Morphological and functional changes in recalcitrant diabetic macular oedema after intravitreal dexamethasone implant

British Journal of Ophthalmology

Volumn 101, Issue 6, 2017, Pages 791-795

  Iacono, Pierluigi ^a   Parodi, Maurizio Battaglia ^b   Scaramuzzi, Matteo ^b   Bandello, Francesco ^b  

^a IRCCS FONDAZIONE BIETTI   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Macula; Retina; Treatment Medical

Indexed keywords

DEXAMETHASONE; VASCULOTROPIN INHIBITOR; DRUG IMPLANT; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; BEST CORRECTED VISUAL ACUITY; CENTRAL MACULAR THICKNESS; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; DISEASE ASSOCIATION; DISEASE DURATION; DRUG EFFICACY; EYE EXAMINATION; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; INTRAVITREAL IMPLANT; LASER COAGULATION; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROLIFERATIVE DIABETIC RETINOPATHY; PROSPECTIVE STUDY; REMISSION; RETINA; RETINAL ELLIPSOID ZONE; RETINAL EXTERNAL LIMITING MEMBRANE; RETINAL OUTER LAYER; RETINAL PIGMENT EPITHELIUM; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VISUAL ACUITY CHART; COMPLICATION; DIABETIC RETINOPATHY; DRUG IMPLANT; EYE FUNDUS; FOLLOW UP; INTRAVITREAL DRUG ADMINISTRATION; MACULAR EDEMA; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; PROCEDURES; RETINA MACULA LUTEA; TREATMENT OUTCOME; VISUAL ACUITY;

ADULT; AGED; DEXAMETHASONE; DIABETIC RETINOPATHY; DRUG IMPLANTS; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; FUNDUS OCULI; GLUCOCORTICOIDS; HUMANS; INTRAVITREAL INJECTIONS; MACULA LUTEA; MACULAR EDEMA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 84987851019     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2016-308726     Document Type: Article

References (19)

1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-31
2. Keenan TD, Johnston RL, Donachie PH, et al. United Kingdom National Ophthalmology Database Study: Diabetic retinopathy; report 1: prevalence of centre-involving diabetic macular oedema and other grades of maculopathy and retinopathy in hospital eye services. Eye (Lond) 2013;27:1397-404
3. Adamis AP, Miller JW, Bernal MT, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994;118:445-50
4. Funatsu H, Yamashita H, Noma H, et al. Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol 2002;133:70-7
5. Qaum T, Xu Q, Joussen AM, et al. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci 2001;42:2408-13
6. Bandello F, Berchicci L, La Spina C, et al. Evidence for anti-VEGF treatment of diabetic macular edema. Ophthalmic Res 2012;48(Suppl 1):16-20
7. Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema. Ophthalmology 1984;91:1464-74
8. Javadzadeh A. The effect of posterior subtenon methylprednisolone acetate in the refractory diabetic macular edema: a prospective nonrandomized interventional case series. BMC Ophthalmol 2006;6:15-19
9. Patel RD, Messner LV, Teitelbaum B, et al. Characterization of ischemic index using ultra-widefield fluorescein angiography in patients with focal and diffuse recalcitrant diabetic macular edema. Am J Ophthalmol 2013;155:1038-1044. e1032
10. Funatsu H, Noma H, Mimura T, et al. Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology 2009;116:73-9
11. Zucchiatti I, Lattanzio R, Querques G, et al. Intravitreal dexamethasone implant in patients with persistent diabetic macular edema. Ophthalmologica 2012;228:117-22
12. Scaramuzzi M, Querques G, Spina CL, et al. Repeated intravitreal dexamethasone implant (Ozurdex) for diabetic macular edema. Retina (Philadelphia, Pa) 2015;35:1216-22
13. Boyer DS, Yoon YH, Belfort R Jr, et al. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology 2014;121:1904-14
14. Uji A, Murakami T, Nishijima K, et al. Association between hyperreflective foci in the outer retina, status of photoreceptor layer, and visual acuity in diabetic macular edema. Am J Ophthalmol 2012;153:710-717.e1
15. Domalpally A, Peng Q, Danis R, et al. Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13. Eye (Lond) 2012;26:919-24
16. Sakamoto A, Nishijima K, Kita M, et al. Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy. Graefes Arch Clin Exp Ophthalmol 2009;247:1325-30
17. Walsh SV, Hopkins AM, Nusrat A. Modulation of tight junction structure and function by cytokines. Adv Drug Deliv Rev 2000;41:303-13
18. Bansal P, Gupta V, Gupta A, et al. Efficacy of intravitreal ozurdex in recalcitrant diabetic macular edema-a single centre experience. Int Ophthalmol 2016; 36:207-16
19. Bansal P, Agarwal A, Gupta V, et al. Structural changes on spectral domain optical coherence tomography in uveitic macular edema post ozurdex injection. Indian J Ophthalmol 2015;63:416-22