Synthesis and structure-activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues

Journal of Medicinal Chemistry

Volumn 49, Issue 7, 2006, Pages 2155-2165

  Pinchuk, Anatoly N ^a,c   Rampy, Mark A ^a   Longino, Marc A ^a,c,d   Skinner, R W Scott ^b   Gross, Milton D ^b   Weichert, Jamey P ^a,c,d   Counsell, Raymond E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; ETHER PHOSPHOLIPID; IODINE 124; METHYL GROUP; NM 324; NM 396; NM 397; NM 404; NM 412; NM 413; PROPANEDIOL DERIVATIVE; RADIOACTIVE IODINE; UNCLASSIFIED DRUG;

ABDOMEN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG RETENTION; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TUMOR LEVEL; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIVER; LUNG CANCER; MALE; NONHUMAN; PHARMACODYNAMICS; PLASMA CLEARANCE; POSITRON; PROSTATE TUMOR; RADIOACTIVITY; RADIOIODINATION; RAT; SCINTIGRAPHY; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ACUTE TOXICITY TESTS; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FEMALE; HUMANS; IODINE RADIOISOTOPES; KIDNEY; LIVER; LUNG NEOPLASMS; MALE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 33645654791     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050252g     Document Type: Article

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