A Pilot Randomized Controlled Trial to Promote Immunosuppressant Adherence in Adult Kidney Transplant Recipients

Nephron

Volumn 135, Issue 1, 2017, Pages 6-14

  Cukor, Daniel ^a,c   Ver Halen, Nisha ^a,c   Pencille, Melissa ^c   Tedla, Fasika ^b   Salifu, Moro ^b,c  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

^c Brooklyn Health Disparities Center   (United States)

Author keywords

Immunosuppressive therapy; Kidney transplant; Randomized clinical trial

Indexed keywords

TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ADULT; AGED; ARTICLE; AWARENESS; BEHAVIOR MODIFICATION; CLINICAL ARTICLE; COGNITIVE BEHAVIORAL THERAPY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; MEDICATION COMPLIANCE; MOTIVATIONAL INTERVIEWING; PATIENT COMPLIANCE; PILOT STUDY; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOEDUCATION; RANDOMIZED CONTROLLED TRIAL; BLOOD; GRAFT RECIPIENT; INTERVIEW; MIDDLE AGED; PROCEDURES; PSYCHOLOGY;

ADULT; AGED; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERVIEWS AS TOPIC; KIDNEY TRANSPLANTATION; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PILOT PROJECTS; TACROLIMUS; TRANSPLANT RECIPIENTS;

EID: 84986558183     PISSN: 16608151     EISSN: 22353186     Source Type: Journal    
DOI: 10.1159/000448627     Document Type: Article

References (69)

1. Osterberg L, Blaschke T: Adherence to medication. N Engl J Med 2005; 353: 487-497
2. Senst BL, Achusim LE, Genest RP, Cosentino LA, Ford CC, Little JA, Raybon SJ, Bates DW: Practical approach to determining costs and frequency of adverse drug events in a health care network. Am J Health Syst Pharm 2001; 58: 1126-1132
3. Schiff GD, Fung S, Speroff T, McNutt RA: Decompensated heart failure: symptoms, patterns of onset, and contributing factors. Am J Med 2003; 114: 625-630
4. Yen EF, Hardinger K, Brennan DC, Woodward RS, Desai NM, Crippin JS, Gage BF, Schnitzler MA: Cost-effectiveness of extending Medicare coverage of immunosuppressive medications to the life of a kidney transplant. Am J Transplant 2004; 4: 1703-1708
5. Matas AJ, Humar A, Gillingham KJ, Payne WD, Gruessner RW, Kandaswamy R, Dunn DL, Najarian JS, Sutherland DE: Five preventable causes of kidney graft loss in the 1990s: a single-center analysis. Kidney Int 2002; 62: 704-714
6. Gaston RS, Hudson SL, Ward M, Jones P, Macon R: Late renal allograft loss: noncompliance masquerading as chronic rejection. Transplant Proc 1999; 31: 21S-23S
7. Dobbels F, Geest S, Van Cleemput J, Droogne W, Vanhaecke J: Effect of late medication non-compliance on outcome after heart transplantation: a 5-year follow-up. J Heart Lung Transplant 2004; 23: 1245-1251
8. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, Held PJ, Port FK: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999; 341: 1725-1730
9. Jindal RM, Joseph JT, Morris MC, Santella RN, Baines LS: Noncompliance after kidney transplantation: a systematic review. Transplant Proc 2003; 35: 2868-2872
10. Butler JA, Peveler RC, Roderick P, Horne R, Mason JC: Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation 2004; 77: 786-789
11. Dew MA, DiMartini AF, Vito Dabbs A, Myaskovsky L, Steel J, Unruh M, Switzer GE, Zomak R, Kormos RL, Greenhouse JB: Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007; 83: 858-873
12. Didlake RH, Dreyfus K, Kerman RH, Van Buren CT, Kahan BD: Patient noncompliance: a major cause of late graft failure in cyclosporine-treated renal transplants. Transplant Proc 1988; 20(3 suppl 3):63-69
13. Chisholm MA, Mulloy LL, Jagadeesan M, DiPiro JT: Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications. Clin Transplant 2001; 15: 330-336
14. Butkus DE, Meydrech EF, Raju SS: Racial differences in the survival of cadaveric renal allografts. Overriding effects of HLA matching and socioeconomic factors. N Engl J Med 1992; 327: 840-845
15. Chisholm MA, Kwong WJ, Spivey CA: Associations of characteristics of renal transplant recipients with clinicians' perceptions of adherence to immunosuppressant therapy. Transplantation 2007; 84: 1145-1150
16. Denhaerynck K, Steiger J, Bock A, Schafer-Keller P, Köfer S, Thannberger N, De Geest S: Prevalence and risk factors of non-adherence with immunosuppressive medication in kidney transplant patients. Am J Transplant 2007; 7: 108-116
17. Kiley DJ, Lam CS, Pollak R: A study of treatment compliance following kidney transplantation. Transplantation 1993; 55: 51-56
18. Rosenberger J, Geckova AM, van Dijk JP, Nagyova I, Roland R, van den Heuvel WJ, Groothoff JW: Prevalence and characteristics of noncompliant behaviour and its risk factors in kidney transplant recipients. Transpl Int 2005; 18: 1072-1078
19. Schweizer RT, Rovelli M, Palmeri D, Vossler E, Hull D, Bartus S: Noncompliance in organ transplant recipients. Transplantation 1990; 49: 374-377
20. Siegal BR, Greenstein SM: Postrenal transplant compliance from the perspective of African-Americans, Hispanic-Americans, and Anglo-Americans. Adv Ren Replace Ther 1997; 4: 46-54
21. Weng FL, Israni AK, Joffe MM, Hoy T, Gaughan CA, Newman M, Abrams JD, Kamoun M, Rosas SE, Mange KC, Strom BL, Brayman KL, Feldman HI: Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol 2005; 16: 1839-1848
22. Geest S, Borgermans L, Gemoets H, Abraham I, Vlaminck H, Evers G, Vanrenterghem Y: Incidence, determinants, and consequences of subclinical noncompliance with immunosuppressive therapy in renal transplant recipients. Transplantation 1995; 59: 340-347
23. Frazier P, Davis-Ali SH, Dahl KE: Correlates of noncompliance among renal transplant recipients. Clin Transplant 1994; 8: 550-557
24. Greenstein S, Siegal B: Compliance and noncompliance in patients with a functioning renal transplant: a multicenter study. Transplantation 1998; 66: 1718-1726
25. Chisholm MA, Lance CE, Mulloy LL: Patient factors associated with adherence to immunosuppressant therapy in renal transplant recipients. Am J Health Syst Pharm 2005; 62: 1775-1781
26. Chisholm MA, Lance CE, Williamson GM, Mulloy LL: Development and validation of the immunosuppressant therapy adherence instrument (ITAS). Patient Educ Couns 2005; 59: 13-20
27. Saha S, Freeman M, Toure J, Tippens KM, Weeks C: Racial and Ethnic Disparities in the VA Healthcare System: A Systematic Review. Washington, Department of Veterans Affairs (US), 2007, pp 423-431
28. Becker MH, Radius SM, Rosenstock IM, et al: Compliance with a medical regimen for asthma: a test of the health belief model. Public Health Rep 1978; 93: 268-277
29. Carpenter CJ: A meta-analysis of the effectiveness of health belief model variables in predicting behavior. Health Commun 2010; 25: 661-669
30. Jones CJ, Smith H, Llewellyn C: Evaluating the effectiveness of health belief model interventions in improving adherence: a systematic review. Health Psychol Rev 2014; 8: 253-269
31. Resnicow K, Jackson A, Wang T, De AK, Mc-Carty F, Dudley WN, Baranowski T: A motivational interviewing intervention to increase fruit and vegetable intake through Black churches: results of the eat for life trial. Am J Public Health 2001; 91: 1686-1693
32. Resnicow K, Baranowski T, Ahluwalia JS, Braithwaite RL: Cultural sensitivity in public health: defined and demystified. Ethn Dis 1999; 9: 10-21
33. Gordon EJ, Gallant M, Sehgal AR, Conti D, Siminoff LA: Medication-taking among adult renal transplant recipients: barriers and strategies. Transpl Int 2009; 22: 534-545
34. Constantiner M, Cukor D: Barriers to immunosuppressive medication adherence in highrisk adult renal transplant recipients. Dial Transplant 2011; 40: 60-66
35. Rosenthal Asher D, Ver Halen N, Cukor D: Depression and nonadherence predict mortality in hemodialysis treated end-stage renal disease patients. Hemodial Int 2012; 16: 387-393
36. Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X: Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008; 2:CD000011
37. Bleser L, Matteson M, Dobbels F, Russell C, Geest S: Interventions to improve medication-adherence after transplantation: a systematic review. Transpl Int 2009; 22: 780-797
38. Low JK, Williams A, Manias E, Crawford K: Interventions to improve medication adherence in adult kidney transplant recipients: a systematic review. Nephrol Dial Transplant 2014; 30: 752-761
39. Garcia MF, Bravin AM, Garcia PD, Contti MM, Nga HS, Takase HM, de Andrade LG: Behavioral measures to reduce non-adherence in renal transplant recipients: a prospective randomized controlled trial. Int Urol Nephrol 2015; 47: 1-7
40. Geest S, Schäfer-Keller P, Denhaerynck K, Thannberger N, Köfer S, Bock A, Surber C, Steiger J: Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant 2006; 20: 359-368
41. Russell C, Conn V, Ashbaugh C, Madsen R, Wakefield M, Webb A, Coffey D, Peace L: Taking immunosuppressive medications effectively (TIMELink): a pilot randomized controlled trial in adult kidney transplant recipients. Clin Transplant 2011; 25: 864-870
42. Russell CL: Culturally responsive interventions to enhance immunosuppressive medication adherence in older African American kidney transplant recipients. Prog Transplant 2006; 16: 187-195; quiz 196
43. Chisholm MA, Lance CE, Williamson GM, Mulloy LL: Development and validation of an immunosuppressant therapy adherence barrier instrument. Nephrol Dial Transplant 2005; 20: 181-188
44. Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, Dobbels F, Fargher E, Morrison V, Lewek P, Matyjaszczyk M, et al: A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 2012; 73: 691-705
45. Thompson N, Nazir N, Cox LS, et al: Unannounced telephone pill counts for assessing varenicline adherence in a pilot clinical trial. Patient Prefer Adherence 2011; 5: 475-482
46. Bangsberg DR: Monitoring adherence to HIV antiretroviral therapy in routine clinical practice: the past, the present, and the future. AIDS Behav 2006; 10: 249-251
47. Loghman-Adham M: Medication noncompliance in patients with chronic disease: issues in dialysis and renal transplantation. Am J Manag Care 2003; 9: 155-171
48. Rudd P, Byyny RL, Zachary V, et al: Pill count measures of compliance in a drug trial: variability and suitability. Am J Hypertens 1988; 1(3 pt 1):309-312
49. van Onzenoort HA, Verberk WJ, Kessels AG, et al: Assessing medication adherence simultaneously by electronic monitoring and pill count in patients with mild-to-moderate hypertension. Am J Hypertens 2010; 23: 149-154
50. Kalichman SC, Amaral CM, Stearns H, White D, Flanagan J, Pope H, Cherry C, Cain D, Eaton L, Kalichman MO: Adherence to antiretroviral therapy assessed by unannounced pill counts conducted by telephone. J Gen Intern Med 2007; 22: 1003-1006
51. Kalichman SC, Amaral CM, Cherry C, Flanagan J, Pope H, Eaton L, Kalichman MO, Cain D, Detorio M, Caliendo A, Schinazi RF: Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity. HIV Clin Trials 2008; 9: 298-308
52. Bangsberg DR, Hecht FM, Charlebois ED, Chesney M, Moss A: Comparing objective measures of adherence to HIV antiretroviral therapy: electronic medication monitors and unannounced pill counts. AIDS Behav 2001; 5: 275-281
53. Ihara H, Shinkuma D, Ichikawa Y, Nojima M, Nagano S, Ikoma F: Intra-and interindividual variation in the pharmacokinetics of tacrolimus (FK506) in kidney transplant recipients-importance of trough level as a practical indicator. Int J Urol 1995; 2: 151-155
54. Beck AT, Steer RA, Carbin MG: Psychometric properties of the beck depression inventory: twenty-five years of evaluation. Clin Psy Rev 1988; 8: 77-100
55. Pinsky BW, Takemoto SK, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR: Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant 2009; 9: 2597-2606
56. Nevins TE, Kruse L, Skeans MA, Thomas W: The natural history of azathioprine compliance after renal transplantation. Kidney Int 2001; 60: 1565-1570
57. Takemoto SK, Pinsky BW, Schnitzler MA, et al: A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007; 7: 2704-2711
58. Schäfer-Keller P, Steiger J, Bock A, Denhaerynck K, De Geest S: Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008; 8: 616-626
59. Beck AT: The current state of cognitive therapy: a 40-year retrospective. Arch Gen Psychiatry 2005; 62: 953-959
60. Meichenbaum D: Cognitive behaviour modification. Cognitive Behav Ther 1977; 6: 185-192
61. Beck JS: Cognitive Behavior Therapy: Basics and Beyond. Guilford Press, 2011
62. Rollnick S, Miller WR, Butler CC: Motivational Interviewing in Health Care: Helping Patients Change Behavior. New York, The Guilford Press, 2008
63. Rubak S, Sandbaek A, Lauritzen T, Christensen B: Motivational interviewing: a systematic review and meta-analysis. Br J Gen Pract 2005; 55: 305-312
64. Burke BL, Arkowitz H, Menchola M: The efficacy of motivational interviewing: a metaanalysis of controlled clinical trials. J Consult Clin Psychol 2003; 71: 843-861
65. Freedland KE, Mohr DC, Davidson KW, Schwartz JE: Usual and unusual care: existing practice control groups in randomized controlled trials of behavioral interventions. Psychosom Med 2011; 73: 323-335
66. Pollock-BarZiv SM, Finkelstein Y, Manlhiot C, Dipchand AI, Hebert D, Ng VL, Solomon M, McCrindle BW, Grant D: Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children. Pediatr Transplant 2010; 14: 968-975
67. Chisholm MA: Enhancing transplant patients' adherence to medication therapy. Clin Transplant 2002; 16: 30-38
68. Muehrer RJ, Becker BN: Life after transplantation: new transitions in quality of life and psychological distress. Semin Dial 2005; 18: 124-131
69. Wainwright SP, Fallon M, Gould D: Psychosocial recovery from adult kidney transplantation: a literature review. J Clin Nurs 1999; 8: 233-245