D.J.3
  • 44
    • 84947026302 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from Unites States medical centers (2011-2014)
    • H.S.Sader, M.Castanheira, D.J.Farrell, et al. Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from Unites States medical centers (2011-2014). Diagn Microbiol Infect Dis. 2015;83(4):389–394.
    • (2015) Diagn Microbiol Infect Dis , vol.83 , Issue.4 , pp. 389-394
    • Sader, H.S.1    Castanheira, M.2    Farrell, D.J.3
  • 45
    • 84934963355 scopus 로고    scopus 로고
    • Ceftazidime/avibactam tested against Gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia
    • H.S.Sader, M.Castanheira, R.K.Flamm, et al. Ceftazidime/avibactam tested against Gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia. Int J Antimicrob Agents. 2015;46(1):53–59.
    • (2015) Int J Antimicrob Agents , vol.46 , Issue.1 , pp. 53-59
    • Sader, H.S.1    Castanheira, M.2    Flamm, R.K.3
  • 46
    • 84929583498 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013
    • H.S.Sader, M.Castanheira, R.E.Mendes, et al. Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013. Antimicrob Agents Chemother. 2015;59(6):3656–3659.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.6 , pp. 3656-3659
    • Sader, H.S.1    Castanheira, M.2    Mendes, R.E.3
  • 47
    • 84929615655 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime-avibactam against 338 molecularly characterized gentamicin-nonsusceptible gram-negative clinical isolates obtained from patients in Canadian hospitals
    • A.J.Denisuik, J.A.Karlowsky, T.Denisuik, et al. In vitro activity of ceftazidime-avibactam against 338 molecularly characterized gentamicin-nonsusceptible gram-negative clinical isolates obtained from patients in Canadian hospitals. Antimicrob Agents Chemother. 2015;59(6):3623–3626.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.6 , pp. 3623-3626
    • Denisuik, A.J.1    Karlowsky, J.A.2    Denisuik, T.3
  • 48
    • 84920099992 scopus 로고    scopus 로고
    • Avibactam reverts the ceftazidime MIC90 of European gram-negative bacterial clinical isolates to the epidemiological cut-off value
    • R.K.Flamm, G.G.Stone, H.S.Sader, et al. Avibactam reverts the ceftazidime MIC90 of European gram-negative bacterial clinical isolates to the epidemiological cut-off value. J Chemother. 2014;26(6):333–338.
    • (2014) J Chemother , vol.26 , Issue.6 , pp. 333-338
    • Flamm, R.K.1    Stone, G.G.2    Sader, H.S.3
  • 49
    • 84857173233 scopus 로고    scopus 로고
    • In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates
    • P.Levasseur, A.M.Girard, M.Claudon, et al. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother. 2012;56(3):1606–1608.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.3 , pp. 1606-1608
    • Levasseur, P.1    Girard, A.M.2    Claudon, M.3
  • 50
    • 82955187694 scopus 로고    scopus 로고
    • In vitro activity of avibactam (NXL104) in combination with beta-lactams against gram-negative bacteria, including OXA-48 beta-lactamase-producing Klebsiella pneumoniae
    • Z.Aktas, C.Kayacan, O.Oncul. In vitro activity of avibactam (NXL104) in combination with beta-lactams against gram-negative bacteria, including OXA-48 beta-lactamase-producing Klebsiella pneumoniae. Int J Antimicrob Agents. 2012;39(1):86–89.
    • (2012) Int J Antimicrob Agents , vol.39 , Issue.1 , pp. 86-89
    • Aktas, Z.1    Kayacan, C.2    Oncul, O.3
  • 51
    • 79955537450 scopus 로고    scopus 로고
    • Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases
    • P.R.Lagace-Wiens, F.Tailor, P.Simner, et al. Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases. Antimicrob Agents Chemother. 2011;55(5):2434–2437.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.5 , pp. 2434-2437
    • Lagace-Wiens, P.R.1    Tailor, F.2    Simner, P.3
  • 52
    • 67749143907 scopus 로고    scopus 로고
    • In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases
    • A.Endimiani, Y.Choudhary, R.A.Bonomo. In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases. Antimicrob Agents Chemother. 2009;53(8):3599–3601.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.8 , pp. 3599-3601
    • Endimiani, A.1    Choudhary, Y.2    Bonomo, R.A.3
  • 53
    • 84896832898 scopus 로고    scopus 로고
    • In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China
    • X.Wang, F.Zhang, C.Zhao, et al. In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China. Antimicrob Agents Chemother. 2014;58(3):1774–1778.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.3 , pp. 1774-1778
    • Wang, X.1    Zhang, F.2    Zhao, C.3
  • 54
    • 84928893993 scopus 로고    scopus 로고
    • In vitro antibacterial activity of the ceftazidime-avibactam combination against enterobacteriaceae, including strains with well-characterized beta-lactamases
    • P.Levasseur, A.M.Girard, C.Miossec, et al. In vitro antibacterial activity of the ceftazidime-avibactam combination against enterobacteriaceae, including strains with well-characterized beta-lactamases. Antimicrob Agents Chemother. 2015;59(4):1931–1934.• Microbiologic study demonstrating restoration of activity of ceftazidime following addition of avibactam in resistant Enterobacteriaceae.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.4 , pp. 1931-1934
    • Levasseur, P.1    Girard, A.M.2    Miossec, C.3
  • 55
    • 84947867553 scopus 로고    scopus 로고
    • Activity of temocillin, mecillinam, ceftazidime, and ceftazidime/avibactam against carbapenem-nonsusceptible Enterobacteriaceae without carbapenemase production
    • N.T.Mutters, S.Zimmermann, M.Kaase, et al. Activity of temocillin, mecillinam, ceftazidime, and ceftazidime/avibactam against carbapenem-nonsusceptible Enterobacteriaceae without carbapenemase production. Eur J Clin Microbiol Infect Dis. 2015;34(12):2429–2437.
    • (2015) Eur J Clin Microbiol Infect Dis , vol.34 , Issue.12 , pp. 2429-2437
    • Mutters, N.T.1    Zimmermann, S.2    Kaase, M.3
  • 56
    • 84955294377 scopus 로고    scopus 로고
    • Activity of ceftazidime-avibactam against fluoroquinolone-resistant Enterobacteriaceae and Pseudomonas aeruginosa
    • C.Pitart, F.Marco, T.A.Keating, et al. Activity of ceftazidime-avibactam against fluoroquinolone-resistant Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2015;59(6):3059–3065.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.6 , pp. 3059-3065
    • Pitart, C.1    Marco, F.2    Keating, T.A.3
  • 57
    • 78650636489 scopus 로고    scopus 로고
    • Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae
    • D.M.Livermore, S.Mushtaq, M.Warner, et al. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. Antimicrob Agents Chemother. 2011;55(1):390–394.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.1 , pp. 390-394
    • Livermore, D.M.1    Mushtaq, S.2    Warner, M.3
  • 58
    • 79956326529 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study)
    • A.Walkty, M.DeCorby, P.R.Lagace-Wiens, et al. In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study). Antimicrob Agents Chemother. 2011;55(6):2992–2994.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.6 , pp. 2992-2994
    • Walkty, A.1    DeCorby, M.2    Lagace-Wiens, P.R.3
  • 59
    • 77957862993 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters
    • S.Mushtaq, M.Warner, D.M.Livermore. In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters. J Antimicrob Chemother. 2010;65(11):2376–2381.• Microbiologic study demonstrating in-vitro resistance to CTZ–AVI via non-β-lactamase mechanisms.
    • (2010) J Antimicrob Chemother , vol.65 , Issue.11 , pp. 2376-2381
    • Mushtaq, S.1    Warner, M.2    Livermore, D.M.3
  • 60
    • 84928412328 scopus 로고    scopus 로고
    • In vitro susceptibility of characterized beta-lactamase-producing gram-negative bacteria isolated in Japan to ceftazidime-, ceftaroline-, and aztreonam-avibactam combinations
    • A.Yoshizumi, Y.Ishii, K.Aoki, et al. In vitro susceptibility of characterized beta-lactamase-producing gram-negative bacteria isolated in Japan to ceftazidime-, ceftaroline-, and aztreonam-avibactam combinations. J Infect Chemother. 2015;21(2):148–151.
    • (2015) J Infect Chemother , vol.21 , Issue.2 , pp. 148-151
    • Yoshizumi, A.1    Ishii, Y.2    Aoki, K.3
  • 61
    • 79959230230 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes
    • D.M.Citron, K.L.Tyrrell, V.Merriam, et al. In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes. Antimicrob Agents Chemother. 2011;55(7):3616–3620.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.7 , pp. 3616-3620
    • Citron, D.M.1    Tyrrell, K.L.2    Merriam, V.3
  • 62
    • 84940937491 scopus 로고    scopus 로고
    • Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum beta-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae
    • R.K.Shields, C.J.Clancy, B.Hao, et al. Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum beta-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae. Antimicrob Agents Chemother. 2015;59(9):5793–5797.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.9 , pp. 5793-5797
    • Shields, R.K.1    Clancy, C.J.2    Hao, B.3
  • 63
    • 84939545950 scopus 로고    scopus 로고
    • Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV beta-lactamases with single amino acid substitutions in the Omega-loop
    • M.L.Winkler, K.M.Papp-Wallace, R.A.Bonomo. Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV beta-lactamases with single amino acid substitutions in the Omega-loop. J Antimicrob Chemother. 2015;70(8):2279–2286.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.8 , pp. 2279-2286
    • Winkler, M.L.1    Papp-Wallace, K.M.2    Bonomo, R.A.3
  • 65
    • 84908638638 scopus 로고    scopus 로고
    • Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum beta-lactamases
    • P.Levasseur, A.M.Girard, L.Lavallade, et al. Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 2014;58(11):6490–6495.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.11 , pp. 6490-6495
    • Levasseur, P.1    Girard, A.M.2    Lavallade, L.3
  • 66
    • 84908271938 scopus 로고    scopus 로고
    • In vivo efficacy of humanized exposures of Ceftazidime-Avibactam in comparison with Ceftazidime against contemporary Enterobacteriaceae isolates
    • S.H.MacVane, J.L.Crandon, W.W.Nichols, et al. In vivo efficacy of humanized exposures of Ceftazidime-Avibactam in comparison with Ceftazidime against contemporary Enterobacteriaceae isolates. Antimicrob Agents Chemother. 2014;58(11):6913–6919.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.11 , pp. 6913-6919
    • MacVane, S.H.1    Crandon, J.L.2    Nichols, W.W.3
  • 68
    • 78650664486 scopus 로고    scopus 로고
    • Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae
    • A.Endimiani, K.M.Hujer, A.M.Hujer, et al. Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2011;55(1):82–85.• In vivo animal model demonstrating efficacy of CTZ–AVI.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.1 , pp. 82-85
    • Endimiani, A.1    Hujer, K.M.2    Hujer, A.M.3
  • 69
    • 84869237392 scopus 로고    scopus 로고
    • Comparative in vitro and in vivo efficacies of human simulated doses of ceftazidime and ceftazidime-avibactam against Pseudomonas aeruginosa
    • J.L.Crandon, V.J.Schuck, M.A.Banevicius, et al. Comparative in vitro and in vivo efficacies of human simulated doses of ceftazidime and ceftazidime-avibactam against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2012;56(12):6137–6146.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.12 , pp. 6137-6146
    • Crandon, J.L.1    Schuck, V.J.2    Banevicius, M.A.3
  • 70
    • 73649114948 scopus 로고    scopus 로고
    • Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America
    • J.S.Solomkin, J.E.Mazuski, J.S.Bradley, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children:guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(2):133–164.
    • (2010) Clin Infect Dis , vol.50 , Issue.2 , pp. 133-164
    • Solomkin, J.S.1    Mazuski, J.E.2    Bradley, J.S.3
  • 71
    • 84877123198 scopus 로고    scopus 로고
    • Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial
    • C.Lucasti, I.Popescu, M.K.Ramesh, et al. Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults:results of a randomized, double-blind, Phase II trial. J Antimicrob Chemother. 2013;68(5):1183–1192.•• Phase II clinical trial.
    • (2013) J Antimicrob Chemother , vol.68 , Issue.5 , pp. 1183-1192
    • Lucasti, C.1    Popescu, I.2    Ramesh, M.K.3
  • 72
    • 84870399321 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam versus imipenem-cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study
    • J.A.Vazquez, L.D.Gonzalez Patzan, D.Stricklin, et al. Efficacy and safety of ceftazidime-avibactam versus imipenem-cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults:results of a prospective, investigator-blinded, randomized study. Curr Med Res Opin. 2012;28(12):1921–1931.•• Phase II clinical trial.
    • (2012) Curr Med Res Opin , vol.28 , Issue.12 , pp. 1921-1931
    • Vazquez, J.A.1    Gonzalez Patzan, L.D.2    Stricklin, D.3
  • 73
    • 84960171720 scopus 로고    scopus 로고
    • beta-Lactamase characterization of Gram-negative pathogens recovered from patients enrolled in the phase 2 trials for ceftazidime-avibactam: clinical efficacies analyzed against subsets of molecularly characterized isolates
    • R.E.Mendes, M.Castanheira, L.Gasink, et al. beta-Lactamase characterization of Gram-negative pathogens recovered from patients enrolled in the phase 2 trials for ceftazidime-avibactam:clinical efficacies analyzed against subsets of molecularly characterized isolates. Antimicrob Agents Chemother. 2015;60(3):1328–1335.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.3 , pp. 1328-1335
    • Mendes, R.E.1    Castanheira, M.2    Gasink, L.3
  • 74
    • 84971578709 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection - results from a randomized, controlled, double-blind, phase 3 program
    • J.E.Mazuski, L.Gasink, J.Armstrong, et al. Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection - results from a randomized, controlled, double-blind, phase 3 program. Clin Infect Dis. 2016 Mar 8. doi:10.1093/cid/ciw133. [Epub ahead of print]•• First published Phase III clinical trial.
    • (2016) Clin Infect Dis
    • Mazuski, J.E.1    Gasink, L.2    Armstrong, J.3
  • 75
    • 84988361957 scopus 로고    scopus 로고
    • cited, Jan, Available from
    • Positive Phase III Results Demonstrate Efficacy Of Antibiotic Medicine AVYCAZ™ (ceftazidime-avibactam) In Complicated Urinary Tract Infections. Allergen, Inc. [cited 2016 Jan 20]. Available from:http://www.allergan.com/news/news/thomson-reuters/positive-phase-iii-results-demonstrate-efficacy-of
    • (2016) Allergen, Inc
  • 76
    • 84988420618 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam and best available therapy in the treatment of ceftazidime-resistant infections - results from a Phase III study
    • Y.Carmeli, J.Armstrong, P.J.Laud et al. Efficacy and safety of ceftazidime-avibactam and best available therapy in the treatment of ceftazidime-resistant infections - results from a Phase III study. Poster presentation, ECCMID, LBEV0061b. 2015.
    • (2015) Poster presentation, ECCMID, LBEV0061b
    • Carmeli, Y.1    Armstrong, J.2    Laud, P.J.3
  • 77
    • 84898609105 scopus 로고    scopus 로고
    • Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam
    • S.Das, J.Armstrong, D.Mathews, et al. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam. J Clin Pharmacol. 2014;54(3):331–340.
    • (2014) J Clin Pharmacol , vol.54 , Issue.3 , pp. 331-340
    • Das, S.1    Armstrong, J.2    Mathews, D.3
  • 78
    • 84934993852 scopus 로고    scopus 로고
    • Ecological effect of ceftazidime/avibactam on the normal human intestinal microbiota
    • M.U.Rashid, S.Rosenborg, G.Panagiotidis, et al. Ecological effect of ceftazidime/avibactam on the normal human intestinal microbiota. Int J Antimicrob Agents. 2015;46(1):60–65.
    • (2015) Int J Antimicrob Agents , vol.46 , Issue.1 , pp. 60-65
    • Rashid, M.U.1    Rosenborg, S.2    Panagiotidis, G.3
  • 79
    • 79953871631 scopus 로고    scopus 로고
    • Combating antimicrobial resistance: policy recommendations to save lives
    • Infectious Diseases Society of America, B.Spellberg, M.Blaser, et al. Combating antimicrobial resistance:policy recommendations to save lives. Clin Infect Dis. 2011;52(Suppl 5):S397–428.
    • (2011) Clin Infect Dis , vol.52 , Issue.5 , pp. S397-S428
    • Spellberg, B.1    Blaser, M.2
  • 80
    • 84942154691 scopus 로고    scopus 로고
    • Fosfomycin for treatment of prostatitis: new tricks for old dogs
    • M.L.Grayson, N.Macesic, J.Trevillyan, et al. Fosfomycin for treatment of prostatitis:new tricks for old dogs. Clin Infect Dis. 2015;61(7):1141–1143.
    • (2015) Clin Infect Dis , vol.61 , Issue.7 , pp. 1141-1143
    • Grayson, M.L.1    Macesic, N.2    Trevillyan, J.3
  • 81
    • 84893256345 scopus 로고    scopus 로고
    • Is fosfomycin a potential treatment alternative for multidrug-resistant gram-negative prostatitis?
    • B.J.Gardiner, A.A.Mahony, A.G.Ellis, et al. Is fosfomycin a potential treatment alternative for multidrug-resistant gram-negative prostatitis? Clin Infect Dis. 2014;58(4):e101–105.
    • (2014) Clin Infect Dis , vol.58 , Issue.4 , pp. e101-e105
    • Gardiner, B.J.1    Mahony, A.A.2    Ellis, A.G.3
  • 82
    • 84884764949 scopus 로고    scopus 로고
    • Kinetics of avibactam inhibition against Class A, C, and D beta-lactamases
    • D.E.Ehmann, H.Jahic, P.L.Ross, et al. Kinetics of avibactam inhibition against Class A, C, and D beta-lactamases. J Biol Chem. 2013;288(39):27960–27971.
    • (2013) J Biol Chem , vol.288 , Issue.39 , pp. 27960-27971
    • Ehmann, D.E.1    Jahic, H.2    Ross, P.L.3
  • 83
    • 84960156283 scopus 로고    scopus 로고
    • The role of the outer membrane and porins in the susceptibility of beta-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam
    • J.M.Pages, S.Peslier, T.A.Keating, et al. The role of the outer membrane and porins in the susceptibility of beta-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam. Antimicrob Agents Chemother. 2015;60(3):1349–1359.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.3 , pp. 1349-1359
    • Pages, J.M.1    Peslier, S.2    Keating, T.A.3
  • 84
    • 84861873121 scopus 로고    scopus 로고
    • NXL104 irreversibly inhibits the beta-lactamase from Mycobacterium tuberculosis
    • H.Xu, S.Hazra, J.S.Blanchard. NXL104 irreversibly inhibits the beta-lactamase from Mycobacterium tuberculosis. Biochemistry. 2012;51(22):4551–4557.
    • (2012) Biochemistry , vol.51 , Issue.22 , pp. 4551-4557
    • Xu, H.1    Hazra, S.2    Blanchard, J.S.3
  • 85
    • 84957878384 scopus 로고    scopus 로고
    • Pharmacodynamics of Ceftazidime and Avibactam in neutropenic mice with thigh- or lung-infection
    • J.Berkhout, M.J.Melchers, A.C.Van Mil, et al. Pharmacodynamics of Ceftazidime and Avibactam in neutropenic mice with thigh- or lung-infection. Antimicrob Agents Chemother. 2015;60(1):368–375.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.1 , pp. 368-375
    • Berkhout, J.1    Melchers, M.J.2    Van Mil, A.C.3
  • 86
    • 79952120627 scopus 로고    scopus 로고
    • Activity of a novel combination against multidrug-resistant nonfermenters: ceftazidime plus NXL104
    • D.Curcio. Activity of a novel combination against multidrug-resistant nonfermenters:ceftazidime plus NXL104. Expert Rev Anti Infect Ther. 2011;9(2):173–176.
    • (2011) Expert Rev Anti Infect Ther , vol.9 , Issue.2 , pp. 173-176
    • Curcio, D.1
  • 87
    • 84928202650 scopus 로고    scopus 로고
    • Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C beta-lactamase enzyme
    • S.D.Lahiri, R.A.Giacobbe, M.R.Johnstone, et al. Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C beta-lactamase enzyme. J Antimicrob Chemother. 2014;69(11):2942–2946.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.11 , pp. 2942-2946
    • Lahiri, S.D.1    Giacobbe, R.A.2    Johnstone, M.R.3
  • 88
    • 84923240983 scopus 로고    scopus 로고
    • In vitro susceptibility of characterized beta-lactamase-producing strains tested with avibactam combinations
    • H.Li, M.Estabrook, G.A.Jacoby, et al. In vitro susceptibility of characterized beta-lactamase-producing strains tested with avibactam combinations. Antimicrob Agents Chemother. 2015;59(3):1789–1793.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.3 , pp. 1789-1793
    • Li, H.1    Estabrook, M.2    Jacoby, G.A.3
  • 89
    • 54549112247 scopus 로고    scopus 로고
    • NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases
    • D.M.Livermore, S.Mushtaq, M.Warner, et al. NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases. J Antimicrob Chemother. 2008;62(5):1053–1056.
    • (2008) J Antimicrob Chemother , vol.62 , Issue.5 , pp. 1053-1056
    • Livermore, D.M.1    Mushtaq, S.2    Warner, M.3
  • 90
    • 84905406150 scopus 로고    scopus 로고
    • Reclaiming the efficacy of beta-lactam-beta-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime
    • K.M.Papp-Wallace, M.L.Winkler, J.A.Gatta, et al. Reclaiming the efficacy of beta-lactam-beta-lactamase inhibitor combinations:avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime. Antimicrob Agents Chemother. 2014;58(8):4290–4297.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.8 , pp. 4290-4297
    • Papp-Wallace, K.M.1    Winkler, M.L.2    Gatta, J.A.3
  • 91
    • 84941621511 scopus 로고    scopus 로고
    • Ceftazidime-avibactam in urinary tract infections due to carbapenemase-producing Klebsiella in kidney transplantation
    • F.Caravaca-Fontan, S.Jimenez-Alvaro, R.Marcen-Letosa, et al. Ceftazidime-avibactam in urinary tract infections due to carbapenemase-producing Klebsiella in kidney transplantation. Nefrologia. 2015;35(4):412–413.
    • (2015) Nefrologia , vol.35 , Issue.4 , pp. 412-413
    • Caravaca-Fontan, F.1    Jimenez-Alvaro, S.2    Marcen-Letosa, R.3
  • 92
    • 84942903035 scopus 로고    scopus 로고
    • First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae
    • R.M.Humphries, S.Yang, P.Hemarajata, et al. First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2015;59(10):6605–6607.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.10 , pp. 6605-6607
    • Humphries, R.M.1    Yang, S.2    Hemarajata, P.3
  • 93
    • 84930510339 scopus 로고    scopus 로고
    • Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC
    • S.D.Lahiri, G.K.Walkup, J.D.Whiteaker, et al. Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC. J Antimicrob Chemother. 2015;70(6):1650–1658.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.6 , pp. 1650-1658
    • Lahiri, S.D.1    Walkup, G.K.2    Whiteaker, J.D.3
  • 94
    • 84940901399 scopus 로고    scopus 로고
    • In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 Carbapenemase
    • D.M.Livermore, M.Warner, D.Jamrozy, et al. In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 Carbapenemase. Antimicrob Agents Chemother. 2015;59(9):5324–5330.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.9 , pp. 5324-5330
    • Livermore, D.M.1    Warner, M.2    Jamrozy, D.3
  • 95
    • 84931291736 scopus 로고    scopus 로고
    • Variants of beta-lactamase KPC-2 that are resistant to inhibition by avibactam
    • K.M.Papp-Wallace, M.L.Winkler, M.A.Taracila, et al. Variants of beta-lactamase KPC-2 that are resistant to inhibition by avibactam. Antimicrob Agents Chemother. 2015;59(7):3710–3717.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.7 , pp. 3710-3717
    • Papp-Wallace, K.M.1    Winkler, M.L.2    Taracila, M.A.3
  • 96
    • 84959570300 scopus 로고    scopus 로고
    • Co-production of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: implications for newer beta-lactam-beta-lactamase inhibitor combinations
    • G.K.Thomson, J.W.Snyder, C.L.McElheny, et al. Co-production of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae:implications for newer beta-lactam-beta-lactamase inhibitor combinations. J Clin Microbiol. 2015;54(3):791–794.
    • (2015) J Clin Microbiol , vol.54 , Issue.3 , pp. 791-794
    • Thomson, G.K.1    Snyder, J.W.2    McElheny, C.L.3
  • 97
    • 84921797970 scopus 로고    scopus 로고
    • Unexpected challenges in treating multidrug-resistant gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa
    • M.L.Winkler, K.M.Papp-Wallace, A.M.Hujer, et al. Unexpected challenges in treating multidrug-resistant gram-negative bacteria:resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2015;59(2):1020–1029.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.2 , pp. 1020-1029
    • Winkler, M.L.1    Papp-Wallace, K.M.2    Hujer, A.M.3
  • 98
    • 77951060664 scopus 로고    scopus 로고
    • Current challenges in antimicrobial chemotherapy: focus on ss-lactamase inhibition
    • C.Bebrone, P.Lassaux, L.Vercheval, et al. Current challenges in antimicrobial chemotherapy:focus on ss-lactamase inhibition. Drugs. 2010;70(6):651–679.
    • (2010) Drugs , vol.70 , Issue.6 , pp. 651-679
    • Bebrone, C.1    Lassaux, P.2    Vercheval, L.3
  • 99
    • 77956666195 scopus 로고    scopus 로고
    • New beta-lactam antibiotics and beta-lactamase inhibitors
    • K.Bush, M.J.Macielag. New beta-lactam antibiotics and beta-lactamase inhibitors. Expert Opin Ther Pat. 2010;20(10):1277–1293.
    • (2010) Expert Opin Ther Pat , vol.20 , Issue.10 , pp. 1277-1293
    • Bush, K.1    Macielag, M.J.2
  • 100
    • 84934286719 scopus 로고    scopus 로고
    • A beta-lactamase inhibitor revival provides new hope for old antibiotics
    • K.Garber. A beta-lactamase inhibitor revival provides new hope for old antibiotics. Nat Rev Drug Discov. 2015;14(7):445–447.
    • (2015) Nat Rev Drug Discov , vol.14 , Issue.7 , pp. 445-447
    • Garber, K.1
  • 101
    • 84946497998 scopus 로고    scopus 로고
    • Ceftazidime-avibactam for the treatment of complicated urinary tract infections and complicated intra-abdominal infections
    • Y.Mawal, I.A.Critchley, T.A.Riccobene, et al. Ceftazidime-avibactam for the treatment of complicated urinary tract infections and complicated intra-abdominal infections. Expert Rev Clin Pharmacol. 2015;8(6):691–707.
    • (2015) Expert Rev Clin Pharmacol , vol.8 , Issue.6 , pp. 691-707
    • Mawal, Y.1    Critchley, I.A.2    Riccobene, T.A.3
  • 102
    • 84939799864 scopus 로고    scopus 로고
    • Focus on ceftazidime-avibactam for optimizing outcomes in complicated intra-abdominal and urinary tract infections
    • D.P.Nicolau. Focus on ceftazidime-avibactam for optimizing outcomes in complicated intra-abdominal and urinary tract infections. Expert Opin Investig Drugs. 2015;24(9):1261–1273.
    • (2015) Expert Opin Investig Drugs , vol.24 , Issue.9 , pp. 1261-1273
    • Nicolau, D.P.1
  • 103
    • 84975871919 scopus 로고    scopus 로고
    • Ceftazidime with beta-lactamase inhibitor approved for complicated infections
    • C.A.Thompson. Ceftazidime with beta-lactamase inhibitor approved for complicated infections. Am J Health Syst Pharm. 2015;72(7):511.
    • (2015) Am J Health Syst Pharm , vol.72 , Issue.7 , pp. 511
    • Thompson, C.A.1
  • 104
    • 84939486487 scopus 로고    scopus 로고
    • The beta-lactams strike sack: ceftazidime-avibactam
    • E.J.Zasowski, J.M.Rybak, M.J.Rybak. The beta-lactams strike sack:ceftazidime-avibactam. Pharmacotherapy. 2015;35(8):755–770.
    • (2015) Pharmacotherapy , vol.35 , Issue.8 , pp. 755-770
    • Zasowski, E.J.1    Rybak, J.M.2    Rybak, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.