Exhaled nitric oxide levels to guide treatment for adults with asthma

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 9, 2016, Pages

  Petsky, Helen L ^a   Kew, Kayleigh M ^b   Turner, Cathy ^c   Chang, Anne B ^a,d  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; NITRIC OXIDE; ANTIASTHMATIC AGENT;

ACUTE DISEASE; ASTHMA; DISEASE EXACERBATION; DISEASE SEVERITY; EOSINOPHILIA; EXHALATION; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION; MAINTENANCE THERAPY; META ANALYSIS (TOPIC); PEAK EXPIRATORY FLOW; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; RESPIRATORY TRACT INFLAMMATION; REVIEW; SENSITIVITY ANALYSIS; SPIROMETRY; SYSTEMATIC REVIEW; TIME TO TREATMENT; ADOLESCENT; BREATH ANALYSIS; CHILD; DISEASE COURSE; META ANALYSIS; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADOLESCENT; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ASTHMA; BREATH TESTS; CHILD; DISEASE PROGRESSION; EXHALATION; HUMANS; NITRIC OXIDE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SPIROMETRY;

EID: 84984793152     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD011440.pub2     Document Type: Review

References (56)

1. Calhoun W, Ameredes B, King T, Icitovic N, Bleecker E, Castro M, et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma. JAMA 2012;308(10):987-97.
2. Hashimoto S, Ten Brinke A, Roldaan A, van Veen I, Moller G, Sont J, et al. Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial. Thorax 2011;66:514-20. [DOI: 10.1136/thx.2010.153411]
3. Honkoop P, Lijmans R, Termeer E, Snoeck-Stroband J, van den Hout W, Bakker M, et al. Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care. Journal of Allergy and Clinical Immunology 2015;135:682-8. [DOI: 10.1016/j.jaci.2014.07.016]
4. Burgess L, McCaffery K, Powell H, Murphy VE, Gibson PG, Turner RM. The influence of asthma control on psychosocial outcomes for pregnant women with asthma. Journal of Asthma 2015 Aug 24 [Epub ahead of print]. [DOI: 10.3109/02770903.2015.103883]
5. Murphy V, Powell H, Gibson P. Exacerbations following step down and step up inhaled corticosteroid therapy in the managing asthma in pregnancy (MAP) study. Respirology 2015;20:54.
6. Murphy VE, Powell H, Gibson PG. Exacerbations of asthma following changes in inhaled corticosteroids (ICS) and long acting beta agonist (LABA) therapy in the managing asthma in pregnancy (MAP) study. Journal of Paediatrics and Child Health 2015;51:64. [Conference abstract]
7. Powell H, Murphy V, Taylor DR, Hensley M, McCaffery K, Giles W, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. The Lancet 2011;378:983-90. [DOI: 10.1016/S0140-6736(11)60971-9]
8. Shaw D, Berry M, Thomas M, Green R, Brightling C, Wardlaw A, et al. The use of exhaled nitric oxide to guide asthma management - A randomized controlled trial. American Journal of Respiratory and Critical Care Medicine 2007;176:231-7. [DOI: 10.1164/rccm.200610-1427OC]
9. Smith AD, Cowan J, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. The New England Journal of Medicine 2005;352:2163-73.
10. Syk J, Malinovschi, Johansson G, Unden A, Andreasson A, Lekander M, et al. Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: A randomized, controlled trial. Journal of Allergy and Clinical Immunology Practice 2013;1:639-48. [DOI: 10.1016/j.jaip.2013.07.013]
11. Anderson WJ, Short PM, Williamson PA, Lipworth BJ. Inhaled corticosteroid dose response using domiciliary exhaled nitric oxide in persistent asthma: the FeNOtype trial. Chest 2012;142:1553-61. [DOI: 10.1378/chest.12-1310]
12. de Jongste JC, Carraro S, Hop WC, CHARISM Study Group, Baraldi E. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. American Journal of Respiratory and Critical Care Medicine 2008;179:93-7. [DOI: 10.1164/rccm.200807-1010OC]
13. Fritsch M, Uxa S, Horak F, Putschoegl B, Dehlink E, Szepfalusi Z, et al. Exhaled nitric oxide in the management of childhood asthma: A prospective 6-months study. Pediatric Pulmonology 2006;41:855-62. [DOI: 10.1002/ppul.20455]
14. Gelb A, Flynn Taylor C, Shinar CM, Gutierrez C, Zamel N. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest 2006;129(6):1492-9. [DOI: 10.1378/chest.129.6.1492]
15. Griese M, Koch M, Latzin P, Beck J. Asthma severity, recommended changes of inhaled therapy and exhaled nitric oxide in children: a prospective, blinded trial. European Journal of Medical Research 2000;5(8):334-40. [PUBMED: PMID 10958766]
16. Gruchalla RS, Sampson HA, Matsui E, David G, Gergen PJ, Calatroni A, et al. Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence. Journal of Allergy and Clinical Immunology 2009;124:213-21. [DOI: 10.1016/j.jaci2009.05.036]
17. Jatakanon A, Kharitonov S, Lim S, Barnes PJ. Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma. Thorax 1999;54(2):108-14. [DOI: 10.1136/thx.54.2.108]
18. Jones SL, Kittelson J, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, et al. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. American Journal of Respiratory and Critical Care Medicine 2001;164(5):738-43. [DOI: 10.1164/ajrccm.164.5.2012125]
19. Jones SL, Herbison P, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, et al. Exhaled NO and assessment of anti-inflammatory effects of inhaled steroids: Dose-response relationship. European Respiratory Journal 2002;20(3):601-8. [DOI: 10.1183/09031936.02.00285302]
20. Kharitonov SA, Yates DH, Chung KF, Barnes PJ. Changes in the dose of inhaled steroid affect exhaled nitric oxide in asthmatic patients. European Respiratory Journal 1996;9(2):196-201. [PUBMED: 8777950]
21. Kharitonov SA, Konnelly LE, Corradi M, Montuschi P, Barnes PJ. Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax 2002;57(1):889-96. [DOI: 10.1136/thorax.57.10.889]
22. Lim S, Jatakanon A, Uasuf C, Chung KF, Barnes PJ. Clinical utility of exhaled nitric oxide as a marker of disease activity in asthma. American Journal of Respiratory and Critical Care Medicine 1998;157(3 Suppl):A611.
23. Malerba M, Ragnoli B, Radaeli A, Tantucci C. Usefulness of exhaled nitric oxide and sputum eosinophils in the long-term control of eosinophilic asthma. Chest 2008;134:733-9. [DOI: 10.1378/chest.08-0763]
24. Peirsman EJ, Carvelli TJ, Hage PY, Hanssens LS, Pattyn L, Raes MM, et al. Exhaled nitric oxide in childhood allergic asthma management: A randomised controlled trial. Pediatric Pulmonology 2014;49:624-31. [DOI: 10.1002/ppul.22873]
25. Petsky HL, Li AM, Au CT, Kynaston JA, Turner C, Chang AB. Management based on exhaled nitric oxide levels adjusted for atopy reduces asthma exacerbations in children: A dual centre randomized controlled trial. Pediatric Pulmonology 2015;50:535-43. [DOI: 10.1002/ppul.23064]
26. Pijnenburg M, Bakker E, Hop W, de Jongste J. Titrating steroids on exhaled nitric oxide in children with asthma. American Journal of Respiratory and Critical Care Medicine 2005;172(7):831-6. [DOI: 10.1164/rccm.200503-458OC]
27. Pike K, Selby A, Price S, Warner J, Connett G, Legg J, et al. Exhaled nitric oxide monitoring does not reduce exacerbation frequency or inhaled corticosteroid dose in paediatric asthma: a randomised controlled trial. The Clinical Respiratory Journal 2013;7(2):204-13. [DOI: 10.1111/j.1752-699X.2012.00306.x]
28. Powell H, Murphy VE, Hensley MJ, Giles W, Clifton VL, Gibson PG. Rhinitis in pregnant women with asthma is associated with poorer asthma control and quality of life. Journal of Asthma 2015 Sep 12 [Epub ahead of print]. [DOI: 10.3109/02770903.2015.1054403]
29. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. The Lancet 2008;372(9643):1065-72. [DOI: 10.1016/S0140-6736(08)61448-8]
30. Verini M, Consilvio NP, Di Pillo S, Cingolani A, Spagnuolo C, Rapino D, et al. FeNO as a marker of airways inflammation: The possible implications in childhood asthma management. Journal of Allergy 2010;2010:7. [DOI: 10.1155/2010/691425]
31. Bergen SV, Beerthuizen T, van den Hout W, Vaessen-Verberne A, Brackel H, Landstra A, et al. Cost-effectiveness of FeNO- and web-based monitoring in pediatric asthma management. European Respiratory Journal. 2015; Vol. 46.
32. Voorend-van Bergen S, Vaessen-Verberne A, Landstra A, Brackel H, van Den Breg N, de Jongste J, et al. FeNO and web-based monitoring in paediatric asthma management: the BATMAN study. European Respiratory Society Annual Congress. 2013; Vol. 42:629s.
33. Voorend-van Bergen S, Vaessen-Verberne AA, Brackel HJ, Landstra AM, van den Berg NJ, Hop WC. Monitoring strategies in children with asthma: a randomised controlled trial. Thorax 2015;70:543-50. [DOI: 10.1136/thoraxjnl-2014-206161]
34. Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. American Journal of Respiratory and Critical Care Medicine 2005;171(10):1077-82. [DOI: 10.1164/rccm.200409-1242OC]
35. Duong-Quy S, Hua-Huy T, Doan-Quynh N, Nguyen-Quoc B, Le-Quang K, Tran-Thanh D, et al. A study of exhaled NO (FeNO) measurement used to determine asthma control, dose of inhaled corticosteroid and cost in a developing country. European Respiratory Journal. 2015; Vol. 46.
36. American Thoracic Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of FeNO. American Journal of Critical Care and Respiratory Medicine 2005;171:912-30. [DOI: 10.1164/rccm.200406-710ST]
37. British Guideline on the Management of Asthma: A national clinical guideline. http://brit-thoracic.org.uk/ (accessed 16 December 2014).
38. Dr Christopher Cates. Visual Rx. Online NNT Calculator. Dr Christopher Cates, 2008.
39. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002;53:91-5.
40. Dupont LJ, Rochette F, Demedts MG, Verleden GM. Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with mild asthma. American Journal of Respiratory and Critical Care Medicine 1998;157:894-8.
41. Essat M, Harnan S, Gomersall T, Tappenden P, Wong R, Pavord I, et al. Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review. European Respiratory Journal 2016;47:751-68. [DOI: 10.1183/13993003.01882-2015]
42. From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2014. http://www.ginasthma.org/local/uploads/files/GINA_Report_2014_Aug12.pdf (accessed 31 October 2014).
43. Gomersal T, Harnan S, Essat M, Tappenden P, Wong R, Lawson R, et al. A systematic review of fractional exhaled nitric oxide in the routine management of childhood asthma. Pediatric Pulmonology 2016;51:316-28. [DOI: 10.1002/ppul.23371]
44. Jan Brozek, Andrew Oxman, Holger Schunemann. GRADEpro Version 3.2. Jan Brozek, Andrew Oxman, Holger Schunemann, 2008.
45. Harnan SE, Tappenden P, Essat M, Gomersall T, Minton J, Wong R, et al. Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath. Health Technology Assessment 2015;19:1-368. [DOI: 10.3310/hta19820]
46. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
47. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils and methacholine responsiveness. Thorax 1998;53:91-5.
48. Karampitsakos T, Gourgoulianis KI. Asthma-COPD Overlap Syndrome (ACOS): Single disease entity or not? Could exhaled nitric oxide be a useful biomarker for the differentiation of ACOS, asthma and COPD?. Medical Hypotheses 2016;91:20-3. [DOI: 10.1016/j.mehy.2016.04.008]
49. Lu M, Wu B, Che D, Qiao R, Gu H. FeNO and asthma treatment in children. Medicine 2015;94:e347. [DOI: 10.1097/MD.0000000000000347]
50. Muller KC, Jorres RA, Magnussen H, Holz O. Comparison of exhaled nitric oxide analysers. Respiratory Medicine 2005;99:631-7.
51. National Asthma Council Australia, Melbourne, 2014 Australian Asthma Handbook, Version 1.0. http://www.nationalasthma.org.au/handbook (accessed 31 October 2014).
52. Petsky HL, Kew KM, Kynaston JA, Turner C, Chang AB. Exhaled nitric oxide levels to guide treatment for children with asthma. Cochrane Database of Systematic Reviews 2015, Issue 1. [DOI: 10.1002/14651858.CD011439]
53. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
54. Wardlaw AJ, Brightling C, Green R, Woltmann G, Pavord I. Eosinophils in asthma and other allergic diseases. British Medical Bulletin 2000;56:985-1003.
55. Weiss KB, Sullivan SD. The health economics of asthma and rhinitis. I. Assessing the economic impact. Journal of Allergy and Clinical Immunology 2001;107:3-8.
56. Petsky HL, Cates CJ, Li A, Kynaston JA, Turner C, Chang AB. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD006340.pub3]