Clinical and neurophysiologic characteristics of unprovoked seizures in patients diagnosed with dementia

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 28, Issue 1, 2016, Pages 56-61

  Sarkis, Rani A ^a   Dickerson, Bradford C ^b   Cole, Andrew J ^b   Chemali, Zeina N ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVETIRACETAM; TAU PROTEIN;

AGED; ANXIETY DISORDER; ARTICLE; CLINICAL FEATURE; COGNITION; DEMENTIA; DIFFUSE LEWY BODY DISEASE; DOWN SYNDROME; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAM; ENCEPHALITIS; EPILEPTIC STATE; FAMILY HISTORY; FEBRILE CONVULSION; FEMALE; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MOOD DISORDER; MULTIINFARCT DEMENTIA; MYOCLONUS; NEUROIMAGING; ONSET AGE; PRIMARY PROGRESSIVE APHASIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEIZURE; SPIKE; TONIC CLONIC SEIZURE; TRAUMATIC BRAIN INJURY; ADULT; FOLLOW UP; MIDDLE AGED; PATHOPHYSIOLOGY; RISK FACTOR; SEIZURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; DEMENTIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SEIZURES;

EID: 84985911002     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.15060143     Document Type: Article

References (32)

1. Amatniek JC, Hauser WA, DelCastillo-Castaneda C, et al: Incidence and predictors of seizures in patients with Alzheimer’s disease. Epilepsia 2006; 47:867-872
2. Hauser WA, Annegers JF, Kurland LT: Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993; 34:453-468
3. Hesdorffer DC, Hauser WA, Annegers JF, et al: Dementia and adult-onset unprovoked seizures. Neurology 1996; 46:727-730
4. Irizarry MC, Jin S, He F, et al: Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol 2012; 69: 368-372
5. Romanelli MF, Morris JC, Ashkin K, et al: Advanced Alzheimer’s disease is a risk factor for late-onset seizures. Arch Neurol 1990; 47:847-850
6. Heyman A, Wilkinson WE, Hurwitz BJ, et al: Early-onset Alzheimer’s disease: clinical predictors of institutionalization and death. Neurology 1987; 37:980-984
7. Picco A, Archetti S, Ferrara M, et al: Seizures can precede cognitive symptoms in late-onset Alzheimer’s disease. J Alzheimers Dis 2011; 27:737-742
8. Vossel KA, Beagle AJ, Rabinovici GD, et al: Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol 2013; 70:1158-1166
9. Friedman D, Honig LS, Scarmeas N: Seizures and epilepsy in Alzheimer’s disease. CNS Neurosci Ther 2012; 18:285-294
10. Corrada MM, Brookmeyer R, Paganini-Hill A, et al: Dementia incidence continues to increase with age in the oldest old: the 90+ study. Ann Neurol 2010; 67:114-121
11. Noebels J: A perfect storm: converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation. Epilepsia 2011; 52(Suppl 1):39-46
12. Nalichowski R, Keogh D, Chueh HC, et al: Calculating the benefits of a Research Patient Data Repository. AMIA Annu Symp Proc 2006; 2006:1044
13. Beghi E, Carpio A, Forsgren L, et al: Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010; 51:671-675
14. Berg AT, Berkovic SF, Brodie MJ, et al: Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 2010; 51:676-685
15. McKhann GM, Knopman DS, Chertkow H, et al: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7:263-269
16. McKeith IG, Dickson DW, Lowe J, et al: Consortium on DLB: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65:1863-1872
17. Gorno-Tempini ML, Hillis AE, Weintraub S, et al: Classification of primary progressive aphasia and its variants. Neurology 2011; 76: 1006-1014
18. Rascovsky K, Hodges JR, Knopman D, et al: Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011; 134:2456-2477
19. van Straaten EC, Scheltens P, Knol DL, et al: Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study. Stroke 2003; 34:1907-1912
20. Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
21. Kwan P, Arzimanoglou A, Berg AT, et al: Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010; 51:1069-1077
22. Sherzai D, Losey T, Vega S, et al: Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999-2008. Epilepsy Behav 2014; 36:53-56
23. Risse SC, Lampe TH, Bird TD, et al: Myoclonus, seizures, and paratonia in Alzheimer disease. Alzheimer Dis Assoc Disord 1990; 4:217-225
24. Rao SC, Dove G, Cascino GD, et al: Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav 2009; 14:118-120
25. Lott IT: Neurological phenotypes for Down syndrome across the life span. Prog Brain Res 2012; 197:101-121
26. Palop JJ, Mucke L: Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci 2010; 13:812-818
27. Roberson ED, Halabisky B, Yoo JW, et al: Amyloid-b/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J Neurosci 2011; 31:700-711
28. Li Z, Hall AM, Kelinske M, et al: Seizure resistance without parkinsonism in aged mice after tau reduction. Neurobiol Aging 2014; 35:2617-2624
29. Scharfman HE: Alzheimer’s disease and epilepsy: insight from animal models. Future Neurol 2012; 7:177-192
30. Drury I, Beydoun A: Interictal epileptiform activity in elderly patients with epilepsy. Electroencephalogr Clin Neurophysiol 1998; 106:369-373
31. Besocke AG, Rosso B, Cristiano E, et al: Outcome of newlydiagnosed epilepsy in older patients. Epilepsy Behav 2013; 27: 29-35
32. Cumbo E, Ligori LD: Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease. Epilepsy Behav 2010; 17:461-466