Low serum sex hormone-binding globulin: Marker of inflammation?

Clinica Chimica Acta

Volumn 413, Issue 7-8, 2012, Pages 803-807

  Liao, Chun Hou ^a   Li, Hung Yuan ^b   Yu, Hong Jeng ^b   Chiang, Han Sun ^a   Lin, Mao Shin ^b   Hua, Cyue Huei ^b   Ma, Wen Ya ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

C reactive protein; Inflammation; Metabolic syndrome; Sex hormone; Sex hormone binding globulin

Indexed keywords

C REACTIVE PROTEIN; ESTRADIOL; FOLLITROPIN; GLUCOSE; INSULIN; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID ANALYSIS; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; POSTMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; INFLAMMATION; MIDDLE AGED; MULTIVARIATE ANALYSIS; SEX HORMONE-BINDING GLOBULIN;

EID: 84862819053     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.01.021     Document Type: Article

References (30)

1. Sutton-Tyrrell K., Wildman R.P., Matthews K.A., et al. Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 2005, 111:1242-1249.
2. Hammes A., Andreassen T.K., Spoelgen R., et al. Role of endocytosis in cellular uptake of sex steroids. Cell 2005, 122:751-762.
3. Porto C.S., Lazari M.F., Abreu L.C., Bardin C.W., Gunsalus G.L. Receptors for androgen-binding proteins: internalization and intracellular signalling. J Steroid Biochem Mol Biol 1995, 53:561-565.
4. Tchernof A., Despres J.P. Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women. Horm Metab Res 2000, 32:526-536.
5. Garces C., Oya I., Lasuncion M.A., et al. Sex hormone-binding globulin and lipid profile in pubertal children. Metabolism 2010, 59:166-171.
6. Brand J.S., van der Tweel I., Grobbee D.E., Emmelot-Vonk M.H., van der Schouw Y.T. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol 2011, 40:189-207.
7. Onat A., Hergenc G., Karabulut A., et al. Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women. Metabolism 2007, 56:1356-1362.
8. Ding E.L., Song Y., Manson J.E., et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009, 361:1152-1163.
9. Koenig W., Sund M., Frohlich M., et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999, 99:237-242.
10. Pepys M.B., Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-1812.
11. Laaksonen D.E., Niskanen L., Punnonen K., et al. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol 2003, 149:601-608.
12. Joffe H.V., Ridker P.M., Manson J.E., et al. Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Ann Epidemiol 2006, 16:105-112.
13. Bell R.J., Davison S.L., Papalia M.A., McKenzie D.P., Davis S.R. Endogenous androgen levels and cardiovascular risk profile in women across the adult life span. Menopause 2007, 14:630-638.
14. Stork S., Bots M.L., Grobbee D.E., van der Schouw Y.T. Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. J Intern Med 2008, 264:245-253.
15. Karim R., Stanczyk F.Z., Hodis H.N., et al. Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause 2010, 17:785-790.
16. Maggio M., Ceda G.P., Lauretani F., et al. SHBG, sex hormones, and inflammatory markers in older women. J Clin Endocrinol Metab 2011, 96:1053-1059.
17. Kupelian V., Chiu G.R., Araujo A.B., et al. Association of sex hormones and C-reactive protein levels in men. Clin Endocrinol (Oxf) 2010, 72:527-533.
18. Nakhai Pour H.R., Grobbee D.E., Muller M., van der Schouw Y.T. Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men. Clin Endocrinol (Oxf) 2007, 66:394-398.
19. Wang C., Nieschlag E., Swerdloff R., et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008, 159:507-514.
20. Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
21. Grundy S.M., Cleeman J.I., Daniels S.R., et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735-2752.
22. Akin F., Bastemir M., Alkis E., Kaptanoglu B. SHBG levels correlate with insulin resistance in postmenopausal women. Eur J Intern Med 2009, 20:162-167.
23. Xu J.-W., Morita I., Ikeda K., Miki T., Yamori Y. C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 2007, 21:564-573.
24. D'Alessandris C., Lauro R., Presta I., Sesti G. C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. Diabetologia 2007, 50:840-849.
25. Tanigaki K., Mineo C., Yuhanna I.S., et al. C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1. Circ Res 2009, 104:1275-1282.
26. Plymate S.R., Matej L.A., Jones R.E., Friedl K.E. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 1988, 67:460-464.
27. Pasquali R., Casimirri F., De Iasio R., et al. Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab 1995, 80:654-658.
28. Zimmermann E., Anty R., Tordjman J., et al. C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. J Hepatol 2011, 55:660-665.
29. Shin J.Y., Kim S.K., Lee M.Y., et al. Serum sex hormone-binding globulin levels are independently associated with nonalcoholic fatty liver disease in patients with type 2 diabetes. Diabetes Res Clin Pract 2011, [Epub ahead of print].
30. Wang Z., Salih E., Burke P.A. Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4alpha phosphorylation by mass spectrometry. Biochemistry 2011, 50:5292-5300.