Chronic toxicity and carcinogenicity study of erythritol in rats

Regulatory Toxicology and Pharmacology

Volumn 24, Issue 2 II, 1996, Pages

  Lina, B A R ^a   Bos Kuijpers, M H M ^a   Til, H P ^a   Bar A ^b  

^a TNO   (Netherlands)

^b Bioresco AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHRITOL;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONTROLLED STUDY; FEMALE; KIDNEY CALCIFICATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029823669     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1996.0108     Document Type: Article

References (29)

1. Bär, A., Til, H. P., and Timonen, M. (1995). Subchronic oral toxicity study with regular and enzymatically depolymerized sodium carboxymethyl cellulose in rats. Food Chem. Toxicol. 33, 909-917.
2. Beck, F. F., Carr, C. J., and Krantz, J. C. (1936). Acute toxicity of certain sugar alcohols and their anhydrides. Proc. Soc. Exp. Biol. Med. 35, 98-99.
3. Beck, F. F., Carr, C. J., and Krantz, J. C. (1938). Sugar alcohols XVI. The fate of erythritol and erythritan in the animal body. Q. J. Pharm. Pharmacol. 11, 234-239.
4. Blijleven, W. G. H. (1990). Examination of erythritol for mutagenic activity in the Ames test. Unpublished Report No. V90.306 from TNO-CIVO Institutes, Zeist, The Netherlands.
5. Bomhard, E., Maruhn, D., and Mager, H. (1991). Excretion of urinary enzymes in female Sprague-Dawley rats in relation to cellular compartment, creatinine excretion and diuresis. Eur. J. Clin. Chem. Clin. Biochem. 29, 775-782.
6. Bornet, F., Dauchy, F., Chevalier, A., and Slama, G. (1992). Étude du devenir métabolique, après ingestion chez l'homme sain, d'un nouvel édulcorant de charge basse calorie: l'érythritol. Gastroenterol. Clin. Biol. 16, A169.
7. Dean, I., Jackson, F., and Greenough, R. J. (1996). Chronic (1-year) oral toxicity study of erythritol in dogs. Regul. Toxicol. Pharmacol., in press.
8. 51Cr-labelled ethylenediaminetetra-acetate as markers of intestinal permeability in man. Clin. Sci. 73, 197-204.
9. Fent, K., Mayer, E., and Zbinden, G. (1988). Nephrotoxicity screening in rats: A validation study. Arch. Toxicol. 61, 349-358.
10. Feron, V. J., De Groot, A. P., Spanjers, M. T., and Til, H. P. (1973). An evaluation of the criterion "organ weight" under conditions of growth retardation. Food Cosmet. Toxicol. 11, 85-94.
11. Gennari, F. J., and Kassirer, J. P. (1974). Osmotic diuresis. N. Engl. J. Med. 291, 714-720.
12. Hämäläinen, M. M., and Mäkinen, K. K. (1986). Alterations in electrolyte and iron metabolism in the rat in relation to peroral administration of galactitol, mannitol and xylitol. J. Nutr. 116, 599-609.
13. Hiele, M., Ghoos, Y., Rutgeerts, P., and Vantrappen, G. (1993). Metabolism of erythritol in humans: Comparison with glucose and lactitol. Br. J. Nutr. 69, 169-176.
14. Hohenegger, M., and Raab, W. (1970). Das Verhalten der Enzymaktivitäten im Harn bei Veränderung der Wasser-und lonenausscheidung. Clin. Chim. Acta 28, 61-65.
15. Jösch, W., and Dubach, U. C. (1967). Einfluss der Diurese auf' die Enzymurie. Clin. Chim. Acta 15, 325-330.
16. Kawanabe, J., Hirasawa, M., Takeuchi, T., Oda, T., and Ikeda, T. (1992). Noncariogenicity of erythritol as a substrate. Caries Res. 26, 358-362.
17. LSRO (1986). Health aspects of sugar alcohols and lactose. Report No. FDA 223-83-2020.
18. Newberne, P. M., Conner, M. W., and Estes, P. (1988). The influence of food additives and related materials on lower bowel structure and function. Toxicol. Pathol. 16, 184-197.
19. Noda, K., Nakayama, K., and Oku, T. (1994). Serum glucose and insulin levels and erythritol balance after oral administration of erythritol in healthy subjects. Eur. J. Clin. Nutr. 48, 286-292.
20. Noda, K., and Oku, T. (1992). Metabolism and disposition of erythritol after oral administration to rats. J. Nutr. 122, 1266-1272.
21. Oku, T., and Noda, K. (1990). Influence of chronic ingestion of newly developed sweetener, erythritol on growth and gastrointestinal function of the rats. Nutr. Res. 10, 987-996.
22. Price, R. G. (1982). Urinary enzymes, nephrotoxicity and renal disease. Toxicology 23, 99-134.
23. Roe, F. J. C. (1989). Relevance for man of the effects of lactose, polyols and other carbohydrates on calcium metabolism seen in rats: A review. Human Toxicol. 8, 87-98.
24. Sinkeldam, E. J., Woutersen, R. A., Hollanders, V. M. H., Til, H. P., Van Garderen-Hoetmer, A., and Bär, A. (1992). Subchronic and chronic toxicity/carcinogenicity feeding studies with lactitol in rats. J. Am. Coll. Toxicol. 11, 165-188.
25. Smits van Proije, A. E., de Groot, A. P., Dreef-Van der Meulen, H. C., and Sinkeldam, E. J. (1990). Chronic toxicity and carcinogenicity study of isomalt in rats and mice. Food Chem. Toxicol. 28, 243-251.
26. Til, H. P., Hollanders, V. M. H., Woutersen, R. A., and Bär, A. (1992). Chronic toxicity and carcinogenicity study of lactitol in mice. J. Am. Coll. Toxicol. 11, 209-217.
27. Til, H. P., Kuper, C. F., Falke, H. E., and Bär, A. (1996). Subchronic oral toxicity studies with erythritol in mice and rats. Regul. Toxicol. Pharmacol., in press.
28. Til, H. P., and van Nesselrooij, J. H. J. (1994). Chronic (78-week) oral toxicity study with erythritol in rats. Unpublished Report No. V93.367 from TNO Nutrition and Food Research, Zeist, The Netherlands.
29. 14C-erythritol in germ-free and conventional rats. Regul. Toxicol. Pharmacol., in press.