Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients

American Journal of Transplantation

Volumn 8, Issue 3, 2008, Pages 616-626

  Schafer Keller P ^a,b   Steiger, J ^b   Bock, A ^c   Denhaerynck, K ^a   De Geest, S ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

Diagnostic value; Kidney transplantation; Medication adherence; Medication compliance

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADULT; AGED; ARTICLE; DIAGNOSTIC ACCURACY; DRUG DETERMINATION; DRUG MONITORING; FEMALE; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PREVALENCE; PRIORITY JOURNAL; SCORING SYSTEM; SELF REPORT; SENSITIVITY AND SPECIFICITY; TREATMENT REFUSAL;

ADULT; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DRUG MONITORING; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; TREATMENT REFUSAL;

EID: 39649101043     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.02127.x     Document Type: Article

References (59)

1. Denhaerynck K, Dobbels F, Cleemput I et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: A literature review. Transpl Int 2005 18 : 1121 1133.
2. Nevins TE, Kruse L, Skeans MA, Thomas W. The natural history of azathioprine compliance after renal transplantation. Kidney Int 2001 60 : 1565 1570.
3. Morrissey PE, Reinert S, Yango A, Gautam A, Monaco A, Gohh R. Factors contributing to acute rejection in renal transplantation: The role of noncompliance. Transplant Proc 2005 37 : 2044 2047.
4. Dickenmann MJ, Nickeleit V, Tsinalis D, Gurke L, Mihatsch MJ, Thiel G. Why do kidney grafts fail?A long-term single-center experience. Transpl Int 2002 15 : 508 514.
5. Cleemput I, Kesteloot K, Vanrenterghem Y, De Geest S. The economic implications of non-adherence after renal transplantation. Pharmacoeconomics 2004 22 : 1217 1234.
6. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005 353 : 487 497.
7. Farmer KC. Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 1999 21 : 1074 1090 discussion 1073.
8. Dunbar-Jacob J, Sereika S, Rohay JM, Burke LE. Electronic methods in assessing adherence to medical regimens. In : Krantz D, Baum A eds). Technology and methods in behavioral medicine. Mahwah, NJ : Lawrence Erlbaum Associates 1998 : 95 113.
9. Troppmann C, Benedetti E, Gruessner RW et al. Retransplantation after renal allograft loss due to noncompliance. Indications, outcome, and ethical concerns. Transplantation 1995 59 : 467 471.
10. De Geest S, Vanhaecke J. Methodological issues in transplant compliance research. Transplant Proc 1999 31 : 81S 83S.
11. Feinstein AR. On white-coat effects and the electronic monitoring of compliance. Arch Intern Med 1990 150 : 1377 1378.
12. O'Carroll RE, McGregor LM, Swanson V, Masterton G, Hayes PC. Adherence to medication after liver transplantation in Scotland: a pilot study. Liver Transpl 2006 12 : 1862 1868.
13. Butler JA, Peveler RC, Roderick P, Horne R, Mason JC. Measuring compliance with drug regimens after renal transplantation: Comparison of self-report and clinician rating with electronic monitoring. Transplantation 2004 77 : 786 789.
14. Shemesh E, Shneider BL, Savitzky JK et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004 113 : 825 832.
15. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: Methods, validity, and applications. J Clin Epidemiol 1997 50 : 105 116.
16. Achille MA, Ouellette A, Fournier S, Vachon M, Hebert MJ. Impact of stress, distress and feelings of indebtedness on adherence to immunosuppressants following kidney transplantation. Clin Transplant 2006 20 : 301 306.
17. McAllister S, Buckner EB, White-Williams C. Medication adherence after heart transplantation: Adolescents and their issues. Prog Transplant 2006 16 : 317 323.
18. Vlaminck H, Maes B, Evers G et al. Prospective study on late consequences of subclinical non-compliance with immunosuppressive therapy in renal transplant patients. Am J Transplant 2004 4 : 1509 1513.
19. Penkower L, Dew MA, Ellis D, Sereika SM, Kitutu JM, Shapiro R. Psychological distress and adherence to the medical regimen among adolescent renal transplant recipients. Am J Transplant 2003 3 : 1418 1425.
20. Siegal B, Halbert RJ, McGuire MJ. Life satisfaction among kidney transplant recipients: Demographic and biological factors. Prog Transplant 2002 12 : 293 298.
21. Dew MA, Kormos RL, Roth LH, Murali S, DiMartini A, Griffith BP. Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation. J Heart Lung Transplant 1999 18 : 549 562.
22. Raiz LR, Kilty KM, Henry ML, Ferguson RM. Medication compliance following renal transplantation. Transplantation 1999 68 : 51 55.
23. Paris W, Dunham S, Sebastian A, Jacobs C, Nour B. Medication nonadherence and its relation to financial restriction. J Transpl Coord 1999 9 : 149 152.
24. Greenstein S, Siegal B. Compliance and noncompliance in patients with a functioning renal transplant: A multicenter study. Transplantation 1998 66 : 1718 1726.
25. Meyers KE, Thomson PD, Weiland H. Noncompliance in children and adolescents after renal transplantation. Transplantation 1996 62 : 186 189.
26. De Geest S, Borgermans L, Gemoets H et al. Incidence, determinants, and consequences of subclinical noncompliance with immunosuppressive therapy in renal transplant recipients. Transplantation 1995 59 : 340 347.
27. Frazier PA, Davis-Ali SH, Dahl KE. Correlates of noncompliance among renal transplant recipients. Clin Transplant 1994 8 : 550 557.
28. Kiley DJ, Lam CS, Pollak R. A study of treatment compliance following kidney transplantation. Transplantation 1993 55 : 51 56.
29. Chisholm MA, Vollenweider LJ, Mulloy LL et al. Renal transplant patient compliance with free immunosuppressive medications. Transplantation 2000 70 : 1240 1244.
30. Takemoto SK, Pinsky BW, Schnitzler MA et al. A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007 7 : 2704 2711.
31. Hilbrands LB, Hoitsma AJ, Koene RA. Medication compliance after renal transplantation. Transplantation 1995 60 : 914 920.
32. Burke LE. Electronic measurement. In : Burke LE, Ockene IS eds). Compliance in Healthcare and Research. Armonk : Futura Publishing Co. 2001 : 117 138.
33. Cramer JA. Microelectronic systems for monitoring and enhancing patient compliance with medication regimens. Drugs 1995 49 : 321 327.
34. Denhaerynck K, Schäfer-Keller P, Young J et al. Challenging electronic medication monitoring as gold standard: A test of its assumptions. BMC Medical Research Methodology submitted.
35. Riekert R. Electronic monitoring of medication adherence: When is high-tech best? J Clin Psychol Med Settings 2002 9 : 25 34.
36. Deschamps AE, Van Wijngaerden E, Denhaerynck K, De Geest S, Vandamme AM. Use of electronic monitoring induces a 40-day intervention effect in HIV patients. J Acquir Immune Defic Syndr 2006 43 : 247 248.
37. Denhaerynck K, Steiger J, Bock A et al. Prevalence and risk factors of non-adherence with immunosuppressive medication in kidney transplant patients. Am J Transplant 2007 7 : 108 116.
38. Russell CL, Conn VS, Ashbaugh C, Madsen R, Hayes K, Ross G. Medication adherence patterns in adult renal transplant recipients. Res Nurs Health 2006 29 : 521 532.
39. Weng FL, Israni AK, Joffe MM et al. Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol 2005 16 : 1839 1848.
40. Dobbels F, De Geest S, van Cleemput J, Droogne W, Vanhaecke J. Effect of late medication non-compliance on outcome after heart transplantation: A 5-year follow-up. J Heart Lung Transplant 2004 23 : 1245 1251.
41. De Geest S, Dobbels F, Martin S, Willems K, Vanhaecke J. Clinical risk associated with appointment noncompliance in heart transplant recipients. Prog Transplant 2000 10 : 162 168.
42. De Geest S. Subclinical noncompliance with immunosuppressive therapy in heart transplant recipients. A cluster analytic study. Leuven : Catholic University Leuven 1998.
43. Grosset KA, Bone I, Reid JL, Grosset D. Measuring therapy adherence in Parkinson's disease: A comparison of methods. J Neurol Neurosurg Psychiatry 2006 77 : 249 251.
44. Liu H, Golin CE, Miller LG et al. A comparison study of multiple measures of adherence to HIV protease inhibitors. Ann Intern Med 2001 134 : 968 977.
45. Miller LG, Liu H, Hays RD et al. How well do clinicians estimate patients' adherence to combination antiretroviral therapy? J Gen Intern Med 2002 17 : 1 11.
46. Deschamps AE, De Saar V, Graeve VD et al. Diagnostic value of measurement methods of adherence to HAART in HIV-infected patients. In : 14th international AIDS conference; 2002; Barcelona 2002.
47. George CF, Peveler RC, Heiliger S, Thompson C. Compliance with tricyclic antidepressants: The value of four different methods of assessment. Br J Clin Pharmacol 2000 50 : 166 171.
48. Bossuyt PM, Reitsma JB, Bruns DE et al. Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Ann Intern Med 2003 138 : 40 44.
49. De Geest S, Denhaerynck K, Schäfer-Keller P, Bock A, Steiger J. Supporting Medication Adherence in Renal Transplantation - the SMART study. Swiss Med Wkly (in press).
50. De Geest S, Schafer-Keller P, Denhaerynck K et al. Supporting medication adherence in renal transplantation (SMART): A pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant 2006 20 : 359 368.
51. Flippin MS, Canter CE, Balzer DT. Increased morbidity and high variability of cyclosporine levels in pediatric heart transplant recipients. J Heart Lung Transplant 2000 19 : 343 349.
52. Siegal BR. Postrenal transplant compliance:report of 519 responses to a self-report questionnaire. Transplant Proc 1993 25 : 2502.
53. Hilbert GA. Accuracy of self-reported measures of compliance. Nurs Res 1985 34 : 319 320.
54. De Geest S, Abraham I, Moons P et al. Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. J Heart Lung Transplant 1998 17 : 854 863.
55. De Geest S, Moons P, Dobbels F, Martin S, Vanhaecke J. Profiles of patients who experienced a late acute rejection due to nonadherence with immunosuppressive therapy. J Cardiovasc Nurs 2001 16 : 1 14.
56. Alcoba M, Cuevas MJ, Perez-Simon MR et al. Assessment of adherence to triple antiretroviral treatment including indinavir: Role of the determination of plasma levels of indinavir. J Acquir Immune Defic Syndr 2003 33 : 253 258.
57. Hugen PW, Langebeek N, Burger DM et al. Assessment of adherence to HIV protease inhibitors: Comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring. J Acquir Immune Defic Syndr 2002 30 : 324 334.
58. Dunbar-Jacob J, Schlenk EA. Patient Adherence to treatment regimen. In : Baum A, Revenson TA, Singer JE eds). Handbook of health psychology. Hillsdale, NJ : Lawrence Erlbaum Associates 2000 : 571 580.
59. McNabb JJ, Nicolau DP, Stoner JA, Ross J. Patterns of adherence to antiretroviral medications: The value of electronic monitoring. AIDS 2003 17 : 1763 1767.