-
1
-
-
84928774156
-
The future of immune checkpoint therapy
-
1 Sharma, P., Allison, J.P., The future of immune checkpoint therapy. Science 348 (2015), 56–61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
2
-
-
84966309581
-
CANCER IMMUNOLOGY. The cancer immunogram
-
2 Blank, C.U., Haanen, J.B., Ribas, A., Schumacher, T.N., CANCER IMMUNOLOGY. The cancer immunogram. Science 352 (2016), 658–660.
-
(2016)
Science
, vol.352
, pp. 658-660
-
-
Blank, C.U.1
Haanen, J.B.2
Ribas, A.3
Schumacher, T.N.4
-
3
-
-
84884683734
-
MHC class I-associated phosphopeptides are the targets of memory-like immunity in leukemia
-
3 Cobbold, M., De La Pena, H., Norris, A., Polefrone, J.M., Qian, J., English, A.M., Cummings, K.L., Penny, S., Turner, J.E., Cottine, J., et al. MHC class I-associated phosphopeptides are the targets of memory-like immunity in leukemia. Sci Transl Med, 5, 2013, 203ra125.
-
(2013)
Sci Transl Med
, vol.5
, pp. 203ra125
-
-
Cobbold, M.1
De La Pena, H.2
Norris, A.3
Polefrone, J.M.4
Qian, J.5
English, A.M.6
Cummings, K.L.7
Penny, S.8
Turner, J.E.9
Cottine, J.10
-
4
-
-
84963553379
-
Genomic correlates of immune-cell infiltrates in colorectal carcinoma
-
4 Giannakis, M., Mu, X.J., Shukla, S.A., Qian, Z.R., Cohen, O., Nishihara, R., Bahl, S., Cao, Y., Amin-Mansour, A., Yamauchi, M., et al. Genomic correlates of immune-cell infiltrates in colorectal carcinoma. Cell Rep, 2016.
-
(2016)
Cell Rep
-
-
Giannakis, M.1
Mu, X.J.2
Shukla, S.A.3
Qian, Z.R.4
Cohen, O.5
Nishihara, R.6
Bahl, S.7
Cao, Y.8
Amin-Mansour, A.9
Yamauchi, M.10
-
5
-
-
84942285381
-
Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1
-
5 Howitt, B.E., Shukla, S.A., Konstantinopoulos, P.A., Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1. JAMA Oncol 1 (2015), 1319–1323.
-
(2015)
JAMA Oncol
, vol.1
, pp. 1319-1323
-
-
Howitt, B.E.1
Shukla, S.A.2
Konstantinopoulos, P.A.3
-
6
-
-
84971669545
-
Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer
-
6 Strickland, K.C., Howitt, B.E., Shukla, S.A., Rodig, S., Ritterhouse, L.L., Liu, J.F., Garber, J.E., Chowdhury, D., Wu, C.J., D'Andrea, A.D., et al. Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget 7 (2016), 13587–13598.
-
(2016)
Oncotarget
, vol.7
, pp. 13587-13598
-
-
Strickland, K.C.1
Howitt, B.E.2
Shukla, S.A.3
Rodig, S.4
Ritterhouse, L.L.5
Liu, J.F.6
Garber, J.E.7
Chowdhury, D.8
Wu, C.J.9
D'Andrea, A.D.10
-
7
-
-
84976406910
-
Neoantigen load, antigen presentation machinery, and immune signatures determine prognosis in clear cell renal cell carcinoma
-
7 Matsushita, H., Sato, Y., Karasaki, T., Nakagawa, T., Kume, H., Ogawa, S., Homma, Y., Kakimi, K., Neoantigen load, antigen presentation machinery, and immune signatures determine prognosis in clear cell renal cell carcinoma. Cancer Immunol Res 4 (2016), 463–471.
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 463-471
-
-
Matsushita, H.1
Sato, Y.2
Karasaki, T.3
Nakagawa, T.4
Kume, H.5
Ogawa, S.6
Homma, Y.7
Kakimi, K.8
-
8
-
-
84899836282
-
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
-
8 Brown, S.D., Warren, R.L., Gibb, E.A., Martin, S.D., Spinelli, J.J., Nelson, B.H., Holt, R.A., Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res 24 (2014), 743–750.
-
(2014)
Genome Res
, vol.24
, pp. 743-750
-
-
Brown, S.D.1
Warren, R.L.2
Gibb, E.A.3
Martin, S.D.4
Spinelli, J.J.5
Nelson, B.H.6
Holt, R.A.7
-
9
-
-
84920962202
-
Molecular and genetic properties of tumors associated with local immune cytolytic activity
-
9 Rooney, M.S., Shukla, S.A., Wu, C.J., Getz, G., Hacohen, N., Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160 (2015), 48–61.
-
(2015)
Cell
, vol.160
, pp. 48-61
-
-
Rooney, M.S.1
Shukla, S.A.2
Wu, C.J.3
Getz, G.4
Hacohen, N.5
-
10
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
10 Schumacher, T.N., Schreiber, R.D., Neoantigens in cancer immunotherapy. Science 348 (2015), 69–74.
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
11
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
11 Snyder, A., Makarov, V., Merghoub, T., Yuan, J., Zaretsky, J.M., Desrichard, A., Walsh, L.A., Postow, M.A., Wong, P., Ho, T.S., et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371 (2014), 2189–2199.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
Yuan, J.4
Zaretsky, J.M.5
Desrichard, A.6
Walsh, L.A.7
Postow, M.A.8
Wong, P.9
Ho, T.S.10
-
12
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
12 Rizvi, N.A., Hellmann, M.D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J.J., Lee, W., Yuan, J., Wong, P., Ho, T.S., et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348 (2015), 124–128.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
Lee, W.7
Yuan, J.8
Wong, P.9
Ho, T.S.10
-
13
-
-
84943516465
-
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
-
13 Van Allen, E.M., Miao, D., Schilling, B., Shukla, S.A., Blank, C., Zimmer, L., Sucker, A., Hillen, U., Geukes Foppen, M.H., Goldinger, S.M., et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350 (2015), 207–211.
-
(2015)
Science
, vol.350
, pp. 207-211
-
-
Van Allen, E.M.1
Miao, D.2
Schilling, B.3
Shukla, S.A.4
Blank, C.5
Zimmer, L.6
Sucker, A.7
Hillen, U.8
Geukes Foppen, M.H.9
Goldinger, S.M.10
-
14
-
-
84964310813
-
Biomarkers in cancer immunotherapy
-
14 Schumacher, T.N., Kesmir, C., van Buuren, M.M., Biomarkers in cancer immunotherapy. Cancer Cell 27 (2015), 12–14.
-
(2015)
Cancer Cell
, vol.27
, pp. 12-14
-
-
Schumacher, T.N.1
Kesmir, C.2
van Buuren, M.M.3
-
15
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
15 Le, D.T., Uram, J.N., Wang, H., Bartlett, B.R., Kemberling, H., Eyring, A.D., Skora, A.D., Luber, B.S., Azad, N.S., Laheru, D., et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372 (2015), 2509–2520.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
Skora, A.D.7
Luber, B.S.8
Azad, N.S.9
Laheru, D.10
-
16
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
16 Rosenberg, J.E., Hoffman-Censits, J., Powles, T., van der Heijden, M.S., Balar, A.V., Necchi, A., Dawson, N., O'Donnell, P.H., Balmanoukian, A., Loriot, Y., et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387 (2016), 1909–1920.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
van der Heijden, M.S.4
Balar, A.V.5
Necchi, A.6
Dawson, N.7
O'Donnell, P.H.8
Balmanoukian, A.9
Loriot, Y.10
-
17
-
-
84961221351
-
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
-
17 Hugo, W., Zaretsky, J.M., Sun, L., Song, C., Moreno, B.H., Hu-Lieskovan, S., Berent-Maoz, B., Pang, J., Chmielowski, B., Cherry, G., et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165 (2016), 35–44.
-
(2016)
Cell
, vol.165
, pp. 35-44
-
-
Hugo, W.1
Zaretsky, J.M.2
Sun, L.3
Song, C.4
Moreno, B.H.5
Hu-Lieskovan, S.6
Berent-Maoz, B.7
Pang, J.8
Chmielowski, B.9
Cherry, G.10
-
18
-
-
84962301577
-
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
-
18 McGranahan, N., Furness, A.J., Rosenthal, R., Ramskov, S., Lyngaa, R., Saini, S.K., Jamal-Hanjani, M., Wilson, G.A., Birkbak, N.J., Hiley, C.T., et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351 (2016), 1463–1469.
-
(2016)
Science
, vol.351
, pp. 1463-1469
-
-
McGranahan, N.1
Furness, A.J.2
Rosenthal, R.3
Ramskov, S.4
Lyngaa, R.5
Saini, S.K.6
Jamal-Hanjani, M.7
Wilson, G.A.8
Birkbak, N.J.9
Hiley, C.T.10
-
19
-
-
84957093642
-
Loss of PTEN promotes resistance to T cell-mediated immunotherapy
-
19 Peng, W., Chen, J.Q., Liu, C., Malu, S., Creasy, C., Tetzlaff, M.T., Xu, C., McKenzie, J.A., Zhang, C., Liang, X., et al. Loss of PTEN promotes resistance to T cell-mediated immunotherapy. Cancer Discov 6 (2016), 202–216.
-
(2016)
Cancer Discov
, vol.6
, pp. 202-216
-
-
Peng, W.1
Chen, J.Q.2
Liu, C.3
Malu, S.4
Creasy, C.5
Tetzlaff, M.T.6
Xu, C.7
McKenzie, J.A.8
Zhang, C.9
Liang, X.10
-
20
-
-
84936953099
-
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
-
20 Spranger, S., Bao, R., Gajewski, T.F., Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523 (2015), 231–235.
-
(2015)
Nature
, vol.523
, pp. 231-235
-
-
Spranger, S.1
Bao, R.2
Gajewski, T.F.3
-
21
-
-
84894107349
-
New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape
-
21 Mittal, D., Gubin, M.M., Schreiber, R.D., Smyth, M.J., New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape. Curr Opin Immunol 27 (2014), 16–25.
-
(2014)
Curr Opin Immunol
, vol.27
, pp. 16-25
-
-
Mittal, D.1
Gubin, M.M.2
Schreiber, R.D.3
Smyth, M.J.4
-
22
-
-
84976406873
-
Neoantigen landscape dynamics during human melanoma-T cell interactions
-
Demonstration of the dynamic changes in the T cell-recognized neoantigen landscape in human cancer.
-
22•• Verdegaal, E.M., de Miranda, N.F., Visser, M., Harryvan, T., van Buuren, M.M., Andersen, R.A., Hadrup, S.R., van der Minne, C.E., Schotte, R., Spits, H., et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature 536 (2016), 91–95 Demonstration of the dynamic changes in the T cell-recognized neoantigen landscape in human cancer.
-
(2016)
Nature
, vol.536
, pp. 91-95
-
-
Verdegaal, E.M.1
de Miranda, N.F.2
Visser, M.3
Harryvan, T.4
van Buuren, M.M.5
Andersen, R.A.6
Hadrup, S.R.7
van der Minne, C.E.8
Schotte, R.9
Spits, H.10
-
23
-
-
84880276438
-
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
-
23 Robbins, P.F., Lu, Y.C., El-Gamil, M., Li, Y.F., Gross, C., Gartner, J., Lin, J.C., Teer, J.K., Cliften, P., Tycksen, E., et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med 19 (2013), 747–752.
-
(2013)
Nat Med
, vol.19
, pp. 747-752
-
-
Robbins, P.F.1
Lu, Y.C.2
El-Gamil, M.3
Li, Y.F.4
Gross, C.5
Gartner, J.6
Lin, J.C.7
Teer, J.K.8
Cliften, P.9
Tycksen, E.10
-
24
-
-
84872841412
-
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
-
24 van Rooij, N., van Buuren, M.M., Philips, D., Velds, A., Toebes, M., Heemskerk, B., van Dijk, L.J., Behjati, S., Hilkmann, H., El Atmioui, D., et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol 31 (2013), e439–e442.
-
(2013)
J Clin Oncol
, vol.31
, pp. e439-e442
-
-
van Rooij, N.1
van Buuren, M.M.2
Philips, D.3
Velds, A.4
Toebes, M.5
Heemskerk, B.6
van Dijk, L.J.7
Behjati, S.8
Hilkmann, H.9
El Atmioui, D.10
-
25
-
-
84949730499
-
Immunogenicity of somatic mutations in human gastrointestinal cancers
-
25 Tran, E., Ahmadzadeh, M., Lu, Y.C., Gros, A., Turcotte, S., Robbins, P.F., Gartner, J.J., Zheng, Z., Li, Y.F., Ray, S., et al. Immunogenicity of somatic mutations in human gastrointestinal cancers. Science 350 (2015), 1387–1390.
-
(2015)
Science
, vol.350
, pp. 1387-1390
-
-
Tran, E.1
Ahmadzadeh, M.2
Lu, Y.C.3
Gros, A.4
Turcotte, S.5
Robbins, P.F.6
Gartner, J.J.7
Zheng, Z.8
Li, Y.F.9
Ray, S.10
-
26
-
-
84928811341
-
Mutant MHC class II epitopes drive therapeutic immune responses to cancer
-
Demonstration of the biased induction of neoantigen specific CD4+ T cell responses and the anti-tumor potential of neoantigen-specific CD4+ T cell responses.
-
26• Kreiter, S., Vormehr, M., van de Roemer, N., Diken, M., Lower, M., Diekmann, J., Boegel, S., Schrors, B., Vascotto, F., Castle, J.C., et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 520 (2015), 692–696 Demonstration of the biased induction of neoantigen specific CD4+ T cell responses and the anti-tumor potential of neoantigen-specific CD4+ T cell responses.
-
(2015)
Nature
, vol.520
, pp. 692-696
-
-
Kreiter, S.1
Vormehr, M.2
van de Roemer, N.3
Diken, M.4
Lower, M.5
Diekmann, J.6
Boegel, S.7
Schrors, B.8
Vascotto, F.9
Castle, J.C.10
-
27
-
-
0032473562
-
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
-
27 Ossendorp, F., Mengede, E., Camps, M., Filius, R., Melief, C.J., Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J Exp Med 187 (1998), 693–702.
-
(1998)
J Exp Med
, vol.187
, pp. 693-702
-
-
Ossendorp, F.1
Mengede, E.2
Camps, M.3
Filius, R.4
Melief, C.J.5
-
28
-
-
84900301377
-
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
-
Demonstration that infusion of neoantigen-specific CD4 T cells can induce tumor control in a patient with metastatic cancer.
-
28•• Tran, E., Turcotte, S., Gros, A., Robbins, P.F., Lu, Y.C., Dudley, M.E., Wunderlich, J.R., Somerville, R.P., Hogan, K., Hinrichs, C.S., et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344 (2014), 641–645 Demonstration that infusion of neoantigen-specific CD4 T cells can induce tumor control in a patient with metastatic cancer.
-
(2014)
Science
, vol.344
, pp. 641-645
-
-
Tran, E.1
Turcotte, S.2
Gros, A.3
Robbins, P.F.4
Lu, Y.C.5
Dudley, M.E.6
Wunderlich, J.R.7
Somerville, R.P.8
Hogan, K.9
Hinrichs, C.S.10
-
29
-
-
84969764539
-
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
-
Development of technology to exploit the healthy donor T cell repertoire to obtain neoantigen-specific TCRs.
-
29• Stronen, E., Toebes, M., Kelderman, S., van Buuren, M.M., Yang, W., van Rooij, N., Donia, M., Boschen, M.L., Lund-Johansen, F., Olweus, J., et al. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science, 2016 Development of technology to exploit the healthy donor T cell repertoire to obtain neoantigen-specific TCRs.
-
(2016)
Science
-
-
Stronen, E.1
Toebes, M.2
Kelderman, S.3
van Buuren, M.M.4
Yang, W.5
van Rooij, N.6
Donia, M.7
Boschen, M.L.8
Lund-Johansen, F.9
Olweus, J.10
-
30
-
-
84857725402
-
Exploiting the mutanome for tumor vaccination
-
30 Castle, J.C., Kreiter, S., Diekmann, J., Lower, M., van de Roemer, N., de Graaf, J., Selmi, A., Diken, M., Boegel, S., Paret, C., et al. Exploiting the mutanome for tumor vaccination. Cancer Res 72 (2012), 1081–1091.
-
(2012)
Cancer Res
, vol.72
, pp. 1081-1091
-
-
Castle, J.C.1
Kreiter, S.2
Diekmann, J.3
Lower, M.4
van de Roemer, N.5
de Graaf, J.6
Selmi, A.7
Diken, M.8
Boegel, S.9
Paret, C.10
-
31
-
-
84883251918
-
Targeting the tumor mutanome for personalized vaccination therapy
-
31 Kreiter, S., Castle, J.C., Tureci, O., Sahin, U., Targeting the tumor mutanome for personalized vaccination therapy. Oncoimmunology 1 (2012), 768–769.
-
(2012)
Oncoimmunology
, vol.1
, pp. 768-769
-
-
Kreiter, S.1
Castle, J.C.2
Tureci, O.3
Sahin, U.4
-
32
-
-
84920921528
-
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
-
32 Gubin, M.M., Zhang, X., Schuster, H., Caron, E., Ward, J.P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C.D., Krebber, W.J., et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515 (2014), 577–581.
-
(2014)
Nature
, vol.515
, pp. 577-581
-
-
Gubin, M.M.1
Zhang, X.2
Schuster, H.3
Caron, E.4
Ward, J.P.5
Noguchi, T.6
Ivanova, Y.7
Hundal, J.8
Arthur, C.D.9
Krebber, W.J.10
-
33
-
-
84920956731
-
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
-
33 Yadav, M., Jhunjhunwala, S., Phung, Q.T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T.K., Fritsche, J., Weinschenk, T., et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 515 (2014), 572–576.
-
(2014)
Nature
, vol.515
, pp. 572-576
-
-
Yadav, M.1
Jhunjhunwala, S.2
Phung, Q.T.3
Lupardus, P.4
Tanguay, J.5
Bumbaca, S.6
Franci, C.7
Cheung, T.K.8
Fritsche, J.9
Weinschenk, T.10
-
34
-
-
84928195112
-
Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
-
First clinical trial in humans with peptide-pulsed DCs showing induction of neoantigen-specific T cell responses.
-
34•• Carreno, B.M., Magrini, V., Becker-Hapak, M., Kaabinejadian, S., Hundal, J., Petti, A.A., Ly, A., Lie, W.R., Hildebrand, W.H., Mardis, E.R., et al. Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science 348 (2015), 803–808 First clinical trial in humans with peptide-pulsed DCs showing induction of neoantigen-specific T cell responses.
-
(2015)
Science
, vol.348
, pp. 803-808
-
-
Carreno, B.M.1
Magrini, V.2
Becker-Hapak, M.3
Kaabinejadian, S.4
Hundal, J.5
Petti, A.A.6
Ly, A.7
Lie, W.R.8
Hildebrand, W.H.9
Mardis, E.R.10
-
35
-
-
84971233983
-
Low mutation burden in ovarian cancer may limit the utility of neoantigen-targeted vaccines
-
35 Martin, S.D., Brown, S.D., Wick, D.A., Nielsen, J.S., Kroeger, D.R., Twumasi-Boateng, K., Holt, R.A., Nelson, B.H., Low mutation burden in ovarian cancer may limit the utility of neoantigen-targeted vaccines. PLoS One, 11, 2016, e0155189.
-
(2016)
PLoS One
, vol.11
, pp. e0155189
-
-
Martin, S.D.1
Brown, S.D.2
Wick, D.A.3
Nielsen, J.S.4
Kroeger, D.R.5
Twumasi-Boateng, K.6
Holt, R.A.7
Nelson, B.H.8
-
36
-
-
84975832642
-
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
-
36 Kranz, L.M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K.C., Meng, M., Fritz, D., Vascotto, F., Hefesna, H., et al. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature, 2016.
-
(2016)
Nature
-
-
Kranz, L.M.1
Diken, M.2
Haas, H.3
Kreiter, S.4
Loquai, C.5
Reuter, K.C.6
Meng, M.7
Fritz, D.8
Vascotto, F.9
Hefesna, H.10
-
37
-
-
84961323160
-
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
-
37 Linnemann, C., van Buuren, M.M., Bies, L., Verdegaal, E.M., Schotte, R., Calis, J.J., Behjati, S., Velds, A., Hilkmann, H., Atmioui, D.E., et al. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Nat Med 21 (2015), 81–85.
-
(2015)
Nat Med
, vol.21
, pp. 81-85
-
-
Linnemann, C.1
van Buuren, M.M.2
Bies, L.3
Verdegaal, E.M.4
Schotte, R.5
Calis, J.J.6
Behjati, S.7
Velds, A.8
Hilkmann, H.9
Atmioui, D.E.10
-
38
-
-
84943329717
-
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
-
38 Cohen, C.J., Gartner, J.J., Horovitz-Fried, M., Shamalov, K., Trebska-McGowan, K., Bliskovsky, V.V., Parkhurst, M.R., Ankri, C., Prickett, T.D., Crystal, J.S., et al. Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes. J Clin Invest 125 (2015), 3981–3991.
-
(2015)
J Clin Invest
, vol.125
, pp. 3981-3991
-
-
Cohen, C.J.1
Gartner, J.J.2
Horovitz-Fried, M.3
Shamalov, K.4
Trebska-McGowan, K.5
Bliskovsky, V.V.6
Parkhurst, M.R.7
Ankri, C.8
Prickett, T.D.9
Crystal, J.S.10
-
39
-
-
84959152038
-
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
-
Development of a blood-based strategy to identify neoantigen and self antigen reactive T cells that may be used for therapy.
-
39• Gros, A., Parkhurst, M.R., Tran, E., Pasetto, A., Robbins, P.F., Ilyas, S., Prickett, T.D., Gartner, J.J., Crystal, J.S., Roberts, I.M., et al. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med 22 (2016), 433–438 Development of a blood-based strategy to identify neoantigen and self antigen reactive T cells that may be used for therapy.
-
(2016)
Nat Med
, vol.22
, pp. 433-438
-
-
Gros, A.1
Parkhurst, M.R.2
Tran, E.3
Pasetto, A.4
Robbins, P.F.5
Ilyas, S.6
Prickett, T.D.7
Gartner, J.J.8
Crystal, J.S.9
Roberts, I.M.10
-
40
-
-
81255198783
-
Prediction of epitopes using neural network based methods
-
40 Lundegaard, C., Lund, O., Nielsen, M., Prediction of epitopes using neural network based methods. J Immunol Methods 374 (2011), 26–34.
-
(2011)
J Immunol Methods
, vol.374
, pp. 26-34
-
-
Lundegaard, C.1
Lund, O.2
Nielsen, M.3
-
41
-
-
84887277467
-
Properties of MHC class I presented peptides that enhance immunogenicity
-
41 Calis, J.J., Maybeno, M., Greenbaum, J.A., Weiskopf, D., De Silva, A.D., Sette, A., Kesmir, C., Peters, B., Properties of MHC class I presented peptides that enhance immunogenicity. PLoS Comput Biol, 9, 2013, e1003266.
-
(2013)
PLoS Comput Biol
, vol.9
, pp. e1003266
-
-
Calis, J.J.1
Maybeno, M.2
Greenbaum, J.A.3
Weiskopf, D.4
De Silva, A.D.5
Sette, A.6
Kesmir, C.7
Peters, B.8
-
42
-
-
84901295133
-
Deconstructing the peptide-MHC specificity of T cell recognition
-
42 Birnbaum, M.E., Mendoza, J.L., Sethi, D.K., Dong, S., Glanville, J., Dobbins, J., Ozkan, E., Davis, M.M., Wucherpfennig, K.W., Garcia, K.C., Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157 (2014), 1073–1087.
-
(2014)
Cell
, vol.157
, pp. 1073-1087
-
-
Birnbaum, M.E.1
Mendoza, J.L.2
Sethi, D.K.3
Dong, S.4
Glanville, J.5
Dobbins, J.6
Ozkan, E.7
Davis, M.M.8
Wucherpfennig, K.W.9
Garcia, K.C.10
-
43
-
-
84929659335
-
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes
-
43 Chowell, D., Krishna, S., Becker, P.D., Cocita, C., Shu, J., Tan, X., Greenberg, P.D., Klavinskis, L.S., Blattman, J.N., Anderson, K.S., TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes. Proc Natl Acad Sci U S A 112 (2015), E1754–E1762.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. E1754-E1762
-
-
Chowell, D.1
Krishna, S.2
Becker, P.D.3
Cocita, C.4
Shu, J.5
Tan, X.6
Greenberg, P.D.7
Klavinskis, L.S.8
Blattman, J.N.9
Anderson, K.S.10
-
44
-
-
84966769739
-
Targeting the heterogeneity of cancer with individualized neoepitope vaccines
-
44 Tureci, O., Vormehr, M., Diken, M., Kreiter, S., Huber, C., Sahin, U., Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res 22 (2016), 1885–1896.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1885-1896
-
-
Tureci, O.1
Vormehr, M.2
Diken, M.3
Kreiter, S.4
Huber, C.5
Sahin, U.6
|