Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients

European Respiratory Journal

Volumn 9, Issue 2, 1996, Pages 196-201

  Kharitonov, S A ^a   Yates, D H ^a   Chung, K F ^a   Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Airway inflammation; Asthma; Inducible nitric oxide synthase; Nitric oxide; Steroids

Indexed keywords

BUDESONIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STEROID;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; PATIENT MONITORING; PNEUMONIA; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ADULT; ANTI-INFLAMMATORY AGENTS; ASTHMA; BUDESONIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG; MALE; MIDDLE AGED; NITRIC OXIDE; PREGNENEDIONES; RESPIRATION; RESPIRATORY FUNCTION TESTS;

EID: 0030069404     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09020196     Document Type: Article

References (30)

1. Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995; 332: 868-875.
2. British Thoracic Society. Guidelines on the management of asthma. Thorax 1993; 48 (Suppl.): S1-S24.
3. National Heart Lung and Blood Institute National Asthma Education Programme Expert Panel Report. Guidelines for the diagnosis and management of asthma. J Allergy Clin Immunol 1991; 88: 425-534.
4. International Consensus Report on Diagnosis and Management of Asthma. Clin Exp Allergy 1992; 22 (Suppl 1): 1-72.
5. Barnes PJ. Effect of corticosteroids on airway hyperresponsiveness. Am Rev Respir Dis 1990; 141: S70-S76.
6. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'Byrne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in non-steroid-dependent asthmatics. Am Rev Respir Dis 1990; 142: 832-836.
7. 2-agonists on lung function, airway responsiveness and symptoms in children with asthma. Am Rev Respir Dis 1992; 146: 547-554.
8. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6: 1268-1270.
9. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne E, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133-135.
10. Persson MG, Zetterstrom O, Argenius V, Ihre E, Gustafsson LE. Single-breath oxide measurements in asthmatic patients and smokers. Lancet 1994; 343: 146-147.
11. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510-1513.
12. Robbins RA, Barnes PJ, Springall DR, et al. Expression of inducible nitric oxide synthase in human bronchial epithelial cells. Biochem Biophys Res Commun 1994; 203: 209-218.
13. Belvisi MG, Barnes PJ, Larkin S, et al. Nitric oxide synthase activity is elevated in inflammatory lung diseases. Eur J Pharmacol 1995; 283: 255-258.
14. Springall DR, Meng Q, Redington A, Howarth PH, Evans TJ, Polak JM. Inducible nitric oxide synthase in asthmatic airway epithelium is reduced by corticosteroid therapy. Am J Respir Crit Care Med 1995; 151: A833.
15. Yates DH, Kharitonov SA, Robbins RA, Thomas PS, Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1995; 152(3): 892-896.
16. Kharitonov SA, Yates DH, Barnes PJ. Regular inhaled budesonide decreases nitric oxide concentration in the exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996; 152: (in press).
17. Barnes PJ Belvisi MG. Nitric oxide and lung disease. Thorax 1993; 48: 1034-1043.
18. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994; 149: 538-551.
19. Xie Q, Kashiwarbara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 1994; 269: 4705-4708.
20. Adcock IM, Brown CR, Kwon OJ, Barnes PJ. Oxidative stress induces NF-κB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem Biophys Res Commun 1994; 199: 1518-1524.
21. Djukanovic R, Roche UR, Wilson JW, et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142: 434-457.
22. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25-29.
23. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151: 1894-1899.
24. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994; 343: 518-519.
25. Lundberg JON, Weitzberg E, Nordvall SL, Kuylenstierna R, Lundberg JM, Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartogener's syndrome. Eur Respir J 1994; 8: 1501-1504.
26. Cremona G, Higenbottam T, Takao M, Hall L, Bower EA. Exhaled nitric oxide in isolated pig lungs. J Appl Physiol 1995; 78: 59-63.
27. Yates DH, Kharitonov SA, Worsdell M, Thomas PS, Barnes PJ. Exhaled nitric oxide is decreased after inhalation of a specific inhibitor of inducible nitric oxide synthase, in asthmatic but not in normal subjects. Am J Respir Crit Care Med 1995; 151: A699.
28. Kharitonov SA, Chung KF, Evans D, O'Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is derived from the lower respiratory tract. Am J Respir Crit Care Med 1996; (in press).
29. Kharitonov SA, Wells AU, O'Connor BJ, Hansell DM, Cole PJ, Barnes PJ. Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med 1995; 151: 1889-1893.
30. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995; 8: 295-297.