Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells

Annals of Surgical Treatment and Research

Volumn 87, Issue 4, 2014, Pages 167-173

  Kil, Won Ho ^a   Kim, Sang Min ^a   Lee, Jeong Eon ^a   Park, Kyoung Sik ^a,b   Nam, Seok Jin ^a  

^a Samsung Medical Center   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

Silibinin; Triple negative breast neoplasms; Xenograft

Indexed keywords

EID: 84986616711     PISSN: 22886575     EISSN: 22886796     Source Type: Journal    
DOI: 10.4174/astr.2014.87.4.167     Document Type: Article

References (14)

1. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
2. Reis-Filho JS, Natrajan R, Vatcheva R, Lam bros MB, Marchio C, Mahler-Araujo B, et al. Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6 'split apart' probes. Histopathology 2008;52:840-6.
3. Mereish KA, Bunner DL, Ragland DR, Creasia DA. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. Pharm Res 1991;8:273-7.
4. Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, et al. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 2006;98:846-55.
5. Jiang C, Agarwal R, Lu J. Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin: inhibi tion of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochem Biophys Res Commun 2000; 276:371-8.
6. Kaur M, Velmurugan B, Tyagi A, Deep G, Katiyar S, Agarwal C, et al. Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol Cancer Ther 2009;8:2366-74.
7. Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 2008;14:7773-80.
8. Kim S, Choi JH, Lim HI, Lee SK, Kim WW, Kim JS, et al. Silibinin prevents TPAinduced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ ERK pathway in MCF-7 human breast cancer cells. Phytomedicine 2009;16:573-80.
9. Kim S, Kim SH, Hur SM, Lee SK, Kim WW, Kim JS, et al. Silibinin prevents TPAinduced MMP-9 expression by downregulation of COX-2 in human breast cancer cells. J Ethnopharmacol 2009;126: 252-7.
10. Bhatia N, Zhao J, Wolf DM, Agarwal R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett 1999;147:77-84.
11. Kim S, Lee HS, Lee SK, Kim SH, Hur SM, Kim JS, et al. 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the downregulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells. Phytomedicine 2010;17:1127-32.
12. Kim S, Han J, Kim JS, Kim JH, Choe JH, Yang JH, et al. Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast cancer cells. Anticancer Res 2011;31:3767-73.
13. Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 2008;14:300-8.
14. Chang HR, Chen PN, Yang SF, Sun YS, Wu SW, Hung TW, et al. Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemo sensitivity to 5-fluorouracil and paclitaxel. Mol Carcinog 2011;50:811-23.