Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise

Journal of Applied Physiology

Volumn 120, Issue 8, 2016, Pages 843-854

  Smith, K J ^a   Wildfong, K W ^a   Hoiland, R L ^a   Harper, M ^a   Lewis, N C ^a   Pool, A ^a   Smith, S L ^a   Kuca, T ^b   Foster, G E ^a   Ainslie, P N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Carbon dioxide; Cerebral blood flow; Exercise; Hyperoxia; Hyperpnea

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADOLESCENT; ADULT; BLOOD FLOW VELOCITY; BRAIN; BRAIN CIRCULATION; BREATHING; CEREBROVASCULAR DISEASE; EXERCISE; FEMALE; HUMAN; HYPEREMIA; HYPEROXIA; HYPERVENTILATION; MALE; METABOLISM; PARTIAL PRESSURE; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTERIOR CEREBRAL ARTERY; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD FLOW VELOCITY; BRAIN; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; EXERCISE; FEMALE; HUMANS; HYPEREMIA; HYPEROXIA; HYPERVENTILATION; MALE; OXYGEN; PARTIAL PRESSURE; POSTERIOR CEREBRAL ARTERY; RESPIRATION; YOUNG ADULT;

EID: 84984673694     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00490.2015     Document Type: Article

References (41)

1. Asmussen E, Nielsen M. Studies on the regulation of respiration in heavy work. Acta Physiol Scand 12: 171-188, 1946.
2. Bannister RG, Cunningham DJ. The effects on the respiration and performance during exercise of adding oxygen to the inspired air. J Physiol 125: 118-137, 1954.
3. Becker HF, Polo O, McNamara SG, Berthon-Jones M, Sullivan CE. Effect of different levels of hyperoxia on breathing in healthy subjects. J Appl Physiol 81: 1683-1690, 1996.
4. Black MA, Cable NT, Thijssen DH, Green DJ. Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51: 203-210, 2008.
5. Coverdale NS, Gati JS, Opalevych O, Perrotta A, Shoemaker JK. Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia. J Appl Physiol 117: 1090-1096, 2014.
6. Evans DH. On the measurement of the mean velocity of blood flow over the cardiac cycle using Doppler ultrasound. Ultrasound Med Biol 11: 735-741, 1985.
7. Fisher JP, Hartwich D, Seifert T, Olesen ND, McNulty CL, Nielsen HB, Van Lieshout JJ, Secher NH. Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals. J Physiol 591: 1859-1870, 2013.
8. Hellström G, Wahlgren NG. Physical exercise increases middle cerebral artery blood flow velocity. Neurosurg Rev 16: 151-156, 1993.
9. Herholz K, Buskies W, Rist M, Pawlik G, Hollmann W, Heiss WD. Regional cerebral blood flow in man at rest and during exercise. J Neurol 234: 9-13, 1987.
10. Jorgensen LG, Perko M, Hanel B, Schroeder TV, Secher NH. Middle cerebral artery flow velocity and blood flow during exercise and muscle ischemia in humans. J Appl Physiol 72: 1123-1132, 1992.
11. Lambertsen CJ, Owen SG, Wendel H, Stroud MW, Lurie AA, Lochner W, Clark GF. Respiratory and cerebral circulatory control during exercise at 21 and 20 atmospheres inspired PO2. J Appl Physiol 14: 966-982, 1959.
12. Linkis P, Jorgensen LG, Olesen HL, Madsen PL, Lassen NA, Secher NH. Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol 78: 12-16, 1995.
13. Madsen PL, Sperling BK, Warming T, Schmidt JF, Secher NH, Wildschiødtz G, Holm S, Lassen NA. Middle cerebral artery blood velocity and cerebral blood flow and O2 uptake during dynamic exercise. J Appl Physiol 74: 245-250, 1993.
14. Marsden KR, Haykowsky MJ, Smirl JD, Jones H, Nelson MD, Altamirano-Diaz LA, Gelinas JC, Tzeng YC, Smith KJ, Willie CK, Bailey DM, Ainslie PN. Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age (Dordr) 34: 725-735, 2012.
15. Mateika JH, Duffin J. The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia. Eur J Appl Physiol Occup Physiol 69: 110-118, 1994.
16. Moraine JJ, Lamotte M, Berré J, Niset G, Leduc A, Naeije R. Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects. Eur J Appl Physiol Occup Physiol 67: 35-38, 1993.
17. Neubauer JA, Strumpf DA, Edelman NH. Regional medullary blood flow during isocapnic hyperpnea in anesthetized cats. J Appl Physiol 55: 447-452, 1983.
18. Ogoh S, Ainslie PN. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol 107: 1370-1380, 2009.
19. Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A, Raven PB. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol 569: 697-704, 2005.
20. Olin JT, Dimmen AC, Subudhi AW, Roach RC. Cerebral blood flow and oxygenation at maximal exercise: the effect of clamping carbon dioxide. Respir Physiol Neurobiol 175: 176-180, 2011.
21. Rasmussen P, Nielsen J, Overgaard M, Krogh Madsen R, Gjedde A, Secher NH, Petersen NC. Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588: 1985-1995, 2010.
22. Rasmussen P, Stie H, Nielsen B, Nybo L. Enhanced cerebral CO2 reactivity during strenuous exercise in man. Eur J Appl Physiol 96: 299-304, 2006.
23. Sato K, Ogoh S, Hirasawa A, Oue A, Sadamoto TA. The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol 589: 2847-2856, 2011.
24. Sato K, Sadamoto T. Different blood flow responses to dynamic exercise between internal carotid and vertebral arteries in women. J Appl Physiol 109: 864-869, 2010.
25. Schöning M, Walter J, Scheel P. Estimation of cerebral blood flow through color duplex sonography of the carotid and vertebral arteries in healthy adults. Stroke 25: 17-22, 1994.
26. Smith KJ, MacLeod D, Willie CK, Lewis NCS, Hoiland RL, Ikeda K, Tymko MM, Donnelly J, Day TA, MacLeod N, Lucas SJ, Ainslie PN. Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery. J Physiol 592: 5507-5527, 2014.
27. Smith KJ, Wong LE, Eves ND, Koelwyn GJ, Smirl JD, Willie CK, Ainslie PN. Regional cerebral blood flow distribution during exercise: influence of oxygen. Respir Physiol Neurobiol 184: 97-105, 2012.
28. Subudhi AW, Lorenz MC, Fulco CS, Roach RC. Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294: H164-H171, 2008.
29. Subudhi AW, Miramon BR, Granger ME, Roach RC. Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106: 1153-1158, 2009.
30. Subudhi AW, Olin JT, Dimmen AC, Polaner DM, Kayser B, Roach RC. Does cerebral oxygen delivery limit incremental exercise performance? J Appl Physiol 111: 1727-1734, 2011.
31. Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300: H2-H12, 2011.
32. Thomas KN, Lewis NC, Hill BG, Ainslie PN. Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow. Am J Physiol Regul Integr Comp Physiol 309: R707-R720, 2015.
33. Trangmar SJ, Chiesa ST, Stock CG, Kalsi KK, Secher NH, Gonzalez-Alonso J. Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans. J Physiol 592: 3143-3160, 2014.
34. Tymko MM, Ainslie PN, Macleod DB, Willie CK, Foster GE. Endtidal-to-arterial CO2 and O2 gas gradients at low-and high-altitude during dynamic end-tidal forcing. Am J Physiol Regul Integr Comp Physiol 308: R895-R906, 2015.
35. Verbree J, Bronzwaer AS, Ghariq E, Versluis MJ, Daemen MJ, van Buchem MA, Dahan A, Van Lieshout JJ, van Osch MJ. Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra high-field MRI. J Appl Physiol 117: 1084-1089, 2014.
36. Welch HG, Bonde-Petersen F, Graham T, Klausen K, Secher N. Effects of hyperoxia on leg blood flow and metabolism during exercise. J Appl Physiol 42: 385-390, 1977.
37. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ, Smirl JD, Day TA, Lucas SJ, Eller LK, Ainslie PN. Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196: 221-237, 2011.
38. Willie CK, Cowan EC, Ainslie PN, Taylor CE, Smith KJ, Sin PY, Tzeng YC. Neurovascular coupling and distribution of cerebral blood flow during exercise. J Neurosci Methods 198: 270-273, 2011.
39. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN. Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590: 3261-3275, 2012.
40. Woodman RJ, Playford DA, Watts GF, Cheetham C, Reed C, Taylor RR, Puddey IB, Beilin LJ, Burke V, Mori TA, Green D. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J Appl Physiol 91: 929-937, 2001.
41. Zarrinkoob L, Ambarki K, Wåhlin A, Birgander R, Eklund A, Malm J. Blood flow distribution in cerebral arteries. J Cereb Blood Flow Methods 35: 648-654. 2015.