Intravitreal dexamethasone implant in patients with persistent diabetic macular edema

Ophthalmologica

Volumn 228, Issue 2, 2012, Pages 117-122

  Zucchiatti, Ilaria ^a   Lattanzio, Rosangela ^a   Querques, Giuseppe ^a,b   Querques, Lea ^a   Del Turco, Claudia ^a   Cascavilla, Maria Lucia ^a   Bandello, Francesco ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

Author keywords

Diabetes; Macular edema; Optical coherence tomography; Ozurdex; Retinopathy

Indexed keywords

AGENTS ACTING ON THE EYE; ANTIBIOTIC AGENT; DEXAMETHASONE; STEROID; TRIAMCINOLONE ACETONIDE; VASCULOTROPIN INHIBITOR;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BEST CORRECTED VISUAL ACUITY; CENTRAL RETINA THICKNESS; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; DIABETIC MACULAR EDEMA; DISEASE DURATION; FEMALE; FOLLOW UP; HUMAN; INTERVENTION STUDY; INTRAOCULAR PRESSURE; INTRAOCULAR PRESSURE ABNORMALITY; LASER COAGULATION; MALE; RETROSPECTIVE STUDY; SIDE EFFECT; THICKNESS; TOPICAL TREATMENT; VISUAL ACUITY; VISUAL SYSTEM PARAMETERS;

ADULT; AGED; ANGIOGENESIS INHIBITORS; DEXAMETHASONE; DIABETIC RETINOPATHY; DRUG IMPLANTS; FEMALE; FLUORESCEIN ANGIOGRAPHY; GLUCOCORTICOIDS; HUMANS; LASER COAGULATION; MACULAR EDEMA; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY; VITREOUS BODY;

EID: 84864601616     PISSN: 00303755     EISSN: 14230267     Source Type: Journal    
DOI: 10.1159/000336225     Document Type: Article

References (21)

1. Early Treatment Diabetic Retinopathy Study Research Group: Photocoagulation for diabetic macular edema: ETDRS report No 4. Int Ophthalmol Clin 1987; 27: 265-272.
2. Early Treatment Diabetic Retinopathy Study Research Group: Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report No 1. Arch Ophthalmol 1985; 103:1796-1806.
3. Schatz H, Madeira D, McDonald HR, Johnson RN: Progressive enlargement of laser scars following grid laser photocoagulation for diffuse diabetic macular edema. Arch Ophthalmol 1991; 109:1549-1551.
4. Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL: Vascular en-dothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997; 46:1473-1480. (Pubitemid 27369086)
5. Funatsu H, Yamashita H, Noma H, Mimura T, Yamashita T, Hori S: Increased levels of vascular endothelial growth factor and in-terleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol 2002; 133: 70-77. (Pubitemid 34076505)
6. Massin P, Bandello F, Garweg JG, Hansen LL, Harding SP, Larsen M, Mitchell P, Sharp D, Wolf-Schnurrbusch UE, Gekkieva M, Weichselberger A, Wolf S: Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care 2010; 33: 2399-2405.
7. Diabetic Retinopathy Clinical Research Network, Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, Ferris FL 3rd, Friedman SM, Glassman AR, Miller KM, Scott IU, Stockdale CR, Sun JK: Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcino-lone plus prompt laser for diabetic macu-lar edema. Ophthalmology 2010; 117:1064-1077.
8. Funatsu H, Noma H, Mimura T, Eguchi S, Hori S: Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology 2009; 116:73-79.
9. Haller JA, Dugel P, Weinberg DV, Chou C, Whitcup SM: Evaluation of safety and performance of an applicator for a novel intra-vitreal dexamethasone drug delivery system for the treatment of macular edema. Retina 2009; 29:46-51.
10. Haller JA, Kuppermann BD, Blumenkranz MS, Williams GA, Weinberg DV, Chou C, Whitcup SM, Dexamethasone DDS Phase II Study Group: Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. Arch Ophthalmol 2010; 128:289-296.
11. Boyer DS, Faber D, Gupta S, Patel SS, Taban-deh H, Li XY, Liu CC, Lou J, Whitcup SM, Ozurdex Champlain study group: Dexa-methasone intravitreal implant for treatment of diabetic macular edema in vitrecto-mized patients. Retina 2011; 31:915-923.
12. Saraiya NV, Goldstein DA: Dexamethasone for ocular inflammation. Expert Opin Phar-macother 2011; 12:1127-1131.
13. Chang-Lin JE, Burke JA, Peng Q, Lin T, Oril-la WC, Ghosn CR, Zhang KM, Kuppermann BD, Robinson MR, Whitcup SM, Welty DF: Pharmacokinetics of a sustained-release dexamethasone intravitreal implant in vit-rectomized and nonvitrectomized eyes. Invest Ophthalmol Vis Sci 2011; 52:4605-4609.
14. Ghosn CR, Li Y, Orilla WC, Lin T, Wheeler L, Burke JA, Robinson MR, Whitcup SM: Treatment of experimental anterior and intermediate uveitis by a dexamethasone intra-vitreal implant. Invest Ophthalmol Vis Sci 2011; 52:2917-2923.
15. Lowder C, Belfort R Jr, Lightman S, Foster CS, Robinson MR, Schiffman RM, Li XY, Cui H, Whitcup SM, Ozurdex HURON Study Group: Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol 2011; 129:545-553.
16. Myung JS, Aaker GD, Kiss S: Treatment of noninfectious posterior uveitis with dexa-methasone intravitreal implant. Clin Oph-thalmol 2010; 4:1423-1426.
17. Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jacques ML, Jiao J, Li XY, Whitcup SM, Ozurdex GENEVA Study Group: Randomized, sham-controlled trial of dexa-methasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 2010; 117:1134-1146.
18. Kuppermann BD, Blumenkranz MS, Haller JA, Williams GA, Weinberg DV, Chou C, Whitcup SM, Dexamethasone DDS Phase II Study Group: Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol 2007; 125: 309-317. (Pubitemid 46425557)
19. Mitchell P, Bandello F, Schmidt-Erfurth U, Lang GE, Massin P, Schlingemann RO, Sut-ter F, Simader C, Burian G, Gerstner O, Weichselberger A, RESTORE Study Group: The RESTORE study: ranibizumab mono-therapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 2011; 118:615-625.
20. Nguyen QD, Shah SM, Khwaja AA, Channa R, Hatef E, Do DV, Boyer D, Heier JS, Abraham P, Thach AB, Lit ES, Foster BS, Kruger E, Dugel P, Chang T, Das A, Ciulla TA, Pollack JS, Lim JI, Eliott D, Campochiaro PA, READ-2 Study Group: Two-year outcomes of the Ranibizumab for Edema of the Maculain Diabetes (READ-2) study. Ophthalmology 2010; 117:2146-2151.
21. Diabetic Retinopathy Clinical Research Network (DRCR.net), Beck RW, Edwards AR, Aiello LP, Bressler NM, Ferris F, Glassman AR, Hartnett E, Ip MS, Kim JE, Kollman C: Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic mac-ular edema. Arch Ophthalmol 2009; 127: 245-251.