Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression

American Journal of Transplantation

Volumn 9, Issue 11, 2009, Pages 2597-2606

  Pinsky, B W ^a   Takemoto, S K ^b   Lentine, K L ^a   Burroughs, T E ^a   Schnitzler, M A ^a   Salvalaggio, P R ^a,c  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adherence; Compliance; Costs; Graft survival; Immunosuppressant adherence; Immunosuppression; Kidney; Patient survival

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ADOLESCENT; ADULT; ALLOGRAFT; ARTICLE; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; GRAFT RECIPIENT; GRAFT REJECTION; HEALTH CARE COST; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDICARE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATIENT COMPLIANCE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SURGICAL INFECTION; SURVIVAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HEALTH CARE COSTS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INFANT, NEWBORN; KAPLAN-MEIERS ESTIMATE; KIDNEY TRANSPLANTATION; LOGISTIC MODELS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEX DISTRIBUTION; YOUNG ADULT;

EID: 70350126613     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02798.x     Document Type: Article

References (23)

1. Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: A systematic review. Transplantation 2004 77 : 769 776.
2. Denhaerynck K, Dobbels F, Cleemput I et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: A literature review. Transpl Int 2005 18 : 1121 1133.
3. Ettenger RB, Rosenthal JT, Marik JL et al. Improved cadaveric renal transplant outcome in children. Pediatr Nephrol 1991 5 : 137 142.
4. Griffin KJ, Elkin TD. Non-adherence in pediatric transplantation: A review of the existing literature. Pediatr Transplant 2001 5 : 246 249.
5. Jarzembowski T, John E, Panaro F et al. Impact of non-compliance on outcome after pediatric kidney transplantation: An analysis in racial subgroups. Pediatr Transplant 2004 8 : 367 371.
6. Chisholm MA. Issues of adherence to immunosuppressant therapy after solid-organ transplantation. Drugs 2002 62 : 567 575.
7. Butler JA, Peveler RC, Roderick P, Smith PW, Horne R, Mason JC. Modifiable risk factors for non-adherence to immunosuppressants in renal transplant recipients: A cross-sectional study. Nephrol Dial Transplant 2004 19 : 3144 3149.
8. De Geest S, Schafer-Keller P, Denhaerynck K et al. Supporting medication adherence in renal transplantation (SMART): A pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant 2006 20 : 359 368.
9. Nevins TE, Kruse L, Skeans MA, Thomas W. The natural history of azathioprine compliance after renal transplantation. Kidney Int 2001 60 : 1565 1570.
10. Chisholm M, Lance C, Mulloy L. Patient factors associated with adherence to immunosuppressant therapy in renal transplant recipients. Am J Health Syst Pharm 2006 62 : 1775 1781.
11. Denhaerynck K, Steiger J, Bock A et al. Prevalence and risk factors of non-adherence with immunosuppressive medication in kidney transplant patients. Am J Transplant 2007 7 : 108 116.
12. Sikka R, Xia F, Aubert RE. Estimating medication persistency using administrative claims data. Am J Manag Care 2005 11 : 449 457.
13. Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health 2007 10 : 3 12.
14. Takemoto SK, Pinsky BW, Schnitzler MA et al. A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007 7 : 2704 2711.
15. World Health Organization 2003. Adherence to Longterm Therapies: Evidence for action. Available from : http://www.who.int/chp/knowledge/publications/ adherence-full-report.pdf. Accessed May 9, 2009.
16. Stirnemann PM, Takemoto SK, Schnitzler MA et al. Agreement of immunosuppression regimens described in Medicare pharmacy claims with the organ procurement and transplantation network survey. J Am Soc Nephrol 2006 17 : 2299 2306.
17. Buchanan PM, Schnitzler MA, Brennan DC et al. Novel methods for tracking long-term maintenance immunosuppression regimens. Clin J Am Soc Nephrol 2008 3 : 117 124.
18. Schnitzler MA, Hollenbeak CS, Cohen DS et al. The economic implications of HLA matching in cadaveric renal transplantation. N Engl J Med 1999 341 : 1440 1446.
19. Hardinger KL, Brennan DC, Lowell J, Schnitzler MA. Long-term outcome of gastrointestinal complications in renal transplant patients treated with mycophenolate mofetil. Transpl Int 2004 17 : 609 616.
20. Lentine KL, Brennan DC, Schnitzler MA. Incidence and predictors of myocardial infarction after kidney transplantation. J Am Soc Nephrol 2005 16 : 496 506.
21. Lentine KL, Schnitzler MA, Abbott KC et al. De novo congestive heart failure after kidney transplantation: A common condition with poor prognostic implications. Am J Kidney Dis 2005 46 : 720 733.
22. Woodward RS, Schnitzler MA, Baty J et al. Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients. Am J Transplant 2003 3 : 590 598.
23. Vlaminck H, Maes B, Evers G et al. Prospective study on late consequences of subclinical non-compliance with immunosuppressive therapy in renal transplant patients. Am J Transplant 2004 4 : 1509 1513.