Analysis of cancer-targeting alkylphosphocholine analogue permeability characteristics using a human induced pluripotent stem cell blood-brain barrier model

Molecular Pharmaceutics

Volumn 13, Issue 9, 2016, Pages 3341-3349

  Clark, Paul A ^a   Al Ahmad, Abraham J ^e   Qian, Tongcheng ^b   Zhang, Ray R ^a,c   Wilson, Hannah K ^b   Weichert, Jamey P ^c,d   Palecek, Sean P ^b   Kuo, John S ^a   Shusta, Eric V ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Wisconsin Electric Machines and Power Electronics Consortium   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d Cellectar   (United States)

^e TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

alkylphosphocholine analogues; blood brain barrier; brain microvascular endothelial cells; induced pluripotent stem cells

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; 2 [2 [2 CHLORO 3 [2 (1,3 DIHYDRO 1,3,3 TRIMETHYL 2H INDOL 2 YLIDENE)ETHYLIDENE] 1 CYCLOHEXEN 1 YL]ETHENYL] 1,3,3 TRIMETHYL 3H INDOLIUM CHLORIDE I 24; 4,4 DIFLUORO 4 BORA 3A,4A DIAZA S INDACENE I 24; BREAST CANCER RESISTANCE PROTEIN; CHOLINE DERIVATIVE; DIAZEPAM; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VALSPODAR; VERLUKAST; ANTINEOPLASTIC AGENT; PHOSPHORYLCHOLINE;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN TUMOR; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ELECTRIC RESISTANCE; GAMMA COUNTER; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; TUMOR VASCULARIZATION; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELLS; PHOSPHORYLCHOLINE;

EID: 84986258338     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00441     Document Type: Article

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