Erythritol Is More Effective Than Xylitol and Sorbitol in Managing Oral Health Endpoints

International Journal of Dentistry

Volumn 2016, Issue , 2016, Pages

  De Cock, Peter ^a   Mäkinen, Kauko ^b   Honkala, Eino ^b   Saag, Mare ^c   Kennepohl, Elke ^d   Eapen, Alex ^e  

^a Cargill R D Centre Europe   (Belgium)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF TARTU   (Estonia)

^d Equinox Scientific Services   (Canada)

^e CARGILL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84986332622     PISSN: 16878728     EISSN: 16878736     Source Type: Journal    
DOI: 10.1155/2016/9868421     Document Type: Review

References (60)

1. D. C. P. Erythritol, Sweeteners and Sugar Alternatives in Food Technology, Edited by K. O'Donnell, M. Kearsley, Wiley-Blackwell, 2012.
2. K. Sugita and M. Yamazaki, "Sweetness of erythritol and its use for foodstuf, " Gakkuen (Internal report of Showa Women's University), 1988.
3. J. Goossens and H. Röper, "Erythritol: a new bulk sweetener, " International Food Ingredients, vol. 1-2, pp. 27-33, 1994.
4. F. R. J. Bornet, A. Blayo, F. Dauchy, and G. Slama, "Gastrointestinal response and plasma and urine determinations in human subjects given erythritol, " Regulatory Toxicology and Pharmacology, vol. 24, part 2, pp. S296-S302, 1996.
5. I. C. Munro, W. O. Bernt, J. F. Borzelleca et al., "Erythritol: an interpretive summary of biochemical, metabolic, toxicological and clinical data, " Food and Chemical Toxicology, vol. 36, no. 12, pp. 1139-1174, 1998.
6. JECFA, Safety Evaluation of Certain Food Additives and Contaminants, WHO Food Additive Series, No. 44, Joint FAO/WHO Expert Committee on Food Additives, 1999.
7. J. Kawanabe, M. Hirasawa, T. Takeuchi, T. Oda, and T. Ikeda, "Noncariogenicity of erythritol as a substrate, " Caries Research, vol. 26, no. 5, pp. 358-362, 1992.
8. K. K. Mäkinen, K. P. Isotupa, T. Kivilompolo, P. L. Mäkinen, J. Toivanen, and E. Söderling, "Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci, " Caries Research, vol. 35, no. 2, pp. 129-135, 2001.
9. K. K. Mäkinen, K. P. Isotupa, T. Kivilompolo et al., "The effect of polyol-combinant saliva stimulants on S. mutans levels in plaque and saliva of patients with mental retardation, " Special Care in Dentistry, vol. 22, no. 5, pp. 187-193, 2002.
10. K. K. Mäkinen, M. Saag, K. P. Isotupa et al., "Similarity of the effects of erythritol and xylitol on some risk factors of dental caries, " Caries Research, vol. 39, no. 3, pp. 207-215, 2005.
11. E. M. Söderling and A.-M. Hietala-Lenkkeri, "Xylitol and erythritol decrease adherence of polysaccharide-producing oral streptococci, " Current Microbiology, vol. 60, no. 1, pp. 25-29, 2010.
12. J. Yao, J.-L. Zhang, Y.-Q. Wu, and Z.-J. Lu, "Contrasting study of erythritol and xylitol on Streptococcus mutans, " Hua Xi Kou Qiang Yi Xue Za Zhi, vol. 27, no. 6, pp. 603-605, 2009.
13. K. White, C. Le, M. Cannon et al., "Inhibition of Streptococcus mutans and sobrinus by xylitol and erythritol (poster), " in Proceedings of the 93rd General Session of the International Association for Dental Research, Boston, Mass, USA, 2015.
14. G. R. Ghezelbash, I. Nahvi, and M. Rabbani, "Comparative inhibitory effect of xylitol and erythritol on the growth and bioflm formation of oral Streptococci, " African Journal of Microbiology Research, vol. 6, no. 20, pp. 4404-4408, 2012.
15. S. Saran, S. Mukherjee, J. Dalal, and R. K. Saxena, "High production of erythritol from Candida sorbosivorans SSE-24 and its inhibitory effect on bioflm formation of Streptococcus mutans, " Bioresource Technology, vol. 198, pp. 31-38, 2015.
16. E. Hashino, M. Kuboniwa, S. A. Alghamdi et al., "Erythritol alters microstructure and metabolomic profiles of bioflm composed of Streptococcus gordonii and Porphyromonas gingivalis, " Molecular Oral Microbiology, vol. 28, no. 6, pp. 435-451, 2013.
17. Y.-N. Park, S.-S. Jeong, J. Zeng et al., "Anti-cariogenic effects of erythritol on growth and adhesion of Streptococcus mutans, " Food Science and Biotechnology, vol. 23, no. 5, pp. 1587-1591, 2014.
18. D. M. P. H. J. Boesten, G. J. M. den Hartog, P. de Cock, D. Bosscher, A. Bonnema, and A. Bast, "Health effects of erythritol, " Nutrafoods, vol. 14, no. 1, pp. 3-9, 2015.
19. Euromonitor, Ingredients: Euromonitor International from Trade Interviews and Industry Sources, Euromonitor International Database, 2014.
20. W. O. Bernt, J. F. Borzelleca, G. Flamm, and I. C. Munro, "Erythritol: a review of biological and toxicological studies, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S191-S197, 1996.
21. B. A. R. Lina, M. H. M. Bos-Kuijpers, H. P. Til, and A. Bär, "Chronic toxicity and carcinogenicity study of erythritol in rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, pp. S264-S279, 1996.
22. K. Noda, K. Nakayama, and J. Modderman, "Fate of erythritol afer single oral administration to rats and dogs, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, pp. S206-S213, 1996.
23. A. E. Smits-van Prooije, D. H. Waalkens-Berendsen, and A. Bär, "Embryotoxicity and teratogenicity study with erythritol in rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S232-S236, 1996.
24. W. Tetzlof, F. Dauchy, S. Medimagh, D. Carr, and A. Bär, "Tolerance to subchronic, high-dose ingestion of erythritol in human volunteers, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S286-S295, 1996.
25. H. P. Til, C. F. Kuper, H. E. Falke, and A. Bär, "Subchronic oral toxicity studies with erythritol in mice and rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S221-S231, 1996.
26. H. P. Til and J. Modderman, "Four-week oral toxicity study with erythritol in rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S214-S220, 1996.
27. 14C-erythritol in germfree and conventional rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, pp. S198-S205, 1996.
28. D. H. Waalkens-Berendsen, A. E. Smits-Van Prooije, M. V. M. Wijnands, and A. Bär, "Two-generation reproduction study of erythritol in rats, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S237-S246, 1996.
29. M. Shimizu, M. Katoh, M. Imamura, and J. Modderman, "Theratology study of erythritol in rabbits, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S247-S253, 1996.
30. I. Dean, F. Jackson, and R. J. Greenough, "Chronic (1-year) oral toxicity study of erythritol in dogs, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S254-S260, 1996.
31. Y. Kawamura, Y. Saito, M. Imamura, and J. P. Modderman, "Mutagenicity studies on erythritol in bacterial reversion assay systems and in Chinese hamster fbroblast cells, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S261-S263, 1996.
32. F. R. J. Bornet, A. Blayo, F. Dauchy, and G. Slama, "Plasma and urine kinetics of erythritol afer oral ingestion by healthy humans, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S280-S285, 1996.
33. M. Ishikawa, M. Miyashita, Y. Kawashima, T. Nakamura, N. Saitou, and J. Modderman, "Effects of oral administration of erythritol on patients with diabetes, " Regulatory Toxicology and Pharmacology, vol. 24, no. 2, part 2, pp. S303-S308, 1996.
34. D. Storey, A. Lee, F. Bornet, and F. Brouns, "Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid, " European Journal of Clinical Nutrition, vol. 61, no. 3, pp. 349-354, 2007.
35. E. Jacqz-Aigrain, B. Kassai, C. Cornu et al., "Gastrointestinal tolerance of erythritol-containing beverage in young children: a double-blind, randomised controlled trial, " European Journal of Clinical Nutrition, vol. 69, no. 6, pp. 746-751, 2016.
36. K. K. Mäkinen, "Sugar alcohol sweeteners as alternatives to sugar with special consideration of xylitol, " Medical Principles and Practice, vol. 20, no. 4, pp. 303-320, 2011.
37. S. Honkala, R. Runnel, M. Saag et al., "Effect of erythritol and xylitol on dental caries prevention in children, " Caries Research, vol. 48, no. 5, pp. 482-490, 2014.
38. K. K. Mäkinen, "Sugar alcohols, caries incidence, and rem-ineralization of caries lesions: a literature review, " International Journal of Dentistry, vol. 2010, Article ID 981072, 23 pages, 2010.
39. A. I. Ismail, W. Sohn, M. Tellez et al., "The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries: Methods, " Community Dentistry and Oral Epidemiology, vol. 35, no. 3, pp. 170-178, 2007.
40. R. Runnel, K. K. Mäkinen, S. Honkala et al., "Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables, " Journal of Dentistry, vol. 41, no. 12, pp. 1236-1244, 2013.
41. A.-M. Hietala-Lenkkeri, K. Pienihäkkinen, S. Hurme, and P. Alanen, "The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fuoridation, " International Journal of Paediatric Dentistry, vol. 22, no. 3, pp. 180-190, 2012.
42. K. K. Mäkinen, C. A. Bennett, P. P. Hujoel et al., "Xylitol chewing gums and caries rates: a 40-month cohort study, " Journal of Dental Research, vol. 74, no. 12, pp. 1904-1913, 1995.
43. K. K. Mäkinen, P. P. Hujoel, C. A. Bennett, K. P. Isotupa, P.-L. Mäkinen, and P. Allen, "Polyol chewing gums and caries rates in primary dentition: a 24-month cohort study, " Caries Research, vol. 30, no. 6, pp. 408-417, 1996.
44. K. K. Mäkinen, D. Pemberton, P. L. Mäkinen et al., "Polyol-combinant saliva stimulants and oral health in Veterans Afairs patients-an exploratory study, " Special Care in Dentistry, vol. 16, no. 3, pp. 104-115, 1996.
45. V. Machiulskiene, B. Nyvad, and V. Baelum, "Caries preventive effect of sugar-substituted chewing gum, " Community Dentistry and Oral Epidemiology, vol. 29, no. 4, pp. 278-288, 2001.
46. C. Dawes and L. M. Macpherson, "Effects of nine diferent chewing-gums and lozenges on salivary fow rate and pH, " Caries Research, vol. 26, no. 3, pp. 176-182, 1992.
47. B. G. Duane, "No evidence of caries reduction found in a school xylitol and erythritol lozenge programme, " Evidence-Based Dentistry, vol. 12, no. 4, pp. 102-103, 2011.
48. T. F. Flemmig, G. J. Petersilka, A. Mehl, R. Hickel, and B. Klaiber, "The effect of working parameters on root substance removal using a piezoelectric ultrasonic scaler in vitro, " Journal of Clinical Periodontology, vol. 25, no. 2, pp. 158-163, 1998.
49. T. T. Hägi, P. Hofmänner, G. E. Salvi, C. A. Ramseier, and A. Sculean, "Clinical outcomes following subgingival application of a novel erythritol powder by means of air polishing in supportive periodontal therapy: a randomized, controlled clinical study, " Quintessence International, vol. 44, no. 10, pp. 753-761, 2013.
50. T. Kocher, J. Fanghänel, H. Sawaf, and R. Litz, "Substance loss caused by scaling with diferent sonic scaler inserts-an in vitro study, " Journal of Clinical Periodontology, vol. 28, no. 1, pp. 9-15, 2001.
51. L. Ritz, A. F. Hefi, and K. H. Rateitschak, "An in vitro investigation on the loss of root substance in scaling with various instruments, " Journal of Clinical Periodontology, vol. 18, no. 9, pp. 643-647, 1991.
52. U. Zappa, B. Smith, C. Simona, H. Graf, D. Case, and W. Kim, "Root substance removal by scaling and root planing, " Journal of Periodontology, vol. 62, no. 12, pp. 750-754, 1991.
53. R. Moëne, F. Décaillet, E. Andersen, and A. Mombelli, "Subgin-gival plaque removal using a new air-polishing device, " Journal of Periodontology, vol. 81, no. 1, pp. 79-88, 2010.
54. T. T. Hägi, P. Hofmanner, S. Eick et al., "The effects of erythritol air-polishing powder on microbiologic and clinical outcomes during supportive periodontal therapy: six-month results of a randomized controlled clinical trial, " Quintessence International, vol. 46, no. 1, pp. 31-41, 2015.
55. N. Müller, R. Möene, J. A. Cancela, and A. Mombelli, "Subgin-gival air-polishing with erythritol during periodontal maintenance: randomized clinical trial of twelve months, " Journal of Clinical Periodontology, vol. 41, no. 9, pp. 883-889, 2014.
56. L. Drago, M. Del Fabbro, M. Bortolin, C. Vassena, E. De Vecchi, and S. Taschieri, "Bioflm removal and antimicrobial activity of two diferent air-polishing powders: an in vitro study, " Journal of Periodontology, vol. 85, no. 11, pp. e363-e369, 2014.
57. C. J. Carr and J. C. Krantz Jr., "Metabolism of the sugar alcohols and their derivatives, " Advances in Carbohydrate Chemistry, vol. 1, pp. 175-192, 1945.
58. J. Kawanabe, "Non-cariogenicity of erythritol as a substrate, " Nichidai Koku Kagaku, vol. 16, no. 1, pp. 27-36, 1990.
59. J. Goossens and M. Gonze, "Nutritional properties and applications of erythritol: a unique combination?" in Advances in Sweeteners, T. H. Grenby, Ed., pp. 150-186, Springer, Boston, Mass, USA, 1996.
60. P. Lif Holgerson, C. Steckśen-Blicks, I. Sjöström, M. Ö berg, and S. Twetman, "Xylitol concentration in saliva and dental plaque afer use of various xylitol-containing products, " Caries Research, vol. 40, no. 5, pp. 393-397, 2006.