Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine

BioMed Research International

Volumn 2016, Issue , 2016, Pages

  Yue, Haiying ^a   Huang, Dongning ^a   Qin, Li ^a   Zheng, Zhiyong ^a   Hua, Li ^a   Wang, Guodong ^a   Huang, Jian ^a   Huang, Haixin ^a  

^a Fourth Affi Liated Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL; THIORIDAZINE; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL KILLING; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; ANIMAL; CELL CYCLE; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; LUNG NEOPLASMS; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIPSYCHOTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASTIC STEM CELLS; THIORIDAZINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84986243837     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2016/6709828     Document Type: Article

References (21)

1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, "Global cancer statistics," CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69-90, 2011.
2. R. L. Siegel, K. D.Miller, and A. Jemal, "Cancer statistics, 2015," CA: A Cancer Journal for Clinicians, vol. 65, no. 1, pp. 5-29, 2015.
3. L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, "Global cancer statistics, 2012," CA: Cancer Journal for Clinicians, vol. 65, no. 2, pp. 87-108, 2015.
4. B. T. Tan, C. Y. Park, L. E. Ailles, and I. L. Weissman, "The cancer stem cell hypothesis: a work in progress," Laboratory Investigation, vol. 86, no. 12, pp. 1203-1207, 2006.
5. D. Bonnet and J. E. Dick, "Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell," Nature Medicine, vol. 3, no. 7, pp. 730-737, 1997.
6. M. Al-Hajj, M. S. Wicha, A. Benito-Hernandez, S. J.Morrison, and M. F. Clarke, "Prospective identification of tumorigenic breast cancer cells," Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 3983-3988, 2003.
7. S. K. Singh, C. Hawkins, I. D. Clarke et al., "Identification of human brain tumour initiating cells," Nature, vol. 432, no. 7015, pp. 396-401, 2004.
8. A. Eramo, F. Lotti, G. Sette et al., "Identification and expansion of the tumorigenic lung cancer stem cell population," Cell Death and Differentiation, vol. 15, no. 3, pp. 504-514, 2008.
9. S. Takaishi, T. Okumura, and T. C.Wang, "Gastric cancer stem cells," Journal of ClinicalOncology, vol. 26,no. 17,pp. 2876-2882, 2008.
10. Y. Y. Shan and J. N. Ke, "Tumor-initiating stem cells in liver cancer," Cancer Biology and Therapy, vol. 7, no. 3, pp. 325-330, 2008.
11. C. Li, C. J. Lee, and D. M. Simeone, "Identification of human pancreatic cancer stem cells,"Methods inMolecular Biology, vol. 568, pp. 161-173, 2009.
12. E. Sachlos, R. M. Risueño, S. Laronde et al., "Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells," Cell, vol. 149, no. 6, pp. 1284-1297, 2012.
13. J. Mu, H. Xu, Y. Yang et al., "Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer,"Oncology Reports, vol. 31, no. 5, pp. 2107-2114, 2014.
14. K.-J. Min, B. R. Seo, Y. C. Bae, Y. H. Yoo, and T. K. Kwon, "Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation ofMcl-1 and c-FLIP(L)," Cell Death and Disease, vol. 5, no. 2, Article ID e1063, 2014.
15. S. Kang, S. M. Dong, B.-R. Kim et al., "Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells," Apoptosis, vol. 17, no. 9, pp. 989-997, 2012.
16. I. Bisson and D. M. Prowse, "WNT signaling regulates selfrenewal and differentiation of prostate cancer cells with stem cell characteristics," Cell Research, vol. 19, no. 6, pp. 683-697, 2009.
17. K. A. Hassan, L. Wang, H. Korkaya et al., "Notch pathway activity identifies cells with cancer stem cell-like properties and correlates withworse survival in lung adenocarcinoma," Clinical Cancer Research, vol. 19, no. 8, pp. 1972-1980, 2013.
18. K. B. Heiden, A. J. Williamson, M. E. Doscas et al., "The sonic hedgehog signaling pathway maintains the cancer stem cell selfrenewal of anaplastic thyroid cancer by inducing snail expression," TheJournal of Clinical Endocrinology andMetabolism, vol. 99, no. 11, pp. E2178-E2187, 2014.
19. A. Wu, A. Mazumder, R. L. Martuza et al., "Biological purging of breast cancer cells using an attenuated replication-competent herpes simplex virus in human hematopoietic stem cell transplantation," Cancer Research, vol. 61, no. 7, pp. 3009-3015, 2001.
20. P. Marcato, C. A. Dean, C. A. Giacomantonio, and P.W. K. Lee, "Oncolytic reovirus effectively targets breast cancer stem cells," MolecularTherapy, vol. 17, no. 6, pp. 972-979, 2009.
21. Y. Yang, H. Xu, J. Shen et al., "RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells," Cell Death and Disease, vol. 6, no. 5, p. e1760, 2015.