메뉴 건너뛰기




Volumn 41, Issue , 2016, Pages 98-103

Neoantigens encoded in the cancer genome

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN; HLA ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN; NEOANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; UNCLASSIFIED DRUG; TUMOR ANTIGEN;

EID: 84984851145     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2016.07.005     Document Type: Review
Times cited : (64)

References (44)
  • 1
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 1 Sharma, P., Allison, J.P., The future of immune checkpoint therapy. Science 348 (2015), 56–61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 5
    • 84942285381 scopus 로고    scopus 로고
    • Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1
    • 5 Howitt, B.E., Shukla, S.A., Konstantinopoulos, P.A., Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1. JAMA Oncol 1 (2015), 1319–1323.
    • (2015) JAMA Oncol , vol.1 , pp. 1319-1323
    • Howitt, B.E.1    Shukla, S.A.2    Konstantinopoulos, P.A.3
  • 6
    • 84971669545 scopus 로고    scopus 로고
    • Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer
    • 6 Strickland, K.C., Howitt, B.E., Shukla, S.A., Rodig, S., Ritterhouse, L.L., Liu, J.F., Garber, J.E., Chowdhury, D., Wu, C.J., D'Andrea, A.D., et al. Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget 7 (2016), 13587–13598.
    • (2016) Oncotarget , vol.7 , pp. 13587-13598
    • Strickland, K.C.1    Howitt, B.E.2    Shukla, S.A.3    Rodig, S.4    Ritterhouse, L.L.5    Liu, J.F.6    Garber, J.E.7    Chowdhury, D.8    Wu, C.J.9    D'Andrea, A.D.10
  • 7
    • 84976406910 scopus 로고    scopus 로고
    • Neoantigen load, antigen presentation machinery, and immune signatures determine prognosis in clear cell renal cell carcinoma
    • 7 Matsushita, H., Sato, Y., Karasaki, T., Nakagawa, T., Kume, H., Ogawa, S., Homma, Y., Kakimi, K., Neoantigen load, antigen presentation machinery, and immune signatures determine prognosis in clear cell renal cell carcinoma. Cancer Immunol Res 4 (2016), 463–471.
    • (2016) Cancer Immunol Res , vol.4 , pp. 463-471
    • Matsushita, H.1    Sato, Y.2    Karasaki, T.3    Nakagawa, T.4    Kume, H.5    Ogawa, S.6    Homma, Y.7    Kakimi, K.8
  • 8
    • 84899836282 scopus 로고    scopus 로고
    • Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
    • 8 Brown, S.D., Warren, R.L., Gibb, E.A., Martin, S.D., Spinelli, J.J., Nelson, B.H., Holt, R.A., Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res 24 (2014), 743–750.
    • (2014) Genome Res , vol.24 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3    Martin, S.D.4    Spinelli, J.J.5    Nelson, B.H.6    Holt, R.A.7
  • 9
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • 9 Rooney, M.S., Shukla, S.A., Wu, C.J., Getz, G., Hacohen, N., Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160 (2015), 48–61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 10
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • 10 Schumacher, T.N., Schreiber, R.D., Neoantigens in cancer immunotherapy. Science 348 (2015), 69–74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 12
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • 12 Rizvi, N.A., Hellmann, M.D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J.J., Lee, W., Yuan, J., Wong, P., Ho, T.S., et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348 (2015), 124–128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6    Lee, W.7    Yuan, J.8    Wong, P.9    Ho, T.S.10
  • 16
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • 16 Rosenberg, J.E., Hoffman-Censits, J., Powles, T., van der Heijden, M.S., Balar, A.V., Necchi, A., Dawson, N., O'Donnell, P.H., Balmanoukian, A., Loriot, Y., et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387 (2016), 1909–1920.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6    Dawson, N.7    O'Donnell, P.H.8    Balmanoukian, A.9    Loriot, Y.10
  • 20
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • 20 Spranger, S., Bao, R., Gajewski, T.F., Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523 (2015), 231–235.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 21
    • 84894107349 scopus 로고    scopus 로고
    • New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape
    • 21 Mittal, D., Gubin, M.M., Schreiber, R.D., Smyth, M.J., New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape. Curr Opin Immunol 27 (2014), 16–25.
    • (2014) Curr Opin Immunol , vol.27 , pp. 16-25
    • Mittal, D.1    Gubin, M.M.2    Schreiber, R.D.3    Smyth, M.J.4
  • 22
    • 84976406873 scopus 로고    scopus 로고
    • Neoantigen landscape dynamics during human melanoma-T cell interactions
    • Demonstration of the dynamic changes in the T cell-recognized neoantigen landscape in human cancer.
    • 22•• Verdegaal, E.M., de Miranda, N.F., Visser, M., Harryvan, T., van Buuren, M.M., Andersen, R.A., Hadrup, S.R., van der Minne, C.E., Schotte, R., Spits, H., et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature 536 (2016), 91–95 Demonstration of the dynamic changes in the T cell-recognized neoantigen landscape in human cancer.
    • (2016) Nature , vol.536 , pp. 91-95
    • Verdegaal, E.M.1    de Miranda, N.F.2    Visser, M.3    Harryvan, T.4    van Buuren, M.M.5    Andersen, R.A.6    Hadrup, S.R.7    van der Minne, C.E.8    Schotte, R.9    Spits, H.10
  • 23
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • 23 Robbins, P.F., Lu, Y.C., El-Gamil, M., Li, Y.F., Gross, C., Gartner, J., Lin, J.C., Teer, J.K., Cliften, P., Tycksen, E., et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med 19 (2013), 747–752.
    • (2013) Nat Med , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3    Li, Y.F.4    Gross, C.5    Gartner, J.6    Lin, J.C.7    Teer, J.K.8    Cliften, P.9    Tycksen, E.10
  • 26
    • 84928811341 scopus 로고    scopus 로고
    • Mutant MHC class II epitopes drive therapeutic immune responses to cancer
    • Demonstration of the biased induction of neoantigen specific CD4+ T cell responses and the anti-tumor potential of neoantigen-specific CD4+ T cell responses.
    • 26• Kreiter, S., Vormehr, M., van de Roemer, N., Diken, M., Lower, M., Diekmann, J., Boegel, S., Schrors, B., Vascotto, F., Castle, J.C., et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 520 (2015), 692–696 Demonstration of the biased induction of neoantigen specific CD4+ T cell responses and the anti-tumor potential of neoantigen-specific CD4+ T cell responses.
    • (2015) Nature , vol.520 , pp. 692-696
    • Kreiter, S.1    Vormehr, M.2    van de Roemer, N.3    Diken, M.4    Lower, M.5    Diekmann, J.6    Boegel, S.7    Schrors, B.8    Vascotto, F.9    Castle, J.C.10
  • 27
    • 0032473562 scopus 로고    scopus 로고
    • Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
    • 27 Ossendorp, F., Mengede, E., Camps, M., Filius, R., Melief, C.J., Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J Exp Med 187 (1998), 693–702.
    • (1998) J Exp Med , vol.187 , pp. 693-702
    • Ossendorp, F.1    Mengede, E.2    Camps, M.3    Filius, R.4    Melief, C.J.5
  • 28
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
    • Demonstration that infusion of neoantigen-specific CD4 T cells can induce tumor control in a patient with metastatic cancer.
    • 28•• Tran, E., Turcotte, S., Gros, A., Robbins, P.F., Lu, Y.C., Dudley, M.E., Wunderlich, J.R., Somerville, R.P., Hogan, K., Hinrichs, C.S., et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344 (2014), 641–645 Demonstration that infusion of neoantigen-specific CD4 T cells can induce tumor control in a patient with metastatic cancer.
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1    Turcotte, S.2    Gros, A.3    Robbins, P.F.4    Lu, Y.C.5    Dudley, M.E.6    Wunderlich, J.R.7    Somerville, R.P.8    Hogan, K.9    Hinrichs, C.S.10
  • 29
    • 84969764539 scopus 로고    scopus 로고
    • Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
    • Development of technology to exploit the healthy donor T cell repertoire to obtain neoantigen-specific TCRs.
    • 29• Stronen, E., Toebes, M., Kelderman, S., van Buuren, M.M., Yang, W., van Rooij, N., Donia, M., Boschen, M.L., Lund-Johansen, F., Olweus, J., et al. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science, 2016 Development of technology to exploit the healthy donor T cell repertoire to obtain neoantigen-specific TCRs.
    • (2016) Science
    • Stronen, E.1    Toebes, M.2    Kelderman, S.3    van Buuren, M.M.4    Yang, W.5    van Rooij, N.6    Donia, M.7    Boschen, M.L.8    Lund-Johansen, F.9    Olweus, J.10
  • 31
    • 84883251918 scopus 로고    scopus 로고
    • Targeting the tumor mutanome for personalized vaccination therapy
    • 31 Kreiter, S., Castle, J.C., Tureci, O., Sahin, U., Targeting the tumor mutanome for personalized vaccination therapy. Oncoimmunology 1 (2012), 768–769.
    • (2012) Oncoimmunology , vol.1 , pp. 768-769
    • Kreiter, S.1    Castle, J.C.2    Tureci, O.3    Sahin, U.4
  • 34
    • 84928195112 scopus 로고    scopus 로고
    • Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
    • First clinical trial in humans with peptide-pulsed DCs showing induction of neoantigen-specific T cell responses.
    • 34•• Carreno, B.M., Magrini, V., Becker-Hapak, M., Kaabinejadian, S., Hundal, J., Petti, A.A., Ly, A., Lie, W.R., Hildebrand, W.H., Mardis, E.R., et al. Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science 348 (2015), 803–808 First clinical trial in humans with peptide-pulsed DCs showing induction of neoantigen-specific T cell responses.
    • (2015) Science , vol.348 , pp. 803-808
    • Carreno, B.M.1    Magrini, V.2    Becker-Hapak, M.3    Kaabinejadian, S.4    Hundal, J.5    Petti, A.A.6    Ly, A.7    Lie, W.R.8    Hildebrand, W.H.9    Mardis, E.R.10
  • 39
    • 84959152038 scopus 로고    scopus 로고
    • Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
    • Development of a blood-based strategy to identify neoantigen and self antigen reactive T cells that may be used for therapy.
    • 39• Gros, A., Parkhurst, M.R., Tran, E., Pasetto, A., Robbins, P.F., Ilyas, S., Prickett, T.D., Gartner, J.J., Crystal, J.S., Roberts, I.M., et al. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med 22 (2016), 433–438 Development of a blood-based strategy to identify neoantigen and self antigen reactive T cells that may be used for therapy.
    • (2016) Nat Med , vol.22 , pp. 433-438
    • Gros, A.1    Parkhurst, M.R.2    Tran, E.3    Pasetto, A.4    Robbins, P.F.5    Ilyas, S.6    Prickett, T.D.7    Gartner, J.J.8    Crystal, J.S.9    Roberts, I.M.10
  • 40
    • 81255198783 scopus 로고    scopus 로고
    • Prediction of epitopes using neural network based methods
    • 40 Lundegaard, C., Lund, O., Nielsen, M., Prediction of epitopes using neural network based methods. J Immunol Methods 374 (2011), 26–34.
    • (2011) J Immunol Methods , vol.374 , pp. 26-34
    • Lundegaard, C.1    Lund, O.2    Nielsen, M.3
  • 44
    • 84966769739 scopus 로고    scopus 로고
    • Targeting the heterogeneity of cancer with individualized neoepitope vaccines
    • 44 Tureci, O., Vormehr, M., Diken, M., Kreiter, S., Huber, C., Sahin, U., Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res 22 (2016), 1885–1896.
    • (2016) Clin Cancer Res , vol.22 , pp. 1885-1896
    • Tureci, O.1    Vormehr, M.2    Diken, M.3    Kreiter, S.4    Huber, C.5    Sahin, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.