The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding

Paediatrics and International Child Health

Volumn 36, Issue 3, 2016, Pages 189-197

  Zash, Rebecca M ^a,b   Shapiro, Roger L ^a,b,f   Leidner, Jean ^c   Wester, Carolyn ^b   McAdam, Alexander J ^d   Hodinka, Richard L ^e   Thior, Ibou ^b   Moffat, Claire ^b   Makhema, Joseph ^b   McIntosh, Kenneth ^d   Essex, Max ^b,f   Lockman, Shahin ^b,f  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

^c Goodtables Data Consulting Norman   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADENOVIRIDAE; ANTIBIOTIC SENSITIVITY; ARTICLE; ARTIFICIAL MILK; BACTERIAL COLONIZATION; BACTERIUM CULTURE; BLOOD CULTURE; BORDETELLA PERTUSSIS; BOTSWANA; BREAST FEEDING; CAMPYLOBACTER; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS EXPOSED INFANT; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN METAPNEUMOVIRUS; HUMAN PARAINFLUENZA VIRUS 3; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFANT; INFANTILE DIARRHEA; INTESTINE PARASITE; MAJOR CLINICAL STUDY; MATERNAL EXPOSURE; NASOPHARYNGEAL ASPIRATION; PNEUMONIA; POLYMERASE CHAIN REACTION; POST EXPOSURE PROPHYLAXIS; RHINOVIRUS; ROTAVIRUS; SALMONELLA ENTERICA SEROVAR TYPHI; SHIGELLA; VIRUS DETECTION; VIRUS LOAD; ADULT; BACTERIUM; FECES; FEMALE; HIV INFECTIONS; ISOLATION AND PURIFICATION; MICROBIOLOGY; NEWBORN; PREVENTION AND CONTROL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY SYSTEM; TRANSMISSION; VERTICAL TRANSMISSION;

ADULT; ANTI-HIV AGENTS; BACTERIA; BOTSWANA; BREAST FEEDING; DIARRHEA, INFANTILE; FECES; FEMALE; HIV INFECTIONS; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PNEUMONIA; RESPIRATORY SYSTEM; ZIDOVUDINE;

EID: 84985960386     PISSN: 20469047     EISSN: 20469055     Source Type: Journal    
DOI: 10.1179/2046905515Y.0000000038     Document Type: Article

References (46)

1. R.L.Shapiro, S.Lockman. Mortality among HIV-exposed infants:the first and final frontier. Clin Infect Dis. 2010;50:445–7.
2. H.Brahmbhatt, G.Kigozi, F.Wabwire-Mangen, D.Serwadda, T.Lutalo, F.Nalugoda, et al. Mortality in HIV-infected and uninfected children of HIV-infected and uninfected mothers in rural Uganda. J Acquir Immune Defic Syndr. 2006;41:504–8.
3. M.Landes, M.van Lettow, A.K.Chan, I.Mayuni, E.J.Schouten, R.A.Bedell. Mortality and health outcomes of HIV-exposed and unexposed children in a PMTCT cohort in Malawi. PLoS One. 2012;7:e47337.
4. I.Thior, S.Lockman, L.M.Smeaton, R.L.Shapiro, C.Wester, S.J.Heymann, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana:a randomized trial:the Mashi Study. JAMA. 2006;296:794–805.
5. L.Kuhn, G.M.Aldrovandi, M.Sinkala, C.Kankasa, K.Semrau, M.Mwiya, et al. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med. 2008;359:130–41.
6. D.Mbori-Ngacha, R.Nduati, G.John, M.Reilly, B.Richardson, A.Mwatha, J.Ndinya-Achola, et al. Morbidity and mortality in breastfed and formula-fed infants of HIV-1-infected women:A randomized clinical trial. JAMA. 2001;286:2413–20.
7. K.K.Venkatesh, G.de Bruyn, E.Marinda, K.Otwombe, R.van Niekerk, M.Urban, et al. Morbidity and mortality among infants born to HIV-infected women in South Africa:implications for child health in resource-limited settings. J Trop Pediatr. 2011;57:109–19.
8. L.Liu, H.L.Johnson, S.Cousens, J.Perin, S.Scott, J.E.Lawn, et al. Global, regional, and national causes of child mortality:an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151–61.
9. L.M.McNally, P.M.Jeena, K.Gajee, S.A.Thula, A.W.Sturm, S.Cassol, et al. Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children:a prospective descriptive study. Lancet. 2007;369:1440–51.
10. V.R.Bachrach, E.Schwarz, L.R.Bachrach. Breastfeeding and the risk of hospitalization for respiratory disease in infancy:a meta-analysis. Arch Pediatr Adolesc Med. 2003;157:237–43.
11. R.S.Mwiru, D.Spiegelman, C.Duggan, K.Peterson, E.Liu, G.Msamanga, et al. Relationship of exclusive breast-feeding to infections and growth of Tanzanian children born to HIV-infected women. Public Health Nutr. 2011;14:1251–8.
12. M.P.Fox, D.Brooks, L.Kuhn, G.Aldrovandi, M.Sinkala, C.Kankasa, et al. Reduced mortality associated with breast-feeding- acquired HIV infection and breast-feeding among HIV-infected children in Zambia. J Acquir Immune Defic Syndr. 2008;48:90–6.
13. G.Kafulafula, D.R.Hoover, T.E.Taha, M.Thigpen, Q.Li, M.G.Fowler, et al. Frequency of gastroenteritis and gastroenteritis-associated mortality with early weaning in HIV-1-uninfected children born to HIV-infected women in Malawi. J Acquir Immune Defic Syndr. 2010;53:6–13.
14. K.H.Asbojornsdottir, J.A.Slyker, N.S.Weiss, D.Mbori-Ngacha, E.Maleche-Obimbo, D.Wamalwa, et al. Breastfeeding is associated with decreased pneumonia incidence among HIV-exposed, uninfected Kenyan infants. AIDS. 2013;27:2809–15.
15. N.C.Rollins, J.Ndirangu, R.M.Bland, A.Coutsoudis, H.M.Coovadia, M.L.Newell. Exclusive breastfeeding, diarrhoeal morbidity and all-cause mortality in infants of HIV-infected and HIV uninfected mothers:an intervention cohort study in KwaZulu Natal, South Africa. PLoS One. 2013;8:e81307.
16. V.M.Pierce, M.Elkan, M.Leet, K.L.McGowan, R.L.Hodinka. Comparison of the Idaho Technology FilmArray System to real-time PCR for detection of respiratory pathogens in children. J Clin Microbiol. 2012;50:364–71.
17. S.Khagayi, D.C.Burton, R.Onkoba, B.Ochieng, A.Ismail, D.Mutonga, et al. High burden of rotavirus gastroenteritis in young children in rural Western Kenya, 2010-2011. Pediatr Infect Dis J. 2014;33:S34–S40.
18. I.J.Bonkoungou, K.Haukka, M.Österblad, A.J.Hakanen, A.S.Traore, N.Barro, et al.Bacterial and viral etiology of childhood diarrhoea in Ouagadougou, Burkina Faso. BMC Pediatr. 2013;13:36.
19. J.M.Sire, B.Garin, L.Chartier, N.K.Fall, A.Tall, A.Seck, et al. Community-acquired infectious diarrhoea in children under 5 years of age in Dakar, Senegal. Paediatr Int Child Health. 2013;33:139–44.
20. K.L.Kotloff, J.P.Nataro, W.C.Blackwelder, D.Nasrin, T.H.Farag, S.Panchalingam, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS):a prospective, case-control study. Lancet. 2013;382:209–22.
21. M.R.Gaafar. Evaluation of enzyme immunoassay techniques for diagnosis of the most common intestinal protozoa in fecal samples. Int J Infect Dis. 2011;15:e541–4.
22. D.M.Goldfarb, A.P.Steenhoff, J.M.Pernica, S.Chong, K.Luinstra, M.Mokomane, et al. Evaluation of anatomically designed flocked rectal swabs for molecular detection of enteric pathogens in children admitted to hospital with severe gastroenteritis in Botswana. J Clin Microbiol. 2014;52:3922–7.
23. A.M.van Eijk, J.T.Brooks, P.M.Adcock, V.Garrett, M.Eberhard, D.H.Rosen, et al. Diarrhoea in children less than two years of age with known HIV status in Kisumu, Kenya. Int J Infect Dis. 2010;14:e220–5.
24. M.Taniuchi, S.U.Sobuz, S.Begum, A.Platts-Mills, J.Liu, Z.Yang, et al. Etiology of diarrhoea in Bangladeshi infants in the first year of life analyzed using molecular methods. J Infect Dis. 2013;208:1794–802.
25. B.Sambe-Ba, E.Espié, M.E.Faye, L.G.Timbiné, M.Sembene, A.Gassama-Sow. Community-acquired diarrhea among children and adults in urban settings in Senegal:clinical, epidemiological and microbiological aspects. BMC Infect Dis. 2013;13:580.
26. T.Vu Nguyen, P.Le Van, C.Le Huy, K.Nguyen Gia, A.Weintraub. Etiology and epidemiology of diarrhoea in children in Hanoi, Vietnam. Int J Infect Dis. 2006;10:298–308.
27. T.L.Creek, A.Kim, L.Lu, A.Bowen, J.Masunge, W.Arvelo, et al. Hospitalization and mortality among primarily nonbreastfed children during a large outbreak of diarrhoea and malnutrition in Botswana, 2006. J Acquir Immune Defic Syndr. 2010;53:14–19.
28. L.M.Mofenson, R.Yogev, J.Korelitz, J.Bethel, K.Krasinski, J.MoyeJr, et al. Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. Pediatr Infect Dis J. 1998;17:872–80.
29. H.J.Zar, A.Dechaboon, D.Hanslo, P.Apolles, K.G.Magnus, G.Hussey. Pneumocystis carinii pneumonia in South African children infected with human immunodeficiency virus. Pediatr Infect Dis J. 2000;19:603–7.
30. W.P.Rennert, D.Kilner, M.Hale, G.Stevens, W.Stevens, H.Crewe-Brown. Tuberculosis in children dying with HIV-related lung disease:clinical-pathological correlations. Int J Tuberc Lung Dis. 2002;6:806–13.
31. M.Cashat-Cruz, J.J.Morales-Aguirre, M.Mendoza-Azpiri. Respiratory tract infections in children in developing countries. Semin Pediatr Infect Dis. 2005;16:84–92.
32. J.A.Berkley, P.Munywoki, M.Ngama, S.Kazungu, J.Abwao, A.Bett, et al. Viral etiology of severe pneumonia among Kenyan infants and children. JAMA. 2010;303:2051–7.
33. D.R.Feikin, M.K.Njenga, G.Bigogo, B.Aura, G.Aol, A.Audi, et al. Viral and bacterial causes of severe acute respiratory illness among children aged less than 5 years in a high malaria prevalence area of western Kenya, 2007-2010. Pediatr Infect Dis J. 2013;32:e14–e19.
34. C.O'Callaghan-Gordo, Q.Bassat, L.Morais, N.Diez-Padrisa, S.Machevo, T.Nhampossa, et al. Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique:a malaria endemic area with high prevalence of human immunodeficiency virus. Pediatr Infect Dis J. 2011;30:39–44.
35. D.J.Nokes, E.A.Okiro, M.Ngama, R.Ochola, L.J.White, P.D.Scott, et al. Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya. Clin Infect Dis. 2008;46:50–7.
36. S.A.Madhi, L.Kuwanda, C.Cutland, K.P.Klugman. Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African children. J Clin Virol. 2006;36:215–21.
37. S.A.Madhi, N.Ramasamy, T.G.Bessellar, H.Saloojee, K.P.Klugman. Lower respiratory tract infections associated with influenza A and B viruses in an area with a high prevalence of pediatric human immunodeficiency type 1 infection. Pediatr Infect Dis J. 2002;21:291–7.
38. A.W.Johnson, K.Osinusi, W.I.Aderele, D.A.Gbadero, O.D.Olaleye, F.A.Adeyemi-Doro. Etiologic agents and outcome determinants of community-acquired pneumonia in urban children:a hospital-based study. J Natl Med Assoc. 2008;100:370–85.
39. T.Hokama, A.Yara, K.Hirayama, F.Takamine. Isolation of respiratory bacterial pathogens from the throats of healthy infants fed by different methods. J Trop Pediatr. 1999;45:173–6.
40. T.Hokama, R.Sakamoto, A.Yara, Y.Asato, F.Takamine, K.Itokazu. Incidence of Haemophilus influenzae in the throats of healthy infants with different feeding methods. Pediatr Int. 1999;41:277–80.
41. D.M.Nayak, N.Kumar, N.Bhaskaranand, C.Nayak. Bacterial profile of the oropharynx in infants:an assessment of the confounding factors for colonization. Indian J Pediatr. 2011;78:807–11.
42. Y.Harabuchi, H.Faden, N.Yamanaka, L.Duffy, J.Wolf, D.Krystofik. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. J Infect Dis. 1994;170:862–6.
43. H.Faden, L.Duffy, R.Wasielewski, J.Wolf, D.Krystofik, Y.Tung. Relationship between nasopharyngeal colonization and the development of otitis media in children. J Infect Dis. 1997;175:1440–5.
44. A.Ruohola, M.M.Pettigrew, L.Lindholm, J.Jalava, K.S.Raisanen, R.Vainiopaa, et al. Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media. J Infect. 2013;66:247–54.
45. Y.Harabuchi, H.Faden, N.Yamanaka, L.Duffy, J.Wolf, D.Krystofik. Human milk secretory IgA antibody to nontypeable Haemophilus influenzae:possible protective effects against nasopharyngeal colonization. J Pediatr. 1994;124:193–8.
46. van den Bergh MR, Biesbroek G, Rossen JW, de Steenhuijsen Piters WA, Bosch AA, van Gils EJ, et al. Associations between pathogens in the upper respiratory tract of young children:interplay between viruses and bacteria. PLoS One. 2012;7:e47711.