The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Cell Death and Disease

Volumn 7, Issue 2, 2016, Pages

  Colangelo, T ^a   Polcaro, G ^a   Ziccardi, P ^a   Muccillo, L ^a   Galgani, M ^b   Pucci, B ^c   Rita Milone, M ^c   Budillon, A ^c   Santopaolo, M ^d   Mazzoccoli, G ^e   Matarese, G ^b,d   Sabatino, L ^a   Colantuoni, V ^a  

^a UNIVERSITY OF SANNIO   (Italy)

^b CNR   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALRETICULIN; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MICRORNA; MICRORNA 27A; MITOXANTRONE; OXALIPLATIN; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; INTERLEUKIN DERIVATIVE; PLATINUM COMPLEX;

APOPTOSIS; ARTICLE; AUTOPHAGY; CD4+ T LYMPHOCYTE; CELL DEATH; CELL MATURATION; CELL PROLIFERATION; CELL SURFACE; COLORECTAL CANCER CELL LINE; CONDITIONED MEDIUM; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EXPOSURE; ENDOPLASMIC RETICULUM STRESS; EX VIVO STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOGENICITY; PRIORITY JOURNAL; UNFOLDED PROTEIN RESPONSE; ANTAGONISTS AND INHIBITORS; COLORECTAL TUMOR; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; GENETICS; HCT 116 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALRETICULIN; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DENDRITIC CELLS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; HCT116 CELLS; HUMANS; INTERFERON-GAMMA; INTERLEUKINS; MICRORNAS; MITOXANTRONE; OLIGONUCLEOTIDES, ANTISENSE; ORGANOPLATINUM COMPOUNDS; PHOSPHATIDYLINOSITOL 3-KINASES; UNFOLDED PROTEIN RESPONSE;

EID: 84984893029     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2016.29     Document Type: Article

References (40)

1. Garg AD, Martin S, Golab J, Agostinis P. Danger signalling during cancer cell death: origins, plasticity and regulation. Cell Death Differ 2014; 21: 26-38.
2. Inoue H, Tani K. Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments. Cell Death Differ 2014; 21: 39-49.
3. Mariño G, Niso-Santano M, Baehrecke EH, Kroemer G. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol 2014; 15: 81-94.
4. Hou W, Zhang Q, Yan Z, Chen R, Zeh III HJ, Kang R et al. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis 2013; 4: e966.
5. Tesniere A, Panaretakis T, Kepp O, Apetoh L, Ghiringhelli F, Zitvogel L et al. Molecular characteristics of immunogenic cancer cell death. Cell Death Differ 2008; 15: 3-12.
6. Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P, Vandenabeele P. Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer 2012; 12: 860-875.
7. Bianchi ME Killing cancer cells, twice with one shot. Cell Death Differ 2014; 21: 1-2.
8. Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J 2009; 28: 578-590.
9. Garg AD, Elsen S, Krysko DV, Vandenabeele P, de Witte P, Agostinis P. Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. Oncotarget 2015; 6: 26841-26860.
10. Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Ann Rev Immunol 2013; 31: 51-72.
11. Raghavan M, Wijeyesakere SJ, Peters LR, Del Cid N. Calreticulin in the immune system: ins and outs. Trends Immunol 2013; 34: 13-21.
12. Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007; 13: 54-61.
13. Di Leva G, Garofalo M, Croce CM. MicroRNAs in cancer. Annu Rev Pathol 2014; 9: 287-314.
14. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends in Mol Med 2014; 20: 460-469.
15. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA. MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer. Oncotarget 2015 (e-pub ahead of print 25 November 2015).
16. Colangelo T, Polcaro T, Ziccardi P, Pucci B, Muccillo L, Galgani M et al. Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer. Cell Death Dis 2016 (in press).
17. Zhang Z, Liu S, Shi R, Zhao G. miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. Cancer Genet 2011; 204: 486-491.
18. Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW et al. miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov 2012; 2: 540-553.
19. Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J 2012; 31: 1062-1079.
20. Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M et al. The cotranslocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ 2008; 15: 1499-1509.
21. Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM. Molecular and translational classifications of DAMPs in immunogenic cell death. Front Immunol 2015; 6: 588.
22. Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334: 1573-1577.
23. Ohsumi Y. Historical landmarks of autophagy research. Cell Res 2014; 24: 9-23.
24. Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ 2012; 19: 1880-1891.
25. Kepp O, Menger L, Vacchelli E, Locher C, Adjemian S, Yamazaki T et al. Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev 2013; 24: 311-318.
26. Martins I, Wang Y, Michaud M, Ma Y, Sukkurwala AQ, Shen S et al. Molecular mechanisms of ATP secretion during immunogenic cell death. Cell Death Differ 2014; 21: 79-91.
27. Wang W, Groenendyk J, Michalak M. Calreticulin signaling in health and disease. Int J Biochem Cell Biol 2012; 44: 842-846.
28. Ali TH, Pisanti S, Ciaglia E, Mortarini R, Anichini A, Garofalo C et al. Enrichment of CD56 (dim) KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients. Nat Comm 2014; 5: 5639.
29. Francipane MG, Alea MP, Lombardo Y, Todaro M, Medema JP, Stassi G. Crucial role of interleukin-4 in the survival of colon cancer stem cells. Cancer Res 2008; 68: 4022-4025.
30. Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D et al. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer 2012; 106: 1833-1841.
31. Guo Y, Xu F, Lu T, Duan Z, Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 2012; 38: 904-910.
32. Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011; 480: 480-489.
33. Dudek AM, Carg AD, Krysko DV, De Ruysscher D, Agostinis P. Inducers of immunogenic cancer cell death. Cytokine Growth Factor Rev 2013; 24: 319-333.
34. Krysko O, Løve AT, Bachert C, Vandenabeele P, Krysko DV. Many faces of DAMPs in cancer therapy. Cell Death Dis 2013; 4: e631.
35. Obeid M, Tesniere A, Panaretakis T, Tufi R, Joza N, van Endert P et al. Ecto-calreticulin in immunogenic chemotherapy. Immunol Rev 2007; 220: 22-34.
36. Peng RQ, Chen YB, Ding Y, Zhang R, Zhang X, Yu XJ et al. Expression of calreticulin is associated with infiltration of T-cells in stage III-B colon cancer. World J Gastroenterol 2010; 16: 2428-2434.
37. Colangelo T, Fucci A, Votino C, Sabatino L, Pancione M, Laudanna C et al. MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. Neoplasia 2013; 15: 1086-1099.
38. Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol 2009; 77: 1814-1826.
39. Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V et al. HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. J Leukoc Biol 2003; 74: 1117-1124.
40. Galgani M, De Rosa V, De Simone S, Leonardi A, D'Oro U, Napolitani G et al. Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. J Biol Chem 2004; 31: 32507-32512.