Effects of Unilateral Upper Limb Training in Two Distinct Prognostic Groups Early after Stroke: The EXPLICIT-Stroke Randomized Clinical Trial

Neurorehabilitation and Neural Repair

Volumn 30, Issue 9, 2016, Pages 804-816

  Kwakkel, Gert ^a,b   Winters, Caroline ^a   Van Wegen, Erwin E H ^a   Nijland, Rinske H M ^b   Van Kuijk, Annette A A ^c   Visser Meily, Anne ^d   De Groot, Jurriaan ^e   De Vlugt, Erwin ^f   Arendzen, J Hans ^e   Geurts, Alexander C H ^c   Meskers, Carel G M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Amsterdam Rehabilitation Research Center Reade   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

constraint induced movement therapy (CIMT); electromyography triggered neuromuscular stimulation (EMG NMS); randomized controlled trial (RCT); stroke; upper limb

Indexed keywords

ADULT; ARTICLE; BRAIN ISCHEMIA; CONSTRAINT INDUCED THERAPY; CONTROLLED STUDY; ELECTROMYOGRAPHY; FEMALE; FINGER EXTENSION; FUNCTIONAL ASSESSMENT; HAND MOVEMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCLE STIMULATOR; NEUROMUSCULAR STIMULATION; OUTCOME VARIABLE; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RANGE OF MOTION; SAMPLE SIZE; STROKE PATIENT; UPPER LIMB; VOLUNTARY MOVEMENT; AGED; ARM; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; EXERCISE; FOLLOW UP; HEMISPHERIC DOMINANCE; MIDDLE AGED; MULTICENTER STUDY; NEUROFEEDBACK; PHYSIOLOGY; PHYSIOTHERAPY; PROCEDURES; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SINGLE BLIND PROCEDURE; STROKE REHABILITATION; TREATMENT OUTCOME;

ADULT; AGED; ARM; FEMALE; FOLLOW-UP STUDIES; FUNCTIONAL LATERALITY; HUMANS; MALE; MIDDLE AGED; NEUROFEEDBACK; PHYSICAL THERAPY MODALITIES; PROGNOSIS; RESTRAINT, PHYSICAL; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; STROKE; STROKE REHABILITATION; TREATMENT OUTCOME; UPPER EXTREMITY;

EID: 84987730775     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968315624784     Document Type: Article

References (50)

1. Kwakkel G, Kollen BJ, Van der Grond J, Prevo AJ,. Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke. Stroke. 2003; 34: 2181-2186.
2. Langhorne P, Bernhardt J, Kwakkel G,. Stroke rehabilitation. Lancet. 2011; 377: 1693-1702.
3. Stinear C,. Prediction of recovery of motor function after stroke. Lancet Neurol. 2010; 9: 1228-1232.
4. Nijland RH, Van Wegen EE, Harmeling-Van der Wel BC, Kwakkel G,. Presence of finger extension and shoulder abduction within 72 hours after stroke predicts functional recovery: early prediction of functional outcome after stroke: the EPOS cohort study. Stroke. 2010; 41: 745-750.
5. Wolf SL, Winstein CJ, Miller JP, et al. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA. 2006; 296: 2095-2104.
6. Dromerick AW, Lang CE, Birkenmeier RL, et al. Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS): a single-center RCT. Neurology. 2009; 73: 195-201.
7. Francisco G, Chae J, Chawla H, et al. Electromyogram-triggered neuromuscular stimulation for improving the arm function of acute stroke survivors: a randomized pilot study. Arch Phys Med Rehabil. 1998; 79: 570-575.
8. Thrasher TA, Zivanovic V, McIlroy W, Popovic MR,. Rehabilitation of reaching and grasping function in severe hemiplegic patients using functional electrical stimulation therapy. Neurorehabil Neural Repair. 2008; 22: 706-714.
9. Bolton DA, Cauraugh JH, Hausenblas HA,. Electromyogram-triggered neuromuscular stimulation and stroke motor recovery of arm/hand functions: a meta-analysis. J Neurol Sci. 2004; 223: 121-127.
10. De Kroon JR, IJzerman MJ, Lankhorst GJ, Zilvold G,. Electrical stimulation of the upper limb in stroke: stimulation of the extensors of the hand vs. alternate stimulation of flexors and extensors. Am J Phys Med Rehabil. 2004; 83: 592-600.
11. Cauraugh J, Light K, Kim S, Thigpen M, Behrman A,. Chronic motor dysfunction after stroke: recovering wrist and finger extension by electromyography-triggered neuromuscular stimulation. Stroke. 2000; 31: 1360-1364.
12. Kimberley TJ, Lewis SM, Auerbach EJ, Dorsey LL, Lojovich JM, Carey JR,. Electrical stimulation driving functional improvements and cortical changes in subjects with stroke. Exp Brain Res. 2004; 154: 450-460.
13. Shin HK, Cho SH, Jeon HS, et al. Cortical effect and functional recovery by the electromyography-triggered neuromuscular stimulation in chronic stroke patients. Neurosci Lett. 2008; 442: 174-179.
14. Murphy TH, Corbett D,. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009; 10: 861-872.
15. Kwakkel G, Meskers CG, Van Wegen EE, et al. Impact of early applied upper limb stimulation: the EXPLICIT-stroke programme design. BMC Neurol. 2008; 8: 49.
16. Nijland R, Kwakkel G, Bakers J, Van Wegen E,. Constraint-induced movement therapy for the upper paretic limb in acute or sub-acute stroke: a systematic review. Int J Stroke. 2011; 6: 425-433.
17. Nijland R, Van Wegen EEH, Van der Krogt H, et al. Characterizing the protocol for early modified constraint-induced movement therapy in the EXPLICIT-stroke trial. Physiother Res Int. 2013; 18: 1-15.
18. Van Peppen RP, Kwakkel G, Wood-Dauphinee S, Hendriks HJ, Van der Wees PJ, Dekker J,. The impact of physical therapy on functional outcomes after stroke: what's the evidence? Clin Rehabil. 2004; 18: 833-862.
19. Lyle RC,. A performance test for assessment of upper limb function in physical rehabilitation treatment and research. Int J Rehabil Res. 1981; 4: 483-492.
20. Van der Lee JH, Roorda LD, Beckerman H, Lankhorst GJ, Bouter LM,. Improving the Action Research Arm Test: a unidimensional hierarchical scale. Clin Rehabil. 2002; 16: 646-653.
21. Nijland R, Van Wegen E, Verbunt J, Van Wijk R, Van Kordelaar J, Kwakkel G,. A comparison of two validated tests for upper limb function after stroke: the Wolf Motor Function Test and the Action Research Arm Test. J Rehabil Med. 2010; 42: 694-696.
22. Yozbatiran N, Der-Yeghiaian L, Cramer SC,. A standardized approach to performing the Action Research Arm Test. Neurorehabil Neural Repair. 2008; 22: 78-90.
23. Van der Lee JH, Beckerman H, Lankhorst GJ, Bouter LM,. Constraint-induced movement therapy. Arch Phys Med Rehabil. 1999; 80: 1606-1607.
24. Badke MB, Duncan PW,. Patterns of rapid motor responses during postural adjustments when standing in healthy subjects and hemiplegic patients. Phys Ther. 1983; 63: 13-20.
25. Duncan PW, Propst M, Nelson SG,. Reliability of the Fugl-Meyer Assessment of sensorimotor recovery following cerebrovascular accident. Phys Ther. 1983; 63: 1606-1610.
26. Gladstone DJ, Danells CJ, Black SE,. The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair. 2002; 16: 232-240.
27. Wolf SL, Catlin PA, Ellis M, Archer AL, Morgan B, Piacentino A,. Assessing Wolf Motor Function Test as outcome measure for research in patients after stroke. Stroke. 2001; 32: 1635-1639.
28. Kwakkel G, Wagenaar RC, Twisk JW, Lankhorst GJ, Koetsier JC,. Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial. Lancet. 1999; 354: 191-196.
29. Collin C, Wade D,. Assessing motor impairment after stroke: a pilot reliability study. J Neurol Neurosurg Psychiatry. 1990; 53: 576-579.
30. Stolk-Hornsveld F, Crow JL, Hendriks EP, Van der Baan R, Harmeling-Van der Wel BC,. The Erasmus MC modifications to the (revised) Nottingham Sensory Assessment: a reliable somatosensory assessment measure for patients with intracranial disorders. Clin Rehabil. 2006; 20: 160-172.
31. Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S,. Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil. 1985; 66: 69-74.
32. Heller A, Wade DT, Wood VA, Sunderland A, Hewer RL, Ward E,. Arm function after stroke: measurement and recovery over the first three months. J Neurol Neurosurg Psychiatry. 1987; 50: 714-719.
33. Van der Lee JH, Beckerman H, Knol DL, De Vet HC, Bouter LM,. Clinimetric properties of the motor activity log for the assessment of arm use in hemiparetic patients. Stroke. 2004; 35: 1410-1414.
34. Duncan PW, Wallace D, Lai SM, Johnson D, Embretson S, Laster LJ,. The Stroke Impact Scale version 2.0. Evaluation of reliability, validity, and sensitivity to change. Stroke. 1999; 30: 2131-2140.
35. Van de, Port IG, Wood-Dauphinee S, Lindeman E, Kwakkel G,. Effects of exercise training programs on walking competency after stroke: a systematic review. Am J Phys Med Rehabil. 2007; 86: 935-951.
36. Thrane G, Askim T, Stock R, et al. Efficacy of constraint-induced movement therapy in early stroke rehabilitation: a randomized controlled multisite trial. Neurorehabil Neural Repair. 2015; 29: 517-525.
37. Van Kordelaar J, Van Wegen EEH, Kwakkel G,. Impact of time on quality of motor control of the paretic upper limb after stroke. Arch Phys Med Rehabil. 2014; 95: 338-344.
38. Van Kordelaar J, Van Wegen EE, Nijland RH, Daffertshofer A, Kwakkel G,. Understanding adaptive motor control of the paretic upper limb early poststroke: the EXPLICIT-stroke program. Neurorehabil Neural Repair. 2013; 27: 854-863.
39. Kitago T, Liang J, Huang VS, et al. Improvement after constraint-induced movement therapy: recovery of normal motor control or task-specific compensation? Neurorehabil Neural Repair. 2013; 27: 99-109.
40. Page SJ, Levine P, Leonard A, Szaflarski JP, Kissela BM,. Modified constraint-induced therapy in chronic stroke: results of a single-blinded randomized controlled trial. Phys Ther. 2008; 88: 333-340.
41. Buma F, Kwakkel G, Ramsey N,. Understanding upper limb recovery after stroke. Restor Neurol Neurosci. 2013; 31: 707-722.
42. Kwakkel G, Veerbeek JM, Van Wegen EE, Wolf SL,. Constraint-induced movement therapy after stroke. Lancet Neurol. 2015; 14: 224-234.
43. Veerbeek JM, van Wegen E, van Peppen R, et al. What is the evidence for physical therapy poststroke? A systematic review and meta-analysis. PLoS One. 2014; 9: e87987.
44. Lohse KR, Lang CE, Boyd LA,. Is more better? Using metadata to explore dose-response relationships in stroke rehabilitation. Stroke. 2014; 45: 2053-2058.
45. Kwakkel G, Kollen B, Twisk J,. Impact of time on improvement of outcome after stroke. Stroke. 2006; 37: 2348-2353.
46. Winters C, Van Wegen EE, Daffertshofer A, Kwakkel G,. Generalizability of the proportional recovery model for the upper extremity after an ischemic stroke. Neurorehabil Neural Repair. 2015; 29: 614-622.
47. Stinear CM, Barber PA, Petoe M, Anwar S, Byblow WD,. The PREP algorithm predicts potential for upper limb recovery after stroke. Brain. 2012; 135 (pt 8): 2527-2535.
48. Von Lewinski F, Hofer S, Kaus J, et al. Efficacy of EMG-triggered electrical arm stimulation in chronic hemiparetic stroke patients. Restor Neurol Neurosci. 2009; 27: 189-197.
49. Hara Y, Obayashi S, Tsujiuchi K, Muraoka Y,. The effects of electromyography-controlled functional electrical stimulation on upper extremity function and cortical perfusion in stroke patients. Clin Neurophysiol. 2013; 124: 2008-2015.
50. Langhorne P, Coupar F, Pollock A,. Motor recovery after stroke: a systematic review. Lancet Neurol. 2009; 8: 741-754.