Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 37, 2016, Pages E5528-E5537

  Jiang, Yuchao ^a,b   Qiu, Yu ^a,c   Minn, Andy J ^a,c   Zhang, Nancy R ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer genomics|phylogeny inference; Clonal deconvolution; Intratumor heterogeneity|cancer evolution

Indexed keywords

CANCER CELL LINE; CLONAL EVOLUTION; CONFERENCE PAPER; COPY NUMBER VARIATION; EPIGENETIC REPRESSION; GENETIC HETEROGENEITY; HUMAN; INTRATUMOR HETEROGENEITY; NEXT GENERATION SEQUENCING; PHYLOGENETIC TREE; PRIORITY JOURNAL; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL; BIOLOGY; EXOME; GENETICS; HIGH THROUGHPUT SEQUENCING; INTERNET; MOLECULAR EVOLUTION; MUTATION; NEOPLASM; PATHOLOGY; PHYLOGENY; PROCEDURES; SOFTWARE;

CLONAL EVOLUTION; COMPUTATIONAL BIOLOGY; DNA COPY NUMBER VARIATIONS; EVOLUTION, MOLECULAR; EXOME; GENETIC HETEROGENEITY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INTERNET; MUTATION; NEOPLASMS; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; SOFTWARE;

EID: 84987678590     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522203113     Document Type: Article

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