Does cerebral oxygen delivery limit incremental exercise performance?

Journal of Applied Physiology

Volumn 111, Issue 6, 2011, Pages 1727-1734

  Subudhi, Andrew W ^a,b   Olin, J Tod ^a,c   Dimmen, Andrew C ^a   Polaner, David M ^c   Kayser, Bengt ^d   Roach, Robert C ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Altitude; Cerebral blood flow; Cerebral oxygenation; Fatigue; Muscle oxygenation; Near infrared spectroscopy

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADULT; ANOXIA; ARTICLE; BICYCLE; BLOOD; BLOOD FLOW VELOCITY; BRAIN; BRAIN CIRCULATION; EXERCISE; EXERCISE TEST; FEMALE; HUMAN; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; ANOXIA; BICYCLING; BLOOD FLOW VELOCITY; BRAIN; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; MALE; OXYGEN; OXYGEN CONSUMPTION; YOUNG ADULT;

EID: 83655193434     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00569.2011     Document Type: Article

References (42)

1. Ainslie PN, Ashmead JC, Ide K, Morgan BJ, Poulin MJ. Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol (Lond) 566: 613-624, 2005. (Pubitemid 41030563)
2. Amann M, Calbet JAL. Convective oxygen transport and fatigue. J Appl Physiol 104: 861-870, 2008. (Pubitemid 351468817)
3. Amann M, Kayser B. Nervous system function during exercise in hypoxia. High Alt Med Biol 10: 149-164, 2009.
4. Amann M, Pegelow DF, Jacques AJ, Dempsey JA. Inspiratory muscle work in acute hypoxia influences locomotor muscle fatigue and exercise performance of healthy humans. Am J Physiol Regul Integr Comp Physiol 293: R2036-R2045, 2007. (Pubitemid 350085682)
5. Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol (Lond) 581: 389-403, 2007. (Pubitemid 46712047)
6. Babcock MA, Pegelow DF, Harms CA, Dempsey JA. Effects of respiratory muscle unloading on exercise-induced diaphragm fatigue. J Appl Physiol 93: 201-206, 2002. (Pubitemid 34686213)
7. Borg GA. Perceived exertion. Exerc Sport Sci Rev 2: 131-153, 1974.
8. Boushel R, Langberg H, Olesen J, Gonzales-Alonzo J, Bülow J, Kjaer M. Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease. Scand J Med Sci Sports 11: 213-222, 2001. (Pubitemid 33643508)
9. Cairns SP. Lactic acid and exercise performance: culprit or friend? Sports Med 36: 279-291, 2006.
10. Calbet JAL, Lundby C, Sander M, Robach P, Saltin B, Boushel R. Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans. Am J Physiol Regul Integr Comp Physiol 291: R447-R453, 2006. (Pubitemid 44035653)
11. Calbet JAL, Rådegran G, Boushel R, Saltin B. On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass. J Physiol (Lond) 587: 477-490, 2009.
12. Dempsey JA, McKenzie DC, Haverkamp HC, Eldridge MW. Update in the understanding of respiratory limitations to exercise performance in fit, active adults. Chest 134: 613-622, 2008.
13. Duncan A, Meek JH, Clemence M, Elwell CE, Tyszczuk L, Cope M, Delpy DT. Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy. Phys Med Biol 40: 295-304, 1995.
14. Graham T, Wilson BA, Sample M, Van Dijk J, Bonen A. The effects of hypercapnia on metabolic responses to progressive exhaustive work. Med Sci Sports Exerc 12: 278-284, 1980. (Pubitemid 11196498)
15. Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Dempsey JA. Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol 82: 1573-1583, 1997. (Pubitemid 27203867)
16. Harms CA, Wetter TJ, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Hanson P, Dempsey JA. Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise. J Appl Physiol 85: 609-618, 1998. (Pubitemid 28365830)
17. Hellström G, Fischer-Colbrie W, Wahlgren NG, Jogestrand T. Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol 81: 413-418, 1996. (Pubitemid 26255538)
18. Jones NL, Robertson DG, Kane JW. Difference between end-tidal and arterial PCO2 in exercise. J Appl Physiol 47: 954-960, 1979. (Pubitemid 10187509)
19. Kato T, Tsukanaka A, Harada T, Kosaka M, Matsui N. Effect of hypercapnia on changes in blood pH, plasma lactate and ammonia due to exercise. Eur J Appl Physiol 95: 400-408, 2005. (Pubitemid 41762545)
20. Kayser B, Narici M, Binzoni T, Grassi B, Cerretelli P. Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass. J Appl Physiol 76: 634-640, 1994. (Pubitemid 24075607)
21. Kory RC, Callahan R, Boren HG, Syner JC. The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med 30: 243-258, 1961.
22. Lennox WG, Gibbs EL. The blood flow in the brain and the leg of man, and the changes induced by alteration of blood gases. J Clin Invest 11: 1155-1177, 1932.
23. Lindall A, Medina A, Grismer JT. A re-evaluation of normal pulmonary function measurements in the adult female. Am Rev Respir Dis 95: 1061-1064, 1967.
24. Lundby C, Boushel R, Robach P, Møller K, Saltin B, Calbet JAL. During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level. J Physiol (Lond) 586: 123-130, 2008.
25. McLellan TM. The influence of a respiratory acidosis on the exercise blood lactate response. Eur J Appl Physiol Occup Physiol 63: 6-11, 1991.
26. Nybo L, Rasmussen P. Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exerc Sport Sci Rev 35: 110-118, 2007. (Pubitemid 47056547)
27. Olin JT, Dimmen AC, Subudhi AW, Roach RC. Cerebral blood flow and oxygenation at maximal exercise: the effect of clamping carbon dioxide. Respir Physiol Neurobiol 175: 176-180, 2011.
28. Pedersen TH, Clausen T, Nielsen OB. Loss of force induced by high extracellular [K] in rat muscle: effect of temperature, lactic acid and beta2-agonist. J Physiol (Lond) 551: 277-286, 2003. (Pubitemid 37062928)
29. Péronnet F, Meyer T, Aguilaniu B, Juneau CE, Faude O, Kindermann W. Bicarbonate infusion and pH clamp moderately reduce hyperventilation during ramp exercise in humans. J Appl Physiol 102: 426-428, 2007. (Pubitemid 46089794)
30. Rasmussen P, Nielsen J, Overgaard M, Krogh-Madsen R, Gjedde A, Secher NH, Petersen NC. Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol (Lond) 588: 1985-1995, 2010.
31. Rasmussen P, Dawson EA, Nybo L, van Lieshout JJ, Secher NH, Gjedde A. Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27: 1082-1093, 2007. (Pubitemid 46659036)
32. Roach RC, Koskolou MD, Calbet JA, Saltin B. Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol Heart Circ Physiol 276: H438-H445, 1999. (Pubitemid 29100610)
33. Romer LM, Polkey MI. Exercise-induced respiratory muscle fatigue: implications for performance. J Appl Physiol 104: 879-888, 2008. (Pubitemid 351468819)
34. Seifert T, Rasmussen P, Secher NH, Nielsen HB. Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade. Acta Physiol (Oxf) 196: 295-302, 2009.
35. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31: 1672-1678, 2000. (Pubitemid 30437522)
36. St. Clair Gibson A, Noakes TD. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med 38: 797-806, 2004. (Pubitemid 39611568)
37. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol 103: 177-183, 2007. (Pubitemid 47092290)
38. Subudhi AW, Lorenz MC, Fulco CS, Roach RC. Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294: H164-H171, 2008.
39. Subudhi AW, Miramon BR, Granger ME, Roach RC. Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106: 1153-1158, 2009.
40. van der Zee P, Cope M, Arridge SR, Essenpreis M, Potter LA, Edwards AD, Wyatt JS, McCormick DC, Roth SC, Reynolds EO. Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of inter optode spacing. Adv Exp Med Biol 316: 143-153, 1992. (Pubitemid 23042476)
41. Vianna LG, Koulouris N, Lanigan C, Moxham J. Effect of acute hypercapnia on limb muscle contractility in humans. J Appl Physiol 69: 1486-1493, 1990. (Pubitemid 20361272)
42. Vogiatzis I, Louvaris Z, Habazettl H, Athanasopoulos D, Andrianopoulos V, Cherouveim E, Wagner H, Roussos C, Wagner PD, Zakynthinos SG. Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes. J Physiol 589: 4027-4039, 2011.