Absence of N-methyl-D-aspartate receptor IgG autoantibodies in schizophrenia: The importance of cross-validation studies

JAMA Psychiatry

Volumn 72, Issue 7, 2015, Pages 731-733

  De Witte, Lot D ^a   Hoffmann, Carolin ^b   Van Mierlo, Hans C ^a   Titulaer, Maarten J ^c   Kahn, René S ^a   Martinez Martinez, Pilar ^b   Losen, Mario ^b   Molenaar, Peter ^b   De Hert, Marc ^c   Roeder, Christian H ^d   Van Beveren, Nico ^c,d   Rutten, Bart P F ^b   Van Os, Jim ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; AUTOANTIBODY; GRIN1 PROTEIN, HUMAN; IMMUNOGLOBULIN G; NERVE PROTEIN;

ADULT; ANTIBODY DETECTION; BLOOD ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LETTER; MAJOR CLINICAL STUDY; MALE; SCHIZOPHRENIA; ADOLESCENT; ANTI N METHYL D ASPARTATE RECEPTOR ENCEPHALITIS; COHORT ANALYSIS; IMMUNOLOGY; REPRODUCIBILITY; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-N-METHYL-D-ASPARTATE RECEPTOR ENCEPHALITIS; AUTOANTIBODIES; COHORT STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; NERVE TISSUE PROTEINS; RECEPTORS, N-METHYL-D-ASPARTATE; REPRODUCIBILITY OF RESULTS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84937468128     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2015.0526     Document Type: Letter

References (7)

1. Gresa-Arribas N, Titulaer MJ, Torrents A, et al. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol. 2014;13(2):167-177.
2. Pollak TA, McCormack R, Peakman M, Nicholson TR, David AS. Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis. Psychol Med. 2014;44(12):2475-2487.
3. Steiner J, Teegen B, Schiltz K, Bernstein H-G, StoeckerW, Bogerts B. Prevalence of N-methyl-D-aspartate receptor autoantibodies in the peripheral blood: healthy control samples revisited. JAMA Psychiatry. 2014;71(7):838-839.
4. van Winkel R, De HertM, Van Eyck D, et al. Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: evaluation of incidence and screening methods. J Clin Psychiatry. 2006;67(10):1493-1500.
5. Schwarz E, Guest PC, Rahmoune H, et al. Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2012;17(5):494-502.
6. Korver N, Quee PJ, Boos HB, Simons CJ, de Haan L; GROUP investigators. Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. Int JMethods Psychiatr Res. 2012;21(3):205-221.
7. Zandi MS, Paterson RW, EllulMA, et al. Clinical relevance of serum antibodies to extracellularN-methyl-d-aspartate receptor epitopes [published online September 22, 2014]. JNeurol Neurosurg Psychiatry. doi:10.1136/jnnp-2014-308736.